bortezomib proteasome, bortezomib, Bortezomib velcade, Velcade, velcade Bortezomib, Bortezomib structure, Bortezomib synthesis, bortezomib multiple myeloma, CAS No. 179324-69-7

HANGZHOU HOLYPHARM BIOTECH CO.,LTD

Country:China (Mainland)

Year Established: 2009Business type: Other

Integral:

1. The description of bortezomib ( Velcade )

Bortezomib (CAS No. 179324-69-7) is a reversible inhibitor of the chymotrypsin-like activity of the 26S proteasome in mammalian cells. This drug is thought to inhibit many proteins (known as proteasomes) that cancer cells need to survive and multiply. It has been shown to have anti-tumor activity in B cell malignancies.

Bortezomib binds to the proteasome and does so "reversibly". Normal healthy (non-cancer) cells are not as prone to damage from this binding after the Bortezomib comes off, as cancer cells are. Malignant cells suffer a breakdown even after inhibition of the proteasome for a short time.

2. Examples of bortezomib's application

Hangzhou Holypharm biotech Co.,Ltd., a professional supplier of active pharmaceutical ingredients and intermediates, has rich experience on a wide range of chemical reaction and professional research team. Their researchers shows some examples of bortezomib's application in proteasome.

For example, in order to detect the Bortezomib's function to p21 protein, we can process PC - 3 cell with different concentrations of bortezomib (0.5, 1.0, 5.0,,50,100,500 10 nM) and find the p21 protein's concentration in untreated cells is very low. But after the processing of bortezomib in 10 nM, p21 protein's concentration increased significantly. Therefore, the bortezomib is very important in chemical research.

HANGZHOU HOLYPHARM BIOTECH CO.,LTD is a professional supplier of active pharmaceutical ingredients and intermediates; agrochemicals and Veterinary products. We are specialized in contract R&D and custom manufacturing. we have rich experience on a wide range of chemical reactions and fermentation from multi gram scale to hundred tons scale according to customers' requirement. Moreover, we are quite strong on registration. Our products have been registered in India, Vietnam, Latin America, Turkey, etc. HANGZHOU HOLYPHARM BIOTECH CO.,LTD is mainly engaged in the importing and exporting of pharmaceutical raw materials and intermediates to the markets of Europe and North America, and B2B e-commerce platform is undoubtedly an important platform for foreign trade enterprises who are looking for domestic opportunities. Holypharm forges their products to the foreign buyers' accustomed searching mode, which is the most effective way to advertise. We have three departments, PHARM DEPT. ,VETERINARY DEPT., AGROCHMICAL DEPT. We gather most qualified staffs with years of practical experience and knowledge in each department . They have better ideas on quality control, registration data, excellent packaging & labeling and logistics. To provide clients with more technology support, we will present efficient regulatory documents to show professional abilities in this field. Professional services The enterprise armed with knowledge will always keep its vitality and development. The human resources department in HANGZHOU HOLYPHARM will train its staff at regular intervals, to help them have a in-depth understanding of business regulations, foreign trade processes, chemical knowledge, communication skills, and so on. After foreign buyers gives the order, the company will give the one-stop services with factory-auditing, inspection, order management, export declaration to freight logistics. In addition, HANGZHOU HOLYPHARM will provide free extra services for foreign buyers like investigation of domestic market and consulting services, which is highly appraised by customers. As a company in the field of chemical export industry for many years, HOLYPHARM is engaged in improving the professional competence of the business staff and their professional services, which is not only the best way to win customers, but also helps to dig out the potential value of the chemical industry chain which are negligent.