2,4-Dinitrophenol supplier

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Name
2,4-Dinitrophenol
EINECS 200-087-7
CAS No. 51-28-5
Article Data482
CAS DataBase
Density 1.651 g/cm₃
Solubility 0.6 g/100 mL (18 ºC)
Melting Point 108-112 °C(lit.)
Formula C₆H₄N₂O₅
Boiling Point 312.1 °C at 760 mmHg
Molecular Weight 184.108
Flash Point 142.8 °C
Transport Information UN 1320 4.1/PG 1
Appearance light yellow crystal powder
Safety 28-37-45-61-28A-36/37-16-7
Risk Codes 23/24/25-33-50-39/23/24/25-11-52/53
Molecular Structure
Hazard Symbols T,N,Xi,F
Synonyms 2,4-Dinitro Phenol,51-28-5;2,4-Dinitro Phenol;Solfo Black BB;Osmotox-Plus;Nitrophene (VAN);Tertrosulphur PBR;1alpha-2,4-Dinitrophenol;Camello mosquito coils;.alpha.-Dinitrophenol;Dinitrofenolo [Italian];Chemox PE;2,4-Dinitrophenol/2,4-Dinitrophenol,2,4-Dinitrophenol,DNP;alpha-Dinitrophenol;Phenol, .alpha.-dinitro-;Nitrophen (VAN);Solfo Black G;Tertrosulphur Black PB;Solfo Black 2B Supra;Dinofan;Solfo Black B;Nitro kleenup;Osmoplastic-R;2, 4-Dinitrofenol;Shirakiku brand mosquito coils;Phenol, 2,4-dinitro-;X 32;1-Hydroxy-2,4-dinitrobenzene;Maroxol-50;Fenoxyl carbon N;Phenol, alpha-dinitro-;Dinitrofenolo;Cobra salts (Impregna salts);
PSA 111.87000
LogP 2.25500

Synthetic route

: 97-00-7
1-chloro-2,4-dinitro-benzene

: 51-28-5
2,4-Dinitrophenol

Conditions

Conditions	Yield
With water; sodium hydroxide at 100℃; for 1.5h;	100%
With potassium carbonate In ethanol	97.5%
Stage #1: 1-chloro-2,4-dinitro-benzene With sodium hydroxide In water; acetonitrile for 1h; Reflux; Stage #2: With hydrogenchloride In water; acetonitrile Kinetics; Thermodynamic data; Solvent; Temperature;	97%

: 1945-92-2
N-(2,4-dinitrophenyl)aminoethanol

: 51-28-5
2,4-Dinitrophenol

Conditions

Conditions	Yield
With ammonium hydroxide; sodium sulfite In methanol at 70℃; for 48h;	100%

: 2687-45-8
triethylamine N-oxide

: 97-00-7
1-chloro-2,4-dinitro-benzene

A: 51-28-5
2,4-Dinitrophenol

B: 554-68-7
triethylamine hydrochloride

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 24h;	A 98% B 98.5%
In N,N-dimethyl-formamide for 24h; Ambient temperature;	A 98% B 98.5%

...Expand

: 108-95-2
phenol

: 51-28-5
2,4-Dinitrophenol

Conditions

Conditions	Yield
With trichloroisocyanuric acid; silica gel; sodium nitrite at 20℃; for 0.25h;	98%
With dinitrogen tetraoxide; ferric nitrate In ethyl acetate for 0.166667h; Heating;	96%
With chromium(III) nitrate; dinitrogen tetraoxide In ethyl acetate for 0.25h; Nitration; reflux;	95%

: 97-02-9
2,4-Dinitroanilin

: 51-28-5
2,4-Dinitrophenol

Conditions

Conditions	Yield
With water; sodium hydroxide at 100℃; for 1.5h;	98%
With potassium hydroxide

: 1184-78-7
trimethylamine-N-oxide

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 97-00-7
1-chloro-2,4-dinitro-benzene

A: 51-28-5
2,4-Dinitrophenol

B: 593-81-7
trimethylamine hydrochloride

Conditions

Conditions	Yield
for 24h; Ambient temperature;	A 97% B 98%

...Expand

: 1184-78-7
trimethylamine-N-oxide

: 97-00-7
1-chloro-2,4-dinitro-benzene

A: 51-28-5
2,4-Dinitrophenol

B: 593-81-7
trimethylamine hydrochloride

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 24h; Ambient temperature;	A 97% B 98%

...Expand

: 100-02-7
4-nitro-phenol

: 51-28-5
2,4-Dinitrophenol

Conditions

Conditions	Yield
With dimethylbromosulphonium bromide; tetrabutylammonium nitrite In acetonitrile at 20℃; for 24h; regioselective reaction;	97%
With perchloric acid; montmorillonite K10 supported ammonium nitrate at 50℃; for 1.5h;	95%
With Zn(NO3)2*2N2O4 In dichloromethane at 20℃; for 5h;	95%

: 99-65-0
meta-dinitrobenzene

: 51-28-5
2,4-Dinitrophenol

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; potassium tert-butylate; ammonia In tetrahydrofuran for 0.25h;	96%
With Cumene hydroperoxide; potassium tert-butylate In N,N,N,N,N,N-hexamethylphosphoric triamide at 15 - 20℃; for 1.5h;	92%
With potassium hydroxide; Cumene hydroperoxide In ammonia at -33℃;	90%

: (E)-O-2,4-dinitrophenyl-2,4-dinitrobenzaldoxime

A: 51-28-5
2,4-Dinitrophenol

B: 4110-33-2
2,4-dinitrobenzonitrile

Conditions

Conditions	Yield
With triethylamine In water; acetonitrile at 25℃; for 7h; Kinetics; Reagent/catalyst;	A n/a B 96%
With triethylamine hydrochloride; triethylamine In water; acetonitrile at 25℃; Rate constant; different Et3N concentrations;
With sodium ethanolate In ethanol at 25℃; Kinetics; Further Variations:; Reagents; Elimination;

: 69-72-7
salicylic acid

A: 51-28-5
2,4-Dinitrophenol

B: 573-56-8
2,6-dinitrophenol

Conditions

Conditions	Yield
With ammonium cerium(IV) nitrate In acetonitrile at 20℃; for 12h;	A 95% B 3%

: 3185-97-5
3-(2,4-dinitrophenylamino)propionic acid

: 51-28-5
2,4-Dinitrophenol

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane; water for 5h; Kinetics; Product distribution; Further Variations:; pH-values; Heating;	94%

: 97-00-7
1-chloro-2,4-dinitro-benzene

A: 51-28-5
2,4-Dinitrophenol

B: 54715-57-0
5-chloro-2,4-dinitrophenol

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; potassium tert-butylate; ammonia In tetrahydrofuran for 0.25h;	A n/a B 93%
With potassium tert-butylperoxide In ammonia at -33℃; Mechanism; competition between hydrogen and halogen substitution; other reagent t-butyl hydroperoxide, cumene hydroperoxide, NaOH, t-BuOK;	A 20% B 50%
With tert.-butylhydroperoxide; potassium tert-butylate; ammonia In tetrahydrofuran for 0.25h;	A 50% B n/a

: 2734-78-3
1-(benzyloxy)-2,4-dinitrobenzene

: 51-28-5
2,4-Dinitrophenol

Conditions

Conditions	Yield
With thiophene; sodium hydrogen sulfate; silica gel for 9h; Heating;	93%

: 1655-52-3
N-(2,4-dinitro-phenyl)-L-alanine

A: 51-28-5
2,4-Dinitrophenol

B: 4615-69-4
2-methyl-5-nitro-1H-benzimidazole 3-oxide

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane; water for 2h; Heating;	A n/a B 88%

: 2,4-dinitrobenzeneboronic acid

: 51-28-5
2,4-Dinitrophenol

Conditions

Conditions	Yield
With hydrazine hydrate; caesium carbonate at 20℃; for 15h;	86%

: 70-34-8
2,4-Dinitrofluorobenzene

: 51-28-5
2,4-Dinitrophenol

Conditions

Conditions	Yield
With sodium hydroxide for 1h; Heating;	85%
With potassium carbonate In dimethyl sulfoxide for 3h; Heating;	79%
With Cumene hydroperoxide; potassium tert-butylate In ammonia at -33℃;	63%

: 108-95-2
phenol

A: 51-28-5
2,4-Dinitrophenol

B: 106-51-4
p-benzoquinone

Conditions

Conditions	Yield
With Zn(NO3)2*2N2O4 In ethyl acetate at 20℃; for 4h;	A 85% B 8%

: 88-75-5
2-hydroxynitrobenzene

: 51-28-5
2,4-Dinitrophenol

Conditions

Conditions	Yield
With ferric nitrate; 1,3-di-n-butyl-imidazolium tetrafluoroborate at 60℃; for 2h;	82%
With Zn(NO3)2*2N2O4 In dichloromethane for 4h; Heating;	82%
With N-Bromosuccinimide; silver nitrate In acetonitrile for 7.5h; Reflux;	75%

: 108-95-2
phenol

A: 51-28-5
2,4-Dinitrophenol

B: 88-89-1
2,4,6-Trinitrophenol

C: 106-51-4
p-benzoquinone

Conditions

Conditions	Yield
With NO+18-crown-6H(NO3)2- In ethyl acetate for 0.166667h; Nitration; Heating;	A 82% B 8% C 3%
With silica-acetate; dinitrogen tetraoxide In ethyl acetate for 0.166667h; Heating;	A 74% B 8% C 10%

...Expand

: 863033-41-4
2',3',5'-tri-O-acetyl-1-(2,4-dinitrobenzenesulfonyl)inosine

: 100-46-9
benzylamine

A: 866325-38-4
1-N-benzyl-2',3',5'-tri-O-acetyladenosine

B: 51-28-5
2,4-Dinitrophenol

Conditions

Conditions	Yield
Stage #1: 2',3',5'-tri-O-acetyl-1-(2,4-dinitrobenzenesulfonyl)inosine; benzylamine In acetonitrile at -30℃; Stage #2: With water In acetonitrile Heating;	A 81% B n/a

...Expand

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 51-28-5
2,4-Dinitrophenol

Conditions

Conditions	Yield
With bismuth (III) nitrate pentahydrate In toluene at 70 - 80℃; for 2h; Inert atmosphere;	77%

: 863033-41-4
2',3',5'-tri-O-acetyl-1-(2,4-dinitrobenzenesulfonyl)inosine

: 75-31-0
isopropylamine

A: 2',3',5'-tri-O-acetyl-1-isopropyladenosine

B: 51-28-5
2,4-Dinitrophenol

Conditions

Conditions	Yield
Stage #1: 2',3',5'-tri-O-acetyl-1-(2,4-dinitrobenzenesulfonyl)inosine; isopropylamine In acetonitrile at -30℃; Stage #2: With water In acetonitrile Heating;	A 76% B n/a

...Expand

: 99-65-0
meta-dinitrobenzene

: 62-53-3
aniline

A: 51-28-5
2,4-Dinitrophenol

B: 961-68-2
N-phenyl-2,4-dinitroaniline

Conditions

Conditions	Yield
With potassium permanganate; tetrabutyl ammonium fluoride In N,N-dimethyl-formamide at 20℃; for 1h;	A 22% B 75%

...Expand

: 1-phenyl-2-(piperidin-1-yl)ethanone O-(2,4-dinitrophenyl)oxime

A: 51-28-5
2,4-Dinitrophenol

B: 99-57-0
2-hydroxy-5-nitroaniline

C: 3649-46-5
2-Phenyl-5,6,7,8-tetrahydro-imidazo<1,2-a>pyridin

Conditions

Conditions	Yield
In dimethyl sulfoxide at 25℃; for 5h; Inert atmosphere; Schlenk technique; Sealed tube; Irradiation;	A 33% B 22% C 75%

...Expand

: 67-56-1
methanol

: 70-34-8
2,4-Dinitrofluorobenzene

A: 51-28-5
2,4-Dinitrophenol

B: 119-27-7
2,4-dinitroanisole

Conditions

Conditions	Yield
With sodium hydroxide; cetyltrimethylammonim bromide In water at 26℃; Product distribution; other alcohols, var. concentrations alcohols;	A 26% B 74%

...Expand

: 88-75-5
2-hydroxynitrobenzene

A: 51-28-5
2,4-Dinitrophenol

B: 573-56-8
2,6-dinitrophenol

Conditions

Conditions	Yield
With perchloric acid; montmorillonite K10 supported ammonium nitrate at 50℃; for 1.5h;	A 73% B 23%
durch Nitrieren; Trennung durch fraktionierte Faellung des Gemisches der Kaliumsalze mit BaCl2;
With tetrachloromethane; nitrosylsulfuric acid at 30℃;
With nitric acid

: 62599-74-0
2,4-dinitrophenyl acrylate

: 100-52-7
benzaldehyde

A: 51-28-5
2,4-Dinitrophenol

: 3-(hydroxy(phenyl)methyl)-5-phenyldihydrofuran-2(3H)-one

Conditions

Conditions	Yield
With samarium; copper(l) iodide; potassium iodide In tetrahydrofuran at 20℃; Molecular sieve; diastereoselective reaction;	A n/a B 73%

...Expand

: 108-95-2
phenol

A: 51-28-5
2,4-Dinitrophenol

B: 573-56-8
2,6-dinitrophenol

Conditions

Conditions	Yield
With thionyl chloride; bismuth subnitrate In dichloromethane at 20℃; for 2h;	A 72% B 14%

: 863033-41-4
2',3',5'-tri-O-acetyl-1-(2,4-dinitrobenzenesulfonyl)inosine

: 75-04-7
ethylamine

A: 2',3',5'-tri-O-acetyl-1-ethyladenosine

B: 51-28-5
2,4-Dinitrophenol

Conditions

Conditions	Yield
Stage #1: 2',3',5'-tri-O-acetyl-1-(2,4-dinitrobenzenesulfonyl)inosine; ethylamine In acetonitrile at -30℃; Stage #2: With water In acetonitrile Heating;	A 72% B n/a

...Expand

: 51-28-5
2,4-Dinitrophenol

: 2316-50-9
2-bromo-4,6-dinitrophenol

Conditions

Conditions	Yield
With benzyltriphenylphosphonium peroxodisulfate; potassium bromide In acetonitrile for 9.5h; Heating;	100%
With N-benzyl-N,N-dimethyl anilinium peroxodisulfate; potassium bromide In acetonitrile for 9.5h; Reflux; regioselective reaction;	91%
With poly(4-vinylpyridinium bromochromate) In acetonitrile at 20℃; for 2h; regioselective reaction;	82%

: 51-28-5
2,4-Dinitrophenol

: 56512-49-3
dabsyl chloride

: 146303-72-2
4-(4-Dimethylamino-phenylazo)-benzenesulfonic acid 2,4-dinitro-phenyl ester

Conditions

Conditions	Yield
With carbonate-bicarbonate buffer In acetone; acetonitrile 1.) 15 min, 2.) reflux;	100%
With carbonate-bicarbonate buffer In acetone for 0.5h; Heating;

: 51-28-5
2,4-Dinitrophenol

: 104293-02-9
1-ethoxy-2-(trimethylsilyl)vinyl acetate

: 4232-27-3
2,4-dinitrophenyl acetate

Conditions

Conditions	Yield
In dichloromethane at 40℃; for 22h;	100%

: 51-28-5
2,4-Dinitrophenol

: 4BF4(1-)*C86H162N6O2(4+)

: 1011-73-0
sodium 2,4-dinitrophenoxide

: BF4(1-)*C110H172CoN14O22(1+)

Conditions

Conditions	Yield
Stage #1: 4BF4(1-)*C86H162N6O2(4+) With cobalt(II) acetate In ethanol at 20℃; for 3h; Stage #2: 2,4-Dinitrophenol With oxygen In dichloromethane for 3h; Stage #3: sodium 2,4-dinitrophenoxide With oxygen In dichloromethane Product distribution / selectivity;	100%

...Expand

: 51-28-5
2,4-Dinitrophenol

: (R,E)-2-cyclohexyl-5,9-dimethyldeca-4,8-dienoic acid

: 2,4-dinitrophenyl (R,E)-2-cyclohexyl-5,9-dimethyldeca-4,8-dienoate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 2.5h;	100%

: 51-28-5
2,4-Dinitrophenol

: (S,Z)-2-cyclohexyl-5,9-dimethyldeca-4,8-dienoic acid

: 2,4-dinitrophenyl (S,Z)-2-cyclohexyl-5,9-dimethyldeca-4,8-dienoate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 2.5h;	100%

: 51-28-5
2,4-Dinitrophenol

: tert-butyl (3-methoxypyridin-4-yl)carbamate

: tert-butyl N-(1-amino-3-methoxy-pyridin-1-ium-4-yl)carbamate 2,4-dinitrophenolate salt

Conditions

Conditions	Yield
In acetonitrile at 40℃; Inert atmosphere;	100%

: 51-28-5
2,4-Dinitrophenol

: C36H58N4O2(2+)*2BF4(1-)

: 71-48-7, 917-69-1, 5931-89-5, 55881-15-7, 68931-68-0, 68931-69-1, 93029-27-7
cobalt(II) acetate

: 1011-73-0
sodium 2,4-dinitrophenoxide

: C42H59CoN6O7(2+)*2BF4(1-)

Conditions

Conditions	Yield
Stage #1: C36H58N4O2(2+)*2BF4(1-); cobalt(II) acetate In ethanol at 20℃; for 2h; Glovebox; Inert atmosphere; Schlenk technique; Stage #2: 2,4-Dinitrophenol With oxygen In dichloromethane for 2h; Stage #3: sodium 2,4-dinitrophenoxide In dichloromethane at 20℃;	100%

...Expand

: 51-28-5
2,4-Dinitrophenol

: C36H52N4O2(2+)*2BF4(1-)

: 71-48-7, 917-69-1, 5931-89-5, 55881-15-7, 68931-68-0, 68931-69-1, 93029-27-7
cobalt(II) acetate

: 1011-73-0
sodium 2,4-dinitrophenoxide

: C42H53CoN6O7(2+)*2BF4(1-)

Conditions

Conditions	Yield
Stage #1: C36H52N4O2(2+)*2BF4(1-); cobalt(II) acetate In ethanol at 20℃; for 2h; Glovebox; Inert atmosphere; Schlenk technique; Stage #2: 2,4-Dinitrophenol With oxygen In dichloromethane for 2h; Stage #3: sodium 2,4-dinitrophenoxide In dichloromethane at 20℃;	100%

...Expand

: 51-28-5
2,4-Dinitrophenol

: 65-85-0
benzoic acid

: 1523-15-5
2,4-dinitrophenyl benzoate

Conditions

Conditions	Yield
With iodine; triethylamine; triphenylphosphine In dichloromethane at 0 - 20℃; for 0.333333h;	99%
With dicyclohexyl-carbodiimide In dichloromethane at 25℃; for 12h;	90%

: 51-28-5
2,4-Dinitrophenol

: 616-38-6
carbonic acid dimethyl ester

: 119-27-7
2,4-dinitroanisole

Conditions

Conditions	Yield
With N-butyl-4-methylpyridinium bromide at 170℃; for 0.5h; Inert atmosphere; Ionic liquid; Green chemistry; chemoselective reaction;	99%

: 51-28-5
2,4-Dinitrophenol

: 99-57-0
2-hydroxy-5-nitroaniline

Conditions

Conditions	Yield
With hydrazine hydrate at 90℃; for 18h;	98%
With hydrazine hydrate In water at 110℃; Sealed tube; Green chemistry;	95%
With hydrazine hydrate In isopropyl alcohol at 110℃; for 0.25h; Catalytic behavior; Sealed tube; chemoselective reaction;	94%

: 75-91-2
tert.-butylhydroperoxide

: 51-28-5
2,4-Dinitrophenol

: 5395-43-7
tri(p-tolyl)antimony

: 108-88-3
toluene

: μ2-oxobis[(2,4-dinitrophenoxo)tris(para-tolyl)antimony] toluene monosolvate

Conditions

Conditions	Yield
Stage #1: tert.-butylhydroperoxide; 2,4-Dinitrophenol; tri(p-tolyl)antimony In diethyl ether at 20℃; for 24h; Stage #2: toluene In octane	98%

...Expand

: 51-28-5
2,4-Dinitrophenol

: 95-86-3
2,4-diaminophenol

Conditions

Conditions	Yield
With sodium tetrahydroborate; pyrographite In tetrahydrofuran; water at 50 - 60℃; for 5h;	97%
With sodium tetrahydroborate In ethanol; water at 45℃; for 0.0833333h;	96%
Stage #1: 2,4-Dinitrophenol With palladium on activated charcoal In methanol at 20℃; for 0.0833333h; Autoclave; Inert atmosphere; Stage #2: With hydrogen In methanol at 65℃; under 3600.36 - 6375.64 Torr; for 1.5h; Pressure; Temperature; Autoclave;	96.16%

: 51-28-5
2,4-Dinitrophenol

: 4903-36-0
N-phenyl-benzimidoyl chloride

: 107569-59-5
2,4-dinitrophenyl N-phenylbenzimidate

Conditions

Conditions	Yield
diethylamine In diethyl ether	96%
triethylamine In 1,4-dioxane

: 51-28-5
2,4-Dinitrophenol

: 98-86-2
acetophenone

: 3-(2-phenyl-2-oxoethyl)-2,4-bis(aci-nitro)cyclohex-5-en-1-one disodium salt

Conditions

Conditions	Yield
With sodium ethanolate at 18 - 20℃; for 0.5h;	96%

: 51-28-5
2,4-Dinitrophenol

: 31562-43-3
tert-butylsulfinyl chloride

: 112881-95-5
2-Methyl-propane-2-sulfinic acid 2,4-dinitro-phenyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 16h; Ambient temperature;	95%

: 51-28-5
2,4-Dinitrophenol

: 591-50-4
iodobenzene

: 2486-07-9
2,4-dinitrophenyl phenyl ether

Conditions

Conditions	Yield
With sodium hydroxide In neat (no solvent) at 90℃; for 6h; Green chemistry;	95%

: 64-67-5
diethyl sulfate

: 51-28-5
2,4-Dinitrophenol

: 610-54-8
2,4-dinitro-1-ethoxybenzene

Conditions

Conditions	Yield
With lithium hydroxide In tetrahydrofuran at 70℃; for 0.5h;	94%

2,4-Dinitrophenol Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

2,4-Dinitrophenol Specification

The IUPAC name of this chemical is 2,4-Dinitrophenol. With the CAS registry number 51-28-5 and EINECS registry number 200-087-7, it is also named as Phenol,2,4-dinitro-. In addition, the molecular formula is C₆H₄N₂O₅ and the molecular weight is 184.11. It is a kind of yellow crystalline solid that has a sweet, musty odor and belongs to the classes of Intermediates of Dyes and Pigments; Aromatic Phenols; Organics; Phenoles and thiophenoles; Analytical Chemistry; Indicator (pH); pH Indicators; Dye Intermediate; Alpha Sort; D; DAlphabetic; DID - DINPesticides; Metabolites; Others; Pesticides; Volatiles/ Semivolatiles. What's more, it sublimes when carefully heated and is volatile with steam. It should be sealed in a cool place and should avoid the light.

Physical properties about this chemical are: (1)ACD/LogP: 1.72; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.251; (4)ACD/LogD (pH 7.4): ; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 7.011; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 7; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 111.87 Å²; (13)Index of Refraction: 1.661; (14)Molar Refractivity: 41.225 cm³; (15)Molar Volume: 111.547 cm³; (16)Polarizability: 16.343 ×10^-24cm³; (17)Surface Tension: 79.667 dyne/cm; (18)Density: 1.651 g/cm³; (19)Flash Point: 142.78 °C; (20)Enthalpy of Vaporization: 57.512 kJ/mol; (21)Boiling Point: 312.097 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.

Preparation of 2,4-Dinitrophenol: it can be prepared by 2,4-dinitrochlorobenzene. At first, add water into the pot, stir and heat it to 60 °C, then add the melting 2,4-dinitrochlorobenzene and continue to heat up to 90 °C. When add in sodium hydroxide solution, you should control the temperature no more than 102-104 °C and insulation for 30 minutes. Then go through the operation of cooling and filtering to get the products.

2,4-Dinitrophenol can be prepared by 2,4-dinitrochlorobenzene

Uses of 2,4-Dinitrophenol: it is mainly used to produce heterogeneous and sulfide dyestuff, such as vulcanization black BN; BRN, etc. Also it can be used as acid base indicator and used to test potassium, ammonium and magnesium, etc. In addition, it can be used to get 2-bromo-4,6-dinitro-phenol. This reaction will need reagents Br₂ and conc.H₂SO₄. The reaction time is 3.5 hours at reaction temperature of 100 °C. The yield is about 78%.

2,4-Dinitrophenol can be used to get 2-bromo-4,6-dinitro-phenol

When you are using this chemical, please be cautious about it as the following:
This chemical is very toxic to aquatic organisms and toxic by inhalation, in contact with skin and if swallowed. And it has danger of very serious irreversible and cumulative effects. In addition, it is highly flammable and harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. During using it, wear suitable protective clothing and gloves and avoid release to the environment. If contact it with skin, wash immediately with plenty of soap-suds. Keep container tightly closed and keep away from sources of ignition. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.). What's more, it is refer to special instructions/safety data sheets.

You can still convert the following datas into molecular structure:
(1)SMILES: c1cc(c(cc1[N+](=O)[O-])[N+](=O)[O-])O
(2)InChI: InChI=1/C6H4N2O5/c9-6-2-1-4(7(10)11)3-5(6)8(12)13/h1-3,9H
(3)InChIKey: UFBJCMHMOXMLKC-UHFFFAOYAV

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	13mg/kg (13mg/kg)		Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
cat	LD50	oral	75mg/kg (75mg/kg)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 62, 1982.
dog	LCLo	inhalation	300mg/m3/30M (300mg/m3)		"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 62, 1982.
dog	LDLo	intravenous	15mg/kg (15mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 187, 1933.
dog	LDLo	oral	30mg/kg (30mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 187, 1933.
dog	LDLo	subcutaneous	20mg/kg (20mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 187, 1933.
guinea pig	LD50	intraperitoneal	28mg/kg (28mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 381, 1958.
guinea pig	LD50	oral	81mg/kg (81mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: TETANY BEHAVIORAL: ATAXIA	Farmakologiya i Toksikologiya Vol. 28, Pg. 493, 1965.
guinea pig	LDLo	skin	700mg/kg (700mg/kg)		Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 10, 1948.
guinea pig	LDLo	subcutaneous	25mg/kg (25mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 192, Pg. 331, 1939.
human	LDLo	oral	36mg/kg (36mg/kg)	BEHAVIORAL: COMA CARDIAC: CHANGE IN RATE	JAMA, Journal of the American Medical Association. Vol. 101, Pg. 1333, 1933.
mammal (species unspecified)	LD50	unreported	40mg/kg (40mg/kg)		"Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 97, 1971.
mouse	LD50	intraperitoneal	26mg/kg (26mg/kg)		Biochemical Pharmacology. Vol. 18, Pg. 1389, 1969.
mouse	LD50	intravenous	56mg/kg (56mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Toxicology and Applied Pharmacology. Vol. 6, Pg. 232, 1964.
mouse	LD50	oral	45mg/kg (45mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: ATAXIA BEHAVIORAL: TETANY	Farmakologiya i Toksikologiya Vol. 28, Pg. 493, 1965.
mouse	LD50	subcutaneous	58mg/kg (58mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Toxicology and Applied Pharmacology. Vol. 6, Pg. 232, 1964.
pigeon	LD50	intramuscular	6500ug/kg (6.5mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 53, Pg. 58, 1935.
rabbit	LD50	oral	30mg/kg (30mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: TETANY BEHAVIORAL: ATAXIA	Farmakologiya i Toksikologiya Vol. 28, Pg. 493, 1965.
rabbit	LDLo	subcutaneous	20mg/kg (20mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 187, 1933.
rat	LD50	intraperitoneal	20mg/kg (20mg/kg)		Journal of Pharmacy and Pharmacology. Vol. 17, Pg. 814, 1965.
rat	LD50	intravenous	72mg/kg (72mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Toxicology and Applied Pharmacology. Vol. 6, Pg. 232, 1964.
rat	LD50	oral	30mg/kg (30mg/kg)		Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
rat	LD50	subcutaneous	25mg/kg (25mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 187, 1933.

Product Name

2,4-Dinitrophenol

Synthetic route

2,4-Dinitrophenol Consensus Reports

2,4-Dinitrophenol Specification

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