As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiryN-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine CAS No.:1289942-66-0 Name: N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine Molecular Structure Molecular Formula: C12H15FN2O3
Cas:1289942-66-0
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:1289942-66-0
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inquiryTIANFUCHEM--1289942-66-0--N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the
Cas:1289942-66-0
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inquiryN-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine CAS: 1289942-66-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates
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Negotiable
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:1289942-66-0
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inquiryN-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine CAS: 1289942-66-0 Specification Name: N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine Molecular Structure Molecular Formula: C12H15FN2O3 Molecular Weight: 254.26
Cas:1289942-66-0
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:1289942-66-0
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:1289942-66-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:1289942-66-0
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inquiryWhy Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
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inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:1289942-66-0
Min.Order:100 Gram
Negotiable
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:1289942-66-0
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:1289942-66-0
Min.Order:10 Gram
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Type:Lab/Research institutions
inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:1289942-66-0
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Type:Lab/Research institutions
inquiryProduct name: N-[3-Fluoro-4-[(Methylamino)carbonyl]phenyl]-2-Methylanine CAS No.:1289942-66-0 Molecule Formula:C12H15FN2O3 Molecule Weight:254.26 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterpri
Cas:1289942-66-0
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryHuarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.
Cas:1289942-66-0
Min.Order:1 Gram
FOB Price: $1.0 / 2.0
Type:Trading Company
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:1289942-66-0
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryWe are leading fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...)
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Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:1289942-66-0
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:1289942-66-0
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:1289942-66-0
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Type:Trading Company
inquirySAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
Cas:1289942-66-0
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inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
Cas:1289942-66-0
Min.Order:1 Kilogram
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inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
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Type:Trading Company
inquiry2-fluoro-4-bromobenzamide
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
Conditions | Yield |
---|---|
With 2-acetylcyclohexanone; water; potassium carbonate; copper(l) chloride In N,N-dimethyl-formamide at 30 - 105℃; for 12h; | 89.1% |
4-bromo-2-fluoro-N-methylbenzanamide
2-Aminoisobutyric acid
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
Conditions | Yield |
---|---|
With 2-acetylcyclohexanone; potassium carbonate; copper(l) chloride In N,N-dimethyl-formamide at 110℃; for 16h; | 88.7% |
With water; potassium carbonate; L-proline; copper(l) chloride In N,N-dimethyl-formamide at 100℃; for 24h; Reagent/catalyst; Solvent; Inert atmosphere; | 87% |
Stage #1: 4-bromo-2-fluoro-N-methylbenzanamide; 2-Aminoisobutyric acid With potassium carbonate; copper(l) chloride In water; N,N-dimethyl-formamide at 30℃; Stage #2: With 2-acetylcyclohexanone In water; N,N-dimethyl-formamide at 105℃; Inert atmosphere; Stage #3: With citric acid In Isopropyl acetate; water pH=4; | 75.4% |
4-bromo-2-fluoro-N-methylbenzanamide
methyl 2-aminoisobutyrate hydrochloride
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
Conditions | Yield |
---|---|
With 2-acetylcyclohexanone; water; potassium carbonate; copper(l) chloride In N,N-dimethyl-formamide at 30 - 105℃; for 12h; | 87.3% |
2-fluoro-4-bromobenzamide
benzyl 2-amino-2-methylpropionate hydrochloride
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
Conditions | Yield |
---|---|
With copper(l) iodide; 2-acetylcyclohexanone; water; potassium carbonate In dimethyl sulfoxide at 40 - 110℃; for 10h; | 83.6% |
2-fluoro-N-methyl-4-amino-benzamide
2-bromo-2-methylpropionic acid
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 72h; | 76% |
With triethylamine In dichloromethane at 20 - 30℃; for 15h; Inert atmosphere; | 12 g |
With triethylamine In dichloromethane at 20 - 30℃; for 15h; Inert atmosphere; |
2-bromo-2-methylpropionic acid
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
Conditions | Yield |
---|---|
Stage #1: 4-amino-2-fluoro-N-methylbenzamide hydrochloride With triethylamine In N,N-dimethyl acetamide at 70℃; for 1h; Stage #2: 2-bromo-2-methylpropionic acid In N,N-dimethyl acetamide at 100℃; for 1.66667h; | 53% |
2-fluoro-4-bromobenzoic acid
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: thionyl chloride / N,N-dimethyl-formamide; Isopropyl acetate / 4.58 h / 21 - 72 °C / Inert atmosphere; Industry scale 2.1: water; Isopropyl acetate / 1.08 h / 2 - 35 °C / Inert atmosphere; Industry scale 3.1: potassium carbonate / copper(l) chloride / N,N-dimethyl-formamide; water / 30 °C 3.2: 105 °C / Inert atmosphere 3.3: pH 4 View Scheme | |
Multi-step reaction with 3 steps 1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 10 - 30 °C 2.1: water; tert-butyl methyl ether / 10 - 30 °C / pH 8 - 9 3.1: potassium carbonate / N,N-dimethyl-formamide; 1,4-dioxane; water / 0.33 h / Inert atmosphere 3.2: 24.33 h / Inert atmosphere; Reflux View Scheme | |
Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide; thionyl chloride / ethyl acetate / 4 h / 20 °C / Inert atmosphere; Reflux 2: ethyl acetate / 0.25 h / 30 - 35 °C 3: potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere View Scheme |
4-bromo-2-fluorobenzoyl chloride
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: water; Isopropyl acetate / 1.08 h / 2 - 35 °C / Inert atmosphere; Industry scale 2.1: potassium carbonate / copper(l) chloride / N,N-dimethyl-formamide; water / 30 °C 2.2: 105 °C / Inert atmosphere 2.3: pH 4 View Scheme | |
Multi-step reaction with 2 steps 1: ethyl acetate / 0.25 h / 30 - 35 °C 2: potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1.1: toluene; N,N-dimethyl-formamide / 1 h / 10 - 15 °C 2.1: copper(l) chloride; N,N-dimethyl-aniline / N,N-dimethyl-formamide / 75 - 80 °C / Inert atmosphere 2.2: 75 - 80 °C / Inert atmosphere 2.3: 0.25 h / Inert atmosphere View Scheme |
2-fluoro-4-nitrobenzoic acid
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: N,N-dimethyl-formamide; thionyl chloride / Isopropyl acetate / 60 °C / Inert atmosphere 2.1: Isopropyl acetate / 5 h / Inert atmosphere 3.1: hydrogen; palladium 10% on activated carbon / methanol / 1 h / 50 °C / 4500.45 Torr / Autoclave 3.2: Heating 4.1: triethylamine / N,N-dimethyl acetamide / 1 h / 70 °C 4.2: 1.67 h / 100 °C View Scheme |
2-fluoro-4-nitrobenzoyl chloride
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: Isopropyl acetate / 5 h / Inert atmosphere 2.1: hydrogen; palladium 10% on activated carbon / methanol / 1 h / 50 °C / 4500.45 Torr / Autoclave 2.2: Heating 3.1: triethylamine / N,N-dimethyl acetamide / 1 h / 70 °C 3.2: 1.67 h / 100 °C View Scheme |
2-fluoro-N-methyl-4-nitro-benzamide
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogen; palladium 10% on activated carbon / methanol / 1 h / 50 °C / 4500.45 Torr / Autoclave 1.2: Heating 2.1: triethylamine / N,N-dimethyl acetamide / 1 h / 70 °C 2.2: 1.67 h / 100 °C View Scheme |
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
p-methoxybenzyl chloride
Conditions | Yield |
---|---|
With potassium carbonate In water; N,N-dimethyl-formamide at 50℃; for 4h; Temperature; | 97% |
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
benzyl alcohol
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In ethyl acetate at 0℃; for 4h; Temperature; Solvent; Inert atmosphere; | 96% |
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
methyl iodide
2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropanoic acid methyl ester
Conditions | Yield |
---|---|
Stage #1: 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid With potassium carbonate In water; N,N-dimethyl-formamide at 30℃; Stage #2: methyl iodide In water; N,N-dimethyl-formamide at 32 - 40℃; for 1.08333h; | 95% |
With potassium carbonate In water; N,N-dimethyl-formamide at 40℃; for 1h; Inert atmosphere; | 78% |
Stage #1: 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid; methyl iodide With potassium carbonate In water; N,N-dimethyl-formamide at 30 - 40℃; for 1h; Stage #2: With acetic acid In water; N,N-dimethyl-formamide at 60℃; for 1h; | 5.1 g |
In dimethyl sulfoxide at 30 - 40℃; for 0.666667h; Inert atmosphere; |
ethanol
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In ethyl acetate at 0 - 30℃; Inert atmosphere; | 95% |
2-Bromoethyl ethyl ether
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 2h; | 93% |
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
2-Bromoethyl methyl ether
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 30℃; Inert atmosphere; | 92.6% |
2-methoxy-ethanol
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere; | 91.3% |
methanol
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropanoic acid methyl ester
Conditions | Yield |
---|---|
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In N,N-dimethyl-formamide at 0 - 30℃; for 8h; Inert atmosphere; | 90% |
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
4-isothiocyanato 2-(trifluoromethyl)benzonitrile
enzalutamide
Conditions | Yield |
---|---|
Stage #1: 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid With triethylamine In dichloromethane; toluene at 30℃; for 0.166667h; Stage #2: 4-isothiocyanato 2-(trifluoromethyl)benzonitrile In toluene at 50 - 60℃; for 4h; Temperature; Solvent; | 88.5% |
With N-ethyl-N,N-diisopropylamine; phenol at 60℃; for 4h; Reagent/catalyst; | 77% |
Stage #1: 4-isothiocyanato 2-(trifluoromethyl)benzonitrile With triethylamine In chloroform at 20℃; for 0.25h; Reflux; Inert atmosphere; Stage #2: 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid In chloroform for 6h; Reagent/catalyst; Reflux; | 76.92% |
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1,2-Epoxy-3-bromopropane
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 8h; | 88.5% |
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
benzyl bromide
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 10h; | 85% |
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
allyl bromide
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 30℃; for 3h; Concentration; Temperature; Inert atmosphere; | 84.5% |
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
propargyl bromide
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 10h; | 81% |
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
ethylamine
Conditions | Yield |
---|---|
Stage #1: 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20 - 30℃; for 0.0833333h; Inert atmosphere; Stage #2: ethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20 - 30℃; for 15h; | 60.6% |
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1-isothiocyanato-3-(pentafluorosulfanyl)benzene
Conditions | Yield |
---|---|
With N,N-dimethyl-formamide In Isopropyl acetate at 84℃; Inert atmosphere; | 38% |
Stage #1: 1-isothiocyanato-3-(pentafluorosulfanyl)benzene With triethylamine In chloroform at 65℃; for 1h; Inert atmosphere; Stage #2: 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid In chloroform at 65℃; for 16h; Inert atmosphere; | 73 mg |
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
4-amino-2-trifluoromethylbenzonitrile
4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; | 36% |
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane | 36% |
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 5h; | 650 mg |
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 8h; | 0.32 g |
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
enzalutamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / N,N-dimethyl-formamide; water / 30 °C 1.2: 1.08 h / 32 - 40 °C 2.1: dimethyl sulfoxide; Isopropyl acetate / 17.5 h / 83 - 84 °C View Scheme | |
Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C 2: 6 h / 100 °C / a sealed-tube View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 50 °C 2: dimethyl sulfoxide / 4 h / 84 °C View Scheme |
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-imidazolidinethione-1-yl)-2-fluorobenzoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / N,N-dimethyl-formamide; water / 30 °C 1.2: 1.08 h / 32 - 40 °C 2.1: dimethyl sulfoxide; Isopropyl acetate / 17.5 h / 83 - 84 °C 3.1: hydrogenchloride / water / 48 h / 120 °C View Scheme | |
Multi-step reaction with 3 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C 2: 6 h / 100 °C / a sealed-tube 3: hydrogenchloride / water / 48 h / 120 °C View Scheme |
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
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