bortezomib proteasome, bortezomib, Bortezomib velcade, Velcade, velcade Bortezomib, Bortezomib structure, Bortezomib synthesis, bortezomib multiple myeloma, CAS No. 179324-69-7

NANJING AILY BIOTECHNOLOGY CO.,LTD

Country:China (Mainland)

Year Established: Business type: Lab/Research institutions

Integral:

1. The description of bortezomib ( Velcade )

Bortezomib (CAS No. 179324-69-7)is a reversible inhibitor of the chymotrypsin-like activity of the 26S proteasome in mammalian cells. This drug is thought to inhibit many proteins (known as proteasomes) that cancer cells need to survive and multiply. It has been shown to have anti-tumor activity in B cell malignancies.

Bortezomib binds to the proteasome and does so "reversibly". Normal healthy (non-cancer) cells are not as prone to damage from this binding after the Bortezomib comes off, as cancer cells are. Malignant cells suffer a breakdown even after inhibition of the proteasome for a short time.

2. Examples of bortezomib's application

Nanjing Aily Biotechnology Co.,Ltd., as a specialized company in chemical manufacture and custom synthesis, has 3 OEM factories, 2 R&D labs and Professional research team. Their researchers shows some examples of bortezomib's application in proteasome.

For example, in order to detect the Bortezomib's function to p21 protein, we can process PC - 3 cell with different concentrations of bortezomib (0.5, 1.0, 5.0,,50,100,500 10 nM) and find the p21 protein's concentration in untreated cells is very low. But after the processing of bortezomib in 10 nM, p21 protein's concentration increased significantly. Therefore, the bortezomib is very important in chemical research.

 <span style="width: 640px; color: #000000; font-size: 12px; word-break: break-all"> </span></p> <div><font size="3" face="Arial">We are a specialized company in chemical manufacture and custom synthesis. Our factory was established in 1997, and set up <span class="scayt-misspell" data-scaytid="5" data-scayt_word="Nanjing">Nanjing</span> <span class="scayt-misspell" data-scaytid="7" data-scayt_word="Aily">Aily</span> Biotechnology Co.,Ltd in 2008. Now we have 3 OEM factories, 2 R&D labs. <span class="scayt-misspell" data-scaytid="9" data-scayt_word="Aily">Aily</span> is striving to improve <span class="scayt-misspell" data-scaytid="13" data-scayt_word="reseach">reseach</span> and development, meet social and customers needs with a unifying strategic <span class="scayt-misspell" data-scaytid="3" data-scayt_word="idea.Pls">idea.Pls</span> find our factory details as <span class="scayt-misspell" data-scaytid="15" data-scayt_word="fallowings">fallowings</span>.</font></div> <div align="left"><font face="Arial"><font size="3">Our factory possess an area of more than 50000 meters square, which contains the office building, production facilities, labs and R&D center. We have more than 100 staff , two-thirds of them are sophisticated technicians who have engaged into chemical synthesis for a long time, and they compose the R&D team of <span class="scayt-misspell" data-scaytid="11" data-scayt_word="Aily">Aily</span> chemicals. This is a highly proficient team of chemists, engineers and technicians. Experience of many years in special chemicals enables us to offer you a variety of complex compounds. <b>From laboratory, pilot plant to large-scale production, we are prepared to execute your highly specialized requirements, including adapting existing units, building additional processing units.</b></font></font></div> <div align="left"><font size="3" face="Arial">We own sophisticated <span class="scayt-misspell" data-scaytid="17" data-scayt_word="infrostructure">infrostructure</span>, advanced technical know-how and precise analytic instruments, the R&D center and labs are equipped with advanced R&D as well as testing appliances such as<b> GC,<span class="scayt-misspell" data-scaytid="19" data-scayt_word="HPLC">HPLC</span> UV-Vis </b>and so forth. Hence the quality of our products is reliable.</font></div> <div align="left"><font size="3" face="Arial">We have set up long-term and stable cooperation with some world top companies. In order to improve the quality of the currents products, develop more new products and cultivate custom manufacture, we are making the best of the talents of its own technicians, meanwhile it has built stable cooperation with a large number of universities and institutes.</font></div> <p> 