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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

5-Bromo-4,7-diazaindole Manufacturer/High quality/Best price/In stock

Cas:875781-43-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 5-Bromo-4,7-diazaindole with high purity

Cas:875781-43-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

High quality 5-Bromo-4,7-diazaindole CAS 875781-43-4 with factory price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Fe

High quality 5-Bromo-4,7-diazaindole CAS 875781-43-4 with factory price

Cas:875781-43-4

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

Good quality Good price Promptly delivery intermediate Appearance:white powder Storage:dry dondition Package:According to the demand of customer Application:intermediate Transportation:According to the demand of custom

875781-43-45-Bromo-4,7-diazaindole

Cas:875781-43-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Chemwill Asia co.,Ltd is one of the leading manufacturer in CHINA. Product quality, process, price and service 5-Bromo-4,7-diazaindole 875781-43-4 Factory PRICE IN STOCK COA CAS 875781-43-4 875781-43-4 highly quality and immedaite deliver

5-Bromo-4,7-diazaindole 875781-43-4 Factory PRICE IN STOCK COA CAS 875781-43-4

Cas:875781-43-4

Min.Order:5 Kiloliter

FOB Price: $3.5 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.

875781-43-4

Cas:875781-43-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 875781-43-4 with competitive price

Cas:875781-43-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

5-Bromo-4,7-diazaindole 875781-43-4

Cas:875781-43-4

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:875781-43-4

Cas:875781-43-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

5-Bromo-4,7-diazaindole

Cas:875781-43-4

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-bromo-5H-pyrrolo[2,3-b]pyrazine

Cas:875781-43-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

5-bromo-4,7-diazaindoleAppearance:white crystalline powder Storage:Shading, sealed, dry place. Package:according to customers' requirements Application:pharmaceutical intermediates raw material Transportation:By air(EMS or EUB or FedEx or TNT ect...

5-bromo-4,7-diazaindole

Cas:875781-43-4

Min.Order:1 Gram

Negotiable

Type:Other

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Siwei Development Group Ltd.

Product name: 5-Bromo-4,7-Diazaindole CAS No.:875781-43-4 Molecule Formula:C6H4BrN3 Molecule Weight:198.02 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS

High Quality 5-Bromo-4,7-Diazaindole in stock

Cas:875781-43-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

1. DMF is available. Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, d

5-Bromo-4,7-diazaindole

Cas:875781-43-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

5-Bromo-4,7-diazaindole

Cas:875781-43-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

5-Bromo-4,7-diazaindole

Cas:875781-43-4

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

DALIAN BAIJIA IMPORT AND EXPORT CO., LTD

Dalian Bajia import and export co. ltd have great engineer make more great quality cargo will meet all customer request . Now we have own lab for cargo even my cargo is so less but quality and quantity and shippment will be promise as we are pro

5-Bromo-4,7-diazaindole

Cas:875781-43-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

5-Bromo-4,7-diazaindole

Cas:875781-43-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

5-Bromo-4,7-diazaindole

Cas:875781-43-4

Min.Order:1 Kilogram

Negotiable

Type:Other

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

5-bromo-4,7-diazaindole

Cas:875781-43-4

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai Finebiotech Co.,Ltd.

Shanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service

2-bromo-5H-pyrrolo[2,3-b]pyrazine

Cas:875781-43-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

5-Bromo-4,7-Diazaindole cas no. 875781-43-4 98%

Cas:875781-43-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:Foil bag or drum Application:Applied in dietary supplements,pharmaceutical or cosmeticeuticals Transportation:by sea or air Port:Beijing or Guangzhou Port

5-Bromo-4,7-diazaindole

Cas:875781-43-4

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

5-Bromo-4,7-diazaindole

Cas:875781-43-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

with high qualityAppearance:white powder Storage:Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Package:25kg/drum Application:as intermediates Transportation:by courier, air or sea Port:At any port from China

5-Bromo-4,7-diazaindole 875781-43-4 Pharmaceutical Intermediates

Cas:875781-43-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

2-Bromo-5H-pyrrolo[2,3-b]pyrazine

Cas:875781-43-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

high purity Storage:normal temperature Package:DRUM Application:mainly for medical use for R&Dpurpose use only Transportation:AIR,SEA Port:BEIJING,SHANGHAI,TIANJIN,SHENZHEN

5-Bromo-4,7-diazaindole

Cas:875781-43-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Fred Technology Co.,Ltd.

Fredchem focus on CRO/CMO business and its own R&D of API/Intermediates Package:Kilograms/MT Application:Pharmaceutical field Transportation:According to customer request Port:Shanghai

5-bromo-4,7-diazaindole

Cas:875781-43-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

5-Bromo-4,7-diazaindole

Cas:875781-43-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen AmoyChem Co.,Ltd

Amoychem is committed to providing the top-quality chemical products and services Internationally. We offer our customers with friendly, professional service and reliable, high performance products that have been manufactured according to the accredi

5-Bromo-4,7-diazaindole

Cas:875781-43-4

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine
875781-41-2

5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine

2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; Reflux;76%
With potassium tert-butylate In 1-methyl-pyrrolidin-2-one for 3h; Heating;69%
Multi-step reaction with 2 steps
1: pyridine / tetrahydrofuran / 96 h
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 h / 75 °C
View Scheme
5-bromo-3-(2-triethylsilylethynyl)pyrazin-2-amine
1416740-15-2

5-bromo-3-(2-triethylsilylethynyl)pyrazin-2-amine

2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
With potassium tert-butylate In 1-methyl-pyrrolidin-2-one at 80℃; for 1.5h;70.3%
N-(5-bromo-3-((trimethylsilyl)ethynyl)pyrazin-2-yl)acetamide
875781-42-3

N-(5-bromo-3-((trimethylsilyl)ethynyl)pyrazin-2-yl)acetamide

2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran for 15h;43%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 75℃; for 20h;42%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 75℃; for 20h;42%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 75℃; for 20h;42%
With tetrabutyl ammonium fluoride In tetrahydrofuran for 15h; Reflux;16%
C10H13BrN4O

C10H13BrN4O

2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
In water for 0.5h;91 g
C10H15BrN4

C10H15BrN4

2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
In water for 0.5h;90 g
C14H23BrN4

C14H23BrN4

2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
In water for 0.5h;90.2 g
5-bromo-3-ethynyl-pyrazin-2-ylamine
1209289-08-6

5-bromo-3-ethynyl-pyrazin-2-ylamine

2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 16 h / 20 - 60 °C
2: water / 0.5 h
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 16 h / 20 - 60 °C
2: water / 0.5 h
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 16 h / 20 - 60 °C
2: water / 0.5 h
View Scheme
C11H16BrN5

C11H16BrN5

2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
In water for 0.5h; Solvent;9.3 kg
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

2-bromo-7-iodo-5H-pyrrolo[2,3-b]pyrazine
875781-44-5

2-bromo-7-iodo-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
With N-iodo-succinimide In N,N-dimethyl-formamide at 20℃; for 1h;100%
With iodine; potassium hydroxide In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;95%
With N-iodo-succinimide In acetone at 20℃; for 4h;89%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

2-bromo-7-iodo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine
875781-45-6

2-bromo-7-iodo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 0 - 20℃; for 3.33333h;99%
formaldehyd
50-00-0

formaldehyd

2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

(2-bromo-5-hydroxymethyl-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanol
1334674-87-1

(2-bromo-5-hydroxymethyl-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanol

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane at 20℃; Inert atmosphere;99%
With sodium hydroxide In 1,4-dioxane; water at 20℃; for 18h;95.5%
Stage #1: formaldehyd; 2-bromo-5H-pyrrolo[2,3-b]pyrazine With sodium hydroxide In 1,4-dioxane; water at 20℃;
Stage #2: With hydrogenchloride In water
87%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

2-bromo-5-(p-toluenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine
1201186-54-0

2-bromo-5-(p-toluenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
Stage #1: 2-bromo-5H-pyrrolo[2,3-b]pyrazine With sodium hydride In N,N-dimethyl-formamide at 0 - 5℃; for 0.5h;
Stage #2: p-toluenesulfonyl chloride In N,N-dimethyl-formamide at 0 - 20℃;
97%
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 30℃; for 8h; Inert atmosphere;86%
With sodium hydride In tetrahydrofuran; mineral oil at -15 - 20℃; for 1h;79.3%
With triethylamine In dichloromethane at 20℃; for 3h; Solvent; Reagent/catalyst; Temperature;56.1%
With sodium hydride In N,N-dimethyl-formamide
4-(isopropylsulfonyl)phenylboronic acid

4-(isopropylsulfonyl)phenylboronic acid

2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

2-(4-(isopropylsulfonyl)phenyl)-5H-pyrrolo[2,3-b]pyrazine
1353571-87-5

2-(4-(isopropylsulfonyl)phenyl)-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; water at 100℃;95%
4-tert-butylbenzenesulfonyl chloride
15084-51-2

4-tert-butylbenzenesulfonyl chloride

2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

2-bromo-5-(4-tert-butylphenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine
1201186-50-6

2-bromo-5-(4-tert-butylphenylsulfonyl)-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
Stage #1: 2-bromo-5H-pyrrolo[2,3-b]pyrazine With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.25h;
Stage #2: 4-tert-butylbenzenesulfonyl chloride In N,N-dimethyl-formamide; mineral oil at 0 - 10℃; for 2h;
91%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

(2-trimethylethylsilylethoxy)methyl chloride
76513-69-4

(2-trimethylethylsilylethoxy)methyl chloride

2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine
1184926-29-1

2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 20℃;90%
Stage #1: 2-bromo-5H-pyrrolo[2,3-b]pyrazine With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.5h;
Stage #2: (2-trimethylethylsilylethoxy)methyl chloride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 3h;
90%
Stage #1: 2-bromo-5H-pyrrolo[2,3-b]pyrazine With sodium hydride In N,N-dimethyl-formamide at 0℃;
Stage #2: (2-trimethylethylsilylethoxy)methyl chloride In N,N-dimethyl-formamide
Stage #3: With water In N,N-dimethyl-formamide Product distribution / selectivity;
86%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

5-(benzenesulfonyl)-2-bromo-5H-pyrrolo[2,3-b]pyrazine

5-(benzenesulfonyl)-2-bromo-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
Stage #1: 2-bromo-5H-pyrrolo[2,3-b]pyrazine With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h;
Stage #2: benzenesulfonyl chloride In tetrahydrofuran; mineral oil for 1h;
88%
Stage #1: 2-bromo-5H-pyrrolo[2,3-b]pyrazine With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h;
Stage #2: benzenesulfonyl chloride In tetrahydrofuran; mineral oil at 20℃; for 12h;
82%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

methyl 3-ethynyl 4-methylbenzoate

methyl 3-ethynyl 4-methylbenzoate

C17H13N3O2

C17H13N3O2

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl acetamide at 50 - 80℃; for 24h; Solvent; Inert atmosphere;88%
formaldehyd
50-00-0

formaldehyd

2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

(2-bromo-7-hydroxymethylpyrrolo[2,3-b]pyrazin-5-yl)methanol

(2-bromo-7-hydroxymethylpyrrolo[2,3-b]pyrazin-5-yl)methanol

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane; water87%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

3,4,5-trimethoxyphenylboronic Acid
182163-96-8

3,4,5-trimethoxyphenylboronic Acid

2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine
1422772-45-9

2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate In 1,4-dioxane; water at 110℃; for 18h;83%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

4-(3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole

4-(3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole

2-[2-methoxy-4-(1-tetrahydropyran-2-ylpyrazol-4-yl)phenyl]-5H-pyrrolo[2,3-b]pyrazine

2-[2-methoxy-4-(1-tetrahydropyran-2-ylpyrazol-4-yl)phenyl]-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane at 90℃; for 16h; Suzuki Coupling; Inert atmosphere;80%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

3,4-Dimethoxyphenylboronic acid
122775-35-3

3,4-Dimethoxyphenylboronic acid

2-(3,4-dimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine
1422772-49-3

2-(3,4-dimethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate In 1,4-dioxane; water at 110℃; for 18h;76.9%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

(2-fluoro-pyridin-3-yl)boronic acid
174669-73-9

(2-fluoro-pyridin-3-yl)boronic acid

2-(2-fluoropyridin-3-yl)-5H-pyrrolo[2,3-b]pyrazine
1270497-00-1

2-(2-fluoropyridin-3-yl)-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; ethanol; water at 140℃; for 0.25h; Inert atmosphere; microwave irradiation; sealed tube;76%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole
832114-00-8

3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole

3,5-dimethyl-4-(5H-pyrrolo[2,3-b]pyrazin-2-yl)isoxazole

3,5-dimethyl-4-(5H-pyrrolo[2,3-b]pyrazin-2-yl)isoxazole

Conditions
ConditionsYield
With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate In water; acetonitrile at 160℃; for 0.333333h; Microwave irradiation;76%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

methyl iodide
74-88-4

methyl iodide

2-bromo-5-methyl-5H-pyrrolo[2,3-b]pyrazine

2-bromo-5-methyl-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
Stage #1: 2-bromo-5H-pyrrolo[2,3-b]pyrazine With sodium hydride In tetrahydrofuran at 0 - 18℃; for 0.5h;
Stage #2: methyl iodide In tetrahydrofuran at 18℃; for 2h;
72%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

pivaloyl chloride
3282-30-2

pivaloyl chloride

1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one
1184852-23-0

1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-one

Conditions
ConditionsYield
Stage #1: 2-bromo-5H-pyrrolo[2,3-b]pyrazine With diethylaluminium chloride In hexane; dichloromethane at 0 - 5℃; for 0.5h;
Stage #2: pivaloyl chloride In hexane; dichloromethane for 15h; Reflux;
63%
Stage #1: 2-bromo-5H-pyrrolo[2,3-b]pyrazine With diethyl aluminiumcholoride In hexane; dichloromethane at 0℃; for 0.5h; Inert atmosphere;
Stage #2: pivaloyl chloride at 0 - 20℃; for 21.1667h;
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

4-pyridylboronic acid
1692-15-5

4-pyridylboronic acid

2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine
1604036-45-4

2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate In water; acetonitrile at 150℃; for 0.5h; Microwave irradiation;60%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In acetonitrile at 150℃; for 0.5h; Suzuki-Miyaura Coupling; Inert atmosphere; Microwave irradiation;0.28 g
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

2-chloro-5H-pyrrolo[2,3-b]pyrazine
889447-19-2

2-chloro-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
With triethylamine; trichlorophosphate In 1,4-dioxane at 110℃; for 6h;54%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

trityl chloride
76-83-5

trityl chloride

2-bromo-5-trityl-5H-pyrrolo[2,3-b]pyrazine

2-bromo-5-trityl-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 40℃; for 2h;52%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

isopropylamine
75-31-0

isopropylamine

2-bromo-N-isopropyl-5H-pyrrolo[2,3-b]pyrazine-7-sulfonamide

2-bromo-N-isopropyl-5H-pyrrolo[2,3-b]pyrazine-7-sulfonamide

Conditions
ConditionsYield
Stage #1: 2-bromo-5H-pyrrolo[2,3-b]pyrazine With chlorosulfonic acid at 0 - 120℃; for 2.5h; Inert atmosphere;
Stage #2: isopropylamine With triethylamine In dichloromethane at 0℃; for 3h; Inert atmosphere;
49%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

1-methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine
747413-21-4

1-methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine

2-(4-(4-methylpiperazin-1-yl)phenyl)-5H-pyrrolo[2,3-b]pyrazine

2-(4-(4-methylpiperazin-1-yl)phenyl)-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate In 1,4-dioxane; water at 100℃; for 16h; Sealed tube; Inert atmosphere;40.5%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

hexamethylenetetramine
100-97-0

hexamethylenetetramine

2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde
1185428-32-3

2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde

Conditions
ConditionsYield
With trifluoroacetic acid at 0 - 110℃; for 12h;40%
With trifluoroacetic acid at 80℃; for 0.25h; Microwave irradiation;0.45 g
(4-bromo-2-fluorophenyl)boronic acid

(4-bromo-2-fluorophenyl)boronic acid

2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

2-(4-bromo-2-fluorophenyl)-5H-pyrrolo[2,3-b]pyrazine

2-(4-bromo-2-fluorophenyl)-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate In 1,4-dioxane; water at 95℃; for 24h; Inert atmosphere;35%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)(4-nitrophenyl)methanol

(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)(4-nitrophenyl)methanol

Conditions
ConditionsYield
With potassium hydroxide In methanol at 20℃; for 48h;25.3%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

2-[(1S)-1-cyclopropylethyl]-7-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-isoindol-1-one

2-[(1S)-1-cyclopropylethyl]-7-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-isoindol-1-one

2-[(1S)-1-cyclopropylethyl]-7-methyl-5-(5H-pyrrolo[2,3-b]pyrazin-2-yl)-2,3-dihydro-1H-isoindol-1-one

2-[(1S)-1-cyclopropylethyl]-7-methyl-5-(5H-pyrrolo[2,3-b]pyrazin-2-yl)-2,3-dihydro-1H-isoindol-1-one

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In water; acetonitrile at 140℃; for 0.5h; Suzuki Coupling; Inert atmosphere; Sealed tube; Microwave irradiation;10%
2-bromo-5H-pyrrolo[2,3-b]pyrazine
875781-43-4

2-bromo-5H-pyrrolo[2,3-b]pyrazine

4-Chlorophenylboronic acid
1679-18-1

4-Chlorophenylboronic acid

2-(4-chloro-phenyl)-5H-pyrrolo[2,3-b]pyrazine

2-(4-chloro-phenyl)-5H-pyrrolo[2,3-b]pyrazine

Conditions
ConditionsYield
With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In water; acetonitrile at 120℃; for 0.166667h; Suzuki Coupling; Microwave irradiation;

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