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Jinon Pharma (Wuhan) Co., Ltd.

3-(trifluoromethyl)benzonitrile cas no:368-77-4 chemical name:2-(trifluoromethyl)benzonitrile structural formul appearance:colorless to pale yellow transparent liquid content: ≥98% (gc) package, storage and transport

3-(Trifluoromethyl)benzonitrile

Cas:368-77-4

Min.Order:1 Metric Ton

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

3-(Trifluoromethyl)benzonitrile Manufacturer/High quality/Best price/In stock

Cas:368-77-4

Min.Order:1 Kilogram

FOB Price: $3.0

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-(Trifluoromethyl)Benzonitrile supplier in China

Cas:368-77-4

Min.Order:1 Metric Ton

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Jinan Finer Chemical Co., Ltd

Product description: Product name 3-(Trifluoromethyl)benzonitrile CAS number 368-77-4 Assay ≥99% Appearance Colorless or yellowish liquid Capacity 200mt/year Application Phar

3-(Trifluoromethyl)benzonitrile

Cas:368-77-4

Min.Order:10 Gram

FOB Price: $12.0

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Intermediates Transportation:by air or by sea Port:shanghai

3-(Trifluoromethyl)benzonitrile

Cas:368-77-4

Min.Order:1 Kilogram

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

3-(Trifluoromethyl)benzonitrile

Cas:368-77-4

Min.Order:1 Kilogram

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Henan Tianfu Chemical Co., Ltd.

3-(Trifluoromethyl)benzonitrile Basic information Product Name: 3-(Trifluoromethyl)benzonitrile Synonyms: M-(TRIFLUOROMETHYL)BENZONITRILE;3-CYANOBENZOTRIFLUORIDE;3-

3-(Trifluoromethyl)benzonitrile 368-77-4

Cas:368-77-4

Min.Order:1 Metric Ton

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 368-77-4 with fast shipping

Cas:368-77-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS 368-77-4 ,3-(Trifluoromethyl)benzonitrile

Cas:368-77-4

Min.Order:10 Kilogram

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Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:liquid Storage:Store in sealed containers at cool & dry plac

High Quality 99% 3-(Trifluoromethyl)benzonitrile CAS No 368-77-4

Cas:368-77-4

Min.Order:100 Gram

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Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzonitrile,3-(trifluoromethyl)- 368-77-4

Cas:368-77-4

Min.Order:1 Kilogram

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

3-(Trifluoromethyl)benzonitrile

Cas:368-77-4

Min.Order:5 Gram

FOB Price: $321.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:368-77-4

Cas:368-77-4

Min.Order:0

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3-(Trifluoromethyl)Benzonitrile

Cas:368-77-4

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-(Trifluoromethyl)benzonitrile

Cas:368-77-4

Min.Order:0 Metric Ton

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Trifluoromethylbenzonitrile

Cas:368-77-4

Min.Order:0

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Type:Lab/Research institutions

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

3-(Trifluoromethyl)benzonitrile

Cas:368-77-4

Min.Order:1 Gram

Negotiable

Type:Other

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

3-(Trifluoromethyl)benzonitrile

Cas:368-77-4

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:Colorless or light yellow liquid Storage:In Room Temperature Package:25kg/drum, or as per your request. Application:medicine , pesticide intermediates Transportation:as per your

3-(Trifluoromethyl)benzonitrile

Cas:368-77-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply Alpha,Alpha,Alpha-Trifluoro-m-tolunitrile

Cas:368-77-4

Min.Order:0

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Type:Other

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Siwei Development Group Ltd.

Product name: 3-(Trifluoromethyl)benzonitrile CAS No.: 368-77-4 Molecule Formula:C8H4F3N Molecule Weight:171.12 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TE

Lower Price 3-(Trifluoromethyl)benzonitrile on stock

Cas:368-77-4

Min.Order:1 Kilogram

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Type:Trading Company

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Wuhan Fortuna Chemical Co.,Ltd

CAS:368-77-4 EINECS:206-711-4 MW:171.12 MF:C8H4F3N Melting point:16-20 °C(lit.) Boling point:189 °C(lit.) Appearance:colorless to light yellow liquid Package:200kg/Steel drum Transportation:by sea Port:Shanghai

3-(Trifluoromethyl)benzonitrile

Cas:368-77-4

Min.Order:0 Metric Ton

Negotiable

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Shanghai Minstar Chemical Co., Ltd

Product Name: 3-(Trifluoromethyl)benzonitrile Synonyms: M-(TRIFLUOROMETHYL)BENZONITRILE;A,A,A-TRIFLUORO-M-TOLUNITRILE;ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLUNITRILE;3-CYANOBENZOTRIFLUORIDE;3-(TRIFLUOROMETHYL)BENZONITRILE;3-(TrifluoroMethyl)benzonitr

3-(Trifluoromethyl)benzonitrile 368-77-4 C8H4F3N

Cas:368-77-4

Min.Order:1 Gram

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

3-(Trifluoromethyl)benzonitrile

Cas:368-77-4

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

3-(Trifluoromethyl)benzonitrile

Cas:368-77-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

3-(Trifluoromethyl)benzonitrile

Cas:368-77-4

Min.Order:1 Gram

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Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

3-(Trifluoromethyl)benzonitrile

Cas:368-77-4

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

3-(Trifluoromethyl)benzonitrile

Cas:368-77-4

Min.Order:0

Negotiable

Type:Manufacturers

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Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

3-(Trifluoromethyl)benzonitrile

Cas:368-77-4

Min.Order:1 Kilogram

Negotiable

Type:Other

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

3-(Trifluoromethyl)benzonitrile

Cas:368-77-4

Min.Order:1 Metric Ton

FOB Price: $1.0

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Synthetic route

m-trifluoromethylphenyl iodide
401-81-0

m-trifluoromethylphenyl iodide

sodium cyanide
143-33-9

sodium cyanide

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

Conditions
ConditionsYield
With sodium tetrahydroborate; zinc(II) chloride; Na2{PdCl2(Ph2P(m-C6H4SO3))2} In n-heptane; water for 3h; Heating;93%
3-Trifluoromethylbenzaldehyde
454-89-7

3-Trifluoromethylbenzaldehyde

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

Conditions
ConditionsYield
With ammonium hydroxide; sodium persulfate; sodium iodide; iron(II) chloride In 1,2-dichloro-ethane at 20 - 50℃; for 16h;92%
With hydroxylamine hydrochloride In methanol; water at 20℃; for 18h; Irradiation;87%
Multi-step reaction with 2 steps
1: hydroxylamine hydrochloride
2: 8 percent Chromat. / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / acetonitrile / 0.5 h / Photolysis
View Scheme
Multi-step reaction with 2 steps
1: hydroxylamine hydrochloride; potassium carbonate / 20 °C
2: potassium carbonate; fluorosulfonyl fluoride / 12 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: hydroxylamine / acetonitrile / 2 h / Reflux
2: triethylamine; fluorosulfonyl fluoride / acetonitrile / 0.5 h / 20 °C
View Scheme
3-bromo-1-trifluoromethylbenzene
401-78-5

3-bromo-1-trifluoromethylbenzene

potassiumhexacyanoferrate(II) trihydrate

potassiumhexacyanoferrate(II) trihydrate

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); tris(2-morpholinophenyl)phosphine; potassium carbonate In water; tert-butyl alcohol at 85℃; for 5h; Schlenk technique; Inert atmosphere;89%
With tetrabutylammomium bromide; copper(II) acetate monohydrate; potassium iodide In water at 180℃; for 22h;83%
sodium cyanide
773837-37-9

sodium cyanide

3-bromo-1-trifluoromethylbenzene
401-78-5

3-bromo-1-trifluoromethylbenzene

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

Conditions
ConditionsYield
With tri-tert-butyl phosphine; [Pd2(dba)5]; zinc In tetrahydrofuran; acetonitrile at 70℃; for 2h;88%
(meta-(trifluoromethyl)phenyl)boronic acid
1423-26-3

(meta-(trifluoromethyl)phenyl)boronic acid

5-bromo-3-thiocyanatoindole

5-bromo-3-thiocyanatoindole

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

Conditions
ConditionsYield
With N,N,N-trimethyl-2-(sulfooxy)ethanaminium palladium(II) chloride; sodium carbonate In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; water for 2h;87%
4-thiocyanatoaniline
2987-46-4

4-thiocyanatoaniline

(meta-(trifluoromethyl)phenyl)boronic acid
1423-26-3

(meta-(trifluoromethyl)phenyl)boronic acid

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

Conditions
ConditionsYield
With N,N,N-trimethyl-2-(sulfooxy)ethanaminium palladium(II) chloride; sodium carbonate In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; water for 2h;87%
3-(trifluoromethyl)benzothioamide
53515-17-6

3-(trifluoromethyl)benzothioamide

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

Conditions
ConditionsYield
With methylene blue; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 25℃; Sealed tube; Irradiation;85%
3-(trifluoromethyl)phenylacetone
21906-39-8

3-(trifluoromethyl)phenylacetone

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

Conditions
ConditionsYield
With aluminum (III) chloride; sodium nitrite In N,N-dimethyl-formamide at 120℃; for 4h; Schlenk technique;84%
3-(trifluoromethyl)benzyl alcohol
349-75-7

3-(trifluoromethyl)benzyl alcohol

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

Conditions
ConditionsYield
With ammonium hydroxide; oxygen In tert-Amyl alcohol under 7500.75 Torr; for 24h; Green chemistry;83%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; ammonium acetate; oxygen; nitric acid; acetic acid at 50℃; under 760.051 Torr; for 12h; Sealed tube;67%
With ammonium hydroxide; oxygen In tert-Amyl alcohol at 130℃; under 3750.38 Torr; for 24h;82 %Chromat.
Multi-step reaction with 3 steps
1: potassium carbonate; fluorosulfonyl fluoride; dimethyl sulfoxide / 12 h / 20 °C
2: hydroxylamine hydrochloride; potassium carbonate / 20 °C
3: potassium carbonate; fluorosulfonyl fluoride / 12 h / 20 °C
View Scheme
3-bromo-1-trifluoromethylbenzene
401-78-5

3-bromo-1-trifluoromethylbenzene

potassium ferrocyanide

potassium ferrocyanide

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

Conditions
ConditionsYield
With dichloro[bis{1-(dicyclohexylphosphanyl)piperidine}]palladium; sodium carbonate In 1-methyl-pyrrolidin-2-one at 140℃; for 14h; Inert atmosphere;82%
With hydrogen tetrachloropalladate; sodium phosphate In N,N-dimethyl-formamide at 120℃; for 8h; Inert atmosphere;80 %Spectr.
4-bromoethylbutanoate
2969-81-5

4-bromoethylbutanoate

2-chloro-5-(trifluoromethyl)benzonitrile
328-87-0

2-chloro-5-(trifluoromethyl)benzonitrile

A

diethyl suberate
2050-23-9

diethyl suberate

B

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

C

ethyl 4-(2-cyano-4-(trifluoromethyl)phenyl)butanoate
1365610-72-5

ethyl 4-(2-cyano-4-(trifluoromethyl)phenyl)butanoate

D

C16H6F6N2

C16H6F6N2

E

butanoic acid ethyl ester
105-54-4

butanoic acid ethyl ester

Conditions
ConditionsYield
With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; 4,4'-Dimethoxy-2,2'-bipyridin; NiI2*3.5H2O; sodium iodide; zinc at 20 - 60℃; for 18h; chemoselective reaction;A n/a
B n/a
C 80%
D n/a
E n/a
3-bromo-1-trifluoromethylbenzene
401-78-5

3-bromo-1-trifluoromethylbenzene

2,2-dimethylmalononitrile
7321-55-3

2,2-dimethylmalononitrile

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

Conditions
ConditionsYield
Stage #1: 3-bromo-1-trifluoromethylbenzene With TurboGrignard In tetrahydrofuran at 0℃; for 2h;
Stage #2: 2,2-dimethylmalononitrile In tetrahydrofuran at 0 - 23℃; for 16h;
79%
3-(TRIFLUOROMETHYL)BENZYLAMINE
2740-83-2

3-(TRIFLUOROMETHYL)BENZYLAMINE

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

Conditions
ConditionsYield
With Dess-Martin periodane In dichloromethane at 25℃; for 0.25h;77%
With C68H64Cl2N6P2Ru2(4+)*2F6P(1-)*2Cl(1-); caesium carbonate In N,N-dimethyl-formamide at 100℃; for 24h; Inert atmosphere; Green chemistry;70.2%
With copper(l) iodide; oxygen In dichloromethane at 20℃; under 760.051 Torr; for 6h; Sealed tube;71 %Spectr.
3-(trifluoromethyl)benzaldehyde oxime
368-83-2

3-(trifluoromethyl)benzaldehyde oxime

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

Conditions
ConditionsYield
With trifluoromethylsulfonic anhydride In dichloromethane at 20℃; for 12h; Inert atmosphere;71%
With fluorosulfonyl fluoride; potassium carbonate at 20℃; for 12h;210 mg
With fluorosulfonyl fluoride; triethylamine In acetonitrile at 20℃; for 0.5h;
3-iodobenzonitrile
69113-59-3

3-iodobenzonitrile

1,10-phenanthroline trifluoroacetic acid cuprous (I)

1,10-phenanthroline trifluoroacetic acid cuprous (I)

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

Conditions
ConditionsYield
With sodium fluoride In N,N-dimethyl-formamide at 140℃; for 8h; Inert atmosphere; Sealed tube;66%
zinc(II) cyanide
557-21-1

zinc(II) cyanide

1-(3-(trifluoromethyl)benzoyl)piperidine-2,6-dione

1-(3-(trifluoromethyl)benzoyl)piperidine-2,6-dione

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

Conditions
ConditionsYield
With palladium diacetate; cyclohexyldiphenylphosphine In 1,4-dioxane at 150℃; for 16h; Inert atmosphere; Schlenk technique; chemoselective reaction;66%
tetra-n-butylammonium cyanide
10442-39-4

tetra-n-butylammonium cyanide

C13H9F3N2S
114650-56-5

C13H9F3N2S

A

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

B

phenyl 4-trifluoromethylphenyl sulfide
53451-90-4

phenyl 4-trifluoromethylphenyl sulfide

Conditions
ConditionsYield
In dimethyl sulfoxide at 25℃; for 1h; Irradiation;A 61%
B 13%
C13H9F3N2S
114650-56-5

C13H9F3N2S

A

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

B

(3-trifluoromethyl-phenyl)-phenyl sulfide
2715-07-3

(3-trifluoromethyl-phenyl)-phenyl sulfide

Conditions
ConditionsYield
With tetramethylammonium cyanide In dimethyl sulfoxide at 25℃; for 1h; Irradiation;A 61%
B 13%
N-cyano-N-phenyl-p-toluenesulfonamide
55305-43-6

N-cyano-N-phenyl-p-toluenesulfonamide

(meta-(trifluoromethyl)phenyl)boronic acid
1423-26-3

(meta-(trifluoromethyl)phenyl)boronic acid

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

Conditions
ConditionsYield
With hydroxo(1,5-cyclooctadiene)rhodium (I) dimer; potassium carbonate In 1,4-dioxane at 80℃; for 4h; Inert atmosphere;58%
3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
214360-46-0

3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

potassium trimethoxy(trifluoromethyl)boranuide

potassium trimethoxy(trifluoromethyl)boranuide

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

Conditions
ConditionsYield
With oxygen; copper diacetate In dimethyl sulfoxide at 60℃; under 760.051 Torr; for 16h;40%
3-trifluoromethylnitrobenzene
98-46-4

3-trifluoromethylnitrobenzene

tetraethylammoniumcyanide
13435-20-6

tetraethylammoniumcyanide

A

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

B

2-nitro-4-trifluoromethyl-benzonitrile
778-94-9

2-nitro-4-trifluoromethyl-benzonitrile

Conditions
ConditionsYield
With tetrabutylammonium tetrafluoroborate In N,N-dimethyl-formamide at 10℃; Electrolysis;A 27%
B n/a
3-trifluoromethylaniline
98-16-8

3-trifluoromethylaniline

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

Conditions
ConditionsYield
With hydrogenchloride Diazotization.Behandlung der Diazoniumsalzloesung mit Kupferkaliumcyanuer;
With alkali-tetracyanocuprate (I)-solution Diazotization;
benzene-1,3-dicarbonitrile
626-17-5

benzene-1,3-dicarbonitrile

ortho-trifluoromethylbenzonitrile anion

ortho-trifluoromethylbenzonitrile anion

A

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

B

C8H4N2(1-)

C8H4N2(1-)

Conditions
ConditionsYield
at 149.9℃; Thermodynamic data; ΔG0;
ethanedinitrile
460-19-5

ethanedinitrile

α,α,α-trifluorotoluene
98-08-8

α,α,α-trifluorotoluene

A

fluorobenzene
462-06-6

fluorobenzene

B

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

C

4-CF3C6H4CN
455-18-5

4-CF3C6H4CN

D

2-(trifluoromethyl)benzonitrile
447-60-9

2-(trifluoromethyl)benzonitrile

Conditions
ConditionsYield
gaseous plasma of glow discharge; Yield given. Further byproducts given. Yields of byproduct given;
ethanedinitrile
460-19-5

ethanedinitrile

α,α,α-trifluorotoluene
98-08-8

α,α,α-trifluorotoluene

A

hydrogen cyanide
74-90-8

hydrogen cyanide

B

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

C

4-CF3C6H4CN
455-18-5

4-CF3C6H4CN

D

2-(trifluoromethyl)benzonitrile
447-60-9

2-(trifluoromethyl)benzonitrile

E

benzonitrile
100-47-0

benzonitrile

F

toluene
108-88-3

toluene

Conditions
ConditionsYield
Product distribution; plasma apparatus; a variety of substituted benzenes and pyridine similarly cyanated;A n/a
B 32 % Chromat.
C 9.1 % Chromat.
D 11 % Chromat.
E 6.0 % Chromat.
F n/a
para-methoxynitrobenzene
100-17-4

para-methoxynitrobenzene

ortho-trifluoromethylbenzonitrile anion

ortho-trifluoromethylbenzonitrile anion

A

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

B

1-methoxy-4-nitro-benzene; radical anion
34473-10-4

1-methoxy-4-nitro-benzene; radical anion

Conditions
ConditionsYield
at 149.9℃; Thermodynamic data; ΔG0;
α,α,α-trifluorotoluene
98-08-8

α,α,α-trifluorotoluene

A

fluorobenzene
462-06-6

fluorobenzene

B

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

C

2-(trifluoromethyl)benzonitrile
447-60-9

2-(trifluoromethyl)benzonitrile

D

benzene
71-43-2

benzene

Conditions
ConditionsYield
gaseous plasma of glow discharge; Yield given. Further byproducts given. Yields of byproduct given;
2,3-dimethylnitrobenzene
83-41-0

2,3-dimethylnitrobenzene

ortho-trifluoromethylbenzonitrile anion

ortho-trifluoromethylbenzonitrile anion

A

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

B

1,2-Dimethyl-3-nitro-benzene
35963-33-8

1,2-Dimethyl-3-nitro-benzene

Conditions
ConditionsYield
at 149.9℃; Thermodynamic data; ΔG0;
(m-(trifluoromethyl)phenyl)bromodiazirine
125330-15-6

(m-(trifluoromethyl)phenyl)bromodiazirine

sodium thiophenolate
930-69-8

sodium thiophenolate

A

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

B

3-(trifluoromethyl)benzene-1-carboximidamide
26130-45-0

3-(trifluoromethyl)benzene-1-carboximidamide

C

diphenyldisulfane
882-33-7

diphenyldisulfane

Conditions
ConditionsYield
In methanol at 25℃; Rate constant;
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

(Z)-N’-hydroxy-3-(trifluoromethyl)benzimidamide
40067-80-9

(Z)-N’-hydroxy-3-(trifluoromethyl)benzimidamide

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium carbonate In ethanol for 22h; Reflux;100%
With hydroxylamine hydrochloride; triethylamine In ethanol Heating;
With hydroxylamine hydrochloride; triethylamine In ethanol at 80℃; for 4h; Inert atmosphere; Schlenk technique;
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

3-(trifluoromethyl)benzene-1-carboximidamide
26130-45-0

3-(trifluoromethyl)benzene-1-carboximidamide

Conditions
ConditionsYield
With lithium hexamethyldisilazane In tetrahydrofuran; toluene at 20℃; Inert atmosphere;100%
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

(3-(trifluoromethyl)phenyl)methanamine hydrochloride
2944-96-9

(3-(trifluoromethyl)phenyl)methanamine hydrochloride

Conditions
ConditionsYield
Stage #1: 3-trifluoromethylbenzonitrile With [2,6-η6:η1-bis(2,4,6-trimethylphenyl)phenylthiolato]triethylphosphineruthenium(II)tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; diethylphenylsilane at 20℃; for 18h; Glovebox; Inert atmosphere;
Stage #2: With hydrogenchloride In diethyl ether at 20℃; for 1h; Glovebox; Inert atmosphere;
99%
Stage #1: 3-trifluoromethylbenzonitrile With hydrogen; C20H40MoN2O2P2; sodium triethylborohydride In tetrahydrofuran; toluene at 100℃; under 37503.8 Torr; for 24h; Autoclave;
Stage #2: With hydrogenchloride In diethyl ether; water
Multi-step reaction with 3 steps
1: C16H11BrMnN3O3 / tetrahydrofuran / 24 h / 120 °C / Inert atmosphere; Sealed tube
2: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C
3: hydrogenchloride / water / 20 °C
View Scheme
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

N'-hydroxy-3-(trifluoromethyl)benzenecarboximidamide
40067-80-9

N'-hydroxy-3-(trifluoromethyl)benzenecarboximidamide

Conditions
ConditionsYield
With hydroxylamine monohydrate In ethanol at 90℃; for 1.5h; Sealed tube;98%
With hydroxylamine hydrochloride; sodium carbonate In ethanol Heating;96%
With hydroxylamine hydrochloride; sodium carbonate In ethanol; water
Triisopropyl borate
5419-55-6

Triisopropyl borate

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

2,2-Dimethyl-1,3-propanediol
126-30-7

2,2-Dimethyl-1,3-propanediol

2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5-(trifluoromethyl)benzonitrile
883898-98-4

2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5-(trifluoromethyl)benzonitrile

Conditions
ConditionsYield
Stage #1: Triisopropyl borate; 3-trifluoromethylbenzonitrile With 2,2,6,6-tetramethylpiperidinyl-lithium In tetrahydrofuran; hexane at -78 - 20℃;
Stage #2: 2,2-Dimethyl-1,3-propanediol In tetrahydrofuran; hexane at 20℃; for 1h;
98%
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

methyllithium
917-54-4

methyllithium

1-methyl-1-[(3-trifluoromethyl)-phenyl]ethylamine
153390-61-5

1-methyl-1-[(3-trifluoromethyl)-phenyl]ethylamine

Conditions
ConditionsYield
Stage #1: methyllithium With cerium(III) chloride In tetrahydrofuran; diethyl ether at -50℃; for 0.5h;
Stage #2: 3-trifluoromethylbenzonitrile In tetrahydrofuran; diethyl ether at -50 - 20℃;
98%
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

5-(3-(trifluoromethyl)phenyl)-1H-tetrazole

5-(3-(trifluoromethyl)phenyl)-1H-tetrazole

Conditions
ConditionsYield
With sodium azide; tetra(n-butyl)ammonium hydrogensulfate In water at 85℃; for 3h; Green chemistry;98%
With sodium azide; triethylamine hydrochloride80%
With sodium azide; N,N-dimethylammonium chloride In N,N-dimethyl-formamide at 110 - 115℃; for 8h;
With sodium azide; triethylamine hydrochloride In toluene at 120℃;
With trimethylsilylazide at 140℃; for 4h; Reagent/catalyst; Temperature; Sealed tube;
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

3-(trifluoromethyl)benzothioamide
53515-17-6

3-(trifluoromethyl)benzothioamide

Conditions
ConditionsYield
With pyridine; hydrogen sulfide; triethylamine at 20℃; Addition;97.5%
With hydrogenchloride; thioacetamide In N,N-dimethyl-formamide at 100℃; for 19h;88%
With pyridine; diammonium sulfide; triethylamine In water at 50℃;
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

3-(TRIFLUOROMETHYL)BENZYLAMINE
2740-83-2

3-(TRIFLUOROMETHYL)BENZYLAMINE

Conditions
ConditionsYield
With sodium tetrahydroborate In water at 95℃; for 1h; chemoselective reaction;97%
With C28H29Cl2CoNP2; hydrogen; sodium triethylborohydride In 1,4-dioxane at 80℃; under 37503.8 Torr; for 6h;87%
With hydrogen; silica gel; nickel In methanol; ammonia at 120℃; under 7600 Torr; for 6h;86%
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

methyl 2-diazo-2-(fluorosulfonyl)acetate

methyl 2-diazo-2-(fluorosulfonyl)acetate

5-methoxy-2-(3-(trifluoromethyl)phenyl)oxazole-4-sulfonyl fluoride

5-methoxy-2-(3-(trifluoromethyl)phenyl)oxazole-4-sulfonyl fluoride

Conditions
ConditionsYield
Stage #1: 3-trifluoromethylbenzonitrile With dirhodium tetraacetate In chloroform at 70℃;
Stage #2: methyl 2-diazo-2-(fluorosulfonyl)acetate In chloroform at 70℃; for 12h;
97%
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

2-amino-benzenethiol
137-07-5

2-amino-benzenethiol

2-(3-(trifluoromethyl)phenyl)benzo[d]thiazole
133389-19-2

2-(3-(trifluoromethyl)phenyl)benzo[d]thiazole

Conditions
ConditionsYield
With ortho-methylbenzoic acid at 120℃; for 14h;96%
With trifluorormethanesulfonic acid In neat (no solvent) at 100℃; for 12h;90%
With sodium hydride 1.) THF, RT, 15 min, 2.) THF, 60 deg C, 3 h; Yield given. Multistep reaction;
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

ethanolamine
141-43-5

ethanolamine

2-(3-(trifluoromethyl)phenyl)-4,5-dihydrooxazole
851513-74-1

2-(3-(trifluoromethyl)phenyl)-4,5-dihydrooxazole

Conditions
ConditionsYield
With chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I); sodium acetate In neat (no solvent) at 100℃; for 16h; Glovebox; Inert atmosphere;95%
With calcium chloride In 5,5-dimethyl-1,3-cyclohexadiene at 125℃;86%
With calcium chloride In 5,5-dimethyl-1,3-cyclohexadiene at 125℃;85%
With calcium chloride In xylene at 125℃; for 24h;77%
With calcium chloride In 5,5-dimethyl-1,3-cyclohexadiene at 125℃; for 24h; Inert atmosphere;77%
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

3-trifluoromethylbenzamide
1801-10-1

3-trifluoromethylbenzamide

Conditions
ConditionsYield
Stage #1: 3-trifluoromethylbenzonitrile With caesium carbonate In 2-pyrrolidinon at 130℃; for 2h; Sealed vessel;
Stage #2: With methanol In 2-pyrrolidinon; dichloromethane at 20℃; Filtering through Celite pad;
95%
With water; sodium hydroxide In ethanol at 90℃; for 17h;95%
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

benzaldehyde p-toluenesulfonylhydrazone
1666-17-7

benzaldehyde p-toluenesulfonylhydrazone

4-phenyl-5-(3-(trifluoromethyl)phenyl)-2H-1,2,3-triazole

4-phenyl-5-(3-(trifluoromethyl)phenyl)-2H-1,2,3-triazole

Conditions
ConditionsYield
With potassium tert-butylate In 5,5-dimethyl-1,3-cyclohexadiene at 90℃; for 4h; Inert atmosphere;95%
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

tert-butyl(trimethylsilyl)phosphine
67033-70-9

tert-butyl(trimethylsilyl)phosphine

tert-butyl-(3-trifluoromethyl-phenyl)-phosphane

tert-butyl-(3-trifluoromethyl-phenyl)-phosphane

Conditions
ConditionsYield
bis-triphenylphosphine-palladium(II) chloride at 100℃; for 40h;94%
2-aminopyridine
504-29-0

2-aminopyridine

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

2-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine
253328-67-5

2-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine

Conditions
ConditionsYield
With zinc(II) iodide In 1,2-dichloro-benzene at 130℃; for 24h; Sealed tube;94%
With 1,10-Phenanthroline; oxygen; copper(I) bromide; zinc(II) iodide In 1,2-dichloro-benzene at 130℃; for 24h;90%
With air; copper-zinc supported on Al2O3-TiO2 In 1,2-dichloro-benzene at 140℃; for 20h; Green chemistry;82%
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

tert-butylmercury chloride
38442-51-2

tert-butylmercury chloride

5-(trifluoromethyl)-2-(1,1-dimethylethyl)benzonitrile

5-(trifluoromethyl)-2-(1,1-dimethylethyl)benzonitrile

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane In dimethyl sulfoxide at 30 - 35℃; for 48h; Irradiation;91%
methanol
67-56-1

methanol

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

methyl 3-(trifluoromethyl)benzimidate hydrochloride
56108-09-9

methyl 3-(trifluoromethyl)benzimidate hydrochloride

Conditions
ConditionsYield
With hydrogenchloride at 20 - 40℃; for 6h;90%
With hydrogenchloride In diethyl ether at 0 - 5℃;80%
With hydrogenchloride In diethyl ether at 3 - 4℃;
With hydrogenchloride In toluene for 20h; Ambient temperature;
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

3-Trifluoromethylbenzaldehyde
454-89-7

3-Trifluoromethylbenzaldehyde

Conditions
ConditionsYield
With formic acid; hydrogen In water at 80℃; under 15751.6 Torr; for 10h;89%
With formic acid; hydrogen; Ni/Al-alloy In water at 80℃; under 18751.9 Torr; for 7h;85%
With hydrogenchloride; diethyl ether; tin(ll) chloride
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

acetamidine hydrochloride
124-42-5

acetamidine hydrochloride

5-methyl-3-(3-(trifluoromethyl)phenyl)-1H-1,2,4-triazole
1094688-10-4

5-methyl-3-(3-(trifluoromethyl)phenyl)-1H-1,2,4-triazole

Conditions
ConditionsYield
With caesium carbonate In dimethyl sulfoxide at 120℃; for 24h; Sealed tube;88%
With oxygen; caesium carbonate; copper(I) bromide In dimethyl sulfoxide at 120℃; for 24h;85%
3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

6-fluorobenzo[d]oxazole

6-fluorobenzo[d]oxazole

C14H7F4NO

C14H7F4NO

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)nickel (0); caesium carbonate; 1,2-bis-(dicyclohexylphosphino)ethane In diethylene glycol dimethyl ether at 140℃; for 24h; Sealed tube;85%
ethanol
64-17-5

ethanol

3-trifluoromethylbenzonitrile
368-77-4

3-trifluoromethylbenzonitrile

O-ethyl 3-trifluoromethylbenzimidate
55308-43-5

O-ethyl 3-trifluoromethylbenzimidate

Conditions
ConditionsYield
With hydrogenchloride In chloroform at -5℃;84%
With acetyl chloride at 25℃;

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