Hunan Kaimir Biotechnology Co., Ltd. is a professional technology company specializing in the research and production of raw materials and intermediates. In 2017, it was recognized as a high-tech enterprise and a small technological innovation giant
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Cas:79617-96-2
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inquirySertraline Basic information Product Name: Sertraline Synonyms: (1s-cis)-1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-n-methyl-1-naphthalenamin;1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-n-m
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
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inquirySertraline CAS:79617-96-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:79617-96-2
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inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu
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1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Description: white crystalline powder, odorless Specific optical rotation :+37.5°~+42.5° Identification: Chemical iden…Appearance:white crystalline powder, odorless Storage:cool and dry Package:25kg/drum Application:Other
Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
sertraline hydrochloride
Sertraline
Conditions | Yield |
---|---|
With sodium hydroxide In water; toluene for 0.25h; pH=> 10; | 93% |
With sodium hydroxide In water; ethyl acetate | 77% |
With ammonium hydroxide In water pH=10; | |
With sodium hydroxide In water | |
With potassium carbonate In water at 20℃; | 10.9 g |
Sertraline
Conditions | Yield |
---|---|
With sodium hydroxide In water; ethyl acetate for 0.25h; pH=> 10; | 93% |
With sodium hydroxide In water; ethyl acetate for 0.25h; pH=> 10; | 93% |
benzyl (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl(methyl)carbamate
Sertraline
Conditions | Yield |
---|---|
With hydrogen In methanol; dichloromethane; water at 20℃; for 5h; Inert atmosphere; | 89% |
(4S)-4-(3,4-dichlorophenyl)-1-tetralone
methylamine
Sertraline
Conditions | Yield |
---|---|
With titanium tetrachloride In tetrahydrofuran; diethyl ether; dichloromethane at -78 - 25℃; | 88% |
cis-(1S,4S)-N-(tert-butoxycarbonyl)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
Sertraline
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 20℃; for 1h; deacylation; | 85% |
C17H16Cl2IN
Sertraline
Conditions | Yield |
---|---|
With tert.-butyl lithium In tetrahydrofuran; toluene at -78℃; | 69% |
Sertraline
Conditions | Yield |
---|---|
With cesium fluoride In N,N-dimethyl-formamide at 95℃; for 20h; diastereoselective reaction; | 65% |
N-methylhydroxyamine hydrochloride
(4S)-4-(3,4-dichlorophenyl)-1-tetralone
Sertraline
Conditions | Yield |
---|---|
Stage #1: N-methylhydroxyamine hydrochloride; (4S)-4-(3,4-dichlorophenyl)-1-tetralone With sodium acetate In ethanol for 15h; Reflux; Stage #2: With Lindlar's catalyst; hydrogen In methanol; dichloromethane at 20℃; under 760.051 Torr; for 20h; | 47% |
cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine
Sertraline
Conditions | Yield |
---|---|
With potassium carbonate; lithium (hydro)trimethoxyaluminate 1) MeCN, 2) THF, reflux, 40 h; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
With lithium (hydro)trimethoxyaluminate In tetrahydrofuran for 40h; Reduction; Methylation; Heating; | 10 mg |
(4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-ylidene)methylamine
A
trans-(1S,4R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
B
Sertraline
C
(4R)-(3,4-Dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone
Conditions | Yield |
---|---|
With (S,S)-(ethylenebis(tetrahydroindenyl))TiF2; phenylsilane In tetrahydrofuran at 20℃; for 24h; kinetic resolution; |
N-chloromethylamine
1-(3,4-dichlorophenyl)-1,2-dihydronaphthalene
A
trans-(1R,4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
B
Sertraline
Conditions | Yield |
---|---|
Stage #1: 1-(3,4-dichlorophenyl)-1,2-dihydronaphthalene With benzo[1,3,2]dioxaborole; (S)-1-(2-(diphenylphosphanyl)naphthalen-1-yl)isoquinoline In dichloromethane at 20℃; for 12h; Stage #2: With diethylzinc In toluene at 20℃; for 2h; Stage #3: N-chloromethylamine In diethyl ether; water at 0℃; for 0.0833333h; Further stages.; |
(S)-N-(4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene)methanamine
A
trans-(1R,4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
B
Sertraline
Conditions | Yield |
---|---|
With hydrogen; nickel In methanol | |
With C32H12BF24(1-)*C36H44IrNOP(1+); hydrogen at 20℃; under 15201 Torr; for 12h; optical yield given as %ee; enantioselective reaction; |
Sertraline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: magnesium / tetrahydrofuran 1.2: CuBr-SMe2 / 13 / -30 - 0 °C 2.1: sodium tetrahydroborate / tetrahydrofuran; water 3.1: triethylamine 4.1: sodium iodide / acetone / Heating 5.1: tetrahydrofuran 6.1: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: magnesium / tetrahydrofuran 1.2: CuBr-SMe2 / 13 / -30 - 0 °C 2.1: sodium tetrahydroborate / tetrahydrofuran; water 3.1: 1H-imidazole; iodine; triphenylphosphine 4.1: hydrogenchloride 5.1: tetrahydrofuran 6.1: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C View Scheme |
Sertraline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sodium tetrahydroborate / tetrahydrofuran; water 2: triethylamine 3: sodium iodide / acetone / Heating 4: tetrahydrofuran 5: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C View Scheme | |
Multi-step reaction with 5 steps 1: sodium tetrahydroborate / tetrahydrofuran; water 2: 1H-imidazole; iodine; triphenylphosphine 3: hydrogenchloride 4: tetrahydrofuran 5: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C View Scheme |
C18H20Cl2O3
Sertraline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1H-imidazole; iodine; triphenylphosphine 2: hydrogenchloride 3: tetrahydrofuran 4: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C View Scheme | |
Multi-step reaction with 4 steps 1: triethylamine 2: sodium iodide / acetone / Heating 3: tetrahydrofuran 4: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C View Scheme |
Sertraline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride 2: tetrahydrofuran 3: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C View Scheme |
Sertraline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: NaI / acetone / Heating 2: 100 percent / tetrahydrofuran 3: 69 percent / t-BuLi / tetrahydrofuran; toluene / -78 °C View Scheme |
C16H13Cl2IO
Sertraline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: tetrahydrofuran 2: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C View Scheme |
o-bromobenzaldehyde dimethyl acetal
Sertraline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: magnesium / tetrahydrofuran 1.2: CuBr-SMe2 / 13 / -30 - 0 °C 2.1: sodium tetrahydroborate / tetrahydrofuran; water 3.1: triethylamine 4.1: sodium iodide / acetone / Heating 5.1: tetrahydrofuran 6.1: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: magnesium / tetrahydrofuran 1.2: CuBr-SMe2 / 13 / -30 - 0 °C 2.1: sodium tetrahydroborate / tetrahydrofuran; water 3.1: 1H-imidazole; iodine; triphenylphosphine 4.1: hydrogenchloride 5.1: tetrahydrofuran 6.1: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C View Scheme |
3,4-Dichlorocinnamic acid
Sertraline
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: pivaloyl chloride; triethylamine; lithium chloride 2.1: magnesium / tetrahydrofuran 2.2: CuBr-SMe2 / 13 / -30 - 0 °C 3.1: sodium tetrahydroborate / tetrahydrofuran; water 4.1: triethylamine 5.1: sodium iodide / acetone / Heating 6.1: tetrahydrofuran 7.1: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: pivaloyl chloride; triethylamine; lithium chloride 2.1: magnesium / tetrahydrofuran 2.2: CuBr-SMe2 / 13 / -30 - 0 °C 3.1: sodium tetrahydroborate / tetrahydrofuran; water 4.1: 1H-imidazole; iodine; triphenylphosphine 5.1: hydrogenchloride 6.1: tetrahydrofuran 7.1: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C View Scheme |
ortho-bromobenzaldehyde
Sertraline
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: toluene-4-sulfonic acid / methanol 2.1: magnesium / tetrahydrofuran 2.2: CuBr-SMe2 / 13 / -30 - 0 °C 3.1: sodium tetrahydroborate / tetrahydrofuran; water 4.1: triethylamine 5.1: sodium iodide / acetone / Heating 6.1: tetrahydrofuran 7.1: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: toluene-4-sulfonic acid / methanol 2.1: magnesium / tetrahydrofuran 2.2: CuBr-SMe2 / 13 / -30 - 0 °C 3.1: sodium tetrahydroborate / tetrahydrofuran; water 4.1: 1H-imidazole; iodine; triphenylphosphine 5.1: hydrogenchloride 6.1: tetrahydrofuran 7.1: tert.-butyl lithium / tetrahydrofuran; toluene / -78 °C View Scheme |
4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one
Sertraline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: BH3*Me2S / (S)-prolinol core-containing second-generation dendrimer / tetrahydrofuran / 0.8 h 2: PCC / CH2Cl2 / 0 - 20 °C 3: TiCl4 / diethyl ether / -78 - 20 °C 4: H2; Raney-Ni / methanol View Scheme | |
Multi-step reaction with 2 steps 1: 91 percent / TiCl4 / diethyl ether / -35 - 20 °C 2: (S,S)-(ethylenebis(tetrahydroindenyl))TiF2; PhSiH3 / tetrahydrofuran / 24 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: TiCl4 / toluene / 17 h / Ambient temperature 2: sodium borohydride / methanol / 1.5 h / Ambient temperature View Scheme |
(4S)-4-(3,4-dichlorophenyl)-1-tetralone
Sertraline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: TiCl4 / diethyl ether / -78 - 20 °C 2: H2; Raney-Ni / methanol View Scheme | |
Multi-step reaction with 4 steps 1: NaBH4 / ethanol 2: 88 percent / dppa, DBU / tetrahydrofuran 3: H2 / Pd-C / ethanol 4: 1) K2CO3, 2) LiAlH(OMe)3 / 1) MeCN, 2) THF, reflux, 40 h View Scheme | |
Multi-step reaction with 2 steps 1: methanol / 6 h / Reflux 2: sodium tetrahydroborate; methanol View Scheme |
(1R,4S)-4-(3,4-dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-ol
Sertraline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: PCC / CH2Cl2 / 0 - 20 °C 2: TiCl4 / diethyl ether / -78 - 20 °C 3: H2; Raney-Ni / methanol View Scheme | |
Multi-step reaction with 4 steps 1: 88 percent / diphenylphosphorylazide; DBU / tetrahydrofuran / 0 - 20 °C 2: H2 / Pd/C / ethanol / 1 h 3: K2CO3 / acetonitrile / 2 h / Heating 4: 10 mg / LiAlH(OMe)3 / tetrahydrofuran / 40 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: 88 percent / dppa, DBU / tetrahydrofuran 2: H2 / Pd-C / ethanol 3: 1) K2CO3, 2) LiAlH(OMe)3 / 1) MeCN, 2) THF, reflux, 40 h View Scheme |
1-(3,4-dichlorophenyl)-1,2-dihydronaphthalene
Sertraline
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: catecholborane / (S)-QUINAP-Rh / toluene / 2 h / 20 °C 1.2: aq. H2O2; flash silica / hexane / 1 h / 0 °C 2.1: catecholborane / (S)-QUINAP-Rh / CH2Cl2 / 12 h / 20 °C 2.2: ZnEt2 / toluene / 2 h / 20 °C 2.3: H2O; diethyl ether / 0.08 h / 0 °C View Scheme |
D-dibenzylaminophenylglycinal
Sertraline
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: 2.62 g / benzene; CH2Cl2 / 15 h / 20 °C 2: 83 percent / Mg / 4 h 3: 76 percent / LiAlH4 / tetrahydrofuran / 0 - 20 °C 4: 0.85 g / pyridinium dichromate / CH2Cl2 / 5 h / 20 °C 5: 1.0 g / tetrahydrofuran / 5 h 6: 78 percent / AlCl3 / CH2Cl2 / 1 h / 20 °C 7: H2 / Pd(OH)2 / methanol / 3 h 8: 0.162 g / methanol / 3 h 9: 84 percent / NaH / tetrahydrofuran / 6 h 10: 85 percent / TFA / CH2Cl2 / 1 h / 20 °C View Scheme |
(+)-(2R)-2-[bis(phenylmethyl)amino]-2-phenylethanol
Sertraline
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1: DMSO; oxalyl chloride; Et3N / CH2Cl2 / -78 - 0 °C 2: 2.62 g / benzene; CH2Cl2 / 15 h / 20 °C 3: 83 percent / Mg / 4 h 4: 76 percent / LiAlH4 / tetrahydrofuran / 0 - 20 °C 5: 0.85 g / pyridinium dichromate / CH2Cl2 / 5 h / 20 °C 6: 1.0 g / tetrahydrofuran / 5 h 7: 78 percent / AlCl3 / CH2Cl2 / 1 h / 20 °C 8: H2 / Pd(OH)2 / methanol / 3 h 9: 0.162 g / methanol / 3 h 10: 84 percent / NaH / tetrahydrofuran / 6 h 11: 85 percent / TFA / CH2Cl2 / 1 h / 20 °C View Scheme |
norsertraline
Sertraline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 0.162 g / methanol / 3 h 2: 84 percent / NaH / tetrahydrofuran / 6 h 3: 85 percent / TFA / CH2Cl2 / 1 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: K2CO3 / acetonitrile / 2 h / Heating 2: 10 mg / LiAlH(OMe)3 / tetrahydrofuran / 40 h / Heating View Scheme |
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; | 99% |
In tetrahydrofuran |
L-tartaric acid
Sertraline
Conditions | Yield |
---|---|
In ethyl acetate | 98% |
Conditions | Yield |
---|---|
In ethanol; ethyl acetate at 25 - 30℃; for 5h; | 98% |
Sertraline
acrylonitrile
Conditions | Yield |
---|---|
With sodium In methanol at 55℃; for 12h; Inert atmosphere; | 98% |
Sertraline
citric acid
(1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine citrate
Conditions | Yield |
---|---|
In water; ethyl acetate at 0 - 60℃; for 1h; Product distribution / selectivity; | 97% |
In propan-1-ol; isopropyl alcohol at 0 - 40℃; for 2h; Product distribution / selectivity; | 96% |
Conditions | Yield |
---|---|
In ethyl acetate for 48h; | 96% |
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; for 4h; | 96% |
Sertraline
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In propan-1-ol at 30℃; for 1h; Product distribution / selectivity; | 96% |
With hydrogenchloride In acetonitrile for 1h; Product distribution / selectivity; | 95% |
With hydrogenchloride In octanol for 1h; Product distribution / selectivity; | 95% |
(R)-Mandelic Acid
Sertraline
(cis-1S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine (R)-mandelate
Conditions | Yield |
---|---|
In ethanol Reflux; | 94% |
Conditions | Yield |
---|---|
In ethanol; ethyl acetate at 25 - 30℃; for 5h; | 92% |
(S)-Mandelic acid
Sertraline
(1S,4S)-sertraline*(S)-mandelic acid
Conditions | Yield |
---|---|
In ethanol; hexane Reflux; | 91% |
Conditions | Yield |
---|---|
In ethyl acetate at 20℃; | 88% |
In ethanol |
4-trifluoromethylbenzoic acid
Sertraline
Conditions | Yield |
---|---|
With potassium phosphate; 18-crown-6 ether; phenylsilane In tetrahydrofuran at 80℃; for 8h; Glovebox; Molecular sieve; Schlenk technique; | 88% |
Conditions | Yield |
---|---|
In ethyl acetate at 25 - 30℃; for 5h; | 86% |
Sertraline
Conditions | Yield |
---|---|
With tris(pentafluorophenyl)borate; phenylsilane at 120℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; | 85% |
Sertraline
Conditions | Yield |
---|---|
Stage #1: tert-butyl ((1H-pyrazol-1-yl)(2,2,2-trifluoroacetamido)methylene)carbamate; Sertraline In tetrahydrofuran at 20℃; Inert atmosphere; Stage #2: With potassium hydrogencarbonate In tetrahydrofuran; methanol Inert atmosphere; | 83% |
Sertraline
acetonitrile
(1S,4S)-4-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydro naphthalen-1-amine
Conditions | Yield |
---|---|
With 18-crown-6 ether; carbon dioxide at 80℃; under 750.075 Torr; for 24h; Inert atmosphere; Schlenk technique; Glovebox; | 83% |
Sertraline
trifluoroacetic acid
Conditions | Yield |
---|---|
With potassium phosphate; 18-crown-6 ether; phenylsilane In tetrahydrofuran at 80℃; for 8h; Glovebox; Molecular sieve; Schlenk technique; | 81% |
carbon dioxide
Sertraline
Conditions | Yield |
---|---|
With cyclopentadienyl iron(II) dicarbonyl dimer; tributylphosphine; phenylsilane In acetonitrile at 30℃; under 760.051 Torr; for 36h; Schlenk technique; Sealed tube; | 80% |
With phenylsilane; tetrabutyl ammonium fluoride at 20℃; for 4h; | 60% |
Sertraline
(1S-cis )-4-(3,4-dichlorophenyl)-7-iodo-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine
Conditions | Yield |
---|---|
With N-iodo-succinimide; trifluorormethanesulfonic acid In dichloromethane for 23h; | 79% |
Conditions | Yield |
---|---|
In ethanol; ethyl acetate at 25 - 30℃; for 5h; | 78% |
carbon dioxide
Sertraline
(1S,4S)-4-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydro naphthalen-1-amine
Conditions | Yield |
---|---|
With cyclopentadienyl iron(II) dicarbonyl dimer; phenylsilane; triphenylphosphine In acetonitrile at 100℃; under 760.051 Torr; for 24h; Schlenk technique; Sealed tube; | 78% |
With diphenylsilane; [1,3-bis(2,4,6-trimethylphenyl)imidazol]-2-ylidene In N,N-dimethyl-formamide at 50℃; under 760.051 Torr; chemoselective reaction; | 75% |
Conditions | Yield |
---|---|
In ethanol; ethyl acetate at 25 - 30℃; for 5h; | 76% |
Conditions | Yield |
---|---|
In ethyl acetate at 25 - 30℃; for 5h; | 67% |
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