Products

Refine

Country

Business Type

Certificate

Display

Huaian Yishu techonology Co.,Ltd

Name:4-nitrobenzyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate CAS:74288-40-7 Molecular structure : Molecular Formula:C16H16N2O7 Molecular weight:348.32 Melting point:109~ 114°C Appearan

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

EAST CHEMSOURCES LIMITED

B-CHETO English name: B-CHETO Chemical name: [5R-(5α,6α(R*))]-6-(1-hydroxyethyl)-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (4-nitrophenyl)methyl ester Category invol

B-CHETO

Cas:74288-40-7

Min.Order:1 Kilogram

FOB Price: $2.0 / 3.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate

Cas:74288-40-7

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Hebei yanxi chemical co.,LTD.

Sleeping pills and stability.This product is white or white crystalline powder;Odourless and slightly bitter taste.Almost insoluble in water, soluble in hydrochloric acid.In acid or alkali and heat hydrolysis, oral drug under the action of gastric

(5R,6S)-4-Nitrobenzyl 6-((R)-1-hydroxyethyl)-3,7-dioxo-1-azabicyclo[3....

Cas:74288-40-7

Min.Order:10000 Gram

FOB Price: $1300.0

Type:Trading Company

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate

Cas:74288-40-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 74288-40-7 with competitive price

Cas:74288-40-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Henan Sinotech Import&Export Corporation

nglish name: Imipenem intermediate ADC-13 Synonyms: 6-[(1R)-1-Hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (5R,6S)-(4-nitrophenyl)methyl ester; ADC 13 CAS NO.:

BCK,KETO

Cas:74288-40-7

Min.Order:100 Gram

FOB Price: $1.0

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

Appearance white or almost white crystalline powder Assay,on dry base 98%min Purity 98%min Melting point

BCK (Mother Nuclide of Imipenem)

Cas:74288-40-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white solid Storage:Store in sealed containers at cool & dry

Carbapenems intermediates CAS No. 74288-40-7

Cas:74288-40-7

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

74288-40-7 Package:As per buy's request ISO/SGS/REACH Certificate Fast Delivery Package:1kg-200KG Drum With Pallet Port:China Main Port

74288-40-7 p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-

Cas:74288-40-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

BCK (Mother Nuclide of Imipenem) 74288-40-7

Cas:74288-40-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate CAS:74288-40-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of ch

p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate CAS:74288-40-7

Cas:74288-40-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

BCK (Mother Nuclide of Imipenem)

Cas:74288-40-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

4-nitrobenzyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate

Cas:74288-40-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

BCK (Mother Nuclide of Imipenem)

Cas:74288-40-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-nitrobenzyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate

Cas:74288-40-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

4-NITROBENZYL (5R,6S)-6-[(1R)-1-HYDROXYETHYL]-3,7-DIOXO-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLATE

Cas:74288-40-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate

Cas:74288-40-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Sulfometuron methyl ester

Cas:74288-40-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate/High quality/Best price

Cas:74288-40-7

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(5R,6S)-6-[(1R)-1-Hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (4-nitrophenyl)-methyl ester

Cas:74288-40-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

4-nitrobenzyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylate

Cas:74288-40-7

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

p-Nitrobenzyl-6-(1-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate

Cas:74288-40-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(3S,4R)-3-[(R)-1-hydroxyethyl)-4-[3-(4-nitrobenzyl)oxycarbonyl-2-oxo-3-diazopropyl]azetidin-2-one
74288-39-4

(3S,4R)-3-[(R)-1-hydroxyethyl)-4-[3-(4-nitrobenzyl)oxycarbonyl-2-oxo-3-diazopropyl]azetidin-2-one

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

Conditions
ConditionsYield
With dirhodium tetraacetate In toluene at 80℃; for 2.5h; Cyclization;
rhodium (II) octanoate dimer In dichloromethane for 4 - 5h; Heating / reflux;
With nitrogen; rhodium(II) acetate In benzene
rhodium(II) acetate

rhodium(II) acetate

(3S,4R)-3-[(R)-1-hydroxyethyl)-4-[3-(4-nitrobenzyl)oxycarbonyl-2-oxo-3-diazopropyl]azetidin-2-one
74288-39-4

(3S,4R)-3-[(R)-1-hydroxyethyl)-4-[3-(4-nitrobenzyl)oxycarbonyl-2-oxo-3-diazopropyl]azetidin-2-one

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

Conditions
ConditionsYield
In toluene
(3S,4R)-3-[(R)-1-hydroxyethyl]-4-[3-(4-nitrobenzyl)oxycarbonyl-2-oxo-3-diazopropyl]azetidin-2one

(3S,4R)-3-[(R)-1-hydroxyethyl]-4-[3-(4-nitrobenzyl)oxycarbonyl-2-oxo-3-diazopropyl]azetidin-2one

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

Conditions
ConditionsYield
With nitrogen; rhodium(II) acetate In benzene
(3S,4R)-benzyl N-(p-toluenesulfonyl)-3-((R)-1-(tert-butyldimethylsilyloxy)ethyl)-azetidin-2-one-4-carboxylate
1180012-46-7

(3S,4R)-benzyl N-(p-toluenesulfonyl)-3-((R)-1-(tert-butyldimethylsilyloxy)ethyl)-azetidin-2-one-4-carboxylate

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: samarium diiodide; samarium; isopropyl alcohol
2: 10% palladium on activated charcoal; hydrogen / tetrahydrofuran
3: lead(IV) tetraacetate / N,N-dimethyl-formamide
4: zinc(II) chloride / dichloromethane
5: hydrogenchloride; methanol
6: dirhodium tetraacetate / toluene
View Scheme
(3S,4R)-benzyl 3-((R)-1-(tert-butyldimethylsilyloxy)ethyl)-azetidin-2-one-4-carboxylate
1180012-50-3

(3S,4R)-benzyl 3-((R)-1-(tert-butyldimethylsilyloxy)ethyl)-azetidin-2-one-4-carboxylate

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 10% palladium on activated charcoal; hydrogen / tetrahydrofuran
2: lead(IV) tetraacetate / N,N-dimethyl-formamide
3: zinc(II) chloride / dichloromethane
4: hydrogenchloride; methanol
5: dirhodium tetraacetate / toluene
View Scheme
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: zinc(II) chloride / dichloromethane
2: hydrogenchloride; methanol
3: dirhodium tetraacetate / toluene
View Scheme
4-nitrobenzyl 3-((tert-butyldimethylsilyl)oxy)-2-diazobut-3-enoate
93788-48-8

4-nitrobenzyl 3-((tert-butyldimethylsilyl)oxy)-2-diazobut-3-enoate

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: zinc(II) chloride / dichloromethane
2: hydrogenchloride; methanol
3: dirhodium tetraacetate / toluene
View Scheme
(3S,4R)-3-<(R)-1'-(dimethyl-t-butylsilyloxy)ethyl>-4-oxoazetidin-2-carboxylic acid
115936-64-6

(3S,4R)-3-<(R)-1'-(dimethyl-t-butylsilyloxy)ethyl>-4-oxoazetidin-2-carboxylic acid

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: lead(IV) tetraacetate / N,N-dimethyl-formamide
2: zinc(II) chloride / dichloromethane
3: hydrogenchloride; methanol
4: dirhodium tetraacetate / toluene
View Scheme
(3S,4R)-3-[(1R)-(tert-butyldimethyl-silyloxy)ethyl]-4-[3-(4-nitrobenzyloxy)carbonyl-2-oxo-3-diazopropyl]azetidin-2-one
93861-39-3

(3S,4R)-3-[(1R)-(tert-butyldimethyl-silyloxy)ethyl]-4-[3-(4-nitrobenzyloxy)carbonyl-2-oxo-3-diazopropyl]azetidin-2-one

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride; methanol
2: dirhodium tetraacetate / toluene
View Scheme
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

ethyl 2-sulfanylacetate
623-51-8

ethyl 2-sulfanylacetate

(5R,6S)-4-nitrobenzyl 3-((2-ethoxy-2-oxoethyl)thio)-6-((R)-1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

(5R,6S)-4-nitrobenzyl 3-((2-ethoxy-2-oxoethyl)thio)-6-((R)-1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

Conditions
ConditionsYield
Stage #1: (5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester With N-ethyl-N,N-diisopropylamine; chlorophosphoric acid diphenyl ester In acetonitrile at 0℃; for 0.75h;
Stage #2: ethyl 2-sulfanylacetate With N-ethyl-N,N-diisopropylamine In acetonitrile at 0℃; for 1h;
74%
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

chlorophosphoric acid diphenyl ester
2524-64-3

chlorophosphoric acid diphenyl ester

(S)-4-mercapto-2-oxoppyrrolidine

(S)-4-mercapto-2-oxoppyrrolidine

4-nitrobenzyl (5R,6S)-6-[(R)-1-hydroxyethyl]-2-[(R)-5-oxopyrrolidin-3-ylthio]-1-carbapen-2-em-3-carboxylate

4-nitrobenzyl (5R,6S)-6-[(R)-1-hydroxyethyl]-2-[(R)-5-oxopyrrolidin-3-ylthio]-1-carbapen-2-em-3-carboxylate

Conditions
ConditionsYield
Stage #1: (5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester; chlorophosphoric acid diphenyl ester With N-ethyl-N,N-diisopropylamine In acetonitrile for 2h; Substitution;
Stage #2: (S)-4-mercapto-2-oxoppyrrolidine With N-ethyl-N,N-diisopropylamine In acetonitrile for 1h; Substitution;
67%
t-butyldimethylsiyl triflate
69739-34-0

t-butyldimethylsiyl triflate

(E)-(4-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)phenyl)methanol

(E)-(4-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)phenyl)methanol

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

(5R,6S)-4-nitrobenzyl 6-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-3-((E)-4-(hydroxymethyl)styryl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

(5R,6S)-4-nitrobenzyl 6-((R)-1-((tert-butyldimethylsilyl)oxy)ethyl)-3-((E)-4-(hydroxymethyl)styryl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

Conditions
ConditionsYield
Stage #1: (5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester With trifluoromethylsulfonic anhydride; triethylamine In dichloromethane at -78℃; for 0.5h; Inert atmosphere;
Stage #2: t-butyldimethylsiyl triflate In dichloromethane at -78℃; for 0.5h; Inert atmosphere;
Stage #3: (E)-(4-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)phenyl)methanol With tris-(dibenzylideneacetone)dipalladium(0); potassium hydroxide In dichloromethane; water; N,N-dimethyl-formamide at -78 - 30℃; for 1h; Inert atmosphere;
59%
p-hydroxymethylphenylboronic acid
59016-93-2

p-hydroxymethylphenylboronic acid

Triethylsilyl trifluoromethanesulfonate
79271-56-0

Triethylsilyl trifluoromethanesulfonate

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

(5R,6S)-4-nitrobenzyl 3-(4-(hydroxymethyl)phenyl)-7-oxo-6-((R)-1-((triethylsilyl)oxy)ethyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

(5R,6S)-4-nitrobenzyl 3-(4-(hydroxymethyl)phenyl)-7-oxo-6-((R)-1-((triethylsilyl)oxy)ethyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

Conditions
ConditionsYield
Stage #1: (5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester With trifluoromethylsulfonic anhydride; triethylamine In dichloromethane at -78℃; for 0.5h; Inert atmosphere;
Stage #2: triethylsilyl trifluoromethyl sulfonate In dichloromethane at -78℃; for 1h; Inert atmosphere;
Stage #3: p-hydroxymethylphenylboronic acid With tris-(dibenzylideneacetone)dipalladium(0); potassium hydroxide In water; N,N-dimethyl-formamide at -78 - 30℃; for 1.5h; Inert atmosphere;
33%
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

trimethylsilyl trifluoromethanesulfonate
27607-77-8

trimethylsilyl trifluoromethanesulfonate

tributylethynyltin
994-89-8

tributylethynyltin

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

(5R,6S)-3-Ethynyl-7-oxo-6-((R)-1-trimethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester

(5R,6S)-3-Ethynyl-7-oxo-6-((R)-1-trimethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-nitro-benzyl ester

Conditions
ConditionsYield
Stage #1: trifluoromethylsulfonic anhydride; (5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester With diisopropylamine In tetrahydrofuran at -78℃; for 0.25h; Addition;
Stage #2: trimethylsilyl trifluoromethanesulfonate With triethylamine In tetrahydrofuran at -78℃; for 0.333333h; Etherification;
Stage #3: tributylethynyltin With trifuran-2-yl-phosphane; tris-(dibenzylideneacetone)dipalladium(0); zinc(II) chloride In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; diethyl ether at 20℃; for 2h; Addition; Stille coupling;
32%
cis-1-cyano-4-mercaptocyclohexane
105675-99-8

cis-1-cyano-4-mercaptocyclohexane

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate
105693-26-3

p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

Conditions
ConditionsYield
With diisopropylamine; chlorophosphoric acid diphenyl ester 1) CH3CN, 0 to 5 deg C, 1 h, 2) CH3CN, RT, 20 h; Yield given. Multistep reaction;
cis-3-mercaptocyclopentanecarboxamide
105676-07-1

cis-3-mercaptocyclopentanecarboxamide

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate
105675-86-3, 105814-13-9

p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

Conditions
ConditionsYield
With diisopropylamine; chlorophosphoric acid diphenyl ester 1) CH3CN, 0 to 5 deg C, 1 h, 2) DMF, RT, 3 d; Yield given. Multistep reaction;
cis-4-mercaptocyclohexanecarboxamide
105676-08-2

cis-4-mercaptocyclohexanecarboxamide

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate
105675-88-5

p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

Conditions
ConditionsYield
With diisopropylamine; chlorophosphoric acid diphenyl ester 1) CH3CN, 0 to 5 deg C, 1 h, 2) DMF, RT, 3 d; Yield given. Multistep reaction;
cis-3-mercapto-1-(p-nitrobenzyloxycarboxylamino)cyclopentane
105675-97-6

cis-3-mercapto-1-(p-nitrobenzyloxycarboxylamino)cyclopentane

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate
105676-04-8, 105814-12-8

p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

Conditions
ConditionsYield
With diisopropylamine; chlorophosphoric acid diphenyl ester 1) CH3CN, 0 to 5 deg C, 1 h, 2) CH3CN, RT, 20 h; Yield given. Multistep reaction;
cis-4-mercapto-1-(p-nitrobenzyloxycarbonylamino)cyclohexane
105675-98-7

cis-4-mercapto-1-(p-nitrobenzyloxycarbonylamino)cyclohexane

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate
105675-87-4

p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

Conditions
ConditionsYield
With diisopropylamine; chlorophosphoric acid diphenyl ester 1) CH3CN, 0 to 5 deg C, 1 h, 2) CH3CN, RT, 6 d; Yield given. Multistep reaction;
cis-4-(p-nitrobenzyloxycarbonylaminomethyl)cyclohexylthiol
105676-03-7

cis-4-(p-nitrobenzyloxycarbonylaminomethyl)cyclohexylthiol

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate
105693-27-4

p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

Conditions
ConditionsYield
With diisopropylamine; chlorophosphoric acid diphenyl ester 1) CH3CN, 0 to 5 deg C, 1 h, 2) DMF, RT, 6 d; Yield given. Multistep reaction;
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

p-nitrobenzyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-2-trifluoromethylsulphonyloxy-carbapen-2-em-3carboxylate
135439-84-8

p-nitrobenzyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-2-trifluoromethylsulphonyloxy-carbapen-2-em-3carboxylate

Conditions
ConditionsYield
With diisopropylamine In tetrahydrofuran at -70℃; for 0.5h; Addition; Title compound not separated from byproducts;
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

chlorophosphoric acid diphenyl ester
2524-64-3

chlorophosphoric acid diphenyl ester

p-nitrobenzyl (5R,6S)-2-diphenoxy phosphoryloxy-6-[(R)-1-hydroxyethyl]-1-carbapen-2-em-3-carboxylate
75321-08-3

p-nitrobenzyl (5R,6S)-2-diphenoxy phosphoryloxy-6-[(R)-1-hydroxyethyl]-1-carbapen-2-em-3-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 0℃; for 1h; Addition;
With dmap; N-ethyl-N,N-diisopropylamine In acetonitrile
p-toluenesulfonylanhydride
4124-41-8

p-toluenesulfonylanhydride

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

(5R,6S)-6-((R)-1-Hydroxy-ethyl)-7-oxo-3-(toluene-4-sulfonyloxy)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester
80735-70-2

(5R,6S)-6-((R)-1-Hydroxy-ethyl)-7-oxo-3-(toluene-4-sulfonyloxy)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at -60 - 0℃;
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

(5R,6S)-6-((R)-1-Hydroxy-ethyl)-3-methoxy-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

(5R,6S)-6-((R)-1-Hydroxy-ethyl)-3-methoxy-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Conditions
ConditionsYield
In 1,4-dioxane at 20℃; Methylation;
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

(5R,6S)-6-((R)-1-Hydroxy-ethyl)-3-methoxy-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid

(5R,6S)-6-((R)-1-Hydroxy-ethyl)-3-methoxy-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dioxane / 20 °C
2: H2 / 10 percent Pd/C / ethyl acetate / 0 °C
View Scheme
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

(5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-7-oxo-3-phenyl-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

(5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-7-oxo-3-phenyl-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Et3N / CH2Cl2 / -60 - 0 °C
2: Et3N / CH2Cl2 / 12 h / -70 °C
3: 67 percent / Bu4N(+)Cl(-), K2CO3 / PdCl2(dppf) / tetrahydrofuran; H2O; CH2Cl2 / 1.67 h / 30 °C
View Scheme
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

(5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-7-oxo-3-(toluene-4-sulfonyloxy)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester
226700-71-6

(5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-7-oxo-3-(toluene-4-sulfonyloxy)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Et3N / CH2Cl2 / -60 - 0 °C
2: Et3N / CH2Cl2 / 12 h / -70 °C
View Scheme
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

(5R,6S)-2-[(2S,4S)-2-carbamoyl-1,1-dimethylpyrrolidinio-4-ylthio]-6-[(R)-1-hydroxyethyl]-1-carbapen-2-em-3-carboxylate

(5R,6S)-2-[(2S,4S)-2-carbamoyl-1,1-dimethylpyrrolidinio-4-ylthio]-6-[(R)-1-hydroxyethyl]-1-carbapen-2-em-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N,N-diisopropylethylamine / acetonitrile / 1 h / 0 °C
2: N,N-diisopropylethylamine / acetonitrile
3: H2 / 10 percent Pd-C / tetrahydrofuran; aq. phosphate buffer / 2.5 h / 20 °C / pH 7
View Scheme
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

(2S,4S)-2-Carbamoyl-4-[(5R,6S)-6-((R)-1-hydroxy-ethyl)-2-(4-nitro-benzyloxycarbonyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-en-3-ylsulfanyl]-1,1-dimethyl-pyrrolidinium

(2S,4S)-2-Carbamoyl-4-[(5R,6S)-6-((R)-1-hydroxy-ethyl)-2-(4-nitro-benzyloxycarbonyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-en-3-ylsulfanyl]-1,1-dimethyl-pyrrolidinium

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-diisopropylethylamine / acetonitrile / 1 h / 0 °C
2: N,N-diisopropylethylamine / acetonitrile
View Scheme
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

p-nitrobenzyl (5R,6S)-2-ethynyl-6-[(1R)-1-hydroxyethyl]carbapen-2-em-3-carboxylate
1026234-25-2

p-nitrobenzyl (5R,6S)-2-ethynyl-6-[(1R)-1-hydroxyethyl]carbapen-2-em-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: diisopropylamine / tetrahydrofuran / 0.25 h / -78 °C
1.2: Et3N / tetrahydrofuran / 0.33 h / -78 °C
1.3: 32 percent / tri(2-furyl)phosphine / tris(dibenzylideneacetone)dipalladium; ZnCl2 / 1-methyl-pyrrolidin-2-one; tetrahydrofuran; diethyl ether / 2 h / 20 °C
2.1: 85 percent / AcOH; aq. Bu4NF / tetrahydrofuran / 1.75 h / 0 - 20 °C
View Scheme
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

(5R,6S)-6-((R)-1-Hydroxy-ethyl)-7-oxo-3-thiazol-4-yl-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

(5R,6S)-6-((R)-1-Hydroxy-ethyl)-7-oxo-3-thiazol-4-yl-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diisopropylamine / tetrahydrofuran / 0.5 h / -70 °C
2: Ph3As / ZnCl2, LiCl; tris(dibenzylideneacetone)dipalladium / tetrahydrofuran / 3 h / 20 °C
View Scheme
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

(5R,6S)-6-((R)-1-Hydroxy-ethyl)-7-oxo-3-thiazol-5-yl-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester
1025902-20-8

(5R,6S)-6-((R)-1-Hydroxy-ethyl)-7-oxo-3-thiazol-5-yl-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diisopropylamine / tetrahydrofuran / 0.5 h / -70 °C
2: Ph3As / ZnCl2, LiCl; tris(dibenzylideneacetone)dipalladium / tetrahydrofuran / 3 h / 20 °C
View Scheme
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

p-Nitrobenzyl-(5R,6S)-6-[(1R)-hydroxyethyl]-2-(1-methylpyrazol-3-yl)-carbapen-2-em-3-carboxylate
165743-32-8

p-Nitrobenzyl-(5R,6S)-6-[(1R)-hydroxyethyl]-2-(1-methylpyrazol-3-yl)-carbapen-2-em-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diisopropylamine / tetrahydrofuran / 0.5 h / -70 °C
2: Ph3As / ZnCl2, LiCl; tris(dibenzylideneacetone)dipalladium / tetrahydrofuran / 3 h / 20 °C
View Scheme
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

(5R,6S)-6-((R)-1-Hydroxy-ethyl)-3-(3-methyl-isoxazol-5-yl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester
1025809-56-6

(5R,6S)-6-((R)-1-Hydroxy-ethyl)-3-(3-methyl-isoxazol-5-yl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: diisopropylamine / tetrahydrofuran / 0.25 h / -78 °C
1.2: Et3N / tetrahydrofuran / 0.33 h / -78 °C
1.3: 32 percent / tri(2-furyl)phosphine / tris(dibenzylideneacetone)dipalladium; ZnCl2 / 1-methyl-pyrrolidin-2-one; tetrahydrofuran; diethyl ether / 2 h / 20 °C
2.1: 85 percent / AcOH; aq. Bu4NF / tetrahydrofuran / 1.75 h / 0 - 20 °C
3.1: Et3N / CH2Cl2; hexane / 1 h / 20 °C
View Scheme
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

(5R,6S)-6-((R)-1-Hydroxy-ethyl)-3-(3-isopropyl-isoxazol-5-yl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester
1026821-85-1

(5R,6S)-6-((R)-1-Hydroxy-ethyl)-3-(3-isopropyl-isoxazol-5-yl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: diisopropylamine / tetrahydrofuran / 0.25 h / -78 °C
1.2: Et3N / tetrahydrofuran / 0.33 h / -78 °C
1.3: 32 percent / tri(2-furyl)phosphine / tris(dibenzylideneacetone)dipalladium; ZnCl2 / 1-methyl-pyrrolidin-2-one; tetrahydrofuran; diethyl ether / 2 h / 20 °C
2.1: 85 percent / AcOH; aq. Bu4NF / tetrahydrofuran / 1.75 h / 0 - 20 °C
3.1: Et3N / CH2Cl2; hexane / 1 h / 20 °C
View Scheme
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

(5R,6S)-6-((R)-1-Hydroxy-ethyl)-3-(3-methoxymethyl-isoxazol-5-yl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester
1025968-65-3

(5R,6S)-6-((R)-1-Hydroxy-ethyl)-3-(3-methoxymethyl-isoxazol-5-yl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diisopropylamine / tetrahydrofuran / 0.5 h / -70 °C
2: Ph3As / ZnCl2, LiCl; tris(dibenzylideneacetone)dipalladium / tetrahydrofuran / 3 h / 20 °C
View Scheme
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

p-nitrobenzyl (5R,6S)-6-[(1R)-hydroxyethyl]-2-(1-phenylpyrazol-3-yl)-carbapen-2-em-3-carboxylate
165743-30-6

p-nitrobenzyl (5R,6S)-6-[(1R)-hydroxyethyl]-2-(1-phenylpyrazol-3-yl)-carbapen-2-em-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diisopropylamine / tetrahydrofuran / 0.5 h / -70 °C
2: 67 percent / Ph3As / ZnCl2, LiCl; tris(dibenzylideneacetone)dipalladium / tetrahydrofuran / 3 h / 20 °C
View Scheme
(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester
74288-40-7

(5R,6S)-6-[(R)-1-hydroxyethyl]-3,7-dioxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid p-nitrobenzyl ester

p-nitrobenzyl (5R,6S)-2-[3-(phenyl)isoxazol-5-yl]-6-[(1R)-1-hydroxyethyl]carbapen-2-em-3-carboxylate
204385-18-2

p-nitrobenzyl (5R,6S)-2-[3-(phenyl)isoxazol-5-yl]-6-[(1R)-1-hydroxyethyl]carbapen-2-em-3-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: diisopropylamine / tetrahydrofuran / 0.25 h / -78 °C
1.2: Et3N / tetrahydrofuran / 0.33 h / -78 °C
1.3: 32 percent / tri(2-furyl)phosphine / tris(dibenzylideneacetone)dipalladium; ZnCl2 / 1-methyl-pyrrolidin-2-one; tetrahydrofuran; diethyl ether / 2 h / 20 °C
2.1: 85 percent / AcOH; aq. Bu4NF / tetrahydrofuran / 1.75 h / 0 - 20 °C
3.1: 62 percent / Et3N / CH2Cl2; hexane / 1 h / 20 °C
View Scheme

Downstream Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View