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HANGZHOU HOLYPHARM BIOTECH CO.,LTD

Country:China (Mainland)

Year Established: 2009Business type: Other

Integral:

1. Caspofungin introduction
Caspofungin acetate
is a hygroscopic, white to off-white powder. It is freely soluble in water and methanol, and slightly soluble in ethanol. The pH of a saturated aqueous solution of caspofungin acetate is approximately 6.6. The empirical formula is C52H88N10O15·2C2H4O2 and the formula weight is 1213.42 g·mol−1Caspofungin acetate is an echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall.

2. Caspofungin dose when use
Caspofungin acetate 50 mg
contains: 39 mg sucrose, 26 mg mannitol, glacial acetic acid, and sodium hydroxide. Caspofungin acetate 70 mg also contains 54 mg sucrose, 36 mg mannitol, glacial acetic acid, and sodium hydroxide.

Invasive aspergillus patients: First day, you can be given a caspofungin dose of 70mg. The next day, you should reduce it to 50mg. When the caspofungin dose is 70mg per day, someone can generally well tolerated. But if more than 70mg, its safety and efficacy have not yet been adequately studied. Esophageal monilial patients: 50mg per day. Because HIV infected people is vulnerable to oropharyngeal candidiasis, so the patient can consider to oral therapy. If some one has a low hypohepatia, you should adjust the amount of caspofungin dose.

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