(R)-4-(4-methoxybenzyl)-3-methylmorpholine
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen In methanol at 50℃; under 9500.64 Torr; for 18h; | 83% |
(5R)-5-methylmorpholin-3-one
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 16h; | 75% |
Stage #1: (5R)-5-methylmorpholin-3-one With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 15.5h; Heating / reflux; Stage #2: With hydrogenchloride; ethanol In tetrahydrofuran |
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
Stage #1: (R)-2-(2-hydroxyethylamino)propan-1-ol With sulfuric acid at 140℃; for 14h; Stage #2: With sodium hydroxide In water at 0℃; | 65% |
2-(prop-2-yn-1-yloxy)ethan-1-amine
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
Stage #1: 2-(prop-2-yn-1-yloxy)ethan-1-amine With C42H58N4O2Ti In toluene at 110℃; for 14h; Inert atmosphere; Schlenk technique; Stage #2: With formic acid; [{(1S,2S-N-p-toluenesulfonyl-1,2-diphenylethanediamine)}(η6-p-cymene)RuCl]; triethylamine In N,N-dimethyl-formamide; toluene at 20℃; for 14h; Inert atmosphere; Schlenk technique; enantioselective reaction; | 65% |
Multi-step reaction with 2 steps 1: bis(N-2,6-diisoprpylphenylbenzamidato)bis(dimethylamido)titanium (IV) / toluene / 14 h / 110 °C / Inert atmosphere; Glovebox; Schlenk technique; Sealed tube 2: formic acid; [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); triethylamine / N,N-dimethyl-formamide / 23 °C / Inert atmosphere; Schlenk technique View Scheme | |
Multi-step reaction with 2 steps 1: bis(N-2,6-diisoprpylphenylbenzamidato)bis(dimethylamido)titanium (IV) / toluene / 14 h / 110 °C / Inert atmosphere; Glovebox; Schlenk technique; Sealed tube 2: formic acid; silver trifluoromethanesulfonate; [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); triethylamine / N,N-dimethyl-formamide / 16 h / 23 °C / Inert atmosphere; Schlenk technique View Scheme |
(3R)-3-methyl-4-(phenylmethyl)morpholine
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal at 80℃; under 45600 - 60800 Torr; for 2h; | |
With hydrogen; palladium 10% on activated carbon In ethanol under 2585.81 Torr; | |
With hydrogen; hydrogenchloride; palladium 10% on activated carbon In 1,4-dioxane; ethyl acetate under 2068.65 Torr; for 18h; |
(R)-2-[Benzyl-(2-hydroxy-ethyl)-amino]-propan-1-ol
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 70percent H2SO4 / 15 h / 140 °C 2: H2 / 10percent Pd/C / 2 h / 80 °C / 45600 - 60800 Torr View Scheme |
(R)-2-bromo-N-(1-hydroxypropan-2-yl)-N-(4-methoxybenzyl)acetamide
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydride / tetrahydrofuran / 25 °C / Inert atmosphere 2: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux 3: palladium on activated charcoal; hydrogen / methanol / 18 h / 50 °C / 9500.64 Torr View Scheme |
(R)-4-(4-methoxybenzyl)-5-methylmorpholin-3-one
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / Inert atmosphere; Reflux 2: palladium on activated charcoal; hydrogen / methanol / 18 h / 50 °C / 9500.64 Torr View Scheme |
Conditions | Yield |
---|---|
In dichloromethane at 23℃; Inert atmosphere; |
2-chloro-N-(2-hydroxy-1-methyl-ethyl)-acetamide
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium tert-butylate / dichloromethane; isopropyl alcohol / 1 h / 0 - 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C View Scheme |
Conditions | Yield |
---|---|
With [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); formic acid; silver trifluoromethanesulfonate; triethylamine In N,N-dimethyl-formamide at 23℃; for 16h; Inert atmosphere; Schlenk technique; enantioselective reaction; | A n/a B n/a |
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
With [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); formic acid; triethylamine In N,N-dimethyl-formamide at 23℃; Reagent/catalyst; Inert atmosphere; Schlenk technique; enantioselective reaction; | n/a |
N-(tert-butyloxycarbonyl)-2-(propargyloxy)aminoethane
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: methanol / 0 - 23 °C 2: bis(N-2,6-diisoprpylphenylbenzamidato)bis(dimethylamido)titanium (IV) / toluene / 14 h / 110 °C / Inert atmosphere; Glovebox; Schlenk technique; Sealed tube 3: formic acid; [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); triethylamine / N,N-dimethyl-formamide / 23 °C / Inert atmosphere; Schlenk technique View Scheme | |
Multi-step reaction with 3 steps 1: methanol / 0 - 23 °C 2: bis(N-2,6-diisoprpylphenylbenzamidato)bis(dimethylamido)titanium (IV) / toluene / 14 h / 110 °C / Inert atmosphere; Glovebox; Schlenk technique; Sealed tube 3: formic acid; silver trifluoromethanesulfonate; [(1S,2S)-N-(p-toluensulfonyl)-1,2-diphenylethanediamine](p-cymene)ruthenium (I); triethylamine / N,N-dimethyl-formamide / 16 h / 23 °C / Inert atmosphere; Schlenk technique View Scheme |
4,6-Dichloro-2-(methylthio)pyrimidine
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 40℃; for 16h; | 99% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 40℃; | 68.1% |
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
In ethanol Reflux; | 97% |
2-chloro-N-methyl-N-(6-(2-morphplino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-2-yl)acetamide
(3R)-3-methylmorpholine
N-methyl-2-[(3R)-3-methylmorpholin-4-yl]-N-[6-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-2-yl]acetamide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane; ISOPROPYLAMIDE at 60℃; for 2h; | 95% |
(1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentanecarboxylic acid
(3R)-3-methylmorpholine
((1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentyl)((R)-3-methylmorpholino)methanone
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 0 - 20℃; for 2h; | 95% |
(1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentanecarboxylic acid
(3R)-3-methylmorpholine
((1R,2R)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)-4-methoxycyclopentyl)((R)-3-methylmorpholino)methanone
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 2h; | 95% |
(3R)-3-methylmorpholine
acetyl chloride
1-[(3R)-3-methylmorpholin-4-yl]ethan-1-one
Conditions | Yield |
---|---|
Stage #1: (3R)-3-methylmorpholine With potassium carbonate In dichloromethane at 20℃; for 0.5h; Stage #2: acetyl chloride In dichloromethane at 20℃; for 18h; | 95% |
Stage #1: (3R)-3-methylmorpholine With potassium carbonate In dichloromethane at 0℃; for 0.5h; Stage #2: acetyl chloride In dichloromethane at 25℃; for 16h; | 88% |
Stage #1: (3R)-3-methylmorpholine With potassium carbonate In dichloromethane at 20℃; for 0.5h; Stage #2: acetyl chloride In dichloromethane at 20℃; for 18h; |
2,4-dichloro-6-piperidin-1-yl-[1,3,5]triazine
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane; dichloromethane at 20℃; | 95% |
(8S)-2-chloro-3-fluoro-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one
(3R)-3-methylmorpholine
(2S)-7-fluoro-8-[(3R)-3-methylmorpholin-4-yl]-2-(trifluoromethyl)-1,2,3,4-tetrahydropyrimido[1,2-a]pyrimidin-6-one
Conditions | Yield |
---|---|
at 100℃; for 18h; | 91% |
2,6-Dichloro-4-morpholino-1,3,5-triazine
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In ethanol at 0 - 20℃; Suzuki Coupling; | 91% |
With N-ethyl-N,N-diisopropylamine In ethanol at 0 - 20℃; | 91% |
With N-ethyl-N,N-diisopropylamine In ethanol at 0 - 20℃; | |
With N-ethyl-N,N-diisopropylamine |
1,3,5-trichloro-2,4,6-triazine
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; | 91% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; | 91% |
In dichloromethane at 0 - 20℃; |
(3R)-3-methylmorpholine
2,4-dichloro-6-(4-nitrophenyl)-1,3,5-triazine
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In water; acetone at 0 - 20℃; for 20h; | 90% |
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 100℃; for 18h; | 90% |
(3R)-3-methylmorpholine
6-bromo-4-chlorothieno[2,3-d]pyrimidine
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane at 100℃; | 88% |
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 1.5h; | 87.47% |
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; | 87% |
2,6-dichloro-4-pyrimidinecarboxylic acid
(3R)-3-methylmorpholine
methyl 2-chloro-6-[(3R)-3-methylmorpholin-4-yl]pyrimidine-4-carboxylate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 18h; | 86% |
(3R)-3-methylmorpholine
2,6-dichloropyrimidine-4-carboxylic acid methyl ester
methyl 2-chloro-6-[(3R)-3-methylmorpholin-4-yl]pyrimidine-4-carboxylate
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 18h; | 86% |
With triethylamine In dichloromethane at 20℃; for 18h; | 79.19% |
With triethylamine In dichloromethane at 20℃; for 16h; Temperature; | 70% |
With triethylamine In dichloromethane at 20℃; for 18h; Inert atmosphere; | 9% |
2,6-dichloro-3-nitropyridin-4-amine
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
With triethylamine In N,N-dimethyl acetamide at 80℃; for 3h; | 86% |
Conditions | Yield |
---|---|
With bis(tri-tert-butylphasphine)palladium dichloride; potassium tert-butylate In toluene for 3h; Reflux; | 84% |
With copper(l) iodide; potassium carbonate; L-proline In dimethyl sulfoxide at 90℃; for 24h; | 5% |
(3R)-3-methylmorpholine
p-toluenesulfonyl chloride
(R)-3-methyl-4-tosylmorpholine
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; | 83% |
With triethylamine In dichloromethane at 0 - 23℃; |
(3R)-3-methylmorpholine
piperic acid
Conditions | Yield |
---|---|
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 8h; | 83% |
(3R)-3-methylmorpholine
((1S,2S)-2-(5-(4-bromophenyl)-1H-imidazol-2-yl)cyclopentyl)((R)-3-methylmorpholino)methanone
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 2h; | 82% |
2,4,6-trichloropyrimidine
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In ethanol at 65℃; for 12h; Cooling with ice; | 81.2% |
With triethylamine In ethanol at 20℃; for 16h; | 71% |
With triethylamine In ethanol at 20℃; for 16h; | 71% |
(3R)-3-methylmorpholine
(R)-4-(2-chloro-6-(methylsulfonylmethyl)pyrimidin-4-yl)-3-methylmorpholine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h; | 81% |
5,7-dichloro-[1,3]thiazolo[5,4-d]pyrimidine
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 20℃; for 1.5h; Inert atmosphere; | 80% |
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
Stage #1: ethyl 2-(4-formylphenyl)thiazole-4-carboxylate; (3R)-3-methylmorpholine In dichloromethane at 20 - 30℃; for 0.5h; Inert atmosphere; Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 30℃; for 16h; Cooling with ice; | 77.3% |
1,3,5-trichloro-2,4,6-triazine
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at -50℃; for 2h; | 76% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at -50℃; for 2h; | 76% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at -50℃; for 10h; |
4,6-dichloro-5-nitropyrimidine
(3R)-3-methylmorpholine
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 0℃; for 0.5h; | 75% |
The cas register number of (R)-3-Methylmorpholine is 74572-04-6. It also can be called as Morpholine,3-methyl-, (3R)- and the Systematic name about this chemical is Morpholine,3-methyl-, (3R)-.
Physical properties about (R)-3-Methylmorpholine are: (1)ACD/LogP: -0.59; (2)ACD/LogD (pH 5.5): -3.55; (3)ACD/LogD (pH 7.4): -2.22; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)Polar Surface Area: 12.47Å2; (11)Index of Refraction: 1.409; (12)Molar Refractivity: 28.1 cm3; (13)Molar Volume: 113.5 cm3; (14)Polarizability: 11.14x10-24cm3; (15)Surface Tension: 26.2 dyne/cm; (16)Enthalpy of Vaporization: 37.45 kJ/mol; (17)Vapour Pressure: 7.14 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: O1C[C@H](NCC1)C
(2)InChI: InChI=1/C5H11NO/c1-5-4-7-3-2-6-5/h5-6H,2-4H2,1H3/t5-/m1/s1
(3)InChIKey: SFWWGMKXCYLZEG-RXMQYKEDBJ
(4)Std. InChI: InChI=1S/C5H11NO/c1-5-4-7-3-2-6-5/h5-6H,2-4H2,1H3/t5-/m1/s1
(5)Std. InChIKey: SFWWGMKXCYLZEG-RXMQYKEDSA-N
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View