Lidocaine supplier | CasNO.137-58-6

Name
Lidocaine
EINECS 205-302-8
CAS No. 137-58-6
Article Data34
CAS DataBase
Density 1.026 g/cm³
Solubility practically insoluble
Melting Point 66-69 °C
Formula C₁₄H₂₂N₂O
Boiling Point 350.8 °C at 760 mmHg
Molecular Weight 234.341
Flash Point 166 °C
Transport Information
Appearance solid
Safety 22-26-36
Risk Codes 22
Molecular Structure
Hazard Symbols Xn
Synonyms 2',6'-Acetoxylidide,2-(diethylamino)- (8CI);2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide;Antrolin;Cuivasil;Dalcaine;ELA-Max;Esracaine;Isicaine;Jetocaine;Leostesin;Lidocadren;Lidoderm;Linisol;Maricaine;Penles;Remicaine;Solarcaine;Solcain;Xilina;Xycaine;Xyline;Xylocaine;Xylocitin;a-Diethylamino-2,6-acetoxylidide;
PSA 32.34000
LogP 2.65670

Synthetic route

: 109-89-7
diethylamine

: 1131-01-7
2-chloro-N-(2,6-dimethylphenyl)acetamide

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 99℃; under 5171.62 Torr; Temperature; Flow reactor;	98%
at 40℃; for 6h; Temperature;	97%
In hexane at 60℃; Temperature; Reflux;	91.1%

: 109-89-7
diethylamine

: 79-04-9
chloroacetyl chloride

: 87-62-7
2,6-dimethylaniline

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions

Conditions	Yield
Stage #1: chloroacetyl chloride; 2,6-dimethylaniline In toluene at 80 - 90℃; for 3h; Large scale; Stage #2: With sodium carbonate; potassium iodide In water; toluene for 0.5h; Large scale; Stage #3: diethylamine In water; toluene Solvent; Temperature; Reagent/catalyst; Large scale;	95.2%
With potassium hydroxide In 1-methyl-pyrrolidin-2-one at 120 - 130℃; under 12929 Torr;

...Expand

: 7409-48-5
(2-diethylaminoethyl)amide

: 87-62-7
2,6-dimethylaniline

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions

Conditions	Yield
With dipotassium peroxodisulfate In water at 100℃; for 0.166667h; Microwave irradiation; Green chemistry;	95%

: 3734-33-6
denatonium benzoate

A: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

B: 2-diethylamino-N-(2,6-dimethyl-phenyl)-3-phenyl-propionamide

Conditions

Conditions	Yield
at 250℃;

: 87-62-7
2,6-dimethylaniline

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetic acid; sodium acetate 2: benzene View Scheme
Multi-step reaction with 2 steps 1: triethylamine / chloroform / 0.02 h / Flow reactor 2: triethylamine / N,N-dimethyl-formamide / 0.19 h / 60 °C View Scheme
Multi-step reaction with 2 steps 1: acetic acid; sodium acetate / water / 24 h / Reflux 2: triethylamine / 1,4-dioxane / 120 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: dichloromethane / 105 °C / 12929 Torr / Flow reactor 2: triethylamine / N,N-dimethyl-formamide / 99 °C / 5171.62 Torr / Flow reactor View Scheme
Multi-step reaction with 2 steps 1: potassium carbonate / acetone / 3 h / 20 °C 2: acetone / 8 h / Reflux View Scheme

: [(2,6-dimethylphenylcarbamoyl)methyl]diethyl-(2-phosphonooxybenzyl)ammonium trifluoroacetate disodium salt

A: 90-01-7
salicylic alcohol

B: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions

Conditions	Yield
With alkaline phosphatase In water at 37℃; for 6h; pH=7.4; Enzyme kinetics; Enzymatic reaction;

: [(2,6-dimethylphenylcarbamoyl)methyl]diethyl-(2-phosphonooxybenzyl)ammonium trifluoroacetate disodium salt

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions

Conditions	Yield
With rat lung homogenate at 37℃; for 3h; Enzyme kinetics;

: [(2,6-dimethylphenylcarbamoyl)methyl]diethyl-(4-phosphonooxybenzyl)ammonium trifluoroacetate disodium salt

A: 623-05-2
(4-hydroxyphenyl)methanol

B: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions

Conditions	Yield
With alkaline phosphatase In water at 37℃; for 6h; pH=7.4; Enzyme kinetics; Enzymatic reaction;

: 178421-96-0
C14H22N2O*C56H98O35

A: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

B: 51166-71-3
heptakis(2,6-di-O-methyl)cyclomaltoheptaose

Conditions

Conditions	Yield
With pluronic copolymer F290 In water at 25℃; Equilibrium constant; Reagent/catalyst;

: 30280-35-4
N,N-diethylglycine methyl ester

: 87-62-7
2,6-dimethylaniline

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions

Conditions	Yield
With sodium methylate at 95℃; for 0.5h; Concentration; Temperature;

: 576-26-1
2.6-dimethylphenol

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonium hydroxide; 2,6-dimethylcyclohexanone; 5%-palladium/activated carbon / 5 h / 180 °C 2: sodium methylate / 0.5 h / 95 °C View Scheme

: 81-20-9
2,6-dimethylnitrobenzene

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: 5%-palladium/activated carbon; hydrogen / methanol / 20 - 25 °C 2.1: potassium carbonate / dichloromethane 2.2: 1 h / 20 °C 3.1: hexane / 60 °C / Reflux View Scheme

: 2-(N-ethylacetamido)2',6'-dimethylacetanilide

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions

Conditions	Yield
With borane-THF In tetrahydrofuran at 20℃;	176 mg

: 119072-54-7, 2769-71-3
2,6-dimethylphenyl isonitrile

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1,2-dichloro-ethane / 45 °C 2: borane-THF / tetrahydrofuran / 20 °C View Scheme

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 57-11-4
stearic acid

: 1001438-56-7
C14H22N2O*C18H36O2

Conditions

Conditions	Yield
for 0.0833333h; Inert atmosphere; Heating;	100%

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 73-78-9
lidocaine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether	100%
With hydrogenchloride; pyrographite In water; 1,2-dichloro-ethane for 0.333333h; pH=3.5; pH-value;	88.72%
With hydrogenchloride In water; acetone at 20℃; pH=<= 4;	80.6%

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 150994-82-4
4-((1,3-bis(octanoyloxy)propan-2-yl)oxy)-4-oxobutanoic acid

: 2-((2,6-dimethylphenyl)amino)-N,N-diethyl-2-oxoethan-1-aminium 4-((1,3-bis(octanoyloxy)propan-2-yl)oxy)-4-oxobutanoate

Conditions

Conditions	Yield
In acetonitrile at 50℃; for 6h;	100%

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: C14H17(2)H5N2O

Conditions

Conditions	Yield
With [(2)H6]acetone; tris(pentafluorophenyl)borate In toluene at 150℃; for 3h; Inert atmosphere;	99%

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 96-32-2
bromoacetic acid methyl ester

: 2-((2,6-dimethylphenyl)amino)-N,N-diethyl-N-(2-methoxy-2-oxoethyl)-2-oxoethan-1-aminium bromide

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 1h; Inert atmosphere;	97%
In acetonitrile at 60℃;

: 526-95-4
gluconic acid

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 2-((2,6-dimethylphenyl)amino)-N,N-diethyl-2-oxoethan-1-aminium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate

Conditions

Conditions	Yield
In ethanol for 5h; pH=2 - 7;	95%

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: N-(4-chloro-2,6-dimethylphenyl)-2-(diethylamino)-acetamide

Conditions

Conditions	Yield
With trichloroisocyanuric acid; brilliant green carbocation In acetonitrile at 20℃; for 0.166667h; Irradiation; regioselective reaction;	94%

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 2903-45-9
lidocaine N-oxide

Conditions

Conditions	Yield
With perfluoro-cis-2-n-butyl-3-n-propyloxaziridine; HCFC-225ca,cb In dichloromethane at -60℃; for 0.333333h;	93%
With dihydrogen peroxide In methanol at 20℃; for 42h;	71%
With 3-chloro-benzenecarboperoxoic acid In dichloromethane
With rat liver microsomes; NADPH In water Product distribution;

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 187283-17-6
(4-bromomethylbenzyl)carbamic acid tert-butyl ester

: C27H40N3O3(1+)*Br(1-)

Conditions

Conditions	Yield
at 80℃; for 0.166667h;	91%
at 80℃; for 0.166667h;	91%

: 590-97-6
acetoxymethyl bromide

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: N-(acetoxymethyl)-2-((2,6-dimethylphenyl)amino)-N,N-diethyl-2-oxoethan-1-aminium bromide

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 1h; Inert atmosphere;	90%
In 1,2-dichloro-ethane at 100℃; for 6h; Sealed tube;	40%

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 47377-16-2
4-tetradecylbenzenesulfonic acid

: lidocaine 4-tetradecylbenzenesulfonate

Conditions

Conditions	Yield
In isopropyl alcohol Heating;	90%

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 373-68-2
tetramethylammonium fluoride

: 31058-85-2
2-(diethylamino)-N-(2,6-dimethylphenyl)-N-methylacetamide

Conditions

Conditions	Yield
In toluene at 100℃; for 12h;	88%

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 79840-57-6
4-octadecylbenzenesulfonic acid

: lidocaine 4-octadecylbenzenesulfonate

Conditions

Conditions	Yield
In ethanol; water Heating;	87%

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 39942-49-9
2-diethylamino-N-(2,6-dimethyl-3-nitro-phenyl)-acetamide

Conditions

Conditions	Yield
With sulfuric acid; nitric acid In water at 0 - 25℃; for 0.75h;	86%

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: C31H60O8S*C5H5N

: C31H60O8S*C14H22N2O

Conditions

Conditions	Yield
In methanol at 20℃; for 0.5h;	85%

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: C14H15(2)H7N2O

Conditions

Conditions	Yield
With d8-isopropanol; 1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II) In toluene at 170℃; for 2h; Inert atmosphere; Microwave irradiation; Sealed tube;	84%
With 1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-μ-hydrotetracarbonyldiruthenium(II); d8-isopropanol In toluene at 170℃; under 12751.3 Torr; for 2h; Microwave irradiation; Inert atmosphere; Sealed tube;	84%

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: C14H20(2)H2N2O

Conditions

Conditions	Yield
With tetrakis(tetrabutylammonium)decatungstate(VI); 2,4,6-Triisopropylthiophenol; water-d2; trifluoroacetic acid In acetonitrile Irradiation;	84%

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 21714-23-8
(2,6-dichlorophenyl)cyanamide

: 3375-31-3
palladium diacetate

: K[Pd(2,6-Cl2pcyd)2(LC)]

Conditions

Conditions	Yield
Stage #1: (2,6-dichlorophenyl)cyanamide With potassium hydroxide In ethanol Reflux; Stage #2: 2-diethylamino-N-(2,6-dimethylphenyl)-acetamide; palladium diacetate With triethylamine In ethanol at 20℃; for 48h; pH=7;	83.33%

...Expand

: ammonium hexafluorophosphate

: 52462-29-0
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: C24H36ClN2ORu(1+)*F6P(1-)

Conditions

Conditions	Yield
Stage #1: [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; 2-diethylamino-N-(2,6-dimethylphenyl)-acetamide In acetone at 20℃; for 5h; Inert atmosphere; Schlenk technique; Stage #2: ammonium hexafluorophosphate Inert atmosphere; Schlenk technique;	81.2%

...Expand

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 540-51-2
2-bromoethanol

: 2-(2,6-dimethylphenylamino)-N,N-diethyl-N-(2-hydroxyethyl)-2-oxoethanaminium bromide

Conditions

Conditions	Yield
at 100℃; for 8h;	81.2%
at 90℃; for 24h; Temperature; Sealed tube;	31%
at 90℃; for 24h;	27.6%
at 80℃;

: 20922-60-5
2,6-dimethylphenylcyanamide

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 3375-31-3
palladium diacetate

: K[Pd(2,6-Me2pcyd)2(LC)]

Conditions

Conditions	Yield
Stage #1: 2,6-dimethylphenylcyanamide With potassium hydroxide In ethanol Reflux; Stage #2: 2-diethylamino-N-(2,6-dimethylphenyl)-acetamide; palladium diacetate With triethylamine In ethanol at 20℃; for 48h; pH=7;	81.14%

...Expand

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 627-18-9
1-bromo-3-propanol

: N-(2-(2,6-dimethylphenylamino)-2-oxoethyl)-N,N-diethyl-3-hydroxypropan-1-aminium bromide

Conditions

Conditions	Yield
at 110℃; for 8h;	80.3%
at 80℃;

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 2,6-diethylphenylcyanamide

: 3375-31-3
palladium diacetate

: K[Pd(2,6-Et2pcyd)2(LC)]

Conditions

Conditions	Yield
Stage #1: 2,6-diethylphenylcyanamide With potassium hydroxide In ethanol Reflux; Stage #2: 2-diethylamino-N-(2,6-dimethylphenyl)-acetamide; palladium diacetate With triethylamine In ethanol at 20℃; for 48h; pH=7;	79.25%

...Expand

: potassium cyanide

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 2-((1-cyanoethyl)(ethyl)amino)-N-(2,6-dimethyl-phenyl)acetamide

Conditions

Conditions	Yield
With 2-Picolinic acid; iron(III) chloride; tert-Butyl peroxybenzoate; 18-crown-6 ether In acetonitrile at 50℃; for 48h;	77%

: dichlorobis(dimethyl sulfoxide)platinum(II)

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 3,5-dichlorophenylcyanamide

: potassium hydroxide

: K[Pt(3,5-(Cl2)2pcyd)2(LC)]

Conditions

Conditions	Yield
Stage #1: 3,5-dichlorophenylcyanamide; potassium hydroxide In ethanol Reflux; Stage #2: dichlorobis(dimethyl sulfoxide)platinum(II); 2-diethylamino-N-(2,6-dimethylphenyl)-acetamide With triethylamine In ethanol at 20℃; pH=Ca. 7;	76.55%

...Expand

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: N-(3-chloro-2,6-dimethylphenyl)-2-(diethylamino)acetamide

Conditions

Conditions	Yield
With hydrogen fluoride; antimony pentafluoride; sodium chloride at -20℃;	75%
With hydrogenchloride; [bis(acetoxy)iodo]benzene In water; 1,2-dichloro-ethane at 50℃; for 2h; Reagent/catalyst; regioselective reaction;	60%

: 137-58-6
2-diethylamino-N-(2,6-dimethylphenyl)-acetamide

: 108-24-7
acetic anhydride

: 2-(N-ethylacetamido)2',6'-dimethylacetanilide

Conditions

Conditions	Yield
With 1H-imidazole; iodosylbenzene; chloro(meso-tetrakis(2,6-dichlorophenyl)porphyrinato)manganese(III) In dichloromethane; acetonitrile at 20℃; for 3h;	74%

Lidocaine Chemical Properties

Molecular Structure:

Molecular Formula: C₁₄H₂₂N₂O
Molecular Weight: 234.3373
IUPAC Name: 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
Classification Code: Anesthetic [topical] ; Anesthetics ; Anesthetics, local ; Anti-arrhythmia agents ; Cardiovascular Agents ; Central Nervous System Agents ; Central Nervous System Depressants ; Drug / Therapeutic Agent ; Human Data ; Mutation data ; Peripheral Nervous System Agents ; Reproductive Effect ; Sensory System Agents
Product Categories: Chiral Reagents ; Intermediates & Fine Chemicals ; Pharmaceuticals
EINECS: 205-302-8
Melting Point: 66-69°C
Index of Refraction: 1.547
Molar Refractivity: 72.42 cm³
Molar Volume: 228.3 cm³
Surface Tension: 39.1 dyne/cm
Density: 1.026 g/cm³
Flash Point: 166 °C
Enthalpy of Vaporization: 59.55 kJ/mol
Boiling Point: 350.8 °C at 760 mmHg
Vapour Pressure of Lidocaine (CAS NO.137-58-6) : 4.28E-05 mmHg at 25 °C

Lidocaine Uses

Lidocaine (CAS NO.137-58-6) is an amide local anesthetic widely used in surface anesthesia, infiltration anesthesia, conduction anesthesia and epidural anesthesia.

Lidocaine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	21mg/kg (21mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Journal of Toxicology, Clinical Toxicology. Vol. 30, Pg. 413, 1992.
child	TDLo	oral	300mg/kg/5D-I (300mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Pediatric Emergency Care. Vol. 10, Pg. 344, 1994.
guinea pig	LD50	subcutaneous	120mg/kg (120mg/kg)		Farmaco, Edizione Scientifica. Vol. 10, Pg. 883, 1955.
guinea pig	LDLo	intravenous	65mg/kg (65mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 130, Pg. 235, 1961.
human	TDLo	intravenous	23mg/kg (23mg/kg)	BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archiv fuer Toxikologie. Vol. 28, Pg. 72, 1971.
man	TDLo	intravenous	1700ug/kg/2M- (1.7mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION CARDIAC: PULSE RATE	American Journal of Emergency Medicine. Vol. 4, Pg. 143, 1986.
man	TDLo	intravenous	8643ug/kg/4H- (8.643mg/kg)	BEHAVIORAL: TOXIC PSYCHOSIS	Annals of Internal Medicine. Vol. 97, Pg. 149, 1982.
mouse	LD50	intraperitoneal	102mg/kg (102mg/kg)	PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Medicinal Chemistry. Vol. 24, Pg. 1059, 1981.
mouse	LD50	intravenous	20mg/kg (20mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 269, 1958.
mouse	LD50	oral	220mg/kg (220mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: REGIDITY LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 1275, 1966.
mouse	LD50	subcutaneous	238mg/kg (238mg/kg)		Journal of Medicinal Chemistry. Vol. 28, Pg. 714, 1985.
rabbit	LDLo	intravenous	41mg/kg (41mg/kg)		Acta Pharmacologica et Toxicologica. Vol. 31, Pg. 273, 1972.
rat	LD50	intraperitoneal	133mg/kg (133mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 243, Pg. 97, 1980.
rat	LD50	intravenous	18mg/kg (18mg/kg)		United States Patent Document. Vol. #5264432,
rat	LD50	oral	317mg/kg (317mg/kg)		Bollettino Chimico Farmaceutico. Vol. 110, Pg. 330, 1971.
rat	LD50	subcutaneous	335mg/kg (335mg/kg)		European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 9, Pg. 188, 1974.
rat	LD50	unreported	39400ug/kg (39.4mg/kg)		Farmakologiya i Toksikologiya Vol. 54(3), Pg. 32, 1991.
women	TDLo	intraspinal	1mL/kg (1mL/kg)	BEHAVIORAL: EUPHORIA BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	Journal of Clinical Pyschopharmacology. Vol. 10, Pg. 442, 1990.
women	TDLo	intravenous	16mg/kg (16mg/kg)	CARDIAC: CHANGE IN RATE LUNGS, THORAX, OR RESPIRATION: DYSPNEA	European Journal of Clinical Pharmacology. Vol. 22, Pg. 129, 1982.
women	TDLo	oral	39mg/kg (39mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: EXCITEMENT CARDIAC: CHANGE IN RATE	New England Journal of Medicine. Vol. 306, Pg. 381, 1982.

Lidocaine Consensus Reports

Reported in EPA TSCA Inventory.

Lidocaine Safety Profile

Safety Information of Lidocaine (CAS NO.137-58-6):
Hazard Codes: Harmful Xn
Risk Statements:22
R22:Harmful if swallowed
Safety Statements:22-26-36
S22:Do not breathe dust
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36:Wear suitable protective clothing
RIDADR:3249
WGK Germany:3
RTECS:AN7525000
HazardClass:6.1(b)
PackingGroup:III
Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects: blood pressure lowering, changes in heart rate, coma, convulsions, distorted perceptions, dyspnea, excitement, hallucinations, muscle contraction or spasticity, pulse rate, respiratory depression, toxic psychosis. An experimental teratogen. Other experimental reproductive effects. A local anesthetic. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.

Lidocaine Specification

First Aid Measures of Lidocaine (CAS NO.137-58-6):
Ingestion:If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Skin:Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Eyes:Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Storage of Lidocaine (CAS NO.137-58-6):
Store in a cool, dry place. Keep container closed when not in use.
Synonyms of Lidocaine (CAS NO.137-58-6) are 2',6'-Acetoxylidide, 2-(diethylamino)- ; 2-(Diethylamino)-2',6'-acetoxylidide ; 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide ; 4-12-00-02538 (Beilstein Handbook Reference) ; Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)- ; Alphacaine ; Anbesol ; Anestacon ; BRN 2215784 ; Cappicaine ; Cito optadren ; Cuivasil ; DentiPatch ; Diethylaminoaceto-2,6-xylidide ; Duncaine ; ; ELA-Max ; Esracaine ; Gravocain ; HSDB 3350 ; Isicaina ; Isicaine ; Jetocaine ; L-Caine ; Leostesin ; Lida-Mantle ; Lidocaina ; Lidocainum ;Maricaine ; Remicaine ; Rucaina ; Solarcaine ; Solcain ; Xilina ; Xilocaina ; Xycaine ; Xylestesin ; Xylocain ; Xylocaine ; Xylocitin ; Xyloneural (free base) ; Xylotox ; alfa-Dietilamino-2,6-dimetilacetanilide ; alfa-Dietilamino-2,6-dimetilacetanilide [Italian] ; alpha-Diethylamino-2,6-dimethylacetanilide

Product Name

Lidocaine

Synthetic route

Lidocaine Chemical Properties

Lidocaine Uses

Lidocaine Toxicity Data With Reference

Lidocaine Consensus Reports

Lidocaine Safety Profile

Lidocaine Specification

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