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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine

Cas:1289942-66-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Hangzhou Think Chemical Co. Ltd

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine CAS No.:1289942-66-0 Name: N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine Molecular Structure Molecular Formula: C12H15FN2O3

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-[3-Fluoro-4-(methylcarbamoyl)anilino]-2-methylpropanoic acid

Cas:1289942-66-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM--1289942-66-0--N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine factory price Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China

TIANFUCHEM--1289942-66-0--N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine factory price

Cas:1289942-66-0

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Pharmaceutical Intermediate N-[3-Fluoro-4-[ (methylamino) Carbonyl]Phenyl]-2-Methylalanine CAS 1289942-66-0

Cas:1289942-66-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Hot sellingCAS 1289942-66-0 with high quality products

Cas:1289942-66-0

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine 1289942-66-0

Cas:1289942-66-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine/ LIDE PHARMA- Factory supply / Best price

Cas:1289942-66-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine CAS: 1289942-66-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine CAS: 1289942-66-0

Cas:1289942-66-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine

Cas:1289942-66-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Lonwin Chemical Group Limited

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine CAS: 1289942-66-0 Specification Name: N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine Molecular Structure Molecular Formula: C12H15FN2O3 Molecular Weight: 254.26

Factory supply N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine

Cas:1289942-66-0

Min.Order:1 Kilogram

Negotiable

Type:Other

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

N-[3-FLUORO-4-[(METHYLAMINO)CARBONYL]PHENYL]-2-METHYLALANINE

Cas:1289942-66-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine

Cas:1289942-66-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine

Cas:1289942-66-0

Min.Order:1 Gram

Negotiable

Type:Other

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine

Cas:1289942-66-0

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine/High quality/Best price

Cas:1289942-66-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

TIANFU CHEM---N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine

Cas:1289942-66-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine/Intermediates of Enzalutamide/ in stock CAS NO.1289942-66-0

Cas:1289942-66-0

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: N-[3-Fluoro-4-[(Methylamino)carbonyl]phenyl]-2-Methylanine CAS No.:1289942-66-0 Molecule Formula:C12H15FN2O3 Molecule Weight:254.26 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterpri

Best Quality N-[3-Fluoro-4-[(Methylamino)carbonyl]phenyl]-2-Methylanine

Cas:1289942-66-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

Huarong Industrial Group Limited established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World.

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine

Cas:1289942-66-0

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]

Cas:1289942-66-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...)

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanineCAS NO.: 1289942-66-0

Cas:1289942-66-0

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine

Cas:1289942-66-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine

Cas:1289942-66-0

Min.Order:1 Kilogram

Negotiable

Type:Other

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Synthetic route

2-fluoro-4-bromobenzamide
292621-45-5

2-fluoro-4-bromobenzamide

propylene 2-amino-2-isobutyrate hydrochloride

propylene 2-amino-2-isobutyrate hydrochloride

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

Conditions
ConditionsYield
With 2-acetylcyclohexanone; water; potassium carbonate; copper(l) chloride In N,N-dimethyl-formamide at 30 - 105℃; for 12h;89.1%
4-bromo-2-fluoro-N-methylbenzanamide
749927-69-3

4-bromo-2-fluoro-N-methylbenzanamide

2-Aminoisobutyric acid
62-57-7

2-Aminoisobutyric acid

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

Conditions
ConditionsYield
With 2-acetylcyclohexanone; potassium carbonate; copper(l) chloride In N,N-dimethyl-formamide at 110℃; for 16h;88.7%
With water; potassium carbonate; L-proline; copper(l) chloride In N,N-dimethyl-formamide at 100℃; for 24h; Reagent/catalyst; Solvent; Inert atmosphere;87%
Stage #1: 4-bromo-2-fluoro-N-methylbenzanamide; 2-Aminoisobutyric acid With potassium carbonate; copper(l) chloride In water; N,N-dimethyl-formamide at 30℃;
Stage #2: With 2-acetylcyclohexanone In water; N,N-dimethyl-formamide at 105℃; Inert atmosphere;
Stage #3: With citric acid In Isopropyl acetate; water pH=4;
75.4%
4-bromo-2-fluoro-N-methylbenzanamide
749927-69-3

4-bromo-2-fluoro-N-methylbenzanamide

methyl 2-aminoisobutyrate hydrochloride
15028-41-8

methyl 2-aminoisobutyrate hydrochloride

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

Conditions
ConditionsYield
With 2-acetylcyclohexanone; water; potassium carbonate; copper(l) chloride In N,N-dimethyl-formamide at 30 - 105℃; for 12h;87.3%
2-fluoro-4-bromobenzamide
292621-45-5

2-fluoro-4-bromobenzamide

benzyl 2-amino-2-methylpropionate hydrochloride
60421-20-7

benzyl 2-amino-2-methylpropionate hydrochloride

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

Conditions
ConditionsYield
With copper(l) iodide; 2-acetylcyclohexanone; water; potassium carbonate In dimethyl sulfoxide at 40 - 110℃; for 10h;83.6%
2-fluoro-N-methyl-4-amino-benzamide
915087-25-1

2-fluoro-N-methyl-4-amino-benzamide

2-bromo-2-methylpropionic acid
2052-01-9

2-bromo-2-methylpropionic acid

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 72h;76%
With triethylamine In dichloromethane at 20 - 30℃; for 15h; Inert atmosphere;12 g
With triethylamine In dichloromethane at 20 - 30℃; for 15h; Inert atmosphere;
2-bromo-2-methylpropionic acid
2052-01-9

2-bromo-2-methylpropionic acid

4-amino-2-fluoro-N-methylbenzamide hydrochloride

4-amino-2-fluoro-N-methylbenzamide hydrochloride

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

Conditions
ConditionsYield
Stage #1: 4-amino-2-fluoro-N-methylbenzamide hydrochloride With triethylamine In N,N-dimethyl acetamide at 70℃; for 1h;
Stage #2: 2-bromo-2-methylpropionic acid In N,N-dimethyl acetamide at 100℃; for 1.66667h;
53%
2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride / N,N-dimethyl-formamide; Isopropyl acetate / 4.58 h / 21 - 72 °C / Inert atmosphere; Industry scale
2.1: water; Isopropyl acetate / 1.08 h / 2 - 35 °C / Inert atmosphere; Industry scale
3.1: potassium carbonate / copper(l) chloride / N,N-dimethyl-formamide; water / 30 °C
3.2: 105 °C / Inert atmosphere
3.3: pH 4
View Scheme
Multi-step reaction with 3 steps
1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 10 - 30 °C
2.1: water; tert-butyl methyl ether / 10 - 30 °C / pH 8 - 9
3.1: potassium carbonate / N,N-dimethyl-formamide; 1,4-dioxane; water / 0.33 h / Inert atmosphere
3.2: 24.33 h / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 3 steps
1: N,N-dimethyl-formamide; thionyl chloride / ethyl acetate / 4 h / 20 °C / Inert atmosphere; Reflux
2: ethyl acetate / 0.25 h / 30 - 35 °C
3: potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere
View Scheme
4-bromo-2-fluorobenzoyl chloride
151982-51-3

4-bromo-2-fluorobenzoyl chloride

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: water; Isopropyl acetate / 1.08 h / 2 - 35 °C / Inert atmosphere; Industry scale
2.1: potassium carbonate / copper(l) chloride / N,N-dimethyl-formamide; water / 30 °C
2.2: 105 °C / Inert atmosphere
2.3: pH 4
View Scheme
Multi-step reaction with 2 steps
1: ethyl acetate / 0.25 h / 30 - 35 °C
2: potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 16 h / 120 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: toluene; N,N-dimethyl-formamide / 1 h / 10 - 15 °C
2.1: copper(l) chloride; N,N-dimethyl-aniline / N,N-dimethyl-formamide / 75 - 80 °C / Inert atmosphere
2.2: 75 - 80 °C / Inert atmosphere
2.3: 0.25 h / Inert atmosphere
View Scheme
2-fluoro-4-nitrobenzoic acid
403-24-7

2-fluoro-4-nitrobenzoic acid

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N,N-dimethyl-formamide; thionyl chloride / Isopropyl acetate / 60 °C / Inert atmosphere
2.1: Isopropyl acetate / 5 h / Inert atmosphere
3.1: hydrogen; palladium 10% on activated carbon / methanol / 1 h / 50 °C / 4500.45 Torr / Autoclave
3.2: Heating
4.1: triethylamine / N,N-dimethyl acetamide / 1 h / 70 °C
4.2: 1.67 h / 100 °C
View Scheme
2-fluoro-4-nitrobenzoyl chloride
403-23-6

2-fluoro-4-nitrobenzoyl chloride

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: Isopropyl acetate / 5 h / Inert atmosphere
2.1: hydrogen; palladium 10% on activated carbon / methanol / 1 h / 50 °C / 4500.45 Torr / Autoclave
2.2: Heating
3.1: triethylamine / N,N-dimethyl acetamide / 1 h / 70 °C
3.2: 1.67 h / 100 °C
View Scheme
2-fluoro-N-methyl-4-nitro-benzamide
915087-24-0

2-fluoro-N-methyl-4-nitro-benzamide

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogen; palladium 10% on activated carbon / methanol / 1 h / 50 °C / 4500.45 Torr / Autoclave
1.2: Heating
2.1: triethylamine / N,N-dimethyl acetamide / 1 h / 70 °C
2.2: 1.67 h / 100 °C
View Scheme
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

p-methoxybenzyl chloride
824-94-2

p-methoxybenzyl chloride

C20H23FN2O4

C20H23FN2O4

Conditions
ConditionsYield
With potassium carbonate In water; N,N-dimethyl-formamide at 50℃; for 4h; Temperature;97%
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

benzyl alcohol
100-51-6

benzyl alcohol

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropionate benzyl

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropionate benzyl

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In ethyl acetate at 0℃; for 4h; Temperature; Solvent; Inert atmosphere;96%
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

methyl iodide
74-88-4

methyl iodide

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropanoic acid methyl ester
1332524-01-2

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropanoic acid methyl ester

Conditions
ConditionsYield
Stage #1: 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid With potassium carbonate In water; N,N-dimethyl-formamide at 30℃;
Stage #2: methyl iodide In water; N,N-dimethyl-formamide at 32 - 40℃; for 1.08333h;
95%
With potassium carbonate In water; N,N-dimethyl-formamide at 40℃; for 1h; Inert atmosphere;78%
Stage #1: 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid; methyl iodide With potassium carbonate In water; N,N-dimethyl-formamide at 30 - 40℃; for 1h;
Stage #2: With acetic acid In water; N,N-dimethyl-formamide at 60℃; for 1h;
5.1 g
In dimethyl sulfoxide at 30 - 40℃; for 0.666667h; Inert atmosphere;
ethanol
64-17-5

ethanol

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

ethyl N-[3-fluoro-4-(methylcarbamoyl)phenyl]-2-methylalaninate

ethyl N-[3-fluoro-4-(methylcarbamoyl)phenyl]-2-methylalaninate

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In ethyl acetate at 0 - 30℃; Inert atmosphere;95%
2-Bromoethyl ethyl ether
592-55-2

2-Bromoethyl ethyl ether

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

C16H23FN2O4

C16H23FN2O4

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 2h;93%
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

2-Bromoethyl methyl ether
6482-24-2

2-Bromoethyl methyl ether

2-methoxyethyl 2-{[3-fluoro-4-(methylcarbamoyl)phenyl]amino}-2-methylpropanoate

2-methoxyethyl 2-{[3-fluoro-4-(methylcarbamoyl)phenyl]amino}-2-methylpropanoate

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide at 30℃; Inert atmosphere;92.6%
2-methoxy-ethanol
109-86-4

2-methoxy-ethanol

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

2-methoxyethyl 2-{[3-fluoro-4-(methylcarbamoyl)phenyl]amino}-2-methylpropanoate

2-methoxyethyl 2-{[3-fluoro-4-(methylcarbamoyl)phenyl]amino}-2-methylpropanoate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Inert atmosphere;91.3%
methanol
67-56-1

methanol

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropanoic acid methyl ester
1332524-01-2

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropanoic acid methyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In N,N-dimethyl-formamide at 0 - 30℃; for 8h; Inert atmosphere;90%
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

4-isothiocyanato 2-(trifluoromethyl)benzonitrile
143782-23-4

4-isothiocyanato 2-(trifluoromethyl)benzonitrile

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
Stage #1: 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid With triethylamine In dichloromethane; toluene at 30℃; for 0.166667h;
Stage #2: 4-isothiocyanato 2-(trifluoromethyl)benzonitrile In toluene at 50 - 60℃; for 4h; Temperature; Solvent;
88.5%
With N-ethyl-N,N-diisopropylamine; phenol at 60℃; for 4h; Reagent/catalyst;77%
Stage #1: 4-isothiocyanato 2-(trifluoromethyl)benzonitrile With triethylamine In chloroform at 20℃; for 0.25h; Reflux; Inert atmosphere;
Stage #2: 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid In chloroform for 6h; Reagent/catalyst; Reflux;
76.92%
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

1,2-Epoxy-3-bromopropane
3132-64-7

1,2-Epoxy-3-bromopropane

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropionate ethyloxirane

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropionate ethyloxirane

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 8h;88.5%
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

benzyl bromide
100-39-0

benzyl bromide

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropionate benzyl

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropionate benzyl

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 10h;85%
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

allyl bromide
106-95-6

allyl bromide

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropionate allyl

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropionate allyl

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 30℃; for 3h; Concentration; Temperature; Inert atmosphere;84.5%
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

propargyl bromide
106-96-7

propargyl bromide

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropionate proparagyl

2-(3-fluoro-4-(methylcarbamoyl)phenylamino)-2-methylpropionate proparagyl

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 10h;81%
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

ethylamine
75-04-7

ethylamine

C14H20FN3O2

C14H20FN3O2

Conditions
ConditionsYield
Stage #1: 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20 - 30℃; for 0.0833333h; Inert atmosphere;
Stage #2: ethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20 - 30℃; for 15h;
60.6%
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

1-isothiocyanato-3-(pentafluorosulfanyl)benzene
1533425-64-7

1-isothiocyanato-3-(pentafluorosulfanyl)benzene

4-(5,5-dimethyl-4-oxo-2-thioxo-3-(3-(pentafluorosulfanyl)phenyl)imidazolidin-1-yl)-2-fluoro-N-methylbenzamide

4-(5,5-dimethyl-4-oxo-2-thioxo-3-(3-(pentafluorosulfanyl)phenyl)imidazolidin-1-yl)-2-fluoro-N-methylbenzamide

Conditions
ConditionsYield
With N,N-dimethyl-formamide In Isopropyl acetate at 84℃; Inert atmosphere;38%
Stage #1: 1-isothiocyanato-3-(pentafluorosulfanyl)benzene With triethylamine In chloroform at 65℃; for 1h; Inert atmosphere;
Stage #2: 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid In chloroform at 65℃; for 16h; Inert atmosphere;
73 mg
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

4-amino-2-trifluoromethylbenzonitrile
654-70-6

4-amino-2-trifluoromethylbenzonitrile

4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide
1289942-55-7

4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N-methyl-benzamide

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;36%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane36%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 5h;650 mg
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 8h;0.32 g
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

enzalutamide
915087-33-1

enzalutamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / N,N-dimethyl-formamide; water / 30 °C
1.2: 1.08 h / 32 - 40 °C
2.1: dimethyl sulfoxide; Isopropyl acetate / 17.5 h / 83 - 84 °C
View Scheme
Multi-step reaction with 2 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
2: 6 h / 100 °C / a sealed-tube
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 50 °C
2: dimethyl sulfoxide / 4 h / 84 °C
View Scheme
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-imidazolidinethione-1-yl)-2-fluorobenzoic acid
1242137-15-0

4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-imidazolidinethione-1-yl)-2-fluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide; water / 30 °C
1.2: 1.08 h / 32 - 40 °C
2.1: dimethyl sulfoxide; Isopropyl acetate / 17.5 h / 83 - 84 °C
3.1: hydrogenchloride / water / 48 h / 120 °C
View Scheme
Multi-step reaction with 3 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
2: 6 h / 100 °C / a sealed-tube
3: hydrogenchloride / water / 48 h / 120 °C
View Scheme
2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid
1289942-66-0

2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methyl propanoic acid

Reaxys ID: 29942157

Reaxys ID: 29942157

Reaxys ID: 29942156

Reaxys ID: 29942156

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