Product Name

  • Name

    (R)-(-)-2-Chloropropan-1-ol

  • EINECS
  • CAS No. 37493-14-4
  • Article Data9
  • CAS DataBase
  • Density 1.082 g/cm3
  • Solubility soluble
  • Melting Point
  • Formula C3H7ClO
  • Boiling Point 133.5 °C at 760 mmHg
  • Molecular Weight 94.541
  • Flash Point 44.4 °C
  • Transport Information UN 2611
  • Appearance clear colourless liquid
  • Safety 36/37/39-27-26-16
  • Risk Codes 36/37/38-20/21/22-10
  • Molecular Structure Molecular Structure of 37493-14-4 ((R)-(-)-2-Chloropropan-1-ol)
  • Hazard Symbols HarmfulXn
  • Synonyms 1-Propanol,2-chloro-, (R)-;(-)-(R)-2-Chloropropanol;(R)-(-)-2-Chloro-1-propanol;(R)-2-Chloro-1-propanol;
  • PSA 20.23000
  • LogP 0.60600

Synthetic route

(R)-ethyl 2-chloropropanoate
42411-39-2

(R)-ethyl 2-chloropropanoate

(R)-(-)-2-chloro-propan-1-ol
37493-14-4

(R)-(-)-2-chloro-propan-1-ol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether for 2h;78%
With lithium aluminium tetrahydride In diethyl ether 1.) 0 deg C, 2.5 h; 2.) up to r.t. 15 h;35%
With lithium aluminium tetrahydride In diethyl ether
With lithium aluminium tetrahydride In diethyl ether at 0℃; Heating;
(S)-Ethyl lactate
687-47-8

(S)-Ethyl lactate

(R)-(-)-2-chloro-propan-1-ol
37493-14-4

(R)-(-)-2-chloro-propan-1-ol

Conditions
ConditionsYield
(i) PCl3, (ii) LiAlH4; Multistep reaction;
(R)-2-chloropropionic acid
7474-05-7

(R)-2-chloropropionic acid

(R)-(-)-2-chloro-propan-1-ol
37493-14-4

(R)-(-)-2-chloro-propan-1-ol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether
propene
187737-37-7

propene

A

(S)-2-chloropropan-1-ol
19210-21-0

(S)-2-chloropropan-1-ol

B

1-chloro-2(S)-hydroxypropane
37493-16-6

1-chloro-2(S)-hydroxypropane

C

(R)-(-)-1-chloro-2-propanol
19141-39-0

(R)-(-)-1-chloro-2-propanol

D

(R)-(-)-2-chloro-propan-1-ol
37493-14-4

(R)-(-)-2-chloro-propan-1-ol

Conditions
ConditionsYield
With copper dichloride; [Pd(CH3CN)2{(S)-BINAP}](BF4)2; 1,3-diacetyl acetone In tetrahydrofuran at 25℃; Product distribution; Further Variations:; Catalysts; Solvents; Reagents;
...Expand
2-chloropropanal
692291-15-9

2-chloropropanal

(R)-(-)-2-chloro-propan-1-ol
37493-14-4

(R)-(-)-2-chloro-propan-1-ol

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol
3-(2-Chloro-4-hydroxy-phenyl)-[1,4]oxazepane-4-carboxylic acid tert-butyl ester

3-(2-Chloro-4-hydroxy-phenyl)-[1,4]oxazepane-4-carboxylic acid tert-butyl ester

(R)-(-)-2-chloro-propan-1-ol
37493-14-4

(R)-(-)-2-chloro-propan-1-ol

3-[2-Chloro-4-((R)-2-hydroxy-1-methyl-ethoxy)-phenyl]-[1,4]oxazepane-4-carboxylic acid tert-butyl ester

3-[2-Chloro-4-((R)-2-hydroxy-1-methyl-ethoxy)-phenyl]-[1,4]oxazepane-4-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With potassium hydroxide In N,N-dimethyl-formamide at 100℃;93%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

(R)-(-)-2-chloro-propan-1-ol
37493-14-4

(R)-(-)-2-chloro-propan-1-ol

(R)-2-chloropropyl p-toluenesulfonate
113787-72-7

(R)-2-chloropropyl p-toluenesulfonate

Conditions
ConditionsYield
With pyridine 1.) 0 deg C, 1.5 h; 2.) up to r.t. 15 h;78%
(R)-(-)-2-chloro-propan-1-ol
37493-14-4

(R)-(-)-2-chloro-propan-1-ol

4-Ethoxycarbonyloxybenzoyl chloride
57045-26-8

4-Ethoxycarbonyloxybenzoyl chloride

(R)-(2-Chloropropyl)-4-ethoxycarbonyloxybenzoate
189076-28-6

(R)-(2-Chloropropyl)-4-ethoxycarbonyloxybenzoate

Conditions
ConditionsYield
With potassium carbonate In diethyl ether for 5h; Heating;72.7%
p-nitrocinnamic acid
619-89-6

p-nitrocinnamic acid

(R)-(-)-2-chloro-propan-1-ol
37493-14-4

(R)-(-)-2-chloro-propan-1-ol

p-Aminozimtsaeure-R(-)-2-chlorpropylester

p-Aminozimtsaeure-R(-)-2-chlorpropylester

Conditions
ConditionsYield
(i) SOCl2, (ii) /BRN= 6312547/, (iii) FeCl2, NH3; Multistep reaction;
trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

(R)-(-)-2-chloro-propan-1-ol
37493-14-4

(R)-(-)-2-chloro-propan-1-ol

(2R)-1-trifluoromethanesulfonyloxy-2-chloropropane
120723-94-6

(2R)-1-trifluoromethanesulfonyloxy-2-chloropropane

Conditions
ConditionsYield
With pyridine In dichloromethane at -60℃;
With pyridine In dichloromethane at -50℃; for 0.5h;11.7 g
4-(4-octoxyphenyl)benzoyl chloride
62918-50-7

4-(4-octoxyphenyl)benzoyl chloride

(R)-(-)-2-chloro-propan-1-ol
37493-14-4

(R)-(-)-2-chloro-propan-1-ol

4'-Octyloxy-biphenyl-4-carboxylic acid (R)-2-chloro-propyl ester

4'-Octyloxy-biphenyl-4-carboxylic acid (R)-2-chloro-propyl ester

Conditions
ConditionsYield
With pyridine In toluene for 48h;
4'-hexyloxy-4-biphenylcarboxylic acid chloride
62918-49-4

4'-hexyloxy-4-biphenylcarboxylic acid chloride

(R)-(-)-2-chloro-propan-1-ol
37493-14-4

(R)-(-)-2-chloro-propan-1-ol

4'-Hexyloxy-biphenyl-4-carboxylic acid (R)-2-chloro-propyl ester

4'-Hexyloxy-biphenyl-4-carboxylic acid (R)-2-chloro-propyl ester

Conditions
ConditionsYield
With pyridine In toluene for 48h;
(R)-(-)-2-chloro-propan-1-ol
37493-14-4

(R)-(-)-2-chloro-propan-1-ol

4'-pentyloxybiphenyl-4-carboxylic acid chloride
94610-77-2

4'-pentyloxybiphenyl-4-carboxylic acid chloride

4'-Pentyloxy-biphenyl-4-carboxylic acid (R)-2-chloro-propyl ester

4'-Pentyloxy-biphenyl-4-carboxylic acid (R)-2-chloro-propyl ester

Conditions
ConditionsYield
With pyridine In toluene for 48h;
(R)-(-)-2-chloro-propan-1-ol
37493-14-4

(R)-(-)-2-chloro-propan-1-ol

4-hydroxy-benzoic acid
99-96-7

4-hydroxy-benzoic acid

(R)-(2-Chloropropyl)-4-hydroxybenzoate
115146-67-3

(R)-(2-Chloropropyl)-4-hydroxybenzoate

Conditions
ConditionsYield
With toluene-4-sulfonic acid In benzene for 12h; Heating;
(R)-(-)-2-chloro-propan-1-ol
37493-14-4

(R)-(-)-2-chloro-propan-1-ol

4-nitro-benzoic acid
62-23-7

4-nitro-benzoic acid

4-Nitro-benzoic acid (R)-2-chloro-propyl ester
110928-53-5

4-Nitro-benzoic acid (R)-2-chloro-propyl ester

Conditions
ConditionsYield
In pyridine

(R)-(-)-2-Chloropropan-1-ol Specification

The (R)-(-)-2-Chloropropan-1-ol with the CAS number 37493-14-4 is also called 1-Propanol, 2-chloro-,(2R)- (9CI). Both the systematic name and IUPAC name are (2R)-2-chloropropan-1-ol. Its molecular formula is C3H7ClO. This chemical belongs to the following product categories: (1)Chiral; (2)API intermediates.

The properties of the (R)-(-)-2-Chloropropan-1-ol are: (1)ACD/LogP: 0.27; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.27; (4)ACD/LogD (pH 7.4): 0.27; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 33.34; (8)ACD/KOC (pH 7.4): 33.34; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 9.23 Å2; (13)Index of Refraction: 1.424; (14)Molar Refractivity: 22.29 cm3; (15)Molar Volume: 87.3 cm3; (16)Polarizability: 8.83×10-24cm3; (17)Surface Tension: 29.8 dyne/cm; (18)Enthalpy of Vaporization: 43.23 kJ/mol; (19)Vapour Pressure: 3.68 mmHg at 25°C.

While using this chemical, you should be very cautious. This chemical is flammable and harmful by inhalation, in contact with skin and if swallowed. It is not only irritating to skin, but also irritating to eyes and respiratory system. Therefore, you should take the following instructions. Firstly, you should wear suitable protective clothing, gloves and eye/face protection. Secondly in case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Thirdly you should keep this chemical away from sources of ignition. Finally you should take off immediately all contaminated clothing.

You can still convert the following datas into molecular structure:
(1)SMILES: Cl[C@H](C)CO
(2)InChI: InChI=1/C3H7ClO/c1-3(4)2-5/h3,5H,2H2,1H3/t3-/m1/s1
(3)InChIKey: VZIQXGLTRZLBEX-GSVOUGTGBS

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