Product Name

  • Name

    (R)-3-Methylmorpholine

  • EINECS
  • CAS No. 74572-04-6
  • Article Data10
  • CAS DataBase
  • Density 0.891 g/cm3
  • Solubility
  • Melting Point
  • Formula C5H11NO
  • Boiling Point 137.1 °C at 760 mmHg
  • Molecular Weight 101.148
  • Flash Point 41.3 °C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 74572-04-6 ((R)-3-Methylmorpholine)
  • Hazard Symbols
  • Synonyms Morpholine,3-methyl-, (R)-;(3R)-3-Methylmorpholine;(R)-3-Methylmorpholine;
  • PSA 21.26000
  • LogP 0.32350

Synthetic route

(R)-4-(4-methoxybenzyl)-3-methylmorpholine
954133-47-2

(R)-4-(4-methoxybenzyl)-3-methylmorpholine

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In methanol at 50℃; under 9500.64 Torr; for 18h;83%
(5R)-5-methylmorpholin-3-one
119844-67-6

(5R)-5-methylmorpholin-3-one

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 16h;75%
Stage #1: (5R)-5-methylmorpholin-3-one With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 15.5h; Heating / reflux;
Stage #2: With hydrogenchloride; ethanol In tetrahydrofuran
(R)-2-(2-hydroxyethylamino)propan-1-ol

(R)-2-(2-hydroxyethylamino)propan-1-ol

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

Conditions
ConditionsYield
Stage #1: (R)-2-(2-hydroxyethylamino)propan-1-ol With sulfuric acid at 140℃; for 14h;
Stage #2: With sodium hydroxide In water at 0℃;
65%
2-(prop-2-yn-1-yloxy)ethan-1-amine
122116-12-5

2-(prop-2-yn-1-yloxy)ethan-1-amine

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

Conditions
ConditionsYield
Stage #1: 2-(prop-2-yn-1-yloxy)ethan-1-amine With C42H58N4O2Ti In toluene at 110℃; for 14h; Inert atmosphere; Schlenk technique;
Stage #2: With formic acid; [{(1S,2S-N-p-toluenesulfonyl-1,2-diphenylethanediamine)}(η6-p-cymene)RuCl]; triethylamine In N,N-dimethyl-formamide; toluene at 20℃; for 14h; Inert atmosphere; Schlenk technique; enantioselective reaction;
65%
Multi-step reaction with 2 steps
1: bis(N-2,6-diisoprpylphenylbenzamidato)bis(dimethylamido)titanium (IV) / toluene / 14 h / 110 °C / Inert atmosphere; Glovebox; Schlenk technique; Sealed tube
2: formic acid; [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); triethylamine / N,N-dimethyl-formamide / 23 °C / Inert atmosphere; Schlenk technique
View Scheme
Multi-step reaction with 2 steps
1: bis(N-2,6-diisoprpylphenylbenzamidato)bis(dimethylamido)titanium (IV) / toluene / 14 h / 110 °C / Inert atmosphere; Glovebox; Schlenk technique; Sealed tube
2: formic acid; silver trifluoromethanesulfonate; [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); triethylamine / N,N-dimethyl-formamide / 16 h / 23 °C / Inert atmosphere; Schlenk technique
View Scheme
(3R)-3-methyl-4-(phenylmethyl)morpholine
74571-98-5

(3R)-3-methyl-4-(phenylmethyl)morpholine

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal at 80℃; under 45600 - 60800 Torr; for 2h;
With hydrogen; palladium 10% on activated carbon In ethanol under 2585.81 Torr;
With hydrogen; hydrogenchloride; palladium 10% on activated carbon In 1,4-dioxane; ethyl acetate under 2068.65 Torr; for 18h;
(R)-2-[Benzyl-(2-hydroxy-ethyl)-amino]-propan-1-ol
74571-95-2

(R)-2-[Benzyl-(2-hydroxy-ethyl)-amino]-propan-1-ol

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70percent H2SO4 / 15 h / 140 °C
2: H2 / 10percent Pd/C / 2 h / 80 °C / 45600 - 60800 Torr
View Scheme
(R)-2-bromo-N-(1-hydroxypropan-2-yl)-N-(4-methoxybenzyl)acetamide
1445590-35-1

(R)-2-bromo-N-(1-hydroxypropan-2-yl)-N-(4-methoxybenzyl)acetamide

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydride / tetrahydrofuran / 25 °C / Inert atmosphere
2: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux
3: palladium on activated charcoal; hydrogen / methanol / 18 h / 50 °C / 9500.64 Torr
View Scheme
(R)-4-(4-methoxybenzyl)-5-methylmorpholin-3-one
570398-22-0

(R)-4-(4-methoxybenzyl)-5-methylmorpholin-3-one

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux
2: palladium on activated charcoal; hydrogen / methanol / 18 h / 50 °C / 9500.64 Torr
View Scheme
3-methylmorpholine
42185-06-8

3-methylmorpholine

C14H15NO4

C14H15NO4

A

C8H15NO2

C8H15NO2

B

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

Conditions
ConditionsYield
In dichloromethane at 23℃; Inert atmosphere;
2-chloro-N-(2-hydroxy-1-methyl-ethyl)-acetamide
1057322-63-0

2-chloro-N-(2-hydroxy-1-methyl-ethyl)-acetamide

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium tert-butylate / dichloromethane; isopropyl alcohol / 1 h / 0 - 20 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C
View Scheme
C5H9NO

C5H9NO

A

(S)-3-methylmorpholine
350595-57-2

(S)-3-methylmorpholine

B

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

Conditions
ConditionsYield
With [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); formic acid; silver trifluoromethanesulfonate; triethylamine In N,N-dimethyl-formamide at 23℃; for 16h; Inert atmosphere; Schlenk technique; enantioselective reaction;A n/a
B n/a
C5H9NO

C5H9NO

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

Conditions
ConditionsYield
With [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); formic acid; triethylamine In N,N-dimethyl-formamide at 23℃; Reagent/catalyst; Inert atmosphere; Schlenk technique; enantioselective reaction;n/a
N-(tert-butyloxycarbonyl)-2-(propargyloxy)aminoethane
634926-63-9

N-(tert-butyloxycarbonyl)-2-(propargyloxy)aminoethane

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: methanol / 0 - 23 °C
2: bis(N-2,6-diisoprpylphenylbenzamidato)bis(dimethylamido)titanium (IV) / toluene / 14 h / 110 °C / Inert atmosphere; Glovebox; Schlenk technique; Sealed tube
3: formic acid; [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); triethylamine / N,N-dimethyl-formamide / 23 °C / Inert atmosphere; Schlenk technique
View Scheme
Multi-step reaction with 3 steps
1: methanol / 0 - 23 °C
2: bis(N-2,6-diisoprpylphenylbenzamidato)bis(dimethylamido)titanium (IV) / toluene / 14 h / 110 °C / Inert atmosphere; Glovebox; Schlenk technique; Sealed tube
3: formic acid; silver trifluoromethanesulfonate; [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); triethylamine / N,N-dimethyl-formamide / 16 h / 23 °C / Inert atmosphere; Schlenk technique
View Scheme
4,6-Dichloro-2-(methylthio)pyrimidine
6299-25-8

4,6-Dichloro-2-(methylthio)pyrimidine

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

(3R)-4-[6-chloro-2-(methylsulfanyl)pyrimidin-4-yl]-3-methylmorpholine

(3R)-4-[6-chloro-2-(methylsulfanyl)pyrimidin-4-yl]-3-methylmorpholine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 40℃; for 16h;99%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 40℃;68.1%
3,6-di-bromo-isothiazolo[4,3-b]pyridine

3,6-di-bromo-isothiazolo[4,3-b]pyridine

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

(R)-4-(6-bromoisothiazolo[4,3-b]pyridin-3-yl)-3-methylmorpholine

(R)-4-(6-bromoisothiazolo[4,3-b]pyridin-3-yl)-3-methylmorpholine

Conditions
ConditionsYield
In ethanol Reflux;97%
2-chloro-N-methyl-N-(6-(2-morphplino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-2-yl)acetamide
1257236-41-1

2-chloro-N-methyl-N-(6-(2-morphplino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-2-yl)acetamide

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

N-methyl-2-[(3R)-3-methylmorpholin-4-yl]-N-[6-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-2-yl]acetamide
1257234-75-5

N-methyl-2-[(3R)-3-methylmorpholin-4-yl]-N-[6-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-2-yl]acetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane; ISOPROPYLAMIDE at 60℃; for 2h;95%
(1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid
1445591-92-3

(1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

((1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentyl)((R)-3-methylmorpholino)methanone
1445590-41-9

((1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentyl)((R)-3-methylmorpholino)methanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0 - 20℃; for 2h;95%
(1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylic acid
1445592-12-0

(1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylic acid

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

((1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentyl)((R)-3-methylmorpholino)methanone
1445590-87-3

((1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentyl)((R)-3-methylmorpholino)methanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 2h;95%
(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

acetyl chloride
75-36-5

acetyl chloride

1-[(3R)-3-methylmorpholin-4-yl]ethan-1-one
1257237-31-2

1-[(3R)-3-methylmorpholin-4-yl]ethan-1-one

Conditions
ConditionsYield
Stage #1: (3R)-3-methylmorpholine With potassium carbonate In dichloromethane at 20℃; for 0.5h;
Stage #2: acetyl chloride In dichloromethane at 20℃; for 18h;
95%
Stage #1: (3R)-3-methylmorpholine With potassium carbonate In dichloromethane at 0℃; for 0.5h;
Stage #2: acetyl chloride In dichloromethane at 25℃; for 16h;
88%
Stage #1: (3R)-3-methylmorpholine With potassium carbonate In dichloromethane at 20℃; for 0.5h;
Stage #2: acetyl chloride In dichloromethane at 20℃; for 18h;
2,4-dichloro-6-piperidin-1-yl-[1,3,5]triazine
19371-31-4

2,4-dichloro-6-piperidin-1-yl-[1,3,5]triazine

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

2-chloro-4-[(3R)-3-methylmorpholin-4-yl]-6-(piperidin-1-yl)-1,3,5-triazine

2-chloro-4-[(3R)-3-methylmorpholin-4-yl]-6-(piperidin-1-yl)-1,3,5-triazine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane; dichloromethane at 20℃;95%
(8S)-2-chloro-3-fluoro-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one
1260585-63-4

(8S)-2-chloro-3-fluoro-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

(2S)-7-fluoro-8-[(3R)-3-methylmorpholin-4-yl]-2-(trifluoromethyl)-1,2,3,4-tetrahydropyrimido[1,2-a]pyrimidin-6-one
1523412-61-4

(2S)-7-fluoro-8-[(3R)-3-methylmorpholin-4-yl]-2-(trifluoromethyl)-1,2,3,4-tetrahydropyrimido[1,2-a]pyrimidin-6-one

Conditions
ConditionsYield
at 100℃; for 18h;91%
2,6-Dichloro-4-morpholino-1,3,5-triazine
6601-22-5

2,6-Dichloro-4-morpholino-1,3,5-triazine

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

2-chloro-4-[(3R)-3-methylmorpholin-4-yl]-6-(morpholin-4-yl)-1,3,5-triazine

2-chloro-4-[(3R)-3-methylmorpholin-4-yl]-6-(morpholin-4-yl)-1,3,5-triazine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In ethanol at 0 - 20℃; Suzuki Coupling;91%
With N-ethyl-N,N-diisopropylamine In ethanol at 0 - 20℃;91%
With N-ethyl-N,N-diisopropylamine In ethanol at 0 - 20℃;
With N-ethyl-N,N-diisopropylamine
1,3,5-trichloro-2,4,6-triazine
108-77-0

1,3,5-trichloro-2,4,6-triazine

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

(3R,3′R)-4,4′-(6-chloro-1,3,5-triazine-2,4-diyl)bis(3-methylmorpholine)

(3R,3′R)-4,4′-(6-chloro-1,3,5-triazine-2,4-diyl)bis(3-methylmorpholine)

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;91%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;91%
In dichloromethane at 0 - 20℃;
(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

2,4-dichloro-6-(4-nitrophenyl)-1,3,5-triazine
90415-38-6

2,4-dichloro-6-(4-nitrophenyl)-1,3,5-triazine

(R)-4-(4-chloro-6-(4-nitrophenyl)-1,3,5-triazin-2-yl)-3-methylmorpholine

(R)-4-(4-chloro-6-(4-nitrophenyl)-1,3,5-triazin-2-yl)-3-methylmorpholine

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; acetone at 0 - 20℃; for 20h;90%
3-(2,6-difluoropyridin-4-yl)-4-methylaniline

3-(2,6-difluoropyridin-4-yl)-4-methylaniline

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

(R)-3-(2-fluoro-6-(3-methylmorpholino)pyridin-4-yl)-4-methylaniline

(R)-3-(2-fluoro-6-(3-methylmorpholino)pyridin-4-yl)-4-methylaniline

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 100℃; for 18h;90%
(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

6-bromo-4-chlorothieno[2,3-d]pyrimidine
56844-12-3

6-bromo-4-chlorothieno[2,3-d]pyrimidine

(R)-4-(6-bromothieno[2,3-d]pyrimidin-4-yl)-3-methylmorpholine

(R)-4-(6-bromothieno[2,3-d]pyrimidin-4-yl)-3-methylmorpholine

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane at 100℃;88%
2,6-dichloropyrimidine-4-carbonitrile

2,6-dichloropyrimidine-4-carbonitrile

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

2-chloro-6-[(3R)-3-methylmorpholin-4-yl]pyrimidine-4-carbonitrile

2-chloro-6-[(3R)-3-methylmorpholin-4-yl]pyrimidine-4-carbonitrile

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 1.5h;87.47%
(3R,5S)-4-(4,6-dichloro-1,3,5-triazin-2-yl)-3,5-dimethylmorpholine

(3R,5S)-4-(4,6-dichloro-1,3,5-triazin-2-yl)-3,5-dimethylmorpholine

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

(3R,5S)-4-(4-chloro-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)-3,5-dimethylmorpholine

(3R,5S)-4-(4-chloro-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)-3,5-dimethylmorpholine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃;87%
2,6-dichloro-4-pyrimidinecarboxylic acid
16492-28-7

2,6-dichloro-4-pyrimidinecarboxylic acid

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

methyl 2-chloro-6-[(3R)-3-methylmorpholin-4-yl]pyrimidine-4-carboxylate
1233339-69-9

methyl 2-chloro-6-[(3R)-3-methylmorpholin-4-yl]pyrimidine-4-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 18h;86%
(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

2,6-dichloropyrimidine-4-carboxylic acid methyl ester
6299-85-0

2,6-dichloropyrimidine-4-carboxylic acid methyl ester

methyl 2-chloro-6-[(3R)-3-methylmorpholin-4-yl]pyrimidine-4-carboxylate
1233339-69-9

methyl 2-chloro-6-[(3R)-3-methylmorpholin-4-yl]pyrimidine-4-carboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 18h;86%
With triethylamine In dichloromethane at 20℃; for 18h;79.19%
With triethylamine In dichloromethane at 20℃; for 16h; Temperature;70%
With triethylamine In dichloromethane at 20℃; for 18h; Inert atmosphere;9%
2,6-dichloro-3-nitropyridin-4-amine
2897-43-0

2,6-dichloro-3-nitropyridin-4-amine

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

(R)-6-chloro-2-(3-methylmorpholino)-3-nitropyridin-4-amine

(R)-6-chloro-2-(3-methylmorpholino)-3-nitropyridin-4-amine

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl acetamide at 80℃; for 3h;86%
bromobenzene
108-86-1

bromobenzene

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

(R)-3-methyl-4-phenylmorpholine

(R)-3-methyl-4-phenylmorpholine

Conditions
ConditionsYield
With bis(tri-tert-butylphasphine)palladium dichloride; potassium tert-butylate In toluene for 3h; Reflux;84%
With copper(l) iodide; potassium carbonate; L-proline In dimethyl sulfoxide at 90℃; for 24h;5%
(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

(R)-3-methyl-4-tosylmorpholine
1438397-95-5

(R)-3-methyl-4-tosylmorpholine

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;83%
With triethylamine In dichloromethane at 0 - 23℃;
(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

piperic acid
136-72-1

piperic acid

(2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-1-((R)-3-methylmorpholino)penta-2,4-dien-1-one

(2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-1-((R)-3-methylmorpholino)penta-2,4-dien-1-one

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 8h;83%
(1S,2S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid hydrochloride

(1S,2S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid hydrochloride

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

((1S,2S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentyl)((R)-3-methylmorpholino)methanone
1445590-70-4

((1S,2S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentyl)((R)-3-methylmorpholino)methanone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 2h;82%
2,4,6-trichloropyrimidine
3764-01-0

2,4,6-trichloropyrimidine

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

(3R)-4-(2,6-dichloropyrimidin-4-yl)-3-methylmorpholine

(3R)-4-(2,6-dichloropyrimidin-4-yl)-3-methylmorpholine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In ethanol at 65℃; for 12h; Cooling with ice;81.2%
With triethylamine In ethanol at 20℃; for 16h;71%
With triethylamine In ethanol at 20℃; for 16h;71%
2,4-dichloro-6-((methylsulfonyl)methyl)pyrimidine

2,4-dichloro-6-((methylsulfonyl)methyl)pyrimidine

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

(R)-4-(2-chloro-6-(methylsulfonylmethyl)pyrimidin-4-yl)-3-methylmorpholine
1233339-73-5

(R)-4-(2-chloro-6-(methylsulfonylmethyl)pyrimidin-4-yl)-3-methylmorpholine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;81%
5,7-dichloro-[1,3]thiazolo[5,4-d]pyrimidine
13479-88-4

5,7-dichloro-[1,3]thiazolo[5,4-d]pyrimidine

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

(R)-4-(5-chlorothiazolo[5,4-d]pyrimidin-7-yl)-3-methylmorpholine

(R)-4-(5-chlorothiazolo[5,4-d]pyrimidin-7-yl)-3-methylmorpholine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 20℃; for 1.5h; Inert atmosphere;80%
ethyl 2-(4-formylphenyl)thiazole-4-carboxylate

ethyl 2-(4-formylphenyl)thiazole-4-carboxylate

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

(R)-2-(4-((3-methylmorpholine)methyl)phenyl)thiazole-4-carboxylic acid ethyl ester

(R)-2-(4-((3-methylmorpholine)methyl)phenyl)thiazole-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: ethyl 2-(4-formylphenyl)thiazole-4-carboxylate; (3R)-3-methylmorpholine In dichloromethane at 20 - 30℃; for 0.5h; Inert atmosphere;
Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 30℃; for 16h; Cooling with ice;
77.3%
1,3,5-trichloro-2,4,6-triazine
108-77-0

1,3,5-trichloro-2,4,6-triazine

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

2,4-dichloro-6-[(3R)-3-methylmorpholin-4-yl]-1,3,5-triazine

2,4-dichloro-6-[(3R)-3-methylmorpholin-4-yl]-1,3,5-triazine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at -50℃; for 2h;76%
With N-ethyl-N,N-diisopropylamine In dichloromethane at -50℃; for 2h;76%
With N-ethyl-N,N-diisopropylamine In dichloromethane at -50℃; for 10h;
4,6-dichloro-5-nitropyrimidine
4316-93-2

4,6-dichloro-5-nitropyrimidine

(3R)-3-methylmorpholine
74572-04-6

(3R)-3-methylmorpholine

(R)-4-(6-chloro-5-nitropyrimidin-4-yl)-3-methylmorpholine

(R)-4-(6-chloro-5-nitropyrimidin-4-yl)-3-methylmorpholine

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0℃; for 0.5h;75%

(R)-3-Methylmorpholine Specification

The cas register number of (R)-3-Methylmorpholine is 74572-04-6. It also can be called as Morpholine,3-methyl-, (3R)- and the Systematic name about this chemical is Morpholine,3-methyl-, (3R)-.

Physical properties about (R)-3-Methylmorpholine are: (1)ACD/LogP: -0.59; (2)ACD/LogD (pH 5.5): -3.55; (3)ACD/LogD (pH 7.4): -2.22; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)Polar Surface Area: 12.47Å2; (11)Index of Refraction: 1.409; (12)Molar Refractivity: 28.1 cm3; (13)Molar Volume: 113.5 cm3; (14)Polarizability: 11.14x10-24cm3; (15)Surface Tension: 26.2 dyne/cm; (16)Enthalpy of Vaporization: 37.45 kJ/mol; (17)Vapour Pressure: 7.14 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O1C[C@H](NCC1)C
(2)InChI: InChI=1/C5H11NO/c1-5-4-7-3-2-6-5/h5-6H,2-4H2,1H3/t5-/m1/s1
(3)InChIKey: SFWWGMKXCYLZEG-RXMQYKEDBJ
(4)Std. InChI: InChI=1S/C5H11NO/c1-5-4-7-3-2-6-5/h5-6H,2-4H2,1H3/t5-/m1/s1
(5)Std. InChIKey: SFWWGMKXCYLZEG-RXMQYKEDSA-N

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