Country:China (Mainland)
Year Established: 1951Business type: Manufacturers
Integral:
1. Betahistine dihydrochloride specification
Appearance: White to almost crystalline powder, very hygroscopic
Assay: 99.75%
Ph: 2.5
Loss on drying: 0.3%
Sulphated ash: 0.06%
IR: Similar to the reference standard
HPLC: Similar to the reference standard
Residual solvents: 0.20%
Solubility: Freely soluble in alcohol (96%)
The information of betahistine dihydrochloride specification above is for reference.
2. Pure betahistine dihydrochloride
Pure betahistine dihydrochloride progressively enhances cAMP formation with a maximal effect, observed up to 10 nM, in CHO(H3R) cells incubated with 3 μM forskolin. In contrast, at concentrations higher than 10 nM betahistine progressively inhibits cAMP formation in CHO(H3R) cells incubated with 3 μM forskolin. What's more, pure betahistine dihydrochloride
(16 mg tid and 48 mg tid) shows that the number of attacks per month decreased in both doses over time in Menière's disease. Betahistine (50 mg/kg) treatment induces symmetrical changes with up-regulation of histidine decarboxylase mRNA in the tuberomammillary nucleus and reduction of [3H]N-alpha-methylhistamine labeling in both the tuberomammillary nucleus, the vestibular nuclei complex and nuclei of the inferior olive in brain sections of cats.
High purity betahistine dihydrochloride is a medicine which is used in Mnire's syndrome. High purity betahistine dihydrochloride is also called as 2-Pyridineethanamine,N-methyl-, dihydrochloride (9CI).
High- Quality omeprazole sodium has wide usage in heath as follows. Among all of the factories, Jinzhou Jiutai Pharmaceutical Co.,Ltd is one of omeprazole sodium good supplier in China.
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