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HUNAN CHEMAPI BIOLOGICAL TECHNOLOGY CO.,LTD.

Hunan Kaimir Biotechnology Co., Ltd. is a professional technology company specializing in the research and production of raw materials and intermediates. In 2017, it was recognized as a high-tech enterprise and a small technological innovation giant

Sertraline

Cas:79617-96-2

Min.Order:1 Metric Ton

Negotiable

Type:Other

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Sertraline

Cas:79617-96-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Sertraline (base and/or unspecified salts)

Cas:79617-96-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Sertraline Basic information Product Name: Sertraline Synonyms: (1s-cis)-1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-n-methyl-1-naphthalenamin;1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-n-m

Sertraline_

Cas:79617-96-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 79617-96-2 with competitive price

Cas:79617-96-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1-Naphthalenamine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1S,4S)- 79617-96-2

Cas:79617-96-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Sertraline CAS:79617-96-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Sertraline CAS:79617-96-2

Cas:79617-96-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-Naphthalenamine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1S,4S)-

Cas:79617-96-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1-Naphthalenamine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1S,4S)-

Cas:79617-96-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Sertraline

Cas:79617-96-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

DB BIOTECH CO., LTD

Q1: Are you a manufacturer?Answer: Yes, we are factory founded on 2002. Q2: How to contact with us?Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours. Q3:Which kind of payment terms do yo

Factory supply sertraline powder with best price

Cas:79617-96-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Sertraline

Cas:79617-96-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

High quality Sertraline cas 79617-96-2 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality

High quality Sertraline cas 79617-96-2

Cas:79617-96-2

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Sertraline

Cas:79617-96-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Sertraline

Cas:79617-96-2

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Wuhan Xinhao Biotechnology Co., Ltd.

1. We can provide customers with "one-stop"packaging service,from research,development,production,export and so on 2. Powerful R&D strength let our technology in a leading level,forever,in turn,to provide customers with better service .

79617-96-2 in Stock Sertraline 99% Powder 79617-96-2

Cas:79617-96-2

Min.Order:100 Gram

FOB Price: $10.0 / 100.0

Type:Trading Company

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

our strengths: 1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line) 2: Various payment items accepted (Btc; MoneyGram; WU) 3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging) 4: Efficient delivery

Best price/In stock Sertraline 79617-96-2

Cas:79617-96-2

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Sertraline

Cas:79617-96-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Sertraline

Cas:79617-96-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Sertraline

Cas:79617-96-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Sertraline

Cas:79617-96-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Sertraline

Cas:79617-96-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

Sertraline

Cas:79617-96-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Sertraline

Cas:79617-96-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Sertraline

Cas:79617-96-2

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou Dawn Ray Pharmaceutical Co.,Ltd

Description: white crystalline powder, odorless Specific optical rotation :+37.5°~+42.5° Identification: Chemical iden…Appearance:white crystalline powder, odorless Storage:cool and dry Package:25kg/drum Application:Other

Sertraline

Cas:79617-96-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Sertraline

Cas:79617-96-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Sertraline

Cas:79617-96-2

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Synthetic route

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
With sodium hydroxide In water; toluene for 0.25h; pH=> 10;93%
With sodium hydroxide In water; ethyl acetate77%
With ammonium hydroxide In water pH=10;
With sodium hydroxide In water
With potassium carbonate In water at 20℃;10.9 g
[(1S,4S)-4-(3,4-dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-methyl-amine D(-)mandelate

[(1S,4S)-4-(3,4-dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-methyl-amine D(-)mandelate

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
With sodium hydroxide In water; ethyl acetate for 0.25h; pH=> 10;93%
With sodium hydroxide In water; ethyl acetate for 0.25h; pH=> 10;93%
benzyl (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl(methyl)carbamate
1346228-89-4

benzyl (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl(methyl)carbamate

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
With hydrogen In methanol; dichloromethane; water at 20℃; for 5h; Inert atmosphere;89%
(4S)-4-(3,4-dichlorophenyl)-1-tetralone
79560-19-3, 79836-44-5, 124379-29-9

(4S)-4-(3,4-dichlorophenyl)-1-tetralone

methylamine
74-89-5

methylamine

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
With titanium tetrachloride In tetrahydrofuran; diethyl ether; dichloromethane at -78 - 25℃;88%
cis-(1S,4S)-N-(tert-butoxycarbonyl)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
267884-85-5

cis-(1S,4S)-N-(tert-butoxycarbonyl)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; for 1h; deacylation;85%
C17H16Cl2IN
234448-58-9

C17H16Cl2IN

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
With tert.-butyl lithium In tetrahydrofuran; toluene at -78℃;69%
N-((1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)-N-methyl-2-(trimethylsilyl)ethane-1-sulfonamide

N-((1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)-N-methyl-2-(trimethylsilyl)ethane-1-sulfonamide

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
With cesium fluoride In N,N-dimethyl-formamide at 95℃; for 20h; diastereoselective reaction;65%
N-methylhydroxyamine hydrochloride
4229-44-1

N-methylhydroxyamine hydrochloride

(4S)-4-(3,4-dichlorophenyl)-1-tetralone
79560-19-3, 79836-44-5, 124379-29-9

(4S)-4-(3,4-dichlorophenyl)-1-tetralone

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
Stage #1: N-methylhydroxyamine hydrochloride; (4S)-4-(3,4-dichlorophenyl)-1-tetralone With sodium acetate In ethanol for 15h; Reflux;
Stage #2: With Lindlar's catalyst; hydrogen In methanol; dichloromethane at 20℃; under 760.051 Torr; for 20h;
47%
cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine
79617-95-1

cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine

Sertraline
79617-96-2

Sertraline

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

norsertraline
87857-41-8

norsertraline

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
With potassium carbonate; lithium (hydro)trimethoxyaluminate 1) MeCN, 2) THF, reflux, 40 h; Yield given. Multistep reaction;
methanol
67-56-1

methanol

C17H14Cl3NO

C17H14Cl3NO

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
With lithium (hydro)trimethoxyaluminate In tetrahydrofuran for 40h; Reduction; Methylation; Heating;10 mg
(4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-ylidene)methylamine
261776-41-4

(4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-ylidene)methylamine

A

trans-(1S,4R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
91797-60-3

trans-(1S,4R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

B

Sertraline
79617-96-2

Sertraline

C

(4R)-(3,4-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone
155748-61-1

(4R)-(3,4-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone

Conditions
ConditionsYield
With (S,S)-(ethylenebis(tetrahydroindenyl))TiF2; phenylsilane In tetrahydrofuran at 20℃; for 24h; kinetic resolution;
N-chloromethylamine
6154-14-9

N-chloromethylamine

1-(3,4-dichlorophenyl)-1,2-dihydronaphthalene
439134-50-6

1-(3,4-dichlorophenyl)-1,2-dihydronaphthalene

A

trans-(1R,4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
79951-46-5

trans-(1R,4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

B

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
Stage #1: 1-(3,4-dichlorophenyl)-1,2-dihydronaphthalene With benzo[1,3,2]dioxaborole; (S)-1-(2-(diphenylphosphanyl)naphthalen-1-yl)isoquinoline In dichloromethane at 20℃; for 12h;
Stage #2: With diethylzinc In toluene at 20℃; for 2h;
Stage #3: N-chloromethylamine In diethyl ether; water at 0℃; for 0.0833333h; Further stages.;
(S)-N-(4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene)methanamine
312620-93-2

(S)-N-(4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene)methanamine

A

trans-(1R,4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
79951-46-5

trans-(1R,4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

B

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
With hydrogen; nickel In methanol
With C32H12BF24(1-)*C36H44IrNOP(1+); hydrogen at 20℃; under 15201 Torr; for 12h; optical yield given as %ee; enantioselective reaction;
C18H13Cl2NO3

C18H13Cl2NO3

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: magnesium / tetrahydrofuran
1.2: CuBr-SMe2 / 13 / -30 - 0 °C
2.1: sodium tetrahydroborate / tetrahydrofuran; water
3.1: triethylamine
4.1: sodium iodide / acetone / Heating
5.1: tetrahydrofuran
6.1: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C
View Scheme
Multi-step reaction with 6 steps
1.1: magnesium / tetrahydrofuran
1.2: CuBr-SMe2 / 13 / -30 - 0 °C
2.1: sodium tetrahydroborate / tetrahydrofuran; water
3.1: 1H-imidazole; iodine; triphenylphosphine
4.1: hydrogenchloride
5.1: tetrahydrofuran
6.1: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C
View Scheme
C27H25Cl2NO5

C27H25Cl2NO5

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium tetrahydroborate / tetrahydrofuran; water
2: triethylamine
3: sodium iodide / acetone / Heating
4: tetrahydrofuran
5: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium tetrahydroborate / tetrahydrofuran; water
2: 1H-imidazole; iodine; triphenylphosphine
3: hydrogenchloride
4: tetrahydrofuran
5: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C
View Scheme
C18H20Cl2O3
234448-56-7

C18H20Cl2O3

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1H-imidazole; iodine; triphenylphosphine
2: hydrogenchloride
3: tetrahydrofuran
4: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C
View Scheme
Multi-step reaction with 4 steps
1: triethylamine
2: sodium iodide / acetone / Heating
3: tetrahydrofuran
4: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C
View Scheme
C18H19Cl2IO2

C18H19Cl2IO2

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride
2: tetrahydrofuran
3: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C
View Scheme
C19H22Cl2O4S

C19H22Cl2O4S

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaI / acetone / Heating
2: 100 percent / tetrahydrofuran
3: 69 percent / t-BuLi / tetrahydrofuran; toluene / -78 °C
View Scheme
C16H13Cl2IO
234448-57-8

C16H13Cl2IO

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrahydrofuran
2: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C
View Scheme
o-bromobenzaldehyde dimethyl acetal
35849-09-3

o-bromobenzaldehyde dimethyl acetal

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: magnesium / tetrahydrofuran
1.2: CuBr-SMe2 / 13 / -30 - 0 °C
2.1: sodium tetrahydroborate / tetrahydrofuran; water
3.1: triethylamine
4.1: sodium iodide / acetone / Heating
5.1: tetrahydrofuran
6.1: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C
View Scheme
Multi-step reaction with 6 steps
1.1: magnesium / tetrahydrofuran
1.2: CuBr-SMe2 / 13 / -30 - 0 °C
2.1: sodium tetrahydroborate / tetrahydrofuran; water
3.1: 1H-imidazole; iodine; triphenylphosphine
4.1: hydrogenchloride
5.1: tetrahydrofuran
6.1: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C
View Scheme
3,4-Dichlorocinnamic acid
7312-27-8

3,4-Dichlorocinnamic acid

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: pivaloyl chloride; triethylamine; lithium chloride
2.1: magnesium / tetrahydrofuran
2.2: CuBr-SMe2 / 13 / -30 - 0 °C
3.1: sodium tetrahydroborate / tetrahydrofuran; water
4.1: triethylamine
5.1: sodium iodide / acetone / Heating
6.1: tetrahydrofuran
7.1: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C
View Scheme
Multi-step reaction with 7 steps
1.1: pivaloyl chloride; triethylamine; lithium chloride
2.1: magnesium / tetrahydrofuran
2.2: CuBr-SMe2 / 13 / -30 - 0 °C
3.1: sodium tetrahydroborate / tetrahydrofuran; water
4.1: 1H-imidazole; iodine; triphenylphosphine
5.1: hydrogenchloride
6.1: tetrahydrofuran
7.1: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C
View Scheme
ortho-bromobenzaldehyde
6630-33-7

ortho-bromobenzaldehyde

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: toluene-4-sulfonic acid / methanol
2.1: magnesium / tetrahydrofuran
2.2: CuBr-SMe2 / 13 / -30 - 0 °C
3.1: sodium tetrahydroborate / tetrahydrofuran; water
4.1: triethylamine
5.1: sodium iodide / acetone / Heating
6.1: tetrahydrofuran
7.1: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C
View Scheme
Multi-step reaction with 7 steps
1.1: toluene-4-sulfonic acid / methanol
2.1: magnesium / tetrahydrofuran
2.2: CuBr-SMe2 / 13 / -30 - 0 °C
3.1: sodium tetrahydroborate / tetrahydrofuran; water
4.1: 1H-imidazole; iodine; triphenylphosphine
5.1: hydrogenchloride
6.1: tetrahydrofuran
7.1: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C
View Scheme
4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one
79560-19-3

4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: BH3*Me2S / (S)-prolinol core-containing second-generation dendrimer / tetrahydrofuran / 0.8 h
2: PCC / CH2Cl2 / 0 - 20 °C
3: TiCl4 / diethyl ether / -78 - 20 °C
4: H2; Raney-Ni / methanol
View Scheme
Multi-step reaction with 2 steps
1: 91 percent / TiCl4 / diethyl ether / -35 - 20 °C
2: (S,S)-(ethylenebis(tetrahydroindenyl))TiF2; PhSiH3 / tetrahydrofuran / 24 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: TiCl4 / toluene / 17 h / Ambient temperature
2: sodium borohydride / methanol / 1.5 h / Ambient temperature
View Scheme
(4S)-4-(3,4-dichlorophenyl)-1-tetralone
79560-19-3, 79836-44-5, 124379-29-9

(4S)-4-(3,4-dichlorophenyl)-1-tetralone

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: TiCl4 / diethyl ether / -78 - 20 °C
2: H2; Raney-Ni / methanol
View Scheme
Multi-step reaction with 4 steps
1: NaBH4 / ethanol
2: 88 percent / dppa, DBU / tetrahydrofuran
3: H2 / Pd-C / ethanol
4: 1) K2CO3, 2) LiAlH(OMe)3 / 1) MeCN, 2) THF, reflux, 40 h
View Scheme
Multi-step reaction with 2 steps
1: methanol / 6 h / Reflux
2: sodium tetrahydroborate; methanol
View Scheme
(1R,4S)-4-(3,4-dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-ol
167026-40-6

(1R,4S)-4-(3,4-dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-ol

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: PCC / CH2Cl2 / 0 - 20 °C
2: TiCl4 / diethyl ether / -78 - 20 °C
3: H2; Raney-Ni / methanol
View Scheme
Multi-step reaction with 4 steps
1: 88 percent / diphenylphosphorylazide; DBU / tetrahydrofuran / 0 - 20 °C
2: H2 / Pd/C / ethanol / 1 h
3: K2CO3 / acetonitrile / 2 h / Heating
4: 10 mg / LiAlH(OMe)3 / tetrahydrofuran / 40 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: 88 percent / dppa, DBU / tetrahydrofuran
2: H2 / Pd-C / ethanol
3: 1) K2CO3, 2) LiAlH(OMe)3 / 1) MeCN, 2) THF, reflux, 40 h
View Scheme
1-(3,4-dichlorophenyl)-1,2-dihydronaphthalene
439134-46-0

1-(3,4-dichlorophenyl)-1,2-dihydronaphthalene

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: catecholborane / (S)-QUINAP-Rh / toluene / 2 h / 20 °C
1.2: aq. H2O2; flash silica / hexane / 1 h / 0 °C
2.1: catecholborane / (S)-QUINAP-Rh / CH2Cl2 / 12 h / 20 °C
2.2: ZnEt2 / toluene / 2 h / 20 °C
2.3: H2O; diethyl ether / 0.08 h / 0 °C
View Scheme
D-dibenzylaminophenylglycinal
174023-92-8

D-dibenzylaminophenylglycinal

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 2.62 g / benzene; CH2Cl2 / 15 h / 20 °C
2: 83 percent / Mg / 4 h
3: 76 percent / LiAlH4 / tetrahydrofuran / 0 - 20 °C
4: 0.85 g / pyridinium dichromate / CH2Cl2 / 5 h / 20 °C
5: 1.0 g / tetrahydrofuran / 5 h
6: 78 percent / AlCl3 / CH2Cl2 / 1 h / 20 °C
7: H2 / Pd(OH)2 / methanol / 3 h
8: 0.162 g / methanol / 3 h
9: 84 percent / NaH / tetrahydrofuran / 6 h
10: 85 percent / TFA / CH2Cl2 / 1 h / 20 °C
View Scheme
(+)-(2R)-2-[bis(phenylmethyl)amino]-2-phenylethanol
193476-02-7

(+)-(2R)-2-[bis(phenylmethyl)amino]-2-phenylethanol

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: DMSO; oxalyl chloride; Et3N / CH2Cl2 / -78 - 0 °C
2: 2.62 g / benzene; CH2Cl2 / 15 h / 20 °C
3: 83 percent / Mg / 4 h
4: 76 percent / LiAlH4 / tetrahydrofuran / 0 - 20 °C
5: 0.85 g / pyridinium dichromate / CH2Cl2 / 5 h / 20 °C
6: 1.0 g / tetrahydrofuran / 5 h
7: 78 percent / AlCl3 / CH2Cl2 / 1 h / 20 °C
8: H2 / Pd(OH)2 / methanol / 3 h
9: 0.162 g / methanol / 3 h
10: 84 percent / NaH / tetrahydrofuran / 6 h
11: 85 percent / TFA / CH2Cl2 / 1 h / 20 °C
View Scheme
norsertraline
87857-41-8

norsertraline

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 0.162 g / methanol / 3 h
2: 84 percent / NaH / tetrahydrofuran / 6 h
3: 85 percent / TFA / CH2Cl2 / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: K2CO3 / acetonitrile / 2 h / Heating
2: 10 mg / LiAlH(OMe)3 / tetrahydrofuran / 40 h / Heating
View Scheme
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

Sertraline
79617-96-2

Sertraline

sertraline p-tosylate
630390-72-6

sertraline p-tosylate

Conditions
ConditionsYield
In ethyl acetate at 20℃;99%
In tetrahydrofuran
Sertraline
79617-96-2

Sertraline

sertraline L-tartaric acid salt

sertraline L-tartaric acid salt

Conditions
ConditionsYield
In ethyl acetate98%
Sertraline
79617-96-2

Sertraline

salicylic acid
69-72-7

salicylic acid

sertraline salicylate
928057-22-1

sertraline salicylate

Conditions
ConditionsYield
In ethanol; ethyl acetate at 25 - 30℃; for 5h;98%
Sertraline
79617-96-2

Sertraline

acrylonitrile
107-13-1

acrylonitrile

3-(((1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)(methyl)amino)propanenitrile

3-(((1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)(methyl)amino)propanenitrile

Conditions
ConditionsYield
With sodium In methanol at 55℃; for 12h; Inert atmosphere;98%
Sertraline
79617-96-2

Sertraline

citric acid
77-92-9

citric acid

(1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine citrate
836597-67-2

(1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine citrate

Conditions
ConditionsYield
In water; ethyl acetate at 0 - 60℃; for 1h; Product distribution / selectivity;97%
In propan-1-ol; isopropyl alcohol at 0 - 40℃; for 2h; Product distribution / selectivity;96%
Sertraline
79617-96-2

Sertraline

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

sertraline fumaric acid salt

sertraline fumaric acid salt

Conditions
ConditionsYield
In ethyl acetate for 48h;96%
(-)-camphor-10-sulfonic acid

(-)-camphor-10-sulfonic acid

Sertraline
79617-96-2

Sertraline

sertraline (-)-camphor-10-sulfonic acid salt

sertraline (-)-camphor-10-sulfonic acid salt

Conditions
ConditionsYield
In ethyl acetate at 20℃; for 4h;96%
Sertraline
79617-96-2

Sertraline

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In propan-1-ol at 30℃; for 1h; Product distribution / selectivity;96%
With hydrogenchloride In acetonitrile for 1h; Product distribution / selectivity;95%
With hydrogenchloride In octanol for 1h; Product distribution / selectivity;95%
(R)-Mandelic Acid
611-71-2

(R)-Mandelic Acid

Sertraline
79617-96-2

Sertraline

(cis-1S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine (R)-mandelate
244223-89-0, 79617-97-3

(cis-1S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine (R)-mandelate

Conditions
ConditionsYield
In ethanol Reflux;94%
Sertraline
79617-96-2

Sertraline

benzene-1,2-dicarboxylic acid
88-99-3

benzene-1,2-dicarboxylic acid

sertraline phthalate
928057-20-9

sertraline phthalate

Conditions
ConditionsYield
In ethanol; ethyl acetate at 25 - 30℃; for 5h;92%
(S)-Mandelic acid
17199-29-0

(S)-Mandelic acid

Sertraline
79617-96-2

Sertraline

(1S,4S)-sertraline*(S)-mandelic acid
1357380-69-8

(1S,4S)-sertraline*(S)-mandelic acid

Conditions
ConditionsYield
In ethanol; hexane Reflux;91%
Sertraline
79617-96-2

Sertraline

benzenesulfonic acid
98-11-3

benzenesulfonic acid

sertraline besylate
630390-70-4

sertraline besylate

Conditions
ConditionsYield
In ethyl acetate at 20℃;88%
In ethanol
4-trifluoromethylbenzoic acid
455-24-3

4-trifluoromethylbenzoic acid

Sertraline
79617-96-2

Sertraline

(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-N-(4-(trifluoromethyl)benzyl)-1,2,3,4-tetrahydronaphthalen-1-amine

(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-N-(4-(trifluoromethyl)benzyl)-1,2,3,4-tetrahydronaphthalen-1-amine

Conditions
ConditionsYield
With potassium phosphate; 18-crown-6 ether; phenylsilane In tetrahydrofuran at 80℃; for 8h; Glovebox; Molecular sieve; Schlenk technique;88%
Adipic acid
124-04-9

Adipic acid

Sertraline
79617-96-2

Sertraline

sertraline adipate
928057-23-2

sertraline adipate

Conditions
ConditionsYield
In ethyl acetate at 25 - 30℃; for 5h;86%
Sertraline
79617-96-2

Sertraline

(S)-1-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalene

(S)-1-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalene

Conditions
ConditionsYield
With tris(pentafluorophenyl)borate; phenylsilane at 120℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;85%
tert-butyl ((1H-pyrazol-1-yl)(2,2,2-trifluoroacetamido)methylene)carbamate

tert-butyl ((1H-pyrazol-1-yl)(2,2,2-trifluoroacetamido)methylene)carbamate

Sertraline
79617-96-2

Sertraline

C23H27Cl2N3O2

C23H27Cl2N3O2

Conditions
ConditionsYield
Stage #1: tert-butyl ((1H-pyrazol-1-yl)(2,2,2-trifluoroacetamido)methylene)carbamate; Sertraline In tetrahydrofuran at 20℃; Inert atmosphere;
Stage #2: With potassium hydrogencarbonate In tetrahydrofuran; methanol Inert atmosphere;
83%
Sertraline
79617-96-2

Sertraline

acetonitrile
75-05-8

acetonitrile

(1S,4S)-4-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydro naphthalen-1-amine
122873-20-5

(1S,4S)-4-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydro naphthalen-1-amine

Conditions
ConditionsYield
With 18-crown-6 ether; carbon dioxide at 80℃; under 750.075 Torr; for 24h; Inert atmosphere; Schlenk technique; Glovebox;83%
Sertraline
79617-96-2

Sertraline

trifluoroacetic acid
76-05-1

trifluoroacetic acid

(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-N-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthalen-1-amine

(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-N-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydronaphthalen-1-amine

Conditions
ConditionsYield
With potassium phosphate; 18-crown-6 ether; phenylsilane In tetrahydrofuran at 80℃; for 8h; Glovebox; Molecular sieve; Schlenk technique;81%
carbon dioxide
124-38-9

carbon dioxide

Sertraline
79617-96-2

Sertraline

N-((1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)-N-methylformamide

N-((1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)-N-methylformamide

Conditions
ConditionsYield
With cyclopentadienyl iron(II) dicarbonyl dimer; tributylphosphine; phenylsilane In acetonitrile at 30℃; under 760.051 Torr; for 36h; Schlenk technique; Sealed tube;80%
With phenylsilane; tetrabutyl ammonium fluoride at 20℃; for 4h;60%
Sertraline
79617-96-2

Sertraline

(1S-cis )-4-(3,4-dichlorophenyl)-7-iodo-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine
291306-20-2

(1S-cis )-4-(3,4-dichlorophenyl)-7-iodo-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine

Conditions
ConditionsYield
With N-iodo-succinimide; trifluorormethanesulfonic acid In dichloromethane for 23h;79%
4-methoxybenzoic acid
100-09-4

4-methoxybenzoic acid

Sertraline
79617-96-2

Sertraline

sertraline 4-methoxybenzoate

sertraline 4-methoxybenzoate

Conditions
ConditionsYield
In ethanol; ethyl acetate at 25 - 30℃; for 5h;78%
carbon dioxide
124-38-9

carbon dioxide

Sertraline
79617-96-2

Sertraline

(1S,4S)-4-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydro naphthalen-1-amine
122873-20-5

(1S,4S)-4-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydro naphthalen-1-amine

Conditions
ConditionsYield
With cyclopentadienyl iron(II) dicarbonyl dimer; phenylsilane; triphenylphosphine In acetonitrile at 100℃; under 760.051 Torr; for 24h; Schlenk technique; Sealed tube;78%
With diphenylsilane; [1,3-bis(2,4,6-trimethylphenyl)imidazol]-2-ylidene In N,N-dimethyl-formamide at 50℃; under 760.051 Torr; chemoselective reaction;75%
p-Toluic acid
99-94-5

p-Toluic acid

Sertraline
79617-96-2

Sertraline

sertraline 4-methylbenzoate
928057-24-3

sertraline 4-methylbenzoate

Conditions
ConditionsYield
In ethanol; ethyl acetate at 25 - 30℃; for 5h;76%
Glutamic acid
617-65-2

Glutamic acid

Sertraline
79617-96-2

Sertraline

sertraline glutamate

sertraline glutamate

Conditions
ConditionsYield
In ethyl acetate at 25 - 30℃; for 5h;67%

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