epothilone, epothilone a, epothilones, epothilone b, (-)-epothilone b, epothilone d, epothilon, CAS No. 152044-53-6

HANGZHOU HOLYPHARM BIOTECH CO.,LTD

Country:China (Mainland)

Year Established: 2009Business type: Other

Integral:

1. The brief introduction of Epothilone

An epothilone is a part of a class of cancer drugs. Epothilones are made from a bacteria. This drug class may offer a clinical benefit in the treatment of a variety of cancers by inducing mitotic arrest and apoptotic cell death. As of September 2008, epothilones a to f have been identified and characterised. Different kinds of Epothilones have different CAS No., Chemical formulae, Molecular masses and structures.

2. The classifications of Epothilone

Epothilone a (CAS No. 152044-53-6) : It is also called (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione.With its Molecular Formula C₂₆H₃₉NO₆S, its Molecular Weight is 493.66. The density is 1.143 and Melting point is 95 ºC.

Epothilone b (CAS No. 152044-54-7) : Its synonyms is Patupilone: (-)-epothilone b; (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione. The Molecular Formula is C₂₇H₄₁NO₆S and Molecular Weight is 507.68. Its Density is 1.136.

Epothilone c (CAS No. 186692-73-9) : With its synonyms (-)-Desoxyepothilone A; Desoxyepothilone A; Epo C; (4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9-tetramethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]oxacyclohexadec-13-ene-2,6-dione, its Molecular Formula is C₂₆H₃₉NO₅S; Molecular Weight is 477.66 and Density is 1.097.

Epothilone d ( CAS No.189453-10-9 ) : Desoxyepothilone B; (3S,7S,14S,15S,16R)-3,15-Dihydroxy-2,2,10,14,16-pentamethyl-7-[1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-6-oxacyclohexadec-9-ene-1,5-dione are the synonyms. And the Molecular Formula is C₂₇H₄₁NO₅S; Molecular Weight is 491.68.

HANGZHOU HOLYPHARM BIOTECH CO.,LTD, a professional supplier of active pharmaceutical ingredients and intermediates, pointed that the different epothilones have different uses as drugs.

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