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inquiryCAS No.99199-90-3 Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Sc
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiry6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran CAS:99199-90-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing i
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:99199-90-3
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inquirySuperior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag,or as your request Application:Used as Pharmaceutical Intermediates Transporta
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
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inquiryBasic Info Chemical Name 6-fluoro-2-(oxiran-2-yl)-3,4-dihydro-2H-chromene Synonyms 6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran; 6-fluoro-2-oxiranyl-1-benzopyran; CAS No. 99199-90-3 Molecular Formula C11H11FO2 Molecular Weight 194.20200 PSA 21.760
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:99199-90-3
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Cas:99199-90-3
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:99199-90-3
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
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inquiryProduct Name: 6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran Synonyms: 6-FLUORO-3,4-DIHYDRO-2H-1-BENZOPYRAN-2-OXARANYL(FOR NEBIVOLOL);6-Fluoro-3,4-D…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton
Cas:99199-90-3
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
Cas:99199-90-3
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inquiryLuyunjia Chemistry Xiamen Limited is a high-tech company specializing in R&D and manufacturing of photoinitiators monomers and oligomers, UV absorbers and pharmaceutical intermediates, and pharmaceutical intermediates of generic drug. and has a h
Cas:99199-90-3
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inquiry6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde
trimethylsulphonium iodide
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
Stage #1: trimethylsulphonium iodide With sodium hydride In dimethyl sulfoxide cooling; Stage #2: 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde In dimethyl sulfoxide at 20℃; for 1h; | 100% |
2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2yl)ethanol
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
Stage #1: 2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2yl)ethanol With sodium hydroxide In water; isopropyl alcohol at 0℃; for 1.5h; Inert atmosphere; Stage #2: With acetic acid In water; isopropyl alcohol; toluene | 96% |
With sodium hydroxide In dichloromethane; water at -10 - 20℃; for 2.66667h; |
6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde
trimethylsulfoxonium iodide
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
Stage #1: trimethylsulfoxonium iodide With sodium hydride In dimethyl sulfoxide for 0.5h; Stage #2: 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde In dichloromethane; dimethyl sulfoxide at 20 - 25℃; for 1h; | 90% |
With sodium hydride In dimethyl sulfoxide at 20 - 25℃; for 1h; | 84% |
Stage #1: trimethylsulfoxonium iodide With potassium tert-butylate In dimethyl sulfoxide at 20 - 40℃; for 1.5h; Stage #2: 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde In dimethyl sulfoxide at 20 - 40℃; for 1.5h; |
1-(6-fluorochroman-2-yl)ethane-1,2-diol
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
Stage #1: 1-(6-fluorochroman-2-yl)ethane-1,2-diol With sodium hydride In tert-butyl methyl ether; dimethyl sulfoxide at 50℃; for 1h; Inert atmosphere; Stage #2: With p-toluenesulfonyl chloride In tert-butyl methyl ether for 1h; Reagent/catalyst; Solvent; Inert atmosphere; | 90% |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 20℃; | 83% |
6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: Et3N; ClCOOEt / tetrahydrofuran / 10 h / 20 °C 1.2: 90 percent / NaBH4 / tetrahydrofuran; H2O / 5 h / 20 °C 2.1: 78 percent / pyridinium chloroformate/SiO2 / CH2Cl2 / 1.5 h / 20 °C 3.1: NaH / dimethylsulfoxide / cooling 3.2: 100 percent / dimethylsulfoxide / 1 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium tetrahydroborate; sulfuric acid / diethyl ether; tetrahydrofuran / 0.75 h / 0 - 35 °C 1.2: pH 7 2.1: sodium hydrogencarbonate / iodine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.17 h / 20 °C 2.2: 24 h / 20 - 25 °C 3.1: sodium hydride / dimethyl sulfoxide / 0.5 h 3.2: 1 h / 20 - 25 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium tetrahydroborate; sulfuric acid / tetrahydrofuran; diethyl ether / 0.5 h / 0 - 35 °C 2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; iodine / dichloromethane; water / 24 h / 20 °C 3: sodium hydride / dimethyl sulfoxide / 1 h / 20 - 25 °C View Scheme |
6-fluoro-4-oxo-4H-1-benzopyran-2-carboxylic acid
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 86 percent / H2 / Pd/C / acetic acid / 70 - 80 °C / 15001.2 Torr 2.1: Et3N; ClCOOEt / tetrahydrofuran / 10 h / 20 °C 2.2: 90 percent / NaBH4 / tetrahydrofuran; H2O / 5 h / 20 °C 3.1: 78 percent / pyridinium chloroformate/SiO2 / CH2Cl2 / 1.5 h / 20 °C 4.1: NaH / dimethylsulfoxide / cooling 4.2: 100 percent / dimethylsulfoxide / 1 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran / 45 - 55 °C / 3000.3 Torr 2.1: n-butyllithium / hexane; tetrahydrofuran / -85 - -75 °C 2.2: -80 - 0 °C 3.1: ethanol; sodium tetrahydroborate / 2 h / 0 °C / Inert atmosphere 4.1: sodium hydroxide / isopropyl alcohol; water / 1.5 h / 0 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1.1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran / 45 - 55 °C / 3000.3 Torr 2.1: n-butyllithium / hexane; tetrahydrofuran / -85 - -75 °C 2.2: -80 - -70 °C 2.3: 2 h / Reflux View Scheme |
(6-fluoro-3,4-dihydro-2H-chromene-2-yl)methanol
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 78 percent / pyridinium chloroformate/SiO2 / CH2Cl2 / 1.5 h / 20 °C 2.1: NaH / dimethylsulfoxide / cooling 2.2: 100 percent / dimethylsulfoxide / 1 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydrogencarbonate / iodine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.17 h / 20 °C 1.2: 24 h / 20 - 25 °C 2.1: sodium hydride / dimethyl sulfoxide / 0.5 h 2.2: 1 h / 20 - 25 °C View Scheme | |
Multi-step reaction with 2 steps 1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; iodine / dichloromethane; water / 24 h / 20 °C 2: sodium hydride / dimethyl sulfoxide / 1 h / 20 - 25 °C View Scheme |
(-)-(R)-methyl 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylate
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: n-butyllithium / hexane; tetrahydrofuran / -85 - -75 °C 1.2: -80 - 0 °C 2.1: ethanol; sodium tetrahydroborate / 2 h / 0 °C / Inert atmosphere 3.1: sodium hydroxide / isopropyl alcohol; water / 1.5 h / 0 °C / Inert atmosphere View Scheme |
(-)-(R)-methyl 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylate
chlorobromomethane
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
Stage #1: (-)-(R)-methyl 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylate; chlorobromomethane With n-butyllithium In tetrahydrofuran; hexane at -85 - -75℃; Stage #2: With borane In tetrahydrofuran; hexane at -80 - -70℃; Stage #3: With water; sodium hydroxide In tetrahydrofuran; hexane for 2h; Reflux; |
1-(5-fluoro-2-hydroxyphenyl)ethan-1-one
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium methylate; methanol / tetrahydrofuran / 5 - 25 °C 1.2: 5 - 15 °C 1.3: Reflux 2.1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran / 45 - 55 °C / 3000.3 Torr 3.1: n-butyllithium / hexane; tetrahydrofuran / -85 - -75 °C 3.2: -80 - 0 °C 4.1: ethanol; sodium tetrahydroborate / 2 h / 0 °C / Inert atmosphere 5.1: sodium hydroxide / isopropyl alcohol; water / 1.5 h / 0 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: sodium methylate; methanol / tetrahydrofuran / 5 - 25 °C 1.2: 5 - 15 °C 1.3: Reflux 2.1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran / 45 - 55 °C / 3000.3 Torr 3.1: n-butyllithium / hexane; tetrahydrofuran / -85 - -75 °C 3.2: -80 - -70 °C 3.3: 2 h / Reflux View Scheme |
2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethan-1-one
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ethanol; sodium tetrahydroborate / 2 h / 0 °C / Inert atmosphere 2: sodium hydroxide / isopropyl alcohol; water / 1.5 h / 0 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: sodium tetrahydroborate; water / tetrahydrofuran / 2 h / -5 - 0 °C / Inert atmosphere 2: sodium hydroxide / dichloromethane; water / 2.67 h / -10 - 20 °C View Scheme |
chlorobromomethane
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
Stage #1: 6-fluoro-3,4-dihydro-2H-benzopyran-2-carboxylic acid ethyl ester; chlorobromomethane With n-butyllithium In tetrahydrofuran; cyclohexane at -60℃; for 2h; Inert atmosphere; Stage #2: With sodium tetrahydroborate In tetrahydrofuran; cyclohexane at -50 - 0℃; for 2h; Inert atmosphere; |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: n-butyllithium; water / hexane; tetrahydrofuran / 3 h / -60 °C / Inert atmosphere 1.2: 2 h / 0 - 30 °C / Inert atmosphere 2.1: sodium hydroxide / dichloromethane; water / 2.67 h / -10 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: n-butyllithium / hexane; tetrahydrofuran / 3 h / -50 °C / Inert atmosphere 2: sodium tetrahydroborate; water / tetrahydrofuran / 2 h / -5 - 0 °C / Inert atmosphere 3: sodium hydroxide / dichloromethane; water / 2.67 h / -10 - 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: n-butyllithium / hexane; tetrahydrofuran / 3 h / -60 °C / Inert atmosphere 2: sodium tetrahydroborate; water / tetrahydrofuran / 2 h / -5 - 0 °C / Inert atmosphere 3: sodium hydroxide / dichloromethane; water / 2.67 h / -10 - 20 °C View Scheme |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sulfuric acid; potassium bromide; sodium nitrite / diethyl ether; water / 20 °C 2: potassium carbonate / acetonitrile / 20 °C View Scheme |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
benzylamine
α,α'-[[(phenylmethyl)imino]bismethylene]bis-[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
Conditions | Yield |
---|---|
In isopropyl alcohol Reflux; | 100% |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
benzylamine
6-fluoro-3,4-dihydro-α-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol
Conditions | Yield |
---|---|
In methanol at 20℃; | 92% |
In isopropyl alcohol for 2h; Heating / reflux; |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
6-fluoro-3,4-dihydro-α-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol
α,α'-[[(phenylmethyl)imino]bismethylene]bis-[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
Conditions | Yield |
---|---|
In ethanol for 4h; Heating; | 82% |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
benzylamine
Conditions | Yield |
---|---|
In tert-Amyl alcohol at 25℃; for 12h; | 58% |
Conditions | Yield |
---|---|
Stage #1: 6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran; C17H16FNO2 In ethanol at 75℃; for 8h; Stage #2: In tert-Amyl alcohol at 25 - 80℃; for 24h; | 46% |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
In tert-butyl alcohol Reflux; | 31% |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
α,α'-[[(phenylmethyl)imino]bismethylene]bis-[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 92 percent / methanol / 20 °C 2: 82 percent / ethanol / 4 h / Heating View Scheme |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
nebivolol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 82 percent / ethanol / 4 h / Heating 2: 65 percent / H2 / Pd/C / 2-methoxy-ethanol / 20 °C / normal pressure View Scheme | |
Multi-step reaction with 3 steps 1: 92 percent / methanol / 20 °C 2: 82 percent / ethanol / 4 h / Heating 3: 65 percent / H2 / Pd/C / 2-methoxy-ethanol / 20 °C / normal pressure View Scheme | |
Multi-step reaction with 2 steps 1: isopropyl alcohol / Reflux 2: ammonium formate / palladium 10% on activated carbon / methanol / 3 h / Reflux View Scheme |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
In hexane; ethyl acetate Purification / work up; Column chromatography; Resolution of diastereomeric mixture; | |
Product distribution / selectivity; Industry scale; Inert atmosphere; fractional distillation; Resolution of diastereomers; high vacuum conditions; | |
Purification / work up; Reflux; |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
6-fluoro-3,4-dihydro-α-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol
Conditions | Yield |
---|---|
In methanol at 65 - 70℃; for 15h; |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
dibenzylamine
Conditions | Yield |
---|---|
In tert-Amyl alcohol at 20℃; |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
benzylamine
Conditions | Yield |
---|---|
Stage #1: 6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran; benzylamine In tert-Amyl alcohol; cyclohexane at 20℃; for 10h; Stage #2: With sodium hydrogen sulfate In tert-Amyl alcohol; cyclohexane Product distribution / selectivity; |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
tert-butylamine
Conditions | Yield |
---|---|
Stage #1: 6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran; tert-butylamine In tert-Amyl alcohol Stage #2: With sodium hydrogen sulfate In tert-Amyl alcohol; ethanol Reflux; |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
nebivolol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: cyclohexane; tert-Amyl alcohol / 10 h / 20 °C 2: ethanol / Reflux 3: hydrogen / 10 wt% Pd(OH)2 on carbon / ethyl acetate; ethanol / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide / tert-Amyl alcohol 2: ethanol / Reflux 3: hydrogen / 10 wt% Pd(OH)2 on carbon / ethyl acetate; ethanol / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: sodium azide / N,N-dimethyl-formamide / tert-Amyl alcohol / 20 °C 2: ethanol / Reflux 3: hydrogen / 10 wt% Pd(OH)2 on carbon / ethyl acetate; ethanol / Inert atmosphere View Scheme |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium azide / N,N-dimethyl-formamide / tert-Amyl alcohol / 20 °C 2: hydrogen / 5%-palladium/activated carbon / ethanol View Scheme | |
Multi-step reaction with 2 steps 1: tert-Amyl alcohol / 20 °C 2: hydrogen / 5%-palladium/activated carbon / ethanol View Scheme |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
With sodium azide; N,N-dimethyl-formamide In tert-Amyl alcohol at 20℃; |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: cyclohexane; tert-Amyl alcohol / 10 h / 20 °C 2: ethanol / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / tert-Amyl alcohol 2: ethanol / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: sodium azide / N,N-dimethyl-formamide / tert-Amyl alcohol / 20 °C 2: ethanol / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: sodium azide / N,N-dimethyl-formamide / tert-Amyl alcohol / 20 °C 2: hydrogen / 5%-palladium/activated carbon / ethanol 3: ethanol / Reflux View Scheme | |
Multi-step reaction with 3 steps 1: tert-Amyl alcohol / 20 °C 2: hydrogen / 5%-palladium/activated carbon / ethanol 3: ethanol / Reflux View Scheme |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: cyclohexane; tert-Amyl alcohol / 10 h / 20 °C 2: ethanol / Reflux 3: hydrogen / 10 wt% Pd(OH)2 on carbon / ethyl acetate; ethanol / Inert atmosphere 4: hydrogenchloride / ethanol View Scheme | |
Multi-step reaction with 4 steps 1: N,N-dimethyl-formamide / tert-Amyl alcohol 2: ethanol / Reflux 3: hydrogen / 10 wt% Pd(OH)2 on carbon / ethyl acetate; ethanol / Inert atmosphere 4: hydrogenchloride / ethanol View Scheme | |
Multi-step reaction with 4 steps 1: sodium azide / N,N-dimethyl-formamide / tert-Amyl alcohol / 20 °C 2: ethanol / Reflux 3: hydrogen / 10 wt% Pd(OH)2 on carbon / ethyl acetate; ethanol / Inert atmosphere 4: hydrogenchloride / ethanol View Scheme |
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
N-benzyloxyamine
Conditions | Yield |
---|---|
N,N-dimethyl-formamide In tert-Amyl alcohol |
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