mandelonitrile synthesis

JiangXi Keyuan Biopharma Co., LTD.

Country:China (Mainland)

Year Established: 2002Business type: Manufacturers

Integral:

Mandelonitrile synthesis

As the method of producing a mandelonitrile compound, it comprises reacting a benzaldehyde compound and hydrogen cyanide in the presence of an alkali metal salt in a water solvent. when the benzaldehyde compound has a substituent at an ortho position, the substituent hinders the reaction, and the yield of a mandelonitrile compound is not satisfactory in some cases.

The present invention has an object of providing a method for producing a mandelonitrile compound in good yield from a benzaldehyde compound having a prescribed substituent at an ortho position.

The present inventors have intensively studied and resultantly found that the above-described object can be attained by reacting a benzaldehyde compound having a prescribed substituent at an ortho position with hydrogen cyanide in an amount of 1.2 to 5 mol with respect to 1 mol of the benzaldehyde compound, in the presence of an organic base in an organic solvent, leading to completion of the present invention.

Keyuan Chemical Co., Ltd. specialized in the production for pigments, pharmaceuticals and other fine chemical intermediates, is one of Medium-sized chemical enterprises which integrates research, development and production. Its main products are including L-Serine (CAS NO.: 56-45-1) and so on. It is comprised of two pars R&D center, occupied 10000m2 and is located in jintan chemical zone in jiangsu province; another production area lied in anhui guangde chemical zone, with a total area at 25000m2. The series of Mandelic acid has got a yearly total capacity at more than 1000 metric tons, and one of DL-Mandelic acid has been up to 600mt per year. It wins the biggest capacity and the greatest variety of goods in the manufacturer of the like product. The series of Mandelic acid also become the most competitive item at home and abroad of our company. Keyuan chemical possesses perfect means in quality control and analysis, with the quality testing system, and the ISO9001 for both R&D center and production area, we can guarantee the stability of product quality. In the coming days, keeping the principle of "improving ourselves, and spirit of upwards", we will try best to make the customers satisfied through constant efforts. Let us go forward hand in hand, and get development together.