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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-2-Oxaranyl supplier in China

Cas:99199-90-3

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-2-Oxaranyl

Cas:99199-90-3

Min.Order:1

Negotiable

Type:Other

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran Manufacturer/High quality/Best price/In stock

Cas:99199-90-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

6-Fluoro-3,4-dihydro-2-oxaranyl-2H-1-benzopyran

Cas:99199-90-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran CAS 99199-90-3

Cas:99199-90-3

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

CAS No.99199-90-3 Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Sc

CAS No.99199-90-3 6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Cas:99199-90-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 99199-90-3 with competitive price

Cas:99199-90-3

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2H-1-Benzopyran,6-fluoro-3,4-dihydro-2-(2-oxiranyl)- 99199-90-3

Cas:99199-90-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran CAS:99199-90-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing i

6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran CAS:99199-90-3

Cas:99199-90-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2H-1-Benzopyran,6-fluoro-3,4-dihydro-2-(2-oxiranyl)-

Cas:99199-90-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2H-1-Benzopyran,6-fluoro-3,4-dihydro-2-(2-oxiranyl)-

Cas:99199-90-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-2-Oxaranyl

Cas:99199-90-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2H-1-Benzopyran,6-fluoro-3,4-dihydro-2-(2-oxiranyl)-

Cas:99199-90-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Cas:99199-90-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-2-Oxaranyl

Cas:99199-90-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag,or as your request Application:Used as Pharmaceutical Intermediates Transporta

2H-1-Benzopyran,6-fluoro-3,4-dihydro-2-(2-oxiranyl)-

Cas:99199-90-3

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Cas:99199-90-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Factory Sells6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Cas:99199-90-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp

6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran 99199-90-3

Cas:99199-90-3

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Cas:99199-90-3

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Basic Info Chemical Name 6-fluoro-2-(oxiran-2-yl)-3,4-dihydro-2H-chromene Synonyms 6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran; 6-fluoro-2-oxiranyl-1-benzopyran; CAS No. 99199-90-3 Molecular Formula C11H11FO2 Molecular Weight 194.20200 PSA 21.760

6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1- benzopyran

Cas:99199-90-3

Min.Order:1 Metric Ton

FOB Price: $66.0

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

99199-90-3 6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Cas:99199-90-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Cas:99199-90-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

99199-90-3 6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Cas:99199-90-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

99199-90-3 6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Cas:99199-90-3

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Cas:99199-90-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

Product Name: 6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran Synonyms: 6-FLUORO-3,4-DIHYDRO-2H-1-BENZOPYRAN-2-OXARANYL(FOR NEBIVOLOL);6-Fluoro-3,4-D…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton

6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Cas:99199-90-3

Min.Order:0

Negotiable

Type:Other

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Cas:99199-90-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Cas:99199-90-3

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Luyunjia Chemistry Xiamen Limited

Luyunjia Chemistry Xiamen Limited is a high-tech company specializing in R&D and manufacturing of photoinitiators monomers and oligomers, UV absorbers and pharmaceutical intermediates, and pharmaceutical intermediates of generic drug. and has a h

hight quality 6-Fluoro-3,4-Dihydro-2-Oxiranyl-2H-1-Benzopyran

Cas:99199-90-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde
409346-73-2

6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde

trimethylsulphonium iodide
2181-42-2

trimethylsulphonium iodide

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Conditions
ConditionsYield
Stage #1: trimethylsulphonium iodide With sodium hydride In dimethyl sulfoxide cooling;
Stage #2: 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde In dimethyl sulfoxide at 20℃; for 1h;
100%
2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2yl)ethanol
1017878-67-9

2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2yl)ethanol

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Conditions
ConditionsYield
Stage #1: 2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2yl)ethanol With sodium hydroxide In water; isopropyl alcohol at 0℃; for 1.5h; Inert atmosphere;
Stage #2: With acetic acid In water; isopropyl alcohol; toluene
96%
With sodium hydroxide In dichloromethane; water at -10 - 20℃; for 2.66667h;
6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde
409346-73-2

6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde

trimethylsulfoxonium iodide
1774-47-6

trimethylsulfoxonium iodide

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Conditions
ConditionsYield
Stage #1: trimethylsulfoxonium iodide With sodium hydride In dimethyl sulfoxide for 0.5h;
Stage #2: 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde In dichloromethane; dimethyl sulfoxide at 20 - 25℃; for 1h;
90%
With sodium hydride In dimethyl sulfoxide at 20 - 25℃; for 1h;84%
Stage #1: trimethylsulfoxonium iodide With potassium tert-butylate In dimethyl sulfoxide at 20 - 40℃; for 1.5h;
Stage #2: 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde In dimethyl sulfoxide at 20 - 40℃; for 1.5h;
1-(6-fluorochroman-2-yl)ethane-1,2-diol
1322623-11-9

1-(6-fluorochroman-2-yl)ethane-1,2-diol

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Conditions
ConditionsYield
Stage #1: 1-(6-fluorochroman-2-yl)ethane-1,2-diol With sodium hydride In tert-butyl methyl ether; dimethyl sulfoxide at 50℃; for 1h; Inert atmosphere;
Stage #2: With p-toluenesulfonyl chloride In tert-butyl methyl ether for 1h; Reagent/catalyst; Solvent; Inert atmosphere;
90%
2-bromo-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2yl)ethanol

2-bromo-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2yl)ethanol

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 20℃;83%
6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid
99199-60-7

6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: Et3N; ClCOOEt / tetrahydrofuran / 10 h / 20 °C
1.2: 90 percent / NaBH4 / tetrahydrofuran; H2O / 5 h / 20 °C
2.1: 78 percent / pyridinium chloroformate/SiO2 / CH2Cl2 / 1.5 h / 20 °C
3.1: NaH / dimethylsulfoxide / cooling
3.2: 100 percent / dimethylsulfoxide / 1 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium tetrahydroborate; sulfuric acid / diethyl ether; tetrahydrofuran / 0.75 h / 0 - 35 °C
1.2: pH 7
2.1: sodium hydrogencarbonate / iodine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.17 h / 20 °C
2.2: 24 h / 20 - 25 °C
3.1: sodium hydride / dimethyl sulfoxide / 0.5 h
3.2: 1 h / 20 - 25 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium tetrahydroborate; sulfuric acid / tetrahydrofuran; diethyl ether / 0.5 h / 0 - 35 °C
2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; iodine / dichloromethane; water / 24 h / 20 °C
3: sodium hydride / dimethyl sulfoxide / 1 h / 20 - 25 °C
View Scheme
6-fluoro-4-oxo-4H-1-benzopyran-2-carboxylic acid
99199-59-4

6-fluoro-4-oxo-4H-1-benzopyran-2-carboxylic acid

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 86 percent / H2 / Pd/C / acetic acid / 70 - 80 °C / 15001.2 Torr
2.1: Et3N; ClCOOEt / tetrahydrofuran / 10 h / 20 °C
2.2: 90 percent / NaBH4 / tetrahydrofuran; H2O / 5 h / 20 °C
3.1: 78 percent / pyridinium chloroformate/SiO2 / CH2Cl2 / 1.5 h / 20 °C
4.1: NaH / dimethylsulfoxide / cooling
4.2: 100 percent / dimethylsulfoxide / 1 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran / 45 - 55 °C / 3000.3 Torr
2.1: n-butyllithium / hexane; tetrahydrofuran / -85 - -75 °C
2.2: -80 - 0 °C
3.1: ethanol; sodium tetrahydroborate / 2 h / 0 °C / Inert atmosphere
4.1: sodium hydroxide / isopropyl alcohol; water / 1.5 h / 0 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran / 45 - 55 °C / 3000.3 Torr
2.1: n-butyllithium / hexane; tetrahydrofuran / -85 - -75 °C
2.2: -80 - -70 °C
2.3: 2 h / Reflux
View Scheme
(6-fluoro-3,4-dihydro-2H-chromene-2-yl)methanol
99199-62-9

(6-fluoro-3,4-dihydro-2H-chromene-2-yl)methanol

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 78 percent / pyridinium chloroformate/SiO2 / CH2Cl2 / 1.5 h / 20 °C
2.1: NaH / dimethylsulfoxide / cooling
2.2: 100 percent / dimethylsulfoxide / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / iodine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.17 h / 20 °C
1.2: 24 h / 20 - 25 °C
2.1: sodium hydride / dimethyl sulfoxide / 0.5 h
2.2: 1 h / 20 - 25 °C
View Scheme
Multi-step reaction with 2 steps
1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; iodine / dichloromethane; water / 24 h / 20 °C
2: sodium hydride / dimethyl sulfoxide / 1 h / 20 - 25 °C
View Scheme
(-)-(R)-methyl 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylate
874649-82-8

(-)-(R)-methyl 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylate

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / -85 - -75 °C
1.2: -80 - 0 °C
2.1: ethanol; sodium tetrahydroborate / 2 h / 0 °C / Inert atmosphere
3.1: sodium hydroxide / isopropyl alcohol; water / 1.5 h / 0 °C / Inert atmosphere
View Scheme
(-)-(R)-methyl 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylate
874649-82-8

(-)-(R)-methyl 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylate

chlorobromomethane
74-97-5

chlorobromomethane

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Conditions
ConditionsYield
Stage #1: (-)-(R)-methyl 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylate; chlorobromomethane With n-butyllithium In tetrahydrofuran; hexane at -85 - -75℃;
Stage #2: With borane In tetrahydrofuran; hexane at -80 - -70℃;
Stage #3: With water; sodium hydroxide In tetrahydrofuran; hexane for 2h; Reflux;
1-(5-fluoro-2-hydroxyphenyl)ethan-1-one
394-32-1

1-(5-fluoro-2-hydroxyphenyl)ethan-1-one

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium methylate; methanol / tetrahydrofuran / 5 - 25 °C
1.2: 5 - 15 °C
1.3: Reflux
2.1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran / 45 - 55 °C / 3000.3 Torr
3.1: n-butyllithium / hexane; tetrahydrofuran / -85 - -75 °C
3.2: -80 - 0 °C
4.1: ethanol; sodium tetrahydroborate / 2 h / 0 °C / Inert atmosphere
5.1: sodium hydroxide / isopropyl alcohol; water / 1.5 h / 0 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: sodium methylate; methanol / tetrahydrofuran / 5 - 25 °C
1.2: 5 - 15 °C
1.3: Reflux
2.1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran / 45 - 55 °C / 3000.3 Torr
3.1: n-butyllithium / hexane; tetrahydrofuran / -85 - -75 °C
3.2: -80 - -70 °C
3.3: 2 h / Reflux
View Scheme
2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethan-1-one
943126-72-5

2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethan-1-one

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanol; sodium tetrahydroborate / 2 h / 0 °C / Inert atmosphere
2: sodium hydroxide / isopropyl alcohol; water / 1.5 h / 0 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: sodium tetrahydroborate; water / tetrahydrofuran / 2 h / -5 - 0 °C / Inert atmosphere
2: sodium hydroxide / dichloromethane; water / 2.67 h / -10 - 20 °C
View Scheme
6-fluoro-3,4-dihydro-2H-benzopyran-2-carboxylic acid ethyl ester

6-fluoro-3,4-dihydro-2H-benzopyran-2-carboxylic acid ethyl ester

chlorobromomethane
74-97-5

chlorobromomethane

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Conditions
ConditionsYield
Stage #1: 6-fluoro-3,4-dihydro-2H-benzopyran-2-carboxylic acid ethyl ester; chlorobromomethane With n-butyllithium In tetrahydrofuran; cyclohexane at -60℃; for 2h; Inert atmosphere;
Stage #2: With sodium tetrahydroborate In tetrahydrofuran; cyclohexane at -50 - 0℃; for 2h; Inert atmosphere;
6-fluoro-3,4-dihydro-2H-benzopyran-2-carboxylic acid ethyl ester

6-fluoro-3,4-dihydro-2H-benzopyran-2-carboxylic acid ethyl ester

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium; water / hexane; tetrahydrofuran / 3 h / -60 °C / Inert atmosphere
1.2: 2 h / 0 - 30 °C / Inert atmosphere
2.1: sodium hydroxide / dichloromethane; water / 2.67 h / -10 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: n-butyllithium / hexane; tetrahydrofuran / 3 h / -50 °C / Inert atmosphere
2: sodium tetrahydroborate; water / tetrahydrofuran / 2 h / -5 - 0 °C / Inert atmosphere
3: sodium hydroxide / dichloromethane; water / 2.67 h / -10 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1: n-butyllithium / hexane; tetrahydrofuran / 3 h / -60 °C / Inert atmosphere
2: sodium tetrahydroborate; water / tetrahydrofuran / 2 h / -5 - 0 °C / Inert atmosphere
3: sodium hydroxide / dichloromethane; water / 2.67 h / -10 - 20 °C
View Scheme
2-amino-1-(-6-fluoro-2-chromanyl) ethanol

2-amino-1-(-6-fluoro-2-chromanyl) ethanol

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid; potassium bromide; sodium nitrite / diethyl ether; water / 20 °C
2: potassium carbonate / acetonitrile / 20 °C
View Scheme
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

benzylamine
100-46-9

benzylamine

α,α'-[[(phenylmethyl)imino]bismethylene]bis-[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
929706-85-4

α,α'-[[(phenylmethyl)imino]bismethylene]bis-[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]

Conditions
ConditionsYield
In isopropyl alcohol Reflux;100%
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

benzylamine
100-46-9

benzylamine

6-fluoro-3,4-dihydro-α-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol
99199-91-4

6-fluoro-3,4-dihydro-α-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol

Conditions
ConditionsYield
In methanol at 20℃;92%
In isopropyl alcohol for 2h; Heating / reflux;
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

6-fluoro-3,4-dihydro-α-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol
99199-91-4

6-fluoro-3,4-dihydro-α-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol

α,α'-[[(phenylmethyl)imino]bismethylene]bis-[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
929706-85-4

α,α'-[[(phenylmethyl)imino]bismethylene]bis-[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]

Conditions
ConditionsYield
In ethanol for 4h; Heating;82%
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

benzylamine
100-46-9

benzylamine

(R*,R*)-(±)-α-[(benzylamino)methyl](6-fluoro-2-chromanyl)methanol

(R*,R*)-(±)-α-[(benzylamino)methyl](6-fluoro-2-chromanyl)methanol

Conditions
ConditionsYield
In tert-Amyl alcohol at 25℃; for 12h;58%
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

C17H16FNO2

C17H16FNO2

C21H21F2NO4

C21H21F2NO4

Conditions
ConditionsYield
Stage #1: 6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran; C17H16FNO2 In ethanol at 75℃; for 8h;
Stage #2: In tert-Amyl alcohol at 25 - 80℃; for 24h;
46%
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

(R*,R*)-6-fluoro-3,4-dihydro-α-hydroxy-2H-2-[1]benzopyran-ethanamine

(R*,R*)-6-fluoro-3,4-dihydro-α-hydroxy-2H-2-[1]benzopyran-ethanamine

[(SRRR)/(RSSS)-α,α'-iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride

[(SRRR)/(RSSS)-α,α'-iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride

Conditions
ConditionsYield
In tert-butyl alcohol Reflux;31%
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

α,α'-[[(phenylmethyl)imino]bismethylene]bis-[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
929706-85-4

α,α'-[[(phenylmethyl)imino]bismethylene]bis-[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 92 percent / methanol / 20 °C
2: 82 percent / ethanol / 4 h / Heating
View Scheme
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

nebivolol
99200-09-6

nebivolol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 82 percent / ethanol / 4 h / Heating
2: 65 percent / H2 / Pd/C / 2-methoxy-ethanol / 20 °C / normal pressure
View Scheme
Multi-step reaction with 3 steps
1: 92 percent / methanol / 20 °C
2: 82 percent / ethanol / 4 h / Heating
3: 65 percent / H2 / Pd/C / 2-methoxy-ethanol / 20 °C / normal pressure
View Scheme
Multi-step reaction with 2 steps
1: isopropyl alcohol / Reflux
2: ammonium formate / palladium 10% on activated carbon / methanol / 3 h / Reflux
View Scheme
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

[1R*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene

[1R*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene

[1S*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene

[1S*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene

Conditions
ConditionsYield
In hexane; ethyl acetate Purification / work up; Column chromatography; Resolution of diastereomeric mixture;
Product distribution / selectivity; Industry scale; Inert atmosphere; fractional distillation; Resolution of diastereomers; high vacuum conditions;
Purification / work up; Reflux;
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

6-fluoro-3,4-dihydro-α-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol
99199-91-4

6-fluoro-3,4-dihydro-α-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol

N-benzyl-(±)-nebivolol

N-benzyl-(±)-nebivolol

Conditions
ConditionsYield
In methanol at 65 - 70℃; for 15h;
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

dibenzylamine
103-49-1

dibenzylamine

[1R*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene

[1R*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene

B

C25H26FNO2

C25H26FNO2

Conditions
ConditionsYield
In tert-Amyl alcohol at 20℃;
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

benzylamine
100-46-9

benzylamine

(S*,R*)-(±)-α-[(benzylamino)methyl](6-fluoro-2-chromanyl)methanol

(S*,R*)-(±)-α-[(benzylamino)methyl](6-fluoro-2-chromanyl)methanol

[1R*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene

[1R*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene

Conditions
ConditionsYield
Stage #1: 6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran; benzylamine In tert-Amyl alcohol; cyclohexane at 20℃; for 10h;
Stage #2: With sodium hydrogen sulfate In tert-Amyl alcohol; cyclohexane Product distribution / selectivity;
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

tert-butylamine
75-64-9

tert-butylamine

C26H33F2NO4

C26H33F2NO4

C26H33F2NO4

C26H33F2NO4

Conditions
ConditionsYield
Stage #1: 6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran; tert-butylamine In tert-Amyl alcohol
Stage #2: With sodium hydrogen sulfate In tert-Amyl alcohol; ethanol Reflux;
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

nebivolol
99200-09-6

nebivolol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: cyclohexane; tert-Amyl alcohol / 10 h / 20 °C
2: ethanol / Reflux
3: hydrogen / 10 wt% Pd(OH)2 on carbon / ethyl acetate; ethanol / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: N,N-dimethyl-formamide / tert-Amyl alcohol
2: ethanol / Reflux
3: hydrogen / 10 wt% Pd(OH)2 on carbon / ethyl acetate; ethanol / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: sodium azide / N,N-dimethyl-formamide / tert-Amyl alcohol / 20 °C
2: ethanol / Reflux
3: hydrogen / 10 wt% Pd(OH)2 on carbon / ethyl acetate; ethanol / Inert atmosphere
View Scheme
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

(S*,R*)-(±)-α-[(benzylamino)methyl](6-fluoro-2-chromanyl)methanol

(S*,R*)-(±)-α-[(benzylamino)methyl](6-fluoro-2-chromanyl)methanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium azide / N,N-dimethyl-formamide / tert-Amyl alcohol / 20 °C
2: hydrogen / 5%-palladium/activated carbon / ethanol
View Scheme
Multi-step reaction with 2 steps
1: tert-Amyl alcohol / 20 °C
2: hydrogen / 5%-palladium/activated carbon / ethanol
View Scheme
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

[1R*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene

[1R*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene

C11H12FN3O2

C11H12FN3O2

Conditions
ConditionsYield
With sodium azide; N,N-dimethyl-formamide In tert-Amyl alcohol at 20℃;
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

N-benzyl-(±)-nebivolol

N-benzyl-(±)-nebivolol

(+/-)-[2R*[1S*,5R*(R*)]]-α,α'-[phenylmethyliminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]

(+/-)-[2R*[1S*,5R*(R*)]]-α,α'-[phenylmethyliminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: cyclohexane; tert-Amyl alcohol / 10 h / 20 °C
2: ethanol / Reflux
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / tert-Amyl alcohol
2: ethanol / Reflux
View Scheme
Multi-step reaction with 2 steps
1: sodium azide / N,N-dimethyl-formamide / tert-Amyl alcohol / 20 °C
2: ethanol / Reflux
View Scheme
Multi-step reaction with 3 steps
1: sodium azide / N,N-dimethyl-formamide / tert-Amyl alcohol / 20 °C
2: hydrogen / 5%-palladium/activated carbon / ethanol
3: ethanol / Reflux
View Scheme
Multi-step reaction with 3 steps
1: tert-Amyl alcohol / 20 °C
2: hydrogen / 5%-palladium/activated carbon / ethanol
3: ethanol / Reflux
View Scheme
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

[(SRRR)/(RSSS)-α,α'-iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride

[(SRRR)/(RSSS)-α,α'-iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: cyclohexane; tert-Amyl alcohol / 10 h / 20 °C
2: ethanol / Reflux
3: hydrogen / 10 wt% Pd(OH)2 on carbon / ethyl acetate; ethanol / Inert atmosphere
4: hydrogenchloride / ethanol
View Scheme
Multi-step reaction with 4 steps
1: N,N-dimethyl-formamide / tert-Amyl alcohol
2: ethanol / Reflux
3: hydrogen / 10 wt% Pd(OH)2 on carbon / ethyl acetate; ethanol / Inert atmosphere
4: hydrogenchloride / ethanol
View Scheme
Multi-step reaction with 4 steps
1: sodium azide / N,N-dimethyl-formamide / tert-Amyl alcohol / 20 °C
2: ethanol / Reflux
3: hydrogen / 10 wt% Pd(OH)2 on carbon / ethyl acetate; ethanol / Inert atmosphere
4: hydrogenchloride / ethanol
View Scheme
6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
99199-90-3

6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran

N-benzyloxyamine
622-33-3

N-benzyloxyamine

[1R*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene

[1R*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene

C18H20FNO3

C18H20FNO3

Conditions
ConditionsYield
N,N-dimethyl-formamide In tert-Amyl alcohol

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