Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:760937-92-6
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inquiryDayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. Near 20 years DayangChem has provided dif
Cas:760937-92-6
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryWe are a professional chemicals, APIs and plant extract leading manufacturer in China. We are specialized in chemical synthesis, process development of pharmaceutical intermediates, active pharmaceutical ingredients (APIs), plant extract and rare c
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inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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Type:Trading Company
inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv
Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
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Type:Trading Company
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryTeneligliptin CAS:760937-92-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermedia
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryAppearance:white powders Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/Couri
Teneligliptin is one of the most competitive products in our company, we can supply it with good quality and best price. Appearance:off-white solid Storage:Room temperature, Keep in Dark Place. Package:According to the demand of customer Application:
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryProduct name: Tenaligliptin CAS No.:760937-92-6 Molecule Formula:C22H30N6OS Molecule Weight:426.58 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS
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Min.Order:1 Kilogram
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Type:Trading Company
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Type:Lab/Research institutions
inquirySAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
tert-butyl (2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidine-1-carboxylate
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Stage #1: tert-butyl (2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]-2-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidine-1-carboxylate With trifluoroacetic acid In dichloromethane at 20℃; for 19h; Stage #2: With sodium hydrogencarbonate In water | 93% |
With ethyl acetate; trifluoroacetic acid In dichloromethane at 20℃; for 19h; | 93% |
With hydrogenchloride at 20 - 40℃; Reagent/catalyst; |
tert-butyl 4-(3-oxobutanoyl)piperazine-1-carboxylate
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: methanesulfonic acid / ethanol / 14 h / 20 °C 1.2: 20 h / 20 °C / pH 3 2.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C 3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 13 h / 20 °C 4.1: ethyl acetate; trifluoroacetic acid / dichloromethane / 19 h / 20 °C View Scheme |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C 2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 13 h / 20 °C 3: ethyl acetate; trifluoroacetic acid / dichloromethane / 19 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: trifluoroacetic acid / dichloromethane / 1.5 h / 25 - 30 °C 1.2: 0 - 5 °C 2.1: sodium tris(acetoxy)borohydride / dichloromethane / 25 - 30 °C 3.1: piperidine / dichloromethane / 25 - 30 °C View Scheme | |
Multi-step reaction with 3 steps 1: trifluoroacetic acid / methanol 2: sodium tris(acetoxy)borohydride / toluene; tetrahydrofuran / 20 - 40 °C 3: hydrogenchloride / 20 - 40 °C View Scheme |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 13 h / 20 °C 2: ethyl acetate; trifluoroacetic acid / dichloromethane / 19 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride / toluene; tetrahydrofuran / 20 - 40 °C 2: hydrogenchloride / 20 - 40 °C View Scheme |
1-Phenyl-3-methyl-5-aminopyrazole
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 5 °C 1.2: 0 - 30 °C 1.3: 2 h / 0 - 5 °C 2.1: sodium tris(acetoxy)borohydride / dichloromethane / 25 - 30 °C 3.1: piperidine / dichloromethane / 25 - 30 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 5 °C 1.2: 0 - 30 °C 2.1: trifluoroacetic acid / dichloromethane / 1.5 h / 25 - 30 °C 2.2: 0 - 5 °C 3.1: sodium tris(acetoxy)borohydride / dichloromethane / 25 - 30 °C 4.1: piperidine / dichloromethane / 25 - 30 °C View Scheme |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
With piperidine In dichloromethane at 25 - 30℃; | 10.5 g |
4R-4-hydroxyproline
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: water / 3 h / 40 - 50 °C 2.1: benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 0.5 h / 0 - 5 °C 2.2: 24 h / 25 - 30 °C 3.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane / 2 h / 0 - 5 °C 4.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 25 - 30 °C 5.1: hydrogen bromide / water; isopropyl alcohol / 16 h / 80 - 85 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: sodium hydrogencarbonate / water; tetrahydrofuran / 25 - 30 °C 2.1: benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 0.5 h / 0 - 5 °C 2.2: 24 h / 25 - 30 °C 3.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 5 °C 4.1: sodium tris(acetoxy)borohydride / dichloromethane / 25 - 30 °C 5.1: piperidine / dichloromethane / 25 - 30 °C View Scheme |
oxaceprol
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 0.5 h / 0 - 5 °C 1.2: 24 h / 25 - 30 °C 2.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane / 2 h / 0 - 5 °C 3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 25 - 30 °C 4.1: hydrogen bromide / water; isopropyl alcohol / 16 h / 80 - 85 °C View Scheme |
N-Fmoc-trans-4-Hydroxy-L-Proline
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 0.5 h / 0 - 5 °C 1.2: 24 h / 25 - 30 °C 2.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 5 °C 3.1: sodium tris(acetoxy)borohydride / dichloromethane / 25 - 30 °C 4.1: piperidine / dichloromethane / 25 - 30 °C View Scheme |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 5 °C 2: sodium tris(acetoxy)borohydride / dichloromethane / 25 - 30 °C 3: piperidine / dichloromethane / 25 - 30 °C View Scheme |
1-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazine acetate
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride / dichloromethane / 25 - 30 °C 2: piperidine / dichloromethane / 25 - 30 °C View Scheme |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine; sulfur trioxide pyridine complex / dichloromethane / 2 h / 0 - 5 °C 2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 25 - 30 °C 3: hydrogen bromide / water; isopropyl alcohol / 16 h / 80 - 85 °C View Scheme |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 25 - 30 °C 2: hydrogen bromide / water; isopropyl alcohol / 16 h / 80 - 85 °C View Scheme |
3-methyl-1-phenylpyrazolin-5(4H)-one
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: trichlorophosphate / 0.67 h / 10 - 30 °C 1.2: 1 h / 110 - 115 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 120 - 130 °C 3.1: sodium carbonate; toluene-4-sulfonic acid / methanol / 80 °C 4.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 25 - 30 °C 5.1: hydrogen bromide / water; isopropyl alcohol / 16 h / 80 - 85 °C View Scheme |
5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 120 - 130 °C 2: sodium carbonate; toluene-4-sulfonic acid / methanol / 80 °C 3: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 25 - 30 °C 4: hydrogen bromide / water; isopropyl alcohol / 16 h / 80 - 85 °C View Scheme |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium carbonate; toluene-4-sulfonic acid / methanol / 80 °C 2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 25 - 30 °C 3: hydrogen bromide / water; isopropyl alcohol / 16 h / 80 - 85 °C View Scheme |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
With hydrogen bromide In water; isopropyl alcohol at 80 - 85℃; for 16h; Time; | 0.360 g |
phenylhydrazine
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: hydrogenchloride / water / 4 h / 110 - 115 °C 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 5 °C 2.2: 0 - 30 °C 2.3: 2 h / 0 - 5 °C 3.1: sodium tris(acetoxy)borohydride / dichloromethane / 25 - 30 °C 4.1: piperidine / dichloromethane / 25 - 30 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: hydrogenchloride / water / 4 h / 110 - 115 °C 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 5 °C 2.2: 0 - 30 °C 3.1: trifluoroacetic acid / dichloromethane / 1.5 h / 25 - 30 °C 3.2: 0 - 5 °C 4.1: sodium tris(acetoxy)borohydride / dichloromethane / 25 - 30 °C 5.1: piperidine / dichloromethane / 25 - 30 °C View Scheme |
5-bromo-3-methyl-1-phenyl-1H-pyrazole
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium t-butanolate / N,N-dimethyl-formamide 2: trifluoroacetic acid / methanol 3: sodium tris(acetoxy)borohydride / toluene; tetrahydrofuran / 20 - 40 °C 4: hydrogenchloride / 20 - 40 °C View Scheme |
iodobenzene
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: pyridine / acetonitrile 2: sodium t-butanolate / N,N-dimethyl-formamide 3: trifluoroacetic acid / methanol 4: sodium tris(acetoxy)borohydride / toluene; tetrahydrofuran / 20 - 40 °C 5: hydrogenchloride / 20 - 40 °C View Scheme |
hydroxy L-proline
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sodium hydrogencarbonate / water; acetone / 20 °C 2: Jones reagent / acetone 3: formaldehyd; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / -10 - 20 °C 4: sodium tris(acetoxy)borohydride / toluene; tetrahydrofuran / 20 - 40 °C 5: hydrogenchloride / 20 - 40 °C View Scheme |
N-tert-butoxycarbonyl-L-cis-4-hydroxyproline
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: Jones reagent / acetone 2: formaldehyd; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / -10 - 20 °C 3: sodium tris(acetoxy)borohydride / toluene; tetrahydrofuran / 20 - 40 °C 4: hydrogenchloride / 20 - 40 °C View Scheme |
N-tert-butoxycarbonyl-4-oxo-L-proline
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: formaldehyd; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / -10 - 20 °C 2: sodium tris(acetoxy)borohydride / toluene; tetrahydrofuran / 20 - 40 °C 3: hydrogenchloride / 20 - 40 °C View Scheme |
(2S)-4-oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic acid tert-butyl ester
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride / toluene; tetrahydrofuran / 20 - 40 °C 2: hydrogenchloride / 20 - 40 °C View Scheme |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
With sodium carbonate In dichloromethane; water for 0.5h; |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
With hydrogen bromide at 30 - 50℃; | 96% |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
With sulfuric acid In tetrahydrofuran; water at 20℃; for 0.5h; | 94% |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
(R)-10-camphorsulfonic acid
Conditions | Yield |
---|---|
In tetrahydrofuran; tert-butyl methyl ether at 20℃; for 1h; | 91% |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
With hydrogen bromide In ethanol at 20℃; for 2h; Reflux; | 90% |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
3,4,5-trihydroxybenzoic acid
Conditions | Yield |
---|---|
In isopropyl alcohol at 20℃; for 1h; | 85% |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
toluene-4-sulfonic acid
Conditions | Yield |
---|---|
In isopropyl alcohol at 20℃; for 1.5h; | 82% |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
benzenesulfonic acid
Conditions | Yield |
---|---|
In isopropyl alcohol at 20℃; for 1h; | 80% |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
L-Tartaric acid
Conditions | Yield |
---|---|
In isopropyl alcohol at 20℃; for 3h; | 78% |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
(2E)-but-2-enedioic acid
Conditions | Yield |
---|---|
In ethanol at 0 - 20℃; for 2h; | 77% |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
1-naphthalenesulfonic acid
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 3h; | 75% |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
naphthalene-2-sulfonate
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 12h; | 74% |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
methanesulfonic acid
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 1.5h; | 72% |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
methanesulfonic acid
Conditions | Yield |
---|---|
In isopropyl alcohol at 20℃; for 2h; | 72% |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
maleic acid
Conditions | Yield |
---|---|
In ethanol at 20℃; for 1h; | 71% |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
(1S)-10-camphorsulfonic acid
Conditions | Yield |
---|---|
In tetrahydrofuran; tert-butyl methyl ether at 20℃; for 5h; | 58% |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
With hydrogenchloride In tetrahydrofuran; ethyl acetate at 20℃; for 1h; | 48% |
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone
Conditions | Yield |
---|---|
With hydrogen bromide In ethanol; water at 20℃; for 2h; Product distribution / selectivity; Heating / reflux; | |
With hydrogen bromide In methanol; water; tert-butyl alcohol at 70 - 75℃; for 1h; | 8 g |
With hydrogen bromide In ethanol; water at 80℃; for 0.5h; | 80 mg |
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