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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Enzalutamide

Cas:915087-33-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Chemvon Biotechnology Co. Ltd.

Chemvon Biotechnology is one of the leading high-technology manufacturer in the field of pharmaceutical and fine chemical industry. From origins as a research group in technology service, chemvon has progressed into an integrated company with a

Enzalutamide

Cas:915087-33-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou ZeErRui Chemical Co., Ltd.

Product Name: Enzalutamide Assay: 99.0% Cas No.: 915087-33-1 Usage:It is used to treat advanced castration-tolerant prostate cancer in men who have spread or relapsed. Appeara

Enzalutamide supplier

Cas:915087-33-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

MDV-3100

Cas:915087-33-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Senova Technology Company Limited

Good price, high purity, mature production technology, accept custom synthesis per customer's requirements Appearance:White Solid Package:As per Customer‘ requirements Application:ANTI-CANCER

Enzalutamide

Cas:915087-33-1

Min.Order:100 Gram

Negotiable

Type:Trading Company

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Shanghai MOF CHEMICAL TECH LIMITED

We are a manufacture, have lab and production base in china. Can provide you competitive price, with qualified compounds and convenience service. We can provide you custom synthesis and custom manufacturing,especially our catalogue product deriva

Competitive price MDV3100 ;Enzalutamide manufacturer in China

Cas:915087-33-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

MDV-3100

Cas:915087-33-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Test Result Appearance White to off-white crystalline powder Conforms Purity, %

High purity Enzalutamide CAS:915087-33-1

Cas:915087-33-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Enzalutamide CAS NO.915087-33-1

Cas:915087-33-1

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White crystalline powder Storage:2-8°C Package:10g/bottle; 10

Manufacturer supply Enzalutamide CAS 915087-33-1 with good quality

Cas:915087-33-1

Min.Order:10 Gram

FOB Price: $5.0 / 30.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Enzalutamide CAS No.: 915087-33-1 Name: Enzalutamide Synonyms: 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluoro-N-methylbenzamide

High purity Enzalutamide CAS No.: 915087-33-1

Cas:915087-33-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

EnzalutaMide manufacturer with low price

Cas:915087-33-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Enzalutamide 915087-33-1 GMP Manufacturer

Cas:915087-33-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Enzalutamide

Cas:915087-33-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Enzalutamide

Cas:915087-33-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Product Name: Enzalutamide Synonyms: Enzalutamide (Xtandi);4-{3-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-5,5-DIMETHYL-4-OXO-2-SULFANYLIDENEIMIDAZOLIDIN-1-YL}-2-FLUO;4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-

915087-33-1 Enzalutamide

Cas:915087-33-1

Min.Order:1 Kilogram

FOB Price: $230.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

CAS 915087-33-1 Enzalutamide Best Price

Cas:915087-33-1

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 915087-33-1 with competitive price

Cas:915087-33-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Manufacturer supply High quality 99% MDV-3100/CAS:915087-33-1

Cas:915087-33-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hubei Vanz Pharm Co.,Ltd

cas 915087-33-1 99 % purity Enzalutamide powder Product Name: Enzalutamide CAS: 915087-33-1 MF: C21H16F4N4O2S MW: 464.44 EINECS: 805-022-1 Appearance:white Storage:room Package:drum Application:Artemisia annua is used as antima

cas 915087-33-1 99 % purity Enzalutamide powder

Cas:915087-33-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White crystal powder Storage:Store in sealed container

99% Enzalutamide CAS 915087-33-1

Cas:915087-33-1

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Factory direct supply High Quality API Enzalutamide Powder

Cas:915087-33-1

Min.Order:10 Gram

FOB Price: $3.2

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediate, MDV-3100 CAS:915087-33-1

Cas:915087-33-1

Min.Order:1 Gram

FOB Price: $80.0 / 84.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

EnzalutamideCAS:915087-33-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

EnzalutamideCAS:915087-33-1

Cas:915087-33-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Lonwin Chemical Group Limited

Enzalutamide CAS: 915087-33-1 Specification Chemical Name enzalutamide Synonyms MDV 3100;XTANDI;UNII-93T0T9GKNU;[14C]-Enzalutamide;N-methyl-4-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidi

Factory supply Enzalutamide

Cas:915087-33-1

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Factory Supply High Purity Enzalutamide CAS 915087-33-1

Cas:915087-33-1

Min.Order:1 Kilogram

FOB Price: $500.0

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

MDV3100 Enzalutamide 915087-33-1

Cas:915087-33-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Synthetic route

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropionate allyl

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropionate allyl

4-isothiocyanato 2-(trifluoromethyl)benzonitrile
143782-23-4

4-isothiocyanato 2-(trifluoromethyl)benzonitrile

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
In dimethyl sulfoxide at 80℃; for 4h; Concentration; Temperature; Edman Degradation;90.9%
In Isopropyl acetate at 75 - 85℃; for 8h;557 g
2-methoxyethyl 2-{[3-fluoro-4-(methylcarbamoyl)phenyl]amino}-2-methylpropanoate

2-methoxyethyl 2-{[3-fluoro-4-(methylcarbamoyl)phenyl]amino}-2-methylpropanoate

4-isothiocyanato 2-(trifluoromethyl)benzonitrile
143782-23-4

4-isothiocyanato 2-(trifluoromethyl)benzonitrile

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
In Isopropyl acetate; dimethyl sulfoxide at 85℃; for 16h;90.3%
4-bromo-2-fluoro-N-methylbenzanamide
749927-69-3

4-bromo-2-fluoro-N-methylbenzanamide

2-(trifluoromethyl)-4-(4,4-dimethyl 5-oxo-2-thioimidazolin-1-yl)benzonitrile
143782-28-9

2-(trifluoromethyl)-4-(4,4-dimethyl 5-oxo-2-thioimidazolin-1-yl)benzonitrile

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
With copper(l) iodide; 2-acetylcyclohexanone; potassium carbonate In N,N-dimethyl-formamide at 110℃; for 22h; Inert atmosphere;88.7%
Stage #1: 2-(trifluoromethyl)-4-(4,4-dimethyl 5-oxo-2-thioimidazolin-1-yl)benzonitrile With sodium hydride In N,N-dimethyl-formamide at 0 - 5℃; for 0.5h;
Stage #2: 4-bromo-2-fluoro-N-methylbenzanamide In N,N-dimethyl-formamide at 0 - 20℃; for 5h;
87.3%
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

4-isothiocyanato 2-(trifluoromethyl)benzonitrile
143782-23-4

4-isothiocyanato 2-(trifluoromethyl)benzonitrile

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
Stage #1: 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid With triethylamine In dichloromethane; toluene at 30℃; for 0.166667h;
Stage #2: 4-isothiocyanato 2-(trifluoromethyl)benzonitrile In toluene at 50 - 60℃; for 4h; Temperature; Solvent;
88.5%
With N-ethyl-N,N-diisopropylamine; phenol at 60℃; for 4h; Reagent/catalyst;77%
Stage #1: 4-isothiocyanato 2-(trifluoromethyl)benzonitrile With triethylamine In chloroform at 20℃; for 0.25h; Reflux; Inert atmosphere;
Stage #2: 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid In chloroform for 6h; Reagent/catalyst; Reflux;
76.92%
4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorobenzoic acid methyl ester

4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorobenzoic acid methyl ester

methylamine
74-89-5

methylamine

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
In tetrahydrofuran; water at -13℃; for 5h;88.18%
In toluene at 50℃; for 0.5h; Solvent; Temperature;86%
In tetrahydrofuran; water at -11 - -7℃; for 22.6667h; Temperature; Large scale;83.6%
ethyl N-[3-fluoro-4-(methylcarbamoyl)phenyl]-2-methylalaninate

ethyl N-[3-fluoro-4-(methylcarbamoyl)phenyl]-2-methylalaninate

4-isothiocyanato 2-(trifluoromethyl)benzonitrile
143782-23-4

4-isothiocyanato 2-(trifluoromethyl)benzonitrile

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
In Isopropyl acetate; dimethyl sulfoxide at 80℃; for 6h; Temperature;88%
With Isopropyl acetate In dimethyl sulfoxide at 90 - 95℃;0.2 g
In Isopropyl acetate; dimethyl sulfoxide at 90 - 95℃;0.2 g
2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropionate benzyl

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropionate benzyl

4-isothiocyanato 2-(trifluoromethyl)benzonitrile
143782-23-4

4-isothiocyanato 2-(trifluoromethyl)benzonitrile

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
In Isopropyl acetate; dimethyl sulfoxide at 85℃; for 6h; Temperature;88%
In dimethyl sulfoxide at 84℃; for 4h; Edman Degradation;86%
With copper(l) iodide; potassium carbonate In dimethyl sulfoxide at 80℃; Bucherer-Bergs Reaction; Inert atmosphere;309 g
2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropanoic acid methyl ester
1332524-01-2

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropanoic acid methyl ester

4-isothiocyanato 2-(trifluoromethyl)benzonitrile
143782-23-4

4-isothiocyanato 2-(trifluoromethyl)benzonitrile

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
In Isopropyl acetate; dimethyl sulfoxide at 70℃; for 6h; Temperature;85%
In Isopropyl acetate; dimethyl sulfoxide at 83 - 84℃; for 17.5h;82%
In Isopropyl acetate; dimethyl sulfoxide at 55 - 85℃; Inert atmosphere;80.2%
2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropionate ethyloxirane

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropionate ethyloxirane

4-isothiocyanato 2-(trifluoromethyl)benzonitrile
143782-23-4

4-isothiocyanato 2-(trifluoromethyl)benzonitrile

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
Edman Degradation;85%
C20H23FN2O4

C20H23FN2O4

4-isothiocyanato 2-(trifluoromethyl)benzonitrile
143782-23-4

4-isothiocyanato 2-(trifluoromethyl)benzonitrile

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
In Isopropyl acetate; dimethyl sulfoxide at 80 - 85℃;83%
2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropionate proparagyl

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropionate proparagyl

4-isothiocyanato 2-(trifluoromethyl)benzonitrile
143782-23-4

4-isothiocyanato 2-(trifluoromethyl)benzonitrile

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
In dimethyl sulfoxide at 84℃; for 4h; Concentration; Temperature; Edman Degradation;82%
C16H23FN2O4

C16H23FN2O4

4-isothiocyanato 2-(trifluoromethyl)benzonitrile
143782-23-4

4-isothiocyanato 2-(trifluoromethyl)benzonitrile

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
In Isopropyl acetate; dimethyl sulfoxide at 80 - 85℃; for 20h;82%
methyl 2-chloroisobutyrate
22421-97-2

methyl 2-chloroisobutyrate

N-(3-trifluoromethyl-4-cyanophenyl)-N'-(3-fluoro-4-methylcarbamoylphenyl)thiourea

N-(3-trifluoromethyl-4-cyanophenyl)-N'-(3-fluoro-4-methylcarbamoylphenyl)thiourea

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 80 - 90℃; for 5h;66.4%
C14H20FN3O2

C14H20FN3O2

4-isothiocyanato 2-(trifluoromethyl)benzonitrile
143782-23-4

4-isothiocyanato 2-(trifluoromethyl)benzonitrile

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
In acetonitrile at 20 - 70℃; for 64h; Molecular sieve; Inert atmosphere;47.3%
N-methyl-2-fluoro-4-(1,1-dimethyl-cyanomethyl)-aminobenzamide
915087-32-0

N-methyl-2-fluoro-4-(1,1-dimethyl-cyanomethyl)-aminobenzamide

thiophosgene
463-71-8

thiophosgene

4-amino-2-trifluoromethylbenzonitrile
654-70-6

4-amino-2-trifluoromethylbenzonitrile

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
Stage #1: N-methyl-2-fluoro-4-(1,1-dimethyl-cyanomethyl)-aminobenzamide; thiophosgene; 4-amino-2-trifluoromethylbenzonitrile In N,N-dimethyl acetamide at 0 - 60℃; Inert atmosphere;
Stage #2: With hydrogenchloride In methanol; N,N-dimethyl acetamide for 2h; Inert atmosphere; Reflux;
41%
N-methyl-2-fluoro-4-(1,1-dimethyl-cyanomethyl)-aminobenzamide
915087-32-0

N-methyl-2-fluoro-4-(1,1-dimethyl-cyanomethyl)-aminobenzamide

4-isothiocyanato 2-(trifluoromethyl)benzonitrile
143782-23-4

4-isothiocyanato 2-(trifluoromethyl)benzonitrile

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
Stage #1: N-methyl-2-fluoro-4-(1,1-dimethyl-cyanomethyl)-aminobenzamide; 4-isothiocyanato 2-(trifluoromethyl)benzonitrile In N,N-dimethyl-formamide at 100℃; for 11h; Microwave irradiation;
Stage #2: With hydrogenchloride In methanol; N,N-dimethyl-formamide for 1.5h; Heating / reflux;
25%
Stage #1: N-methyl-2-fluoro-4-(1,1-dimethyl-cyanomethyl)-aminobenzamide; 4-isothiocyanato 2-(trifluoromethyl)benzonitrile In N,N-dimethyl-formamide at 100℃; for 11h; Microwave irradiation;
Stage #2: With hydrogenchloride; methanol In water; N,N-dimethyl-formamide for 1h; Reflux;
23.1%
Stage #1: N-methyl-2-fluoro-4-(1,1-dimethyl-cyanomethyl)-aminobenzamide; 4-isothiocyanato 2-(trifluoromethyl)benzonitrile In N,N-dimethyl-formamide at 120℃; for 16h;
Stage #2: With hydrogenchloride; water In ethanol; N,N-dimethyl-formamide for 1h; Reflux;
17.1%
4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide
1289942-55-7

4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
With dmap; thiophosgene In acetonitrile at 40 - 60℃; for 24h; Solvent; Reagent/catalyst; Temperature; Inert atmosphere;19.1%
thiophosgene
463-71-8

thiophosgene

4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide
1289942-55-7

4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
at 100℃; for 6h; a sealed-tube;4%
at 100℃; for 6h; Sealed tube;1.5%
C21H17F4N5OS

C21H17F4N5OS

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
With hydrogenchloride; water In methanol; N,N-dimethyl-formamide for 1.5h; Heating / reflux;
With hydrogenchloride; water In methanol; N,N-dimethyl-formamide for 1.5h; Reflux; Inert atmosphere;30 mg
2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: thionyl chloride / N,N-dimethyl-formamide; Isopropyl acetate / 4.58 h / 21 - 72 °C / Inert atmosphere; Industry scale
2.1: water; Isopropyl acetate / 1.08 h / 2 - 35 °C / Inert atmosphere; Industry scale
3.1: potassium carbonate / copper(l) chloride / N,N-dimethyl-formamide; water / 30 °C
3.2: 105 °C / Inert atmosphere
3.3: pH 4
4.1: potassium carbonate / N,N-dimethyl-formamide; water / 30 °C
4.2: 1.08 h / 32 - 40 °C
5.1: dimethyl sulfoxide; Isopropyl acetate / 17.5 h / 83 - 84 °C
View Scheme
Multi-step reaction with 5 steps
1.1: thionyl chloride / N,N-dimethyl-formamide; Isopropyl acetate / 4.58 h / 21 - 72 °C / Inert atmosphere; Industry scale
2.1: water; Isopropyl acetate / 1.08 h / 2 - 35 °C / Inert atmosphere; Industry scale
3.1: potassium carbonate / copper(l) chloride / N,N-dimethyl-formamide; water / 30 °C
3.2: 105 °C / Inert atmosphere
3.3: pH 4
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
5.1: 6 h / 100 °C / a sealed-tube
View Scheme
Multi-step reaction with 4 steps
1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 10 - 30 °C
2.1: water; tert-butyl methyl ether / 10 - 30 °C / pH 8 - 9
3.1: potassium carbonate / N,N-dimethyl-formamide; 1,4-dioxane; water / 0.33 h / Inert atmosphere
3.2: 24.33 h / Inert atmosphere; Reflux
4.1: triethylamine / dichloromethane / 23 - 28 °C / Inert atmosphere
View Scheme
4-bromo-2-fluorobenzoyl chloride
151982-51-3

4-bromo-2-fluorobenzoyl chloride

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: water; Isopropyl acetate / 1.08 h / 2 - 35 °C / Inert atmosphere; Industry scale
2.1: potassium carbonate / copper(l) chloride / N,N-dimethyl-formamide; water / 30 °C
2.2: 105 °C / Inert atmosphere
2.3: pH 4
3.1: potassium carbonate / N,N-dimethyl-formamide; water / 30 °C
3.2: 1.08 h / 32 - 40 °C
4.1: dimethyl sulfoxide; Isopropyl acetate / 17.5 h / 83 - 84 °C
View Scheme
Multi-step reaction with 4 steps
1.1: water; Isopropyl acetate / 1.08 h / 2 - 35 °C / Inert atmosphere; Industry scale
2.1: potassium carbonate / copper(l) chloride / N,N-dimethyl-formamide; water / 30 °C
2.2: 105 °C / Inert atmosphere
2.3: pH 4
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
4.1: 6 h / 100 °C / a sealed-tube
View Scheme
Multi-step reaction with 3 steps
1.1: water; tert-butyl methyl ether / 10 - 30 °C / pH 8 - 9
2.1: potassium carbonate / N,N-dimethyl-formamide; 1,4-dioxane; water / 0.33 h / Inert atmosphere
2.2: 24.33 h / Inert atmosphere; Reflux
3.1: triethylamine / dichloromethane / 23 - 28 °C / Inert atmosphere
View Scheme
4-amino-2-trifluoromethylbenzonitrile
654-70-6

4-amino-2-trifluoromethylbenzonitrile

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: n-heptane; water / 16.5 h / 5 - 46.4 °C / Industry scale; Inert atmosphere
2: dimethyl sulfoxide; Isopropyl acetate / 17.5 h / 83 - 84 °C
View Scheme
Multi-step reaction with 2 steps
1.1: water / 1 h / 20 °C
2.1: N,N-dimethyl-formamide / 16 h / 120 °C
2.2: 1 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: dichloromethane; water / 0.25 h / 20 - 30 °C / Inert atmosphere
1.2: 4 h
2.1: triethylamine / chloroform / 0.25 h / 20 °C / Reflux; Inert atmosphere
2.2: 6 h / Reflux
View Scheme
4-bromo-2-fluoro-N-methylbenzanamide
749927-69-3

4-bromo-2-fluoro-N-methylbenzanamide

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / copper(l) chloride / N,N-dimethyl-formamide; water / 30 °C
1.2: 105 °C / Inert atmosphere
1.3: pH 4
2.1: potassium carbonate / N,N-dimethyl-formamide; water / 30 °C
2.2: 1.08 h / 32 - 40 °C
3.1: dimethyl sulfoxide; Isopropyl acetate / 17.5 h / 83 - 84 °C
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate / copper(l) chloride / N,N-dimethyl-formamide; water / 30 °C
1.2: 105 °C / Inert atmosphere
1.3: pH 4
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
3.1: 6 h / 100 °C / a sealed-tube
View Scheme
Multi-step reaction with 2 steps
1.1: potassium carbonate / N,N-dimethyl-formamide; 1,4-dioxane; water / 0.33 h / Inert atmosphere
1.2: 24.33 h / Inert atmosphere; Reflux
2.1: triethylamine / dichloromethane / 23 - 28 °C / Inert atmosphere
View Scheme
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / N,N-dimethyl-formamide; water / 30 °C
1.2: 1.08 h / 32 - 40 °C
2.1: dimethyl sulfoxide; Isopropyl acetate / 17.5 h / 83 - 84 °C
View Scheme
Multi-step reaction with 2 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
2: 6 h / 100 °C / a sealed-tube
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 50 °C
2: dimethyl sulfoxide / 4 h / 84 °C
View Scheme
2-fluoro-4-nitrobenzoic acid
403-24-7

2-fluoro-4-nitrobenzoic acid

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C
1.2: 1 h
2.1: acetic acid; iron / ethyl acetate / 16 h / Reflux
3.1: acetic acid / 16 h / 80 °C / Sealed tube
4.1: N,N-dimethyl-formamide / 16 h / 120 °C
4.2: 1 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 5.5 h / 0 - 25 °C
2: palladium 10% on activated carbon; hydrogen / methanol / 27 °C / 1500.15 - 1875.19 Torr
3: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / tetrahydrofuran / 8 h / 80 - 85 °C
4: Isopropyl acetate / dimethyl sulfoxide / 90 - 95 °C
View Scheme
Multi-step reaction with 5 steps
1.1: N,N-dimethyl-formamide; thionyl chloride / Isopropyl acetate / 60 °C / Inert atmosphere
2.1: Isopropyl acetate / 5 h / Inert atmosphere
3.1: hydrogen; palladium 10% on activated carbon / methanol / 1 h / 50 °C / 4500.45 Torr / Autoclave
3.2: Heating
4.1: triethylamine / N,N-dimethyl acetamide / 1 h / 70 °C
4.2: 1.67 h / 100 °C
5.1: N-ethyl-N,N-diisopropylamine; phenol / 4 h / 60 °C
View Scheme
2-fluoro-N-methyl-4-nitro-benzamide
915087-24-0

2-fluoro-N-methyl-4-nitro-benzamide

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetic acid; iron / ethyl acetate / 16 h / Reflux
2.1: acetic acid / 16 h / 80 °C / Sealed tube
3.1: N,N-dimethyl-formamide / 16 h / 120 °C
3.2: 1 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 27 °C / 1500.15 - 1875.19 Torr
2: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / tetrahydrofuran / 8 h / 80 - 85 °C
3: Isopropyl acetate / dimethyl sulfoxide / 90 - 95 °C
View Scheme
Multi-step reaction with 3 steps
1.1: hydrogen; palladium 10% on activated carbon / methanol / 1 h / 50 °C / 4500.45 Torr / Autoclave
1.2: Heating
2.1: triethylamine / N,N-dimethyl acetamide / 1 h / 70 °C
2.2: 1.67 h / 100 °C
3.1: N-ethyl-N,N-diisopropylamine; phenol / 4 h / 60 °C
View Scheme
2-fluoro-N-methyl-4-amino-benzamide
915087-25-1

2-fluoro-N-methyl-4-amino-benzamide

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: acetic acid / 16 h / 80 °C / Sealed tube
2.1: N,N-dimethyl-formamide / 16 h / 120 °C
2.2: 1 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / tetrahydrofuran / 8 h / 80 - 85 °C
2: Isopropyl acetate / dimethyl sulfoxide / 90 - 95 °C
View Scheme
Multi-step reaction with 2 steps
1: acetic acid / acetone / 85 °C
2: pyridine / 60 - 90 °C
View Scheme
2-fluoro-4-nitrotoluene
1427-07-2

2-fluoro-4-nitrotoluene

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium bromide; sulfuric acid / water / 80 - 85 °C
1.2: 27 h / 80 - 85 °C
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 5.5 h / 0 - 25 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 27 °C / 1500.15 - 1875.19 Torr
4.1: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / tetrahydrofuran / 8 h / 80 - 85 °C
5.1: Isopropyl acetate / dimethyl sulfoxide / 90 - 95 °C
View Scheme
Multi-step reaction with 5 steps
1.1: periodic acid; chromium(VI) oxide / acetonitrile / 1 h
2.1: thionyl chloride / N,N-dimethyl-formamide / 1 h / -5 °C
2.2: 1 h
3.1: acetic acid; iron / ethyl acetate / 1 h / Reflux
4.1: magnesium sulfate / 12 h / 80 °C
5.1: N,N-dimethyl acetamide / 100 °C
5.2: 1.5 h / Reflux
View Scheme
4-amino-2-fluoro-N-methylbenzamide hydrochloride

4-amino-2-fluoro-N-methylbenzamide hydrochloride

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / N,N-dimethyl acetamide / 1 h / 70 °C
1.2: 1.67 h / 100 °C
2.1: N-ethyl-N,N-diisopropylamine; phenol / 4 h / 60 °C
View Scheme
2-fluoro-4-nitrobenzoyl chloride
403-23-6

2-fluoro-4-nitrobenzoyl chloride

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: Isopropyl acetate / 5 h / Inert atmosphere
2.1: hydrogen; palladium 10% on activated carbon / methanol / 1 h / 50 °C / 4500.45 Torr / Autoclave
2.2: Heating
3.1: triethylamine / N,N-dimethyl acetamide / 1 h / 70 °C
3.2: 1.67 h / 100 °C
4.1: N-ethyl-N,N-diisopropylamine; phenol / 4 h / 60 °C
View Scheme
enzalutamide
915087-33-1

enzalutamide

4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-imidazolidinethione-1-yl)-2-fluorobenzoic acid
1242137-15-0

4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-imidazolidinethione-1-yl)-2-fluorobenzoic acid

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane for 2h; Reflux;95%
With hydrogenchloride In 1,4-dioxane; water for 2h; Reflux;95%
With hydrogenchloride In water at 120℃; for 48h; Pressure vessel;
With hydrogenchloride In water at 120℃; for 48h;
enzalutamide
915087-33-1

enzalutamide

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

t-butyl (4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioimidazolidin-1-yl)-2-fluorophenyl)(methyl)formamide

t-butyl (4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioimidazolidin-1-yl)-2-fluorophenyl)(methyl)formamide

Conditions
ConditionsYield
With dmap In dichloromethane at 25℃; for 12h;92.3%
enzalutamide
915087-33-1

enzalutamide

tetramethylammonium fluoride
373-68-2

tetramethylammonium fluoride

4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N,N-dimethylbenzamide

4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N,N-dimethylbenzamide

Conditions
ConditionsYield
In toluene at 100℃; for 12h;53%
enzalutamide
915087-33-1

enzalutamide

4-(3-(4-cyano-3-(difluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide

4-(3-(4-cyano-3-(difluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide

Conditions
ConditionsYield
With 2,2,6,6-tetramethyl-piperidine; 1,2,2,6,6-pentamethylpiperidine; 4-sulfanylphenol; 1,3-dicyano-2,4,5,6-tetrakis(N,N-diphenylamino)-benzene In 1,2-dichloro-ethane at 25℃; for 12h; Sealed tube; Irradiation; Inert atmosphere;40%
enzalutamide
915087-33-1

enzalutamide

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

isopropyl (2S)-2-[[[4-(hydroxymethyl)phenoxy](methoxymethyl)phosphoryl]amino]propanoate

isopropyl (2S)-2-[[[4-(hydroxymethyl)phenoxy](methoxymethyl)phosphoryl]amino]propanoate

isopropyl (2S)-2-[[[4-[[[4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-2-fluorobenzoyl]-methylcarbamoyl]oxymethyl]phenoxy](methoxymethyl)phosphoryl]amino]propanoate

isopropyl (2S)-2-[[[4-[[[4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-2-fluorobenzoyl]-methylcarbamoyl]oxymethyl]phenoxy](methoxymethyl)phosphoryl]amino]propanoate

Conditions
ConditionsYield
Stage #1: enzalutamide With chloro-trimethyl-silane; triethylamine In tetrahydrofuran at 60℃; for 0.5h; Cooling with ice;
Stage #2: bis(trichloromethyl) carbonate In tetrahydrofuran at 60℃; for 2h;
Stage #3: isopropyl (2S)-2-[[[4-(hydroxymethyl)phenoxy](methoxymethyl)phosphoryl]amino]propanoate With dmap In tetrahydrofuran at 20℃; for 1h; Cooling with ice;
27.76%
enzalutamide
915087-33-1

enzalutamide

2(13)CN(1-)*Zn(2+)

2(13)CN(1-)*Zn(2+)

C21(13)CH19F3N4O2S

C21(13)CH19F3N4O2S

Conditions
ConditionsYield
With C10H12O2NiC8H12-1,5-cyclo; triphenylborane; diphenyl(methyl)phosphine In 1-methyl-pyrrolidin-2-one at 100℃; for 18h; Inert atmosphere; Glovebox; Sealed tube;13%
enzalutamide
915087-33-1

enzalutamide

4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide
1242137-18-3

4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide

Conditions
ConditionsYield
With dihydrogen peroxide In ethanol; water for 1h; Reflux;

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