875-72-9Relevant articles and documents
Worrell et al.
, p. 3525,3526,3528,3530,3531 (1974)
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Alford,J.R. et al.
, p. 880 - 883 (1971)
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Synthetic Photochemistry. LX. One-pot Formation of Spirocyclic 3-Acetyl-2-hydroxy-2-cyclopentenone Derivatives from Methylenecycloalkanes and Methyl 2,4-Dioxopentanoate
Hatsui, Toshihide,Ikeda, Shin-ya,Takeshita, Hitoshi
, p. 870 - 876 (1993)
A series of proto-photocycloadducts of methyl 2,4-dioxopentanoate to methylenecycloalkanes and -alkenes spontaneously caused retro-benzilic acid rearrangement in high yields.The results are utterly different from those of sterically-crowded acyclic alkenes, with which the rearrangement occurred by thermolysis as a minor process.
Energetics and Structure of the 1- and 2-Adamantyl Radicals and Their Corresponding Carbonium Ions by Photoelectron Spectroscopy
Kruppa, Gary H.,Beauchamp, J. L.
, p. 2162 - 2169 (1986)
The first photoelectron bands of the 1- and 2-adamantyl radicals, formed by flash vacuum photolysis of 1- and 2-adamantylmethyl nitrite, have been obtained.The adiabatic (IPa) and vertical (IPv) ionization potentials of the 1-adamantyl radical are 6.21 +/- 0.03 and 6.36 +/- 0.05 eV, respectively.IPa and IPv for the 2-adamantyl radical are 6.73 +/- 0.03 and 6.99 +/- 0.05 eV, respectively.The difference in hydride affinities between the 1-adamantyl and tert-butyl cations (Sharma, R.B.; Sen Sharma, D.K.; Hiraoka, K.; Kebarle, P.J.Am.Chem.Soc. 1985, 107, 3747) combined with the difference in IPa between the tert-butyl and 1-adamantyl radicals (0.49 +/- 0.06 eV) yield a value of 99 kcal/mol for the tertiary C-H bond energy in adamantane, 3.7 +/- 1.2 kcal/mol greater than the tertiary C-H bond energy in isobutane (assumed to be 95 kcal/mol).The effects of the geometrical constraints imposed by the adamantyl cage on the homolytic and heterolytic C-H-bond cleavage energies are disscussed for the 1- and 2-adamantyl cases.The width of the Franck-Condon envelope obtained is related to the geometry changes that occur upon ionization.The surprisingly broad envelope observed for the planar 2-adamantyl radical indicates that the Franck-Condon envelope for the 1-adamantyl radical should not be interpreted as exclusively due to changes at the bridgehead position.Thermal decomposition products of the 1- and 2-adamantyl radicals are observed, and the pathways for thermal decompositions of the radicals are discussed.To confirm expected trends in ionization potentials and band shapes or tertiary radicals, the first photoelectron band of the 2-methyl-2-butyl radical has been obtained.The IPa of the 2-methyl-2-butyl radical is 6.65 +/- 0.04 eV with IPv = 6.91 +/- 0.05 eV.
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Hughes,L.,Ungold,K.U.,Walton,J.C.
, p. 7494 (1988)
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Oxo 2-Adamantylidene Complexes of Mo(VI) and W(VI)
Boudjelel, Maxime,Zhai, Feng,Schrock, Richard R.,Hoveyda, Amir H.,Tsay, Charlene
supporting information, p. 838 - 842 (2021/04/09)
Molybdenum and tungsten oxo 2-adamantylidene (Adene) complexes that contain two nonafluoro-tert-butoxide (ORF9) ligands have been prepared through addition of 2-methylene-or 2-ethylideneadamantane to neophylidene or neopentylidene complexes. The isolated oxo complexes include W(O)(Adene)(ORF9)2(PPh2Me) (1W), W(O)(Adene)(ORF9)2 (2W), W(O)(Adene)(2,5-dimethylpyrrolide)2 (3W), W(O)(Adene)(2,5-dimethylpyrrolide)(2,6-dimesitylphenoxide) (4W), Mo(O)(Adene)(ORF9)2(PPhMe2) (1Mo), and Mo(O)(Adene)(ORF9)2 (2Mo). Compound 2W is a dimer that contains unsymmetrically bridging oxo ligands; it dissociates readily and reversibly into monomers, especially in the presence of a donor such as THF. In contrast, 2Mo is a monomer. Both 2W and 2Mo are remarkably stable thermally. The pale-blue complexes Mo(Adene)(ORF9)2Cl2 (5Mo) and W(Adene)(ORF9)2Cl2 (5W) are formed upon addition of PCl5 to 2Mo and 2W, respectively. The oxo complexes are reactive olefin metathesis initiators, while 5Mo and 5W are relatively poor initiators. We ascribe the thermal stability of 2Mo and 2W to resistance of the 2-adamantylidene ligands to couple bimolecularly, to the absence of an α-hydrogen in the alkylidene, or both.
COMPOUNDS AND METHODS FOR IDO AND TDO MODULATION, AND INDICATIONS THEREFOR
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, (2019/10/15)
Disclosed are compounds of Formula (I) and (Ia) or a pharmaceutically acceptable salt, a solvate, a tautomer, a stereoisomer or a deuterated analog thereof, wherein R4, R5, R6, and R7 are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
COMPOUNDS AND METHODS FOR IDO AND TDO MODULATION, AND INDICATIONS THEREFOR
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, (2018/04/20)
Disclosed are compounds of Formula I (a) or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein R4, R5, R6, R7, G1, G2 and Ring A are as described in any of the embodiments described in this disclosure; compositions thereof; and uses thereof.
