Products

Refine

Country

Business Type

Certificate

Display

SEASONS BIOTECHNOLOGY CO., LTD

1. High-quality products, cost-effective prices, best reputation and professional services. 2. Strong technology team and service team, Professional data management system. 3. Professional synthesis and formulations laboratory and production

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Anacetrapib in stock

Cas:875446-37-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Anacetrapib 875446-37-0 GMP Manufacturer

Cas:875446-37-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Anacetrapib

Cas:875446-37-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Anacetrapib

Cas:875446-37-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 875446-37-0 with best quality

Cas:875446-37-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

TIANFUCHEM-- Anacetrapib

Cas:875446-37-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

MK-0859 875446-37-0

Cas:875446-37-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Anacetrapib CAS:875446-37-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Anacetrapib CAS:875446-37-0

Cas:875446-37-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

MK-0859

Cas:875446-37-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Anacetrapib manufacturer with low price

Cas:875446-37-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:875446-37-0

Cas:875446-37-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:As

Anacetrapib

Cas:875446-37-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

MK-0859 Anacetrapib 875446-37-0

Cas:875446-37-0

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Anacetrapib

Cas:875446-37-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Anacetrapib

Cas:875446-37-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Anacetrapib

Cas:875446-37-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystal powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Tr

MK-0859

Cas:875446-37-0

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: Anacetrapib Synonyms: Anacetrapib;Mk0859;Mk-0859;Unii-p7T269pr6s;(4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-3-[[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphen

TIANFUCHEM-- Anacetrapib

Cas:875446-37-0

Min.Order:1 Metric Ton

FOB Price: $20.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Anacetrapib in stock CAS NO.875446-37-0

Cas:875446-37-0

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best OfferAnacetrapib

Cas:875446-37-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Anacetrapib

Cas:875446-37-0

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: Anacetrpib CAS No.:875446-37-0 Molecule Formula:C30H25F10NO3 Molecule Weight:637.51 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS

Lower Price Anacetrpib

Cas:875446-37-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Anacetrapib

Cas:875446-37-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFUCHEM-- Anacetrapib

Cas:875446-37-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFUCHEM-- Anacetrapib

Cas:875446-37-0

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Wuhu Nuowei Chemistry Technologies Co., Ltd.

Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma

Anacetrapib

Cas:875446-37-0

Min.Order:100 Gram

Negotiable

Type:Manufacturers

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/Anacetrapib/SAGECHEM/Manufacturer in China

Cas:875446-37-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl

2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one
875444-08-9

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl-formamide at 60℃; for 17h;92%
Stage #1: (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one With sodium hexamethyldisilazane In N,N-dimethyl-formamide at -15℃; for 1h;
Stage #2: 2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl In N,N-dimethyl-formamide at -15 - 12℃;
88%
Stage #1: (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one With sodium hexamethyldisilazane In N,N-dimethyl-formamide at -15℃; for 1h;
Stage #2: 2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl In N,N-dimethyl-formamide at -10 - 12℃;
88%
C37H33F10NO4

C37H33F10NO4

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
With potassium hydroxide In tetrahydrofuran; methanol at 20℃; Inert atmosphere;89%
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl

2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Stage #1: (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one With sodium hexamethyldisilazane In N,N-dimethyl-formamide at -15℃; for 1.5h;
Stage #2: 2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)biphenyl In N,N-dimethyl-formamide at -15 - 12℃;
88%
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one
875444-08-9

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol
875548-97-3

(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Stage #1: [4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-1,1'-biphenyl-2-yl]methanol With thionyl chloride In dichloromethane at 5 - 20℃;
Stage #2: (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one With tetra-(n-butyl)ammonium iodide; potassium carbonate In dichloromethane at 60℃;
72%
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-iodo-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one
875446-35-8

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-iodo-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]boronic acid
875446-29-0

[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]boronic acid

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; water; benzene at 100℃; for 14h; Heating / reflux;
With potassium carbonate; palladium diacetate In water; acetone for 1h; Heating / reflux;
C34H29F10NO8(2-)*2Na(1+)

C34H29F10NO8(2-)*2Na(1+)

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
In water-d2 at 37℃; for 3.75h; pH=7.52; Sodium phosphate buffer;
1-bromo-2-(bromomethyl)-4-(trifluoromethyl)benzene
886496-63-5

1-bromo-2-(bromomethyl)-4-(trifluoromethyl)benzene

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one
875444-08-9

(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran / 0 °C
1.2: 0 - 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / ethanol; water; toluene / Reflux
View Scheme
[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]boronic acid
875446-29-0

[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]boronic acid

(4S,5R)-5-(3,5-bis-trifluoromethyl-phenyl)-3-(2-bromo-5-trifluoromethyl-benzyl)-4-methyl-oxazolidin-2-one
1185737-50-1

(4S,5R)-5-(3,5-bis-trifluoromethyl-phenyl)-3-(2-bromo-5-trifluoromethyl-benzyl)-4-methyl-oxazolidin-2-one

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water; toluene Suzuki coupling; Reflux;
1-(2-fluoro-4-methoxyphenyl)-1-ethanone
74457-86-6

1-(2-fluoro-4-methoxyphenyl)-1-ethanone

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: tetrahydrofuran / 1 h / -15 - 0 °C
2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h / 40 °C / 775.74 Torr
3.1: N-Bromosuccinimide / acetonitrile / 35 °C
4.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
4.2: Inert atmosphere
5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 24 h / 35 °C / Inert atmosphere
6.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 0 - 20 °C
7.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
7.2: -15 - 12 °C
View Scheme
Multi-step reaction with 7 steps
1.1: tetrahydrofuran / 1 h / -15 - 0 °C
2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h / 40 °C / 775.74 Torr
3.1: N-Bromosuccinimide / acetonitrile / 35 °C
4.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
4.2: Inert atmosphere
5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 30 - 45 °C / Inert atmosphere
6.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 0 - 20 °C
7.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
7.2: -15 - 12 °C
View Scheme
Multi-step reaction with 7 steps
1.1: tetrahydrofuran / 1 h / -15 - 0 °C
2.1: N-Bromosuccinimide / acetonitrile / 60 °C
3.1: trifluoroacetic acid; 1,1,3,3-Tetramethyldisiloxane / 1,2-dichloro-ethane / 0.25 h / -20 - -10 °C
4.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
4.2: 1 h / 15 - 20 °C / pH 2
5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
6.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
7.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
7.2: -10 - 12 °C
View Scheme
2-(2-fluoro-4-methoxyphenyl)-2-isopropanol
96826-25-4

2-(2-fluoro-4-methoxyphenyl)-2-isopropanol

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h / 40 °C / 775.74 Torr
2.1: N-Bromosuccinimide / acetonitrile / 35 °C
3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
3.2: Inert atmosphere
4.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 24 h / 35 °C / Inert atmosphere
5.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 0 - 20 °C
6.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
6.2: -15 - 12 °C
View Scheme
Multi-step reaction with 6 steps
1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h / 40 °C / 775.74 Torr
2.1: N-Bromosuccinimide / acetonitrile / 35 °C
3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
3.2: Inert atmosphere
4.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 30 - 45 °C / Inert atmosphere
5.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 0 - 20 °C
6.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
6.2: -15 - 12 °C
View Scheme
Multi-step reaction with 6 steps
1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 1 h / 40 °C / 775.74 Torr
2.1: N-Bromosuccinimide / acetonitrile / 35 °C
3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
3.2: 1 h / 15 - 20 °C / pH 2
4.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
5.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
6.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
6.2: -10 - 12 °C
View Scheme
[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]boronic acid
875446-29-0

[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]boronic acid

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 24 h / 35 °C / Inert atmosphere
2.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 0 - 20 °C
3.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
3.2: -15 - 12 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 30 - 45 °C / Inert atmosphere
2.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 0 - 20 °C
3.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
3.2: -15 - 12 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
2.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
3.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
3.2: -10 - 12 °C
View Scheme
2-(2-fluoro-4-methoxyphenyl)isopropane

2-(2-fluoro-4-methoxyphenyl)isopropane

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: N-Bromosuccinimide / acetonitrile / 35 °C
2.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 24 h / 35 °C / Inert atmosphere
4.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 0 - 20 °C
5.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
5.2: -15 - 12 °C
View Scheme
Multi-step reaction with 5 steps
1.1: N-Bromosuccinimide / acetonitrile / 35 °C
2.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 30 - 45 °C / Inert atmosphere
4.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 0 - 20 °C
5.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
5.2: -15 - 12 °C
View Scheme
Multi-step reaction with 5 steps
1.1: N-Bromosuccinimide / acetonitrile / 35 °C
2.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
2.2: 1 h / 15 - 20 °C / pH 2
3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
4.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
5.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
5.2: -10 - 12 °C
View Scheme
1-bromo-4-fluoro-2-methoxy-5-(propan-2-yl)-benzene
944317-92-4

1-bromo-4-fluoro-2-methoxy-5-(propan-2-yl)-benzene

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 24 h / 35 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 0 - 20 °C
4.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
4.2: -15 - 12 °C
View Scheme
Multi-step reaction with 4 steps
1.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 30 - 45 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 0 - 20 °C
4.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
4.2: -15 - 12 °C
View Scheme
Multi-step reaction with 4 steps
1.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
1.2: 1 h / 15 - 20 °C / pH 2
2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
4.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
4.2: -10 - 12 °C
View Scheme
(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol
875548-97-3

(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 0 - 20 °C
2.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
2.2: -15 - 12 °C
View Scheme
Multi-step reaction with 2 steps
1.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
2.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
2.2: -10 - 12 °C
View Scheme
Multi-step reaction with 2 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 10 - 20 °C
2.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
2.2: -10 °C
View Scheme
Multi-step reaction with 4 steps
1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
2: isopropyl alcohol / 2 h / 35 - 40 °C
3: sodium tetrahydroborate / methanol / 2 h / 20 °C
4: tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 70 - 75 °C
View Scheme
Multi-step reaction with 2 steps
1: thionyl chloride; N,N-dimethyl-formamide / 10 - 15 °C
2: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 17 h / 60 °C
View Scheme
2,4-difluorobromobenzene
348-57-2

2,4-difluorobromobenzene

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: tetrahydrofuran / 5 h / 65 - 68 °C
2.1: aluminum (III) chloride / 1,2-dichloro-ethane / 1 h / -10 - 5 °C
3.1: tetrahydrofuran / 1 h / -15 - 0 °C
4.1: trifluoroacetic acid; 1,1,3,3-Tetramethyldisiloxane / 1,2-dichloro-ethane / 0.25 h / -20 - -10 °C
5.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
5.2: 1 h / 15 - 20 °C / pH 2
6.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
7.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
8.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
8.2: -10 - 12 °C
View Scheme
Multi-step reaction with 8 steps
1.1: tetrahydrofuran / 5 h / 65 - 68 °C
2.1: aluminum (III) chloride / 1,2-dichloro-ethane / 1 h / -10 - 5 °C
3.1: tetrahydrofuran / 1 h / -15 - 0 °C
4.1: trifluoroacetic acid; 1,1,3,3-Tetramethyldisiloxane / 1,2-dichloro-ethane / 0.25 h / -20 - -10 °C
5.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
5.2: 1 h / 15 - 20 °C / pH 2
6.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
7.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
8.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
8.2: -10 - 12 °C
View Scheme
Multi-step reaction with 9 steps
1.1: tetrahydrofuran / 5 h / 65 - 68 °C
2.1: aluminum (III) chloride / 1,2-dichloro-ethane / 1 h / -10 - 5 °C
3.1: tetrahydrofuran / 1 h / -15 - 0 °C
4.1: sulfuric acid / 12 h / Reflux
5.1: hydrogen; hydrogen bromide / 5%-palladium/activated carbon / water; methanol / 0.25 h / 20 °C / 3102.97 Torr / Inert atmosphere
6.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
6.2: 1 h / 15 - 20 °C / pH 2
7.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
8.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
9.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
9.2: -10 - 12 °C
View Scheme
1-bromo-4-fluoro-2-methoxybenzene
450-88-4

1-bromo-4-fluoro-2-methoxybenzene

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 1 h / -10 - 5 °C
2.1: tetrahydrofuran / 1 h / -15 - 0 °C
3.1: trifluoroacetic acid; 1,1,3,3-Tetramethyldisiloxane / 1,2-dichloro-ethane / 0.25 h / -20 - -10 °C
4.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
4.2: 1 h / 15 - 20 °C / pH 2
5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
6.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
7.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
7.2: -10 - 12 °C
View Scheme
Multi-step reaction with 7 steps
1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 1 h / -10 - 5 °C
2.1: tetrahydrofuran / 1 h / -15 - 0 °C
3.1: trifluoroacetic acid; 1,1,3,3-Tetramethyldisiloxane / 1,2-dichloro-ethane / 0.25 h / -20 - -10 °C
4.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
4.2: 1 h / 15 - 20 °C / pH 2
5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
6.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
7.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
7.2: -10 - 12 °C
View Scheme
Multi-step reaction with 8 steps
1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 1 h / -10 - 5 °C
2.1: tetrahydrofuran / 1 h / -15 - 0 °C
3.1: sulfuric acid / 12 h / Reflux
4.1: hydrogen; hydrogen bromide / 5%-palladium/activated carbon / water; methanol / 0.25 h / 20 °C / 3102.97 Torr / Inert atmosphere
5.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
5.2: 1 h / 15 - 20 °C / pH 2
6.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
7.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
8.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
8.2: -10 - 12 °C
View Scheme
1-(5-bromo-2-fluoro-4-methoxyphenyl)ethan-1-one
914221-54-8

1-(5-bromo-2-fluoro-4-methoxyphenyl)ethan-1-one

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: tetrahydrofuran / 1 h / -15 - 0 °C
2.1: trifluoroacetic acid; 1,1,3,3-Tetramethyldisiloxane / 1,2-dichloro-ethane / 0.25 h / -20 - -10 °C
3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
3.2: 1 h / 15 - 20 °C / pH 2
4.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
5.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
6.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
6.2: -10 - 12 °C
View Scheme
Multi-step reaction with 6 steps
1.1: tetrahydrofuran / 1 h / -15 - 0 °C
2.1: trifluoroacetic acid; 1,1,3,3-Tetramethyldisiloxane / 1,2-dichloro-ethane / 0.25 h / -20 - -10 °C
3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
3.2: 1 h / 15 - 20 °C / pH 2
4.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
5.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
6.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
6.2: -10 - 12 °C
View Scheme
Multi-step reaction with 7 steps
1.1: tetrahydrofuran / 1 h / -15 - 0 °C
2.1: sulfuric acid / 12 h / Reflux
3.1: hydrogen; hydrogen bromide / 5%-palladium/activated carbon / water; methanol / 0.25 h / 20 °C / 3102.97 Torr / Inert atmosphere
4.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
4.2: 1 h / 15 - 20 °C / pH 2
5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
6.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
7.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
7.2: -10 - 12 °C
View Scheme
(4'-fluoro-2'-methoxy-5'-(prop-1-en-2-yl)-4-(trifluoromethyl)biphenyl-2-yl)methanol
1383814-85-4

(4'-fluoro-2'-methoxy-5'-(prop-1-en-2-yl)-4-(trifluoromethyl)biphenyl-2-yl)methanol

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / 1551.49 Torr / Inert atmosphere
2.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
3.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
3.2: -10 - 12 °C
View Scheme
Multi-step reaction with 3 steps
1: hydrogen; 5%-palladium/activated carbon / methanol / 20 °C / 1551.49 Torr
2: thionyl chloride / N,N-dimethyl-formamide / 5 h / 10 - 20 °C
3: sodium hexamethyldisilazane / N,N-dimethyl-formamide / -15 - 12 °C
View Scheme
2-(5-bromo-2-fluoro-4-methoxyphenyl)propan-2-ol
958029-46-4

2-(5-bromo-2-fluoro-4-methoxyphenyl)propan-2-ol

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: trifluoroacetic acid; 1,1,3,3-Tetramethyldisiloxane / 1,2-dichloro-ethane / 0.25 h / -20 - -10 °C
2.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
2.2: 1 h / 15 - 20 °C / pH 2
3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
4.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
5.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
5.2: -10 - 12 °C
View Scheme
Multi-step reaction with 5 steps
1.1: trifluoroacetic acid; 1,1,3,3-Tetramethyldisiloxane / 1,2-dichloro-ethane / 0.25 h / -20 - -10 °C
2.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
2.2: 1 h / 15 - 20 °C / pH 2
3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
4.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
5.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
5.2: -10 - 12 °C
View Scheme
Multi-step reaction with 6 steps
1.1: sulfuric acid / 12 h / Reflux
2.1: hydrogen; hydrogen bromide / 5%-palladium/activated carbon / water; methanol / 0.25 h / 20 °C / 3102.97 Torr / Inert atmosphere
3.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
3.2: 1 h / 15 - 20 °C / pH 2
4.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
5.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
6.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
6.2: -10 - 12 °C
View Scheme
1-bromo-4-fluoro-2-methoxy-5-(1-methylvinyl)benzene
1383814-82-1

1-bromo-4-fluoro-2-methoxy-5-(1-methylvinyl)benzene

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogen; hydrogen bromide / 5%-palladium/activated carbon / water; methanol / 0.25 h / 20 °C / 3102.97 Torr / Inert atmosphere
2.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
2.2: 1 h / 15 - 20 °C / pH 2
3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
4.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
5.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
5.2: -10 - 12 °C
View Scheme
Multi-step reaction with 5 steps
1.1: hydrogen; hydrogen bromide / 5%-palladium/activated carbon / water; methanol / 0.25 h / 20 °C / 3102.97 Torr / Inert atmosphere
2.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
2.2: 1 h / 15 - 20 °C / pH 2
3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
4.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
5.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
5.2: -10 - 12 °C
View Scheme
Multi-step reaction with 5 steps
1.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere
1.2: -35 °C
2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
3.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / 1551.49 Torr / Inert atmosphere
4.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
5.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
5.2: -10 - 12 °C
View Scheme
4-fluoro-2-methoxy-5-(2-propenyl)phenylboronic acid
1383814-83-2

4-fluoro-2-methoxy-5-(2-propenyl)phenylboronic acid

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / 1551.49 Torr / Inert atmosphere
3.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
4.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
4.2: -10 - 12 °C
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
2.1: hydrogen / 5%-palladium/activated carbon / methanol / 20 °C / 1551.49 Torr / Inert atmosphere
3.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
4.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
4.2: -10 - 12 °C
View Scheme
Multi-step reaction with 4 steps
1.1: hydrogen / 5%-palladium/activated carbon / methanol / 0.5 h / 20 °C / 1292.9 Torr / Inert atmosphere
2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 32 h / 20 - 45 °C / Inert atmosphere
3.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 10 - 20 °C
4.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
4.2: -10 - 12 °C
View Scheme
2-fluoro-4-methoxy-1-(prop-1-en-2-yl)benzene
875446-55-2

2-fluoro-4-methoxy-1-(prop-1-en-2-yl)benzene

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogen / palladium on activated carbon / methanol / 50 °C / 2250.23 Torr / Inert atmosphere
1.2: 40 °C
2.1: n-butyllithium / toluene; hexane / -80 - -55 °C / Inert atmosphere
2.3: 1 h / 15 - 20 °C / pH 2
3.1: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; tetrahydrofuran / 32 h / 35 - 45 °C / Inert atmosphere
4.1: thionyl chloride / N,N-dimethyl-formamide / 10 - 20 °C
5.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
5.2: -10 °C
View Scheme
C10H12BrFMgO
1383676-72-9

C10H12BrFMgO

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: toluene; tetrahydrofuran / 5 - 10 °C
1.3: 15 - 20 °C / pH 2
2.1: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; tetrahydrofuran / 32 h / 35 - 45 °C / Inert atmosphere
3.1: thionyl chloride / N,N-dimethyl-formamide / 10 - 20 °C
4.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C
4.2: -10 °C
View Scheme
C9H11I2NO

C9H11I2NO

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere
2.1: copper(l) chloride; potassium tert-butylate; 1,10-Phenanthroline / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
2.2: 18 h / 50 °C / Inert atmosphere
3.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / -20 °C / Inert atmosphere
3.2: 18 h / 20 °C
View Scheme
(4S,5R)-5-(3,5-diiodophenyl)-4-methyloxazolidin-2-one

(4S,5R)-5-(3,5-diiodophenyl)-4-methyloxazolidin-2-one

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: copper(l) chloride; potassium tert-butylate; 1,10-Phenanthroline / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
1.2: 18 h / 50 °C / Inert atmosphere
2.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / -20 °C / Inert atmosphere
2.2: 18 h / 20 °C
View Scheme
(1R,2S)-1-(3,5-diiodophenyl)-2-nitropropan-1-ol

(1R,2S)-1-(3,5-diiodophenyl)-2-nitropropan-1-ol

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogenchloride; zinc / 1 h / 0 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere
3.1: copper(l) chloride; potassium tert-butylate; 1,10-Phenanthroline / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
3.2: 18 h / 50 °C / Inert atmosphere
4.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / -20 °C / Inert atmosphere
4.2: 18 h / 20 °C
View Scheme
3,5-diiodobenzaldehyde
17352-25-9

3,5-diiodobenzaldehyde

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: / tetrahydrofuran / 20 h / -60 - 20 °C / Inert atmosphere
2.1: hydrogenchloride; zinc / 1 h / 0 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere
4.1: copper(l) chloride; potassium tert-butylate; 1,10-Phenanthroline / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
4.2: 18 h / 50 °C / Inert atmosphere
5.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / -20 °C / Inert atmosphere
5.2: 18 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: / tetrahydrofuran / 64 h / -60 °C
2.1: hydrogenchloride; zinc / 1 h / 0 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere
4.1: copper(l) chloride; potassium tert-butylate; 1,10-Phenanthroline / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
4.2: 18 h / 50 °C / Inert atmosphere
5.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / -20 °C / Inert atmosphere
5.2: 18 h / 20 °C
View Scheme
2-(3-(trifluoromethyl)phenyl)-4,5-dihydrooxazole
851513-74-1

2-(3-(trifluoromethyl)phenyl)-4,5-dihydrooxazole

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium phosphate; potassium acetate; triphenylphosphine; dichloro(benzene)ruthenium(II) dimer / 1-methyl-pyrrolidin-2-one / 42 h / 110 - 130 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine; methyl chloroformate / tetrahydrofuran / 0.75 h / 62 °C
2.2: 13 h / 0 - 20 °C
3.1: thionyl chloride / N,N-dimethyl-formamide / 5 h / 10 - 20 °C
4.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / -15 - 12 °C
View Scheme
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

anacetrapib
875446-37-0

anacetrapib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: calcium chloride / 5,5-dimethyl-1,3-cyclohexadiene / 24 h / 125 °C / Inert atmosphere
2.1: potassium phosphate; potassium acetate; triphenylphosphine; dichloro(benzene)ruthenium(II) dimer / 1-methyl-pyrrolidin-2-one / 42 h / 110 - 130 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine; methyl chloroformate / tetrahydrofuran / 0.75 h / 62 °C
3.2: 13 h / 0 - 20 °C
4.1: thionyl chloride / N,N-dimethyl-formamide / 5 h / 10 - 20 °C
5.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / -15 - 12 °C
View Scheme
anacetrapib
875446-37-0

anacetrapib

(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-hydroxy-4-(trifluoromethyl)biphenyl-2-yl)methyl)-4-methyl-1,3-oxazolidin-2-one
875550-05-3

(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((4'-fluoro-5'-isopropyl-2'-hydroxy-4-(trifluoromethyl)biphenyl-2-yl)methyl)-4-methyl-1,3-oxazolidin-2-one

Conditions
ConditionsYield
Stage #1: anacetrapib With boron tribromide In dichloromethane at 15 - 16℃; for 1h;
Stage #2: With water In dichloromethane
60%
anacetrapib
875446-37-0

anacetrapib

(1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-[({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}methyl)amino]propan-1-ol
1220703-07-0

(1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-[({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}methyl)amino]propan-1-ol

Conditions
ConditionsYield
With water; potassium hydroxide In isopropyl alcohol at 75℃; Sealed tube;
Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View