3-(trifluoromethyl)benzonitrile cas no:368-77-4 chemical name:2-(trifluoromethyl)benzonitrile structural formul appearance:colorless to pale yellow transparent liquid content: ≥98% (gc) package, storage and transport
Cas:368-77-4
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:368-77-4
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inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
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inquiryProduct description: Product name 3-(Trifluoromethyl)benzonitrile CAS number 368-77-4 Assay ≥99% Appearance Colorless or yellowish liquid Capacity 200mt/year Application Phar
Cas:368-77-4
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inquiryhigh quality Appearance:Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Intermediates Transportation:by air or by sea Port:shanghai
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiry3-(Trifluoromethyl)benzonitrile Basic information Product Name: 3-(Trifluoromethyl)benzonitrile Synonyms: M-(TRIFLUOROMETHYL)BENZONITRILE;3-CYANOBENZOTRIFLUORIDE;3-
Cas:368-77-4
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:368-77-4
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:368-77-4
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:liquid Storage:Store in sealed containers at cool & dry plac
Cas:368-77-4
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Cas:368-77-4
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inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:368-77-4
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:368-77-4
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:368-77-4
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inquiryWhy Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
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Cas:368-77-4
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inquirySuperior quality, moderate price & quick delivery. Appearance:Colorless or light yellow liquid Storage:In Room Temperature Package:25kg/drum, or as per your request. Application:medicine , pesticide intermediates Transportation:as per your
Cas:368-77-4
Min.Order:1 Kilogram
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h
Cas:368-77-4
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inquiryProduct name: 3-(Trifluoromethyl)benzonitrile CAS No.: 368-77-4 Molecule Formula:C8H4F3N Molecule Weight:171.12 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TE
Cas:368-77-4
Min.Order:1 Kilogram
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Type:Trading Company
inquiryCAS:368-77-4 EINECS:206-711-4 MW:171.12 MF:C8H4F3N Melting point:16-20 °C(lit.) Boling point:189 °C(lit.) Appearance:colorless to light yellow liquid Package:200kg/Steel drum Transportation:by sea Port:Shanghai
Cas:368-77-4
Min.Order:0 Metric Ton
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inquiryProduct Name: 3-(Trifluoromethyl)benzonitrile Synonyms: M-(TRIFLUOROMETHYL)BENZONITRILE;A,A,A-TRIFLUORO-M-TOLUNITRILE;ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLUNITRILE;3-CYANOBENZOTRIFLUORIDE;3-(TRIFLUOROMETHYL)BENZONITRILE;3-(TrifluoroMethyl)benzonitr
Cas:368-77-4
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:368-77-4
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
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inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
Cas:368-77-4
Min.Order:1 Kilogram
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:368-77-4
Min.Order:1 Gram
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:368-77-4
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inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
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inquirym-trifluoromethylphenyl iodide
sodium cyanide
3-trifluoromethylbenzonitrile
Conditions | Yield |
---|---|
With sodium tetrahydroborate; zinc(II) chloride; Na2{PdCl2(Ph2P(m-C6H4SO3))2} In n-heptane; water for 3h; Heating; | 93% |
Conditions | Yield |
---|---|
With ammonium hydroxide; sodium persulfate; sodium iodide; iron(II) chloride In 1,2-dichloro-ethane at 20 - 50℃; for 16h; | 92% |
With hydroxylamine hydrochloride In methanol; water at 20℃; for 18h; Irradiation; | 87% |
Multi-step reaction with 2 steps 1: hydroxylamine hydrochloride 2: 8 percent Chromat. / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / acetonitrile / 0.5 h / Photolysis View Scheme | |
Multi-step reaction with 2 steps 1: hydroxylamine hydrochloride; potassium carbonate / 20 °C 2: potassium carbonate; fluorosulfonyl fluoride / 12 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydroxylamine / acetonitrile / 2 h / Reflux 2: triethylamine; fluorosulfonyl fluoride / acetonitrile / 0.5 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); tris(2-morpholinophenyl)phosphine; potassium carbonate In water; tert-butyl alcohol at 85℃; for 5h; Schlenk technique; Inert atmosphere; | 89% |
With tetrabutylammomium bromide; copper(II) acetate monohydrate; potassium iodide In water at 180℃; for 22h; | 83% |
sodium cyanide
3-bromo-1-trifluoromethylbenzene
3-trifluoromethylbenzonitrile
Conditions | Yield |
---|---|
With tri-tert-butyl phosphine; [Pd2(dba)5]; zinc In tetrahydrofuran; acetonitrile at 70℃; for 2h; | 88% |
Conditions | Yield |
---|---|
With N,N,N-trimethyl-2-(sulfooxy)ethanaminium palladium(II) chloride; sodium carbonate In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; water for 2h; | 87% |
4-thiocyanatoaniline
(meta-(trifluoromethyl)phenyl)boronic acid
3-trifluoromethylbenzonitrile
Conditions | Yield |
---|---|
With N,N,N-trimethyl-2-(sulfooxy)ethanaminium palladium(II) chloride; sodium carbonate In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; water for 2h; | 87% |
3-(trifluoromethyl)benzothioamide
3-trifluoromethylbenzonitrile
Conditions | Yield |
---|---|
With methylene blue; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 25℃; Sealed tube; Irradiation; | 85% |
3-(trifluoromethyl)phenylacetone
3-trifluoromethylbenzonitrile
Conditions | Yield |
---|---|
With aluminum (III) chloride; sodium nitrite In N,N-dimethyl-formamide at 120℃; for 4h; Schlenk technique; | 84% |
Conditions | Yield |
---|---|
With ammonium hydroxide; oxygen In tert-Amyl alcohol under 7500.75 Torr; for 24h; Green chemistry; | 83% |
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; ammonium acetate; oxygen; nitric acid; acetic acid at 50℃; under 760.051 Torr; for 12h; Sealed tube; | 67% |
With ammonium hydroxide; oxygen In tert-Amyl alcohol at 130℃; under 3750.38 Torr; for 24h; | 82 %Chromat. |
Multi-step reaction with 3 steps 1: potassium carbonate; fluorosulfonyl fluoride; dimethyl sulfoxide / 12 h / 20 °C 2: hydroxylamine hydrochloride; potassium carbonate / 20 °C 3: potassium carbonate; fluorosulfonyl fluoride / 12 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
With dichloro[bis{1-(dicyclohexylphosphanyl)piperidine}]palladium; sodium carbonate In 1-methyl-pyrrolidin-2-one at 140℃; for 14h; Inert atmosphere; | 82% |
With hydrogen tetrachloropalladate; sodium phosphate In N,N-dimethyl-formamide at 120℃; for 8h; Inert atmosphere; | 80 %Spectr. |
4-bromoethylbutanoate
2-chloro-5-(trifluoromethyl)benzonitrile
A
diethyl suberate
B
3-trifluoromethylbenzonitrile
C
ethyl 4-(2-cyano-4-(trifluoromethyl)phenyl)butanoate
E
butanoic acid ethyl ester
Conditions | Yield |
---|---|
With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; 4,4'-Dimethoxy-2,2'-bipyridin; NiI2*3.5H2O; sodium iodide; zinc at 20 - 60℃; for 18h; chemoselective reaction; | A n/a B n/a C 80% D n/a E n/a |
3-bromo-1-trifluoromethylbenzene
2,2-dimethylmalononitrile
3-trifluoromethylbenzonitrile
Conditions | Yield |
---|---|
Stage #1: 3-bromo-1-trifluoromethylbenzene With TurboGrignard In tetrahydrofuran at 0℃; for 2h; Stage #2: 2,2-dimethylmalononitrile In tetrahydrofuran at 0 - 23℃; for 16h; | 79% |
Conditions | Yield |
---|---|
With Dess-Martin periodane In dichloromethane at 25℃; for 0.25h; | 77% |
With C68H64Cl2N6P2Ru2(4+)*2F6P(1-)*2Cl(1-); caesium carbonate In N,N-dimethyl-formamide at 100℃; for 24h; Inert atmosphere; Green chemistry; | 70.2% |
With copper(l) iodide; oxygen In dichloromethane at 20℃; under 760.051 Torr; for 6h; Sealed tube; | 71 %Spectr. |
Conditions | Yield |
---|---|
With trifluoromethylsulfonic anhydride In dichloromethane at 20℃; for 12h; Inert atmosphere; | 71% |
With fluorosulfonyl fluoride; potassium carbonate at 20℃; for 12h; | 210 mg |
With fluorosulfonyl fluoride; triethylamine In acetonitrile at 20℃; for 0.5h; |
3-iodobenzonitrile
3-trifluoromethylbenzonitrile
Conditions | Yield |
---|---|
With sodium fluoride In N,N-dimethyl-formamide at 140℃; for 8h; Inert atmosphere; Sealed tube; | 66% |
Conditions | Yield |
---|---|
With palladium diacetate; cyclohexyldiphenylphosphine In 1,4-dioxane at 150℃; for 16h; Inert atmosphere; Schlenk technique; chemoselective reaction; | 66% |
tetra-n-butylammonium cyanide
C13H9F3N2S
A
3-trifluoromethylbenzonitrile
B
phenyl 4-trifluoromethylphenyl sulfide
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 25℃; for 1h; Irradiation; | A 61% B 13% |
C13H9F3N2S
A
3-trifluoromethylbenzonitrile
B
(3-trifluoromethyl-phenyl)-phenyl sulfide
Conditions | Yield |
---|---|
With tetramethylammonium cyanide In dimethyl sulfoxide at 25℃; for 1h; Irradiation; | A 61% B 13% |
N-cyano-N-phenyl-p-toluenesulfonamide
(meta-(trifluoromethyl)phenyl)boronic acid
3-trifluoromethylbenzonitrile
Conditions | Yield |
---|---|
With hydroxo(1,5-cyclooctadiene)rhodium (I) dimer; potassium carbonate In 1,4-dioxane at 80℃; for 4h; Inert atmosphere; | 58% |
3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
3-trifluoromethylbenzonitrile
Conditions | Yield |
---|---|
With oxygen; copper diacetate In dimethyl sulfoxide at 60℃; under 760.051 Torr; for 16h; | 40% |
3-trifluoromethylnitrobenzene
tetraethylammoniumcyanide
A
3-trifluoromethylbenzonitrile
B
2-nitro-4-trifluoromethyl-benzonitrile
Conditions | Yield |
---|---|
With tetrabutylammonium tetrafluoroborate In N,N-dimethyl-formamide at 10℃; Electrolysis; | A 27% B n/a |
Conditions | Yield |
---|---|
With hydrogenchloride Diazotization.Behandlung der Diazoniumsalzloesung mit Kupferkaliumcyanuer; | |
With alkali-tetracyanocuprate (I)-solution Diazotization; |
Conditions | Yield |
---|---|
at 149.9℃; Thermodynamic data; ΔG0; |
ethanedinitrile
α,α,α-trifluorotoluene
A
fluorobenzene
B
3-trifluoromethylbenzonitrile
C
4-CF3C6H4CN
D
2-(trifluoromethyl)benzonitrile
Conditions | Yield |
---|---|
gaseous plasma of glow discharge; Yield given. Further byproducts given. Yields of byproduct given; |
ethanedinitrile
α,α,α-trifluorotoluene
A
hydrogen cyanide
B
3-trifluoromethylbenzonitrile
C
4-CF3C6H4CN
D
2-(trifluoromethyl)benzonitrile
E
benzonitrile
F
toluene
Conditions | Yield |
---|---|
Product distribution; plasma apparatus; a variety of substituted benzenes and pyridine similarly cyanated; | A n/a B 32 % Chromat. C 9.1 % Chromat. D 11 % Chromat. E 6.0 % Chromat. F n/a |
para-methoxynitrobenzene
A
3-trifluoromethylbenzonitrile
B
1-methoxy-4-nitro-benzene; radical anion
Conditions | Yield |
---|---|
at 149.9℃; Thermodynamic data; ΔG0; |
α,α,α-trifluorotoluene
A
fluorobenzene
B
3-trifluoromethylbenzonitrile
C
2-(trifluoromethyl)benzonitrile
D
benzene
Conditions | Yield |
---|---|
gaseous plasma of glow discharge; Yield given. Further byproducts given. Yields of byproduct given; |
2,3-dimethylnitrobenzene
A
3-trifluoromethylbenzonitrile
B
1,2-Dimethyl-3-nitro-benzene
Conditions | Yield |
---|---|
at 149.9℃; Thermodynamic data; ΔG0; |
(m-(trifluoromethyl)phenyl)bromodiazirine
sodium thiophenolate
A
3-trifluoromethylbenzonitrile
B
3-(trifluoromethyl)benzene-1-carboximidamide
C
diphenyldisulfane
Conditions | Yield |
---|---|
In methanol at 25℃; Rate constant; |
3-trifluoromethylbenzonitrile
(Z)-N’-hydroxy-3-(trifluoromethyl)benzimidamide
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride; sodium carbonate In ethanol for 22h; Reflux; | 100% |
With hydroxylamine hydrochloride; triethylamine In ethanol Heating; | |
With hydroxylamine hydrochloride; triethylamine In ethanol at 80℃; for 4h; Inert atmosphere; Schlenk technique; |
3-trifluoromethylbenzonitrile
3-(trifluoromethyl)benzene-1-carboximidamide
Conditions | Yield |
---|---|
With lithium hexamethyldisilazane In tetrahydrofuran; toluene at 20℃; Inert atmosphere; | 100% |
3-trifluoromethylbenzonitrile
(3-(trifluoromethyl)phenyl)methanamine hydrochloride
Conditions | Yield |
---|---|
Stage #1: 3-trifluoromethylbenzonitrile With [2,6-η6:η1-bis(2,4,6-trimethylphenyl)phenylthiolato]triethylphosphineruthenium(II)tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; diethylphenylsilane at 20℃; for 18h; Glovebox; Inert atmosphere; Stage #2: With hydrogenchloride In diethyl ether at 20℃; for 1h; Glovebox; Inert atmosphere; | 99% |
Stage #1: 3-trifluoromethylbenzonitrile With hydrogen; C20H40MoN2O2P2; sodium triethylborohydride In tetrahydrofuran; toluene at 100℃; under 37503.8 Torr; for 24h; Autoclave; Stage #2: With hydrogenchloride In diethyl ether; water | |
Multi-step reaction with 3 steps 1: C16H11BrMnN3O3 / tetrahydrofuran / 24 h / 120 °C / Inert atmosphere; Sealed tube 2: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C 3: hydrogenchloride / water / 20 °C View Scheme |
3-trifluoromethylbenzonitrile
N'-hydroxy-3-(trifluoromethyl)benzenecarboximidamide
Conditions | Yield |
---|---|
With hydroxylamine monohydrate In ethanol at 90℃; for 1.5h; Sealed tube; | 98% |
With hydroxylamine hydrochloride; sodium carbonate In ethanol Heating; | 96% |
With hydroxylamine hydrochloride; sodium carbonate In ethanol; water |
Triisopropyl borate
3-trifluoromethylbenzonitrile
2,2-Dimethyl-1,3-propanediol
2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5-(trifluoromethyl)benzonitrile
Conditions | Yield |
---|---|
Stage #1: Triisopropyl borate; 3-trifluoromethylbenzonitrile With 2,2,6,6-tetramethylpiperidinyl-lithium In tetrahydrofuran; hexane at -78 - 20℃; Stage #2: 2,2-Dimethyl-1,3-propanediol In tetrahydrofuran; hexane at 20℃; for 1h; | 98% |
3-trifluoromethylbenzonitrile
methyllithium
1-methyl-1-[(3-trifluoromethyl)-phenyl]ethylamine
Conditions | Yield |
---|---|
Stage #1: methyllithium With cerium(III) chloride In tetrahydrofuran; diethyl ether at -50℃; for 0.5h; Stage #2: 3-trifluoromethylbenzonitrile In tetrahydrofuran; diethyl ether at -50 - 20℃; | 98% |
3-trifluoromethylbenzonitrile
Conditions | Yield |
---|---|
With sodium azide; tetra(n-butyl)ammonium hydrogensulfate In water at 85℃; for 3h; Green chemistry; | 98% |
With sodium azide; triethylamine hydrochloride | 80% |
With sodium azide; N,N-dimethylammonium chloride In N,N-dimethyl-formamide at 110 - 115℃; for 8h; | |
With sodium azide; triethylamine hydrochloride In toluene at 120℃; | |
With trimethylsilylazide at 140℃; for 4h; Reagent/catalyst; Temperature; Sealed tube; |
3-trifluoromethylbenzonitrile
3-(trifluoromethyl)benzothioamide
Conditions | Yield |
---|---|
With pyridine; hydrogen sulfide; triethylamine at 20℃; Addition; | 97.5% |
With hydrogenchloride; thioacetamide In N,N-dimethyl-formamide at 100℃; for 19h; | 88% |
With pyridine; diammonium sulfide; triethylamine In water at 50℃; |
Conditions | Yield |
---|---|
With sodium tetrahydroborate In water at 95℃; for 1h; chemoselective reaction; | 97% |
With C28H29Cl2CoNP2; hydrogen; sodium triethylborohydride In 1,4-dioxane at 80℃; under 37503.8 Torr; for 6h; | 87% |
With hydrogen; silica gel; nickel In methanol; ammonia at 120℃; under 7600 Torr; for 6h; | 86% |
3-trifluoromethylbenzonitrile
Conditions | Yield |
---|---|
Stage #1: 3-trifluoromethylbenzonitrile With dirhodium tetraacetate In chloroform at 70℃; Stage #2: methyl 2-diazo-2-(fluorosulfonyl)acetate In chloroform at 70℃; for 12h; | 97% |
3-trifluoromethylbenzonitrile
2-amino-benzenethiol
2-(3-(trifluoromethyl)phenyl)benzo[d]thiazole
Conditions | Yield |
---|---|
With ortho-methylbenzoic acid at 120℃; for 14h; | 96% |
With trifluorormethanesulfonic acid In neat (no solvent) at 100℃; for 12h; | 90% |
With sodium hydride 1.) THF, RT, 15 min, 2.) THF, 60 deg C, 3 h; Yield given. Multistep reaction; |
3-trifluoromethylbenzonitrile
ethanolamine
2-(3-(trifluoromethyl)phenyl)-4,5-dihydrooxazole
Conditions | Yield |
---|---|
With chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I); sodium acetate In neat (no solvent) at 100℃; for 16h; Glovebox; Inert atmosphere; | 95% |
With calcium chloride In 5,5-dimethyl-1,3-cyclohexadiene at 125℃; | 86% |
With calcium chloride In 5,5-dimethyl-1,3-cyclohexadiene at 125℃; | 85% |
With calcium chloride In xylene at 125℃; for 24h; | 77% |
With calcium chloride In 5,5-dimethyl-1,3-cyclohexadiene at 125℃; for 24h; Inert atmosphere; | 77% |
Conditions | Yield |
---|---|
Stage #1: 3-trifluoromethylbenzonitrile With caesium carbonate In 2-pyrrolidinon at 130℃; for 2h; Sealed vessel; Stage #2: With methanol In 2-pyrrolidinon; dichloromethane at 20℃; Filtering through Celite pad; | 95% |
With water; sodium hydroxide In ethanol at 90℃; for 17h; | 95% |
Conditions | Yield |
---|---|
With potassium tert-butylate In 5,5-dimethyl-1,3-cyclohexadiene at 90℃; for 4h; Inert atmosphere; | 95% |
3-trifluoromethylbenzonitrile
tert-butyl(trimethylsilyl)phosphine
Conditions | Yield |
---|---|
bis-triphenylphosphine-palladium(II) chloride at 100℃; for 40h; | 94% |
2-aminopyridine
3-trifluoromethylbenzonitrile
2-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine
Conditions | Yield |
---|---|
With zinc(II) iodide In 1,2-dichloro-benzene at 130℃; for 24h; Sealed tube; | 94% |
With 1,10-Phenanthroline; oxygen; copper(I) bromide; zinc(II) iodide In 1,2-dichloro-benzene at 130℃; for 24h; | 90% |
With air; copper-zinc supported on Al2O3-TiO2 In 1,2-dichloro-benzene at 140℃; for 20h; Green chemistry; | 82% |
3-trifluoromethylbenzonitrile
tert-butylmercury chloride
Conditions | Yield |
---|---|
With 1,4-diaza-bicyclo[2.2.2]octane In dimethyl sulfoxide at 30 - 35℃; for 48h; Irradiation; | 91% |
methanol
3-trifluoromethylbenzonitrile
methyl 3-(trifluoromethyl)benzimidate hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride at 20 - 40℃; for 6h; | 90% |
With hydrogenchloride In diethyl ether at 0 - 5℃; | 80% |
With hydrogenchloride In diethyl ether at 3 - 4℃; | |
With hydrogenchloride In toluene for 20h; Ambient temperature; |
Conditions | Yield |
---|---|
With formic acid; hydrogen In water at 80℃; under 15751.6 Torr; for 10h; | 89% |
With formic acid; hydrogen; Ni/Al-alloy In water at 80℃; under 18751.9 Torr; for 7h; | 85% |
With hydrogenchloride; diethyl ether; tin(ll) chloride |
3-trifluoromethylbenzonitrile
acetamidine hydrochloride
5-methyl-3-(3-(trifluoromethyl)phenyl)-1H-1,2,4-triazole
Conditions | Yield |
---|---|
With caesium carbonate In dimethyl sulfoxide at 120℃; for 24h; Sealed tube; | 88% |
With oxygen; caesium carbonate; copper(I) bromide In dimethyl sulfoxide at 120℃; for 24h; | 85% |
Conditions | Yield |
---|---|
With bis(1,5-cyclooctadiene)nickel (0); caesium carbonate; 1,2-bis-(dicyclohexylphosphino)ethane In diethylene glycol dimethyl ether at 140℃; for 24h; Sealed tube; | 85% |
ethanol
3-trifluoromethylbenzonitrile
O-ethyl 3-trifluoromethylbenzimidate
Conditions | Yield |
---|---|
With hydrogenchloride In chloroform at -5℃; | 84% |
With acetyl chloride at 25℃; |
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