(S)-(-)-1-(1-Naphthyl)ethylamine supplier

Name
(S)-(-)-1-(1-Naphthyl)ethylamine
EINECS 223-425-5
CAS No. 10420-89-0
Article Data48
CAS DataBase
Density 1.067
Solubility
Melting Point
Formula C₁₂H₁₃N
Boiling Point 289.9 °C at 760 mmHg
Molecular Weight 171.242
Flash Point 144.3 °C
Transport Information
Appearance Colorless to light yellow liqui
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols
Synonyms 1-Naphthalenemethanamine, alpha-methyl-, (alphaS)-;1-Naphthalenemethanamine, alpha-methyl-, (S)-(-)-;(S)-alpha-Methyl-1-naphthalenemethanamine;[(1S)-1-naphthalen-1-ylethyl]azanium;(1S)-1-naphthalen-1-ylethanamine;(S)-(-)-1-(1-naphthyl) ethylamine;(S)-(-)-1-(1-Naphtyl)Ethylamine;(S)-(-)-alpha-(1-naphthyl)ethylamine;(S)-1-(1-Naphthyl)ethylamine;
PSA 26.02000
LogP 3.55980

Synthetic route

: 13755-29-8
sodium tetrafluoroborate

: (-)-(RS)-(η-C5H5)Re(NO)(PPH3)(CONHCH(CH3)C10H7)

: (-)-(R)-[(η-C5H5)Re(NO)(PPh3)(CO)]BF4

B: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
With CF3COOH In dichloromethane To a soln. of complex in CH2Cl2 was added CF3CO2H, the mixt. was stirred for 10 min (N2 atm.); evapd., extd. with H2O, NaBF4 was added;; ppt. was filtered, recrystd. from CH2Cl2-hexane;;	A 98% B n/a

...Expand

: 17640-21-0
isopropyl methoxyacetate

: 42882-31-5
(RS)-1-(1-naphthyl)ethylamine

A: (R)-2-methoxy-N-[1-(naphthalen-1-yl)]acetamide

B: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
With immobilized lipase B from Candida antarctica (Novozyme 435) In diethyl ether	A 93% B 92%
With Novozym 435 at 47℃; Molecular sieve; Enzymatic reaction; optical yield given as %ee; enantioselective reaction;	A 48% B 45%
With Candida antacrtica lipase B at 20℃; Enzymatic reaction; optical yield given as %ee;

...Expand

: (-)-(RS)-(η5-C5Me5)Re(NO)(PPh3)(CONHCH(CH3)C10H7)

: (-)-(R)-(η5-C5Me5)Re(NO)(PPh3)(CO)}BF4

B: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
With CF3CO2H; NaBF4 In dichloromethane addn. of CF3CO2H to Re complex soln.; stirring, 20 min.; evapn.; dissoln. in methanol; addn. of H2O and solid NaBF4; pptn.; filtration; drying (vac.); recrystn. from CH2Cl2-hexane; filtration; washing with ether; drying under vac.; elem. anal.;	A 91% B 76%

: 370839-71-7
Pyridine-2-sulfonic acid ((S)-1-naphthalen-1-yl-ethyl)-amide

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
With magnesium In methanol at 0℃; for 2h;	90%

: (S)-Hydroxy-naphthalen-2-yl-acetic acid; compound with (S)-1-naphthalen-1-yl-ethylamine

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
With hydrogenchloride In water	75%

: 42882-31-5
(RS)-1-(1-naphthyl)ethylamine

A: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

B: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
Stage #1: (RS)-1-(1-naphthyl)ethylamine With (S)-isopropylidene glycerol 3-carboxy-2-naphthoate In methanol at 20℃; Stage #2: With sulfuric acid In ethyl acetate	A n/a B 47%

: 143-07-7
lauric acid

: 42882-31-5
(RS)-1-(1-naphthyl)ethylamine

A: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

B: 74496-21-2
(R)-N-lauroyl-α-(1-naphthyl)ethylamine

C: 61761-45-3
N-((S)-1-(naphthalen-1-yl)ethyl)dodecanamide

Conditions

Conditions	Yield
With Candida antarctica lipase B In n-heptane at 80℃; for 25h;	A 45% B n/a C n/a

...Expand

: 123-66-0
Ethyl hexanoate

: 42882-31-5
(RS)-1-(1-naphthyl)ethylamine

A: Hexanoic acid ((R)-1-naphthalen-1-yl-ethyl)-amide

B: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

C: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
With Candida antarctica lipase In di-isopropyl ether at 30℃; for 120h;	A 42% B n/a C n/a

...Expand

: 106-33-2
ethyl laurate

: 42882-31-5
(RS)-1-(1-naphthyl)ethylamine

A: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

B: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

C: 74496-21-2
(R)-N-lauroyl-α-(1-naphthyl)ethylamine

Conditions

Conditions	Yield
With Candida antarctica lipase In di-isopropyl ether at 30℃; for 120h;	A n/a B n/a C 37%

...Expand

: 42882-31-5
(RS)-1-(1-naphthyl)ethylamine

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
With D-(+)-camphoric acid

: 54279-03-7
methyl 1-naphthyl ketone O-methyloxime

A: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

B: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
With (2S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol-borane In tetrahydrofuran at 30℃; for 24h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: dimethyl-(1-naphthalen-1-yl-ethyl)-borane

A: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

B: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
With hydroxylamine-O-sulfonic acid In tetrahydrofuran for 10h; Substitution; Title compound not separated from byproducts;

: (2-Methoxy-6-methyl-phenyl)-((S)-1-naphthalen-1-yl-ethyl)-amine

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
With ammonium cerium(IV) nitrate In methanol; water

: 42882-31-5
(RS)-1-(1-naphthyl)ethylamine

: 141-78-6
ethyl acetate

A: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

B: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

C: 72407-64-8
(1R)-N-acetyl-(1-naphthyl)ethylamine

D: 82796-68-7
(S)-N-(1-(naphthalen-1-yl)ethyl)acetamide

Conditions

Conditions	Yield
With Candida antarctica lipase B at 60℃; Title compound not separated from byproducts;

...Expand

: 941-98-0
1'-naphthacetophenone

A: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

B: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
Stage #1: 1'-naphthacetophenone With [((R)-tol-binap)RuCl2(DMF)x]; ammonia; ammonium formate In methanol at 85℃; for 30h; Leuckart-Wallach reaction; Stage #2: With hydrogenchloride In ethanol for 1h; Heating; Title compound not separated from byproducts;
With pyridoxal 5'-phosphate; isopropylamine In aq. phosphate buffer at 45℃; for 24h; pH=9; Enzymatic reaction; enantioselective reaction;	A n/a B n/a
With pyridoxal 5'-phosphate; isopropylamine In aq. phosphate buffer at 45℃; for 24h; pH=9; Enzymatic reaction; enantioselective reaction;	A n/a B n/a

: 42882-31-5
(RS)-1-(1-naphthyl)ethylamine

: 498542-91-9
(1S,2S)-N-acetyl-1,2-bis(trifluoromethanesulfonamido) cyclohexane

A: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

B: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

C: 72407-64-8
(1R)-N-acetyl-(1-naphthyl)ethylamine

D: 82796-68-7
(S)-N-(1-(naphthalen-1-yl)ethyl)acetamide

Conditions

Conditions	Yield
With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone at -20℃; for 24h; Title compound not separated from byproducts;
With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone at -20℃; Product distribution; Further Variations:; Temperatures; Reagents;

...Expand

: 328309-97-3
N-(1-(1-Naphthyl)ethylidene)2'-methoxy-6'-methylaniline

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: chiral 1,1'-bisphosphanoferrocene; H2 / {Ir(cod)Cl}2 / CH2Cl2 / 20 °C / 51714.8 Torr 2: CAN / methanol; H2O View Scheme

: 1956-40-7, 100485-51-6, 100485-59-4
1-(1-naphthalenyl)ethanone oxime

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 74.9 percent / H2, conc. ammonia / Raney nickel / aq. ethanol / 24 h / 3040 Torr / Ambient temperature View Scheme
Multi-step reaction with 3 steps 1: ammonia; hydrogen / methanol; water / 58 - 62 °C / 2574.5 - 2942.29 Torr 2: ethanol / 0.75 h / 60 - 65 °C / Resolution of racemate 3: ammonia / water; toluene View Scheme

: 100485-59-4
(Z)-1-(naphthalen-1-yl)ethanone oxime

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaH / dimethylformamide / 1.) 0 deg C, 1 h, 2.) ambient temp., 5 h 2: (S)-(-)-2-amino-3-methyl-1,1-diphenylbutanol*borane / tetrahydrofuran / 24 h / 30 °C View Scheme

: 1025949-34-1
(1R)‐1‐(naphthalen‐1‐yl)ethyl methanesulfonate

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
With ammonia In toluene at 87℃; under 2250.23 Torr; for 5h;	n/a

: C3H5ClO2*C12H13N

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
With sodium hydroxide In water; toluene pH=> 10;	n/a

: 13755-29-8
sodium tetrafluoroborate

: 82336-31-0
(+)-(SS)-(η-C5H5)Re(NO)(PPH3)(CONHCH(CH3)C10H7)

: (+)-(S)-{(η5-C5H5)Re(NO)PPh3(CO)2}BF4

B: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
With CF3COOH In dichloromethane To a soln. of complex in CH2Cl2 was added CF3CO2H, the mixt. was stirred for 10 min (N2 atm.); evapd., extd. with H2O, NaBF4 was added;; ppt. was filtered, recrystd. from CH2Cl2-hexane;;

...Expand

: 42882-31-5
(RS)-1-(1-naphthyl)ethylamine

A: 941-98-0
1'-naphthacetophenone

B: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
With D-amino acid oxidase; ATA-117; pyridoxal 5'-phosphate; 2-oxo-propionic acid at 30℃; for 3h; pH=8; Resolution of racemate; aq. phosphate buffer; Enzymatic reaction; optical yield given as %ee; enantioselective reaction;

: 941-98-0
1'-naphthacetophenone

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: hydroxylamine hydrochloride; sodium hydroxide / methanol; water / 20 - 35 °C / pH 6 - 6.5 2: ammonia; hydrogen / methanol; water / 58 - 62 °C / 2574.5 - 2942.29 Torr 3: ethanol / 0.75 h / 60 - 65 °C / Resolution of racemate 4: ammonia / water; toluene View Scheme
Multi-step reaction with 3 steps 1.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / pH 5 / Reflux 2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 2.2: 18 h / 20 °C 3.1: C19H23BNO3(1-)*H(1+); borane-THF / 1,4-dioxane / 72 h / Inert atmosphere View Scheme
With pyridoxal 5'-phosphate; ω-transaminases from ochrobactrum anthropi mutant W58A; isopropylamine In aq. phosphate buffer; dimethyl sulfoxide at 37℃; under 300 Torr; for 15h; pH=7; Kinetics; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;	n/a
With dipotassium hydrogenphosphate; pyridoxal 5'-phosphate In aq. phosphate buffer; dimethyl sulfoxide at 45℃; for 48h; pH=9; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;	n/a
With pyridoxal 5'-phosphate; isopropylamine In aq. phosphate buffer at 45℃; for 24h; pH=9; Enzymatic reaction; enantioselective reaction;	n/a

: 1243166-48-4
(1S)-1-(naphthalen-1-yl)ethanamine (R)-mandelate

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
With ammonia In water; toluene

: C9H11O2PS*C12H13N

A: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

B: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

Conditions

Conditions	Yield
With potassium hydroxide Inert atmosphere;

: 5707-04-0
Phenylselenyl chloride

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 101685-18-1
N-<(S)-1-(1-Naphthyl)-ethyl>benzeneselenamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 2h;	100%

: 50-00-0
formaldehyd

: 131543-46-9
Glyoxal

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 1,3-bis[(S)-1-naphthalen-1-yl-propyl]-3H-imidazol-1-ium tetrafluoroborate

Conditions

Conditions	Yield
Stage #1: formaldehyd In toluene for 0.5h; cooling; Stage #2: (S)-1-(1-Naphthyl)ethylamine With tetrafluoroboric acid In water; toluene at 0℃; for 0.25h; Stage #3: Glyoxal In water; toluene at 20 - 40℃; for 12.5h;	100%

...Expand

: 108-86-1
bromobenzene

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 880647-65-4
(S)-N-(1-(1-naphthyl)ethyl)aniline

Conditions

Conditions	Yield
With sodium t-butanolate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0) In toluene at 80℃;	100%
With potassium tert-butylate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 80℃; for 12h; Inert atmosphere;	97%

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 68262-71-5
Boc-Arg(MTS)-OH

: 905593-24-0
[4-(N'-2,4,6-trimethylphenylsulfonyl-guanidino)-1(S)-(1-naphthalen-1(S)-yl-ethylcarbamoyl)-butyl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 12h;	100%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane

: fac,cis-[(CH3CH2CH2N(CH2CH2PPh2)2)RuCl2(C=C(H)Ph)]

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: (S)-(-)-fac,cis-[(CH3CH2CH2N(CH2CH2PPh2)2)RuCl2(=C(NHCH(Me)(1-naphthyl))CH2Ph)]

Conditions

Conditions	Yield
In tetrahydrofuran room temp.;	100%
In tetrahydrofuran N2-atmosphere; addn. of 3-fold excess of amine to suspension of Ru-complex, stirring (1 h, in dark); evapn., pptn. on addn. of petroleum ether, recrystn. (CH2Cl2:petroleum ether); elem. anal.;	90%

: 927679-54-7
(1α,5α,6α)-3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: C18H20N2O

Conditions

Conditions	Yield
Stage #1: (1α,5α,6α)-3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid; (S)-1-(1-Naphthyl)ethylamine With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 18h; Stage #2: With trifluoroacetic acid In dichloromethane at 20℃; for 4h;	100%
Multi-step reaction with 2 steps 1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C 2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C View Scheme

: 905857-50-3
(2R)-2-tert-butyloxy-4-(9-fluorenylmethoxy)carbonylaminobutyric acid

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: [3-tert-butoxy-3-(1-naphthalen-1-yl-ethylcarbamoyl)-propyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h;	99%

: 905857-46-7
(2S)-2-tert-butyloxy-4-(9-fluorenylmethoxy)carbonylaminobutyric acid

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: [3-tert-butoxy-3-(1-naphthalen-1-yl-ethylcarbamoyl)-propyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h;	99%

: [Co(II)(dimethylglyoxamato)(NO2)(H2O)]

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: bis(dimethylglyoxamato)nitro[S-1-naphthylethylamine]cobalt(III)

Conditions

Conditions	Yield
In ethanol 1 equiv. of amine was added to EtOH soln. of Co-complex at 45 °C,30 min; solid was filtered off, further product was recovered after partial evapn. of solvent at room temp.;	99%

: 1082072-42-1
C17H18O6S2

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 1082072-47-6
C28H27NO3S

Conditions

Conditions	Yield
With triethylamine In chloroform at 20℃; for 72h;	99%

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 17261-28-8
ortho-diphenylphosphinobenzoic acid

: 573992-51-5
C31H26NOP

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 24℃; for 12h;	99%

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 2476-35-9
5-bromo-2-methoxybenzoic acid

: C20H18BrNO2

Conditions

Conditions	Yield
Stage #1: 5-bromo-2-methoxybenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 2.5h; Inert atmosphere; Stage #2: (S)-1-(1-Naphthyl)ethylamine With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere;	99%

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: (S)-(-)-1-(1-naphthyl)ethylamine sulfonyl fluoride

Conditions

Conditions	Yield
With 1-(fluorosulfuryl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate In acetonitrile at 0 - 20℃; for 4h;	99%
With 1-(fluorosulfuryl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate In acetonitrile at 20℃; for 2h; Cooling with ice;	99%

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 98-09-9
benzenesulfonyl chloride

: (S)-N-(1-(naphthalen-1-yl)ethyl)benzenesulfonamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 1.08333h;	99%

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 118-93-4
o-hydroxyacetophenone

: 77383-02-9
2-{1-[(E)-(S)-1-Naphthalen-1-yl-ethylimino]-ethyl}-phenol

Conditions

Conditions	Yield
With dibutyltin diacetate In toluene for 96h; Reflux; Inert atmosphere;	98%
With toluene-4-sulfonic acid In benzene for 24h; Heating;

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 648908-35-4
3-acetamino-3-methyltridecanoic acid

: (S)-3-acetamino-3-methyltridecanoic acid N-{1-(1-naphthyl)ethyl}amide

Conditions

Conditions	Yield
Stage #1: 3-acetamino-3-methyltridecanoic acid With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0℃; for 1h; Stage #2: (S)-1-(1-Naphthyl)ethylamine In dichloromethane for 3h;	98%

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 13750-81-7
N-methyl-2-imidazolcarboxaldehyde

: (S)-[(1-methyl-1H-imidazol-2-ylmethylene)-(1-(1-naphthyl)-ethanamine)]

Conditions

Conditions	Yield
With magnesium sulfate In chloroform for 24h; Inert atmosphere; Reflux;	98%

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: C11H16O3

: C9H12O3*C12H13N

Conditions

Conditions	Yield
Stage #1: C11H16O3 With triethylsilane; Wilkinson's catalyst In toluene at 20℃; Inert atmosphere; Stage #2: With sodium hydroxide In methanol; water at 70℃; for 1h; Stage #3: (S)-1-(1-Naphthyl)ethylamine In ethanol for 2h;	98%

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 1450657-28-9
1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one

: (1S)-N-1-(naphthyl)ethyl-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonyl-vinylamine

Conditions

Conditions	Yield
Stage #1: 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one With toluene-4-sulfonic acid In ethanol at 5 - 15℃; Inert atmosphere; Stage #2: (S)-1-(1-Naphthyl)ethylamine In ethanol at 10℃; Inert atmosphere;	97.7%

: 585-76-2
m-bromobenzoic acid

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 1325230-19-0
C19H16BrNO

Conditions

Conditions	Yield
Stage #1: m-bromobenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 1h; Stage #2: (S)-1-(1-Naphthyl)ethylamine With pyridine In dichloromethane at 0 - 20℃; for 2h;	97%

: 566938-58-7
1-(3-iodopropyl)-3-(trifluoromethyl)benzene

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: (S)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 70℃; for 12h;	97%
With potassium carbonate In acetonitrile	95%

: 131543-46-9
Glyoxal

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 141734-24-9
N,N'-bis[(S)-1-naphthyl-ethyl]ethanediimine

Conditions

Conditions	Yield
With formic acid; magnesium sulfate In dichloromethane; water at 20℃; for 16h;	96%
With formic acid; magnesium sulfate In dichloromethane at 20℃; for 5h;

: 75-15-0
carbon disulfide

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: (S,S)-N,N'-bis[1-(1-naphthyl)ethyl]thiourea

Conditions

Conditions	Yield
at 48℃;	96%

: 612-62-4
2-Chloroquinoline

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 927706-66-9
C21H18N2

Conditions

Conditions	Yield
With sodium t-butanolate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride In 1,2-dimethoxyethane at 50℃; for 48h; Product distribution / selectivity; Buchwald-Hartwig Reaction;	96%

: 612-59-9
3-chloroquinoline

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 1033752-68-9
(S)-N-(1-(naphthalene-1-yl)ethyl)isoquinolin-3-amine

Conditions

Conditions	Yield
With [(1,3-(2,6-diisopropylphenyl)imidazol-2-ylidene)(3-chloropyridyl)palladium(II) dichloride]; caesium carbonate In 1,2-dimethoxyethane at 80℃; for 24h; Buchwald-Hartwig amination; Inert atmosphere;	96%

: 10420-89-0
(S)-1-(1-Naphthyl)ethylamine

: 1451270-92-0
C26H28BrN3O3

: 1451271-13-8
C38H40N4O3

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 1h;	96%

(S)-(-)-1-(1-Naphthyl)ethylamine Chemical Properties

IUPAC Name: 1-Naphthalen-1-ylethanamine
Empirical Formula: C₁₂H₁₃N
Molecular Weight: 171.2383 g/mol
Index of Refraction: 1.629
Density: 1.064 g/cm³
Flash Point: 144.3 °C
Storage tempreture: 2-8 °C
Sensitive: Air sensitive
alpha: -60 °(c=2, MeOH)
Appearance: Colorless to light yellow liqui
Enthalpy of Vaporization: 52.92 kJ/mol
Boiling Point: 289.9 °C at 760 mmHg
Vapour Pressure: 0.00214 mmHg at 25 °C
Product Category of (S)-(-)-1-(1-Naphthyl)ethylamine (CAS NO.10420-89-0): Amines (Chiral); Analytical Chemistry; Chiral Building Blocks; Enantiomer Excess & Absolute Configuration Determination; Optical Resolution; Synthetic Organic Chemistry; Miscellaneous

(S)-(-)-1-(1-Naphthyl)ethylamine Toxicity Data With Reference

(S)-(-)-1-(1-Naphthyl)ethylamine (CAS NO.10420-89-0) hasn't been listed as a carcinogen by NTP, IARC, ACGIH, or CA Prop 65.

(S)-(-)-1-(1-Naphthyl)ethylamine Safety Profile

Safety Information of (S)-(-)-1-(1-Naphthyl)ethylamine (CAS NO.10420-89-0):
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37/39:Wear suitable gloves and eye/face protection.

(S)-(-)-1-(1-Naphthyl)ethylamine Specification

(S)-(-)-1-(1-Naphthyl)ethylamine , its cas register number is 10420-89-0. It also can be called (S)-(-)-alpha-(1-Naphthyl)ethylamine ; and 1-(1-Naphthyl)ethylamine . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. While, it's inhaled: Remove from exposure and move to fresh air immediately. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately.
In addition, (S)-(-)-1-(1-Naphthyl)ethylamine (CAS NO.10420-89-0) could be stable under normal temperatures and pressures. It is not compatible with incompatible materials, acids, acid chlorides, acid anhydrides, chloroformates, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: irritating and toxic fumes and gases.

Product Name

(S)-(-)-1-(1-Naphthyl)ethylamine

Synthetic route

(S)-(-)-1-(1-Naphthyl)ethylamine Chemical Properties

(S)-(-)-1-(1-Naphthyl)ethylamine Toxicity Data With Reference

(S)-(-)-1-(1-Naphthyl)ethylamine Safety Profile

(S)-(-)-1-(1-Naphthyl)ethylamine Specification

Related Products

Hot Products