(S)-(+)-1,2-Propanediol supplier

Name
(S)-(+)-1,2-Propanediol
EINECS
CAS No. 4254-15-3
Article Data116
CAS DataBase
Density 1.036 g/cm³
Solubility soluble in water
Melting Point -59 °C
Formula C₃H₈O₂
Boiling Point 184.8 °C at 760 mmHg
Molecular Weight 76.0953
Flash Point 107.2 °C
Transport Information
Appearance Colorless to light yellow liquid
Safety 24/25-36/37/39-26
Risk Codes 36/37/38-22
Molecular Structure
Hazard Symbols Xn
Synonyms 1,2-Propanediol,(S)-(+)- (8CI);(+)-(S)-1,2-Propanediol;(+)-1,2-Propanediol;(S)-(+)-Propane-1,2-diol;(S)-(+)-Propylene glycol;(S)-1,2-Propanediol;(S)-2-Hydroxy-1-propanol;(S)-2-Hydroxypropanol;(S)-Propylene glycol;1,2(S)-Propanediol;3-Deoxy-sn-glycerol;L-(+)-Propanediol;L-(+)-Propyleneglycol;L-1,2-Propanediol;d-Propylene glycol;
PSA 40.46000
LogP -0.64050

Synthetic route

: 116-09-6
hydroxy-2-propanone

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); hydrogen bromide; hydrogen; (S)-[(5,6),(5’,6’)-bis(ethylenedioxy)biphenyl-2,2’ diyl]bis(diphenylphosphine) In ethanol; water at 60℃; under 825.083 Torr; for 1h; pH=1.34; Catalytic behavior; Pressure; Temperature; pH-value; Reagent/catalyst; Autoclave;	100%
With hydrogen; RuBr2[(S)-(C6H2OCH2CH2OP(C6H5)2)2] In methanol at 80℃; under 22501.8 Torr; for 40h;	89%
With potassium hydroxide; ammonium formate; 2-hydroxyethanethiol In water for 216h; GDH, FDH, NAD, pH = 7.5 - 8.3;	50%

: 1067232-34-1
(4S,1'R,2'S)-N(3)-[1'-(m-chlorobenzoyl)-2'-hydroxy-propan-1'-yl]-4-phenyl-5,5-dimethyloxazolidin-2-one

A: 4254-15-3
(S)-1,2-Propanediol

B: 168297-84-5
(4S)-5,5-dimethyl-4-phenyl-1,3-oxazolidin-2-one

Conditions

Conditions	Yield
With sodium tetrahydroborate In methanol for 0.166667h;	A 37% B 99%

: 687-47-8
(S)-Ethyl lactate

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether for 0.5h; Heating;	97%
Stage #1: (S)-Ethyl lactate With lithium aluminium tetrahydride In diethyl ether at 0 - 20℃; for 4h; Stage #2: With water In tetrahydrofuran; diethyl ether at 0℃;	86%
With lithium aluminium tetrahydride In diethyl ether	80%

: 13807-91-5, 89401-28-5, 103129-25-5, 85483-97-2
(2S)-1-(benzyloxy)propan-2-ol

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol for 30h;	96%

: 27871-49-4
(S)-Methyl lactate

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether at 0 - 20℃; for 2.25h;	90%
With lithium aluminium tetrahydride In tetrahydrofuran at 25℃; for 1h;
With hydrogen; Nishimura catalyst <(45.9% Rh/19.9% Pt) oxide> In methanol at 25℃; under 75007.5 Torr;	77 % Spectr.

: 85550-19-2
(S)-1-triphenylmethoxypropan-2-ol

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
With silica gel supported sodium hydrogen sulfate In methanol; dichloromethane at 20℃;	81%

: 76946-21-9
(2S)-2-(tetrahydro-2H-pyran-2-yloxy)propan-1-ol

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
With hydrogenchloride In methanol for 12h;	80%

: 4511-42-6
L,L-dilactide

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
With [RuH(CO)(BPy-tPNN*)]; hydrogen In tetrahydrofuran at 110℃; under 38002.6 Torr; for 12h; Inert atmosphere;	73%
With hydrogen In methanol at 100℃; under 112511 Torr; for 15h; Autoclave; stereoselective reaction;	80 %Chromat.

: 1369852-90-3
(S)-1-(9H-fluoren-9-yloxy)propan-2-ol

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol	73%

: 41274-09-3
(R)-3-tosyloxy-1,2-propanediol

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 4h;	72%

: 33106-64-8
(S)-2-(benzyloxy)propan-1-ol

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; palladium on activated charcoal In ethanol for 1h;	70%
With hydrogenchloride; hydrogen; palladium on activated charcoal In ethanol for 1h; Product distribution; reactions of derivatives;	70%

: 122151-36-4
(S)-2-O-(4'-methoxybenzyl)propan-1,2-diol

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; palladium on activated charcoal In ethanol for 1h;	60%

: 122151-37-5
(S)-2-(p-chlorobenzyloxy)-1-propanol

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen; palladium on activated charcoal In ethanol for 1h;	56%

: 75-56-9, 16033-71-9
methyloxirane

A: 4254-15-3
(S)-1,2-Propanediol

B: 15448-47-2
(R)-propylene oxide

Conditions

Conditions	Yield
With [(R,R)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminato(2-)]cobalt(III) acetate; water at 0 - 20℃; for 12h;	A 50% B 48%
With [(R,R)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminato(2-)]cobalt(III) acetate; water at 0 - 20℃; for 14h;	A 50% B 44%
With water; Cr(III)-endo,endo-2,5-diaminonorbornane-salen at 1℃; for 34h;	A 48% B 45%

: 75-56-9, 16033-71-9
methyloxirane

A: 4254-15-3
(S)-1,2-Propanediol

B: 16088-62-3
(S)-Propylene oxide

Conditions

Conditions	Yield
With C72H102Co2F12N4O12P2; water at 0 - 20℃; for 2.5h; optical yield given as %ee;	A 50% B 43%
With (R,R)-N,N′-bis(3,5-di-tertbutylsalicylidene)-1,2-cyclohexanediaminocobalt(III) acetate In water at 0℃; for 14h; Inert atmosphere;	A 43% B 45%

: 75-56-9, 16033-71-9
methyloxirane

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
With water In tetrahydrofuran at 0 - 20℃; for 18h; Catalytic behavior; Reagent/catalyst; enantioselective reaction;	49%
With (R,R)-(-)-N,N′-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminocobalt(II); water; acetic acid In toluene at 0 - 20℃;	41%
Co(Salen)/SBA-16-C8 In tetrahydrofuran; water at 9.84℃; for 28h;

: 79-33-4
L-Lactic acid

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran	48.6%
With lithium aluminium tetrahydride
With sulfuric acid; hydrogen; platinum(IV) oxide; rhenium(VII) oxide In water at 80℃; under 150015 Torr; for 5h; Product distribution / selectivity;	n/a
With sulfuric acid; hydrogen; platinum(IV) oxide In water at 80℃; under 150015 Torr; for 5h; Product distribution / selectivity;

: 75-56-9, 16033-71-9
methyloxirane

A: 4254-15-3
(S)-1,2-Propanediol

B: 4254-14-2
(2R)-propane-1,2-diol

C: 16088-62-3
(S)-Propylene oxide

Conditions

Conditions	Yield
With (S,S)-[N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino]cobalt(III) acetate; water at 20℃; for 14h;	A n/a B n/a C 46%
With water; (R,R)-[Co(salen)]2*GaCl3 at 20℃; for 3h;	A n/a B n/a C 43%
With Aspergillus niger epoxide hydrolases immobilized onto modified Eupergit C In aq. phosphate buffer; dimethyl sulfoxide at 25℃; for 4h; pH=6.5; Kinetics; Reagent/catalyst; pH-value; Enzymatic reaction; enantioselective reaction;	A n/a B n/a C 43%

...Expand

: 75-56-9, 16033-71-9
methyloxirane

A: 4254-15-3
(S)-1,2-Propanediol

B: 4254-14-2
(2R)-propane-1,2-diol

C: 15448-47-2
(R)-propylene oxide

Conditions

Conditions	Yield
With water; chiral ((substituted salen)Co)2-InCl3 at 20℃; for 2h;	A n/a B n/a C 45%
With (S,S)-[N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino]cobalt(III) acetate; water In tetrahydrofuran at 19.84℃; for 3h; Kinetics; Reagent/catalyst; Solvent; optical yield given as %ee; enantioselective reaction;	A n/a B n/a C 43%
With water; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; (R,R)-(salen)Co(III)(OAc) In tetrahydrofuran at 20℃; for 24h;
fluorous (R,R)-(salen)cobalt(III) In water at 25℃; for 24h; Title compound not separated from byproducts;

...Expand

: 75-56-9, 16033-71-9
methyloxirane

A: 4254-15-3
(S)-1,2-Propanediol

B: 15448-47-2
(R)-propylene oxide

C: 16088-62-3
(S)-Propylene oxide

Conditions

Conditions	Yield
With (S,S)-[N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino]cobalt(III) acetate; (salen)Co(III)-ZnCl2; water In dichloromethane at 19.84℃; for 3h; Kinetics; Reagent/catalyst; Solvent; optical yield given as %ee; enantioselective reaction;	A 43% B n/a C n/a
With 4CF3O3S(1-)Co(3+)Y(3+)*C36H52N2O2(2-); water In neat (no solvent) at 20℃; for 6h; Overall yield = 23 %; enantioselective reaction;	A n/a B n/a C n/a

...Expand

: 1169946-48-8
(S)-1-[bis(4-methoxyphenyl)methoxy]propan-2-ol

A: 4254-15-3
(S)-1,2-Propanediol

B: 726-18-1
4,4'-dianisylmethane

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In methanol for 2h;	A 13% B n/a

: 40425-15-8
(R)-3-iodo-1,2-propanediol

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
With sodium hydroxide; nickel Hydrogenation;

: 141396-05-6
(S)-1-O-benzoyl-1,2-dihydroxypropane

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
With sodium hydroxide at 125℃;

: 50-00-0
formaldehyd

: 75-56-9, 16033-71-9
methyloxirane

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
at 50℃; Erwaermen des Reaktionsgemisches mit Salzsaeure; dextrorotatory form;

: 57-55-6
propylene glycol

: 4254-15-3
(S)-1,2-Propanediol

: 951-98-4
2-Oxo-propionic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

: 4254-15-3
(S)-1,2-Propanediol

: 20918-91-6
ethyl (S)-2-acetyloxypropanoate

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether for 1h; Heating;

: 918-10-5
(S)-(-)-2-hydroxy-2,3,3-trimethylbutanoic acid

: 4254-15-3
(S)-1,2-Propanediol

: 141859-89-4
1-Dimethylsilanyloxy-propan-2-one

A: 4254-15-3
(S)-1,2-Propanediol

B: 4254-14-2
(2R)-propane-1,2-diol

Conditions

Conditions	Yield
With potassium carbonate; 1,2-bis((2R,5R)-2,5-diethylphosphoranylidene)benzene 1) CH2Cl2, 2 h, 20-25 deg C, 2) MeOH, 4 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
With potassium carbonate; (-)-1,2-bis[(2R,5R)-2,5-diisoprohylphospholano]benzene 1) CH2Cl2, 2 h, 20-25 deg C, 2) MeOH, 4 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
With potassium carbonate; (-)-1,2-bis[(2R,5R)-2,5-diisoprohylphospholano]benzene Product distribution; multistep reaction: asymmetric intramolecular hydrosilylation of hydroxyketones; other catalysts aand silylketones;

: 162427-78-3
1-O-β-D-glucosyl-(2S)-propylene glycol

: 4254-15-3
(S)-1,2-Propanediol

Conditions

Conditions	Yield
With β-galactosidase In various solvent(s) at 35℃;

: 110-87-2
3,4-dihydro-2H-pyran

: 4254-15-3
(S)-1,2-Propanediol

: 81601-30-1
(2S)-1-tetrahydropyranyloxy-2-hydroxypropane

Conditions

Conditions	Yield
With hydrogenchloride for 24h; Product distribution; Ambient temperature; regioselective pyranylation of (S)-1,2-propanediol;	99%
With hydrogenchloride for 24h; Ambient temperature;	98%

: 4254-15-3
(S)-1,2-Propanediol

: 616-38-6
carbonic acid dimethyl ester

: 51260-39-0
(S)-(+)-4-methyl[1,3]dioxolan-2-one

Conditions

Conditions	Yield
With sodium methylate In methanol at 60 - 115℃; for 25h;	97%

: 4254-15-3
(S)-1,2-Propanediol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 113534-13-7
(2S)-1-{[(1,1-dimethylethyl)dimethylsilyl]oxy}-2-propanol

Conditions

Conditions	Yield
With 1H-imidazole In dichloromethane at 0 - 20℃; for 4h;	96%
With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine In dichloromethane for 5h; Ambient temperature;	90%
With dmap; triethylamine In dichloromethane at 22℃; for 18h;	90%

: 4254-15-3
(S)-1,2-Propanediol

: 76-83-5
trityl chloride

: 85550-19-2
(S)-1-triphenylmethoxypropan-2-ol

Conditions

Conditions	Yield
With pyridine for 7h; Ambient temperature;	93%
With triethylamine In dichloromethane at 0 - 20℃;	76%
With dmap; triethylamine In dichloromethane; N,N-dimethyl-formamide for 8h; Ambient temperature;	60%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 16h;
With dmap; triethylamine In dichloromethane at 23℃; for 14h;

: 4254-15-3
(S)-1,2-Propanediol

: 14470-28-1
mono-4-methoxytrityl chloride

: 129247-67-2, 138247-71-9
(R)-1-O-<(p-methoxyphenyl)diphenylmethyl>-1,2-propanediol

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 3.5h; Inert atmosphere;	93%
With dmap; triethylamine In dichloromethane; ethyl acetate 1.) 0 deg C, 30 min, 2.) RT, 15 h;

: 4254-15-3
(S)-1,2-Propanediol

: C14H12I(1+)*C2F3O2(1-)

: (S)-1-(((R)-2'-iodo-6,6'-dimethyl-[1,1'-biphenyl]-2-yl)oxy)propan-2-ol

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate); triethylamine; 2,6-bis[(4R)-5,5-dihydro-4-phenyl-2-oxazolyl]pyridine; 10-hydroxy-4a,10a-dihydrobenzo[b][1,4]benzoxaborinine In 1,2-dichloro-ethane at 40℃; for 24h; Inert atmosphere; Schlenk technique; diastereoselective reaction;	93%

: 4254-15-3
(S)-1,2-Propanediol

: 174953-30-1
(S)-(+)-4-methyl-2,2-dioxo-1,3,2-dioxathiolane

Conditions

Conditions	Yield
Stage #1: (S)-1,2-Propanediol With thionyl chloride In dichloromethane at 20℃; Reflux; Inert atmosphere; Stage #2: With sodium periodate; ruthenium (III) chloride trihydrate In dichloromethane; water; acetonitrile at 0 - 20℃;	90%
With ruthenium trichloride; sodium periodate; thionyl chloride Yield given. Multistep reaction;
With ruthenium trichloride; sodium periodate; thionyl chloride 1.) CCl4, 60 deg C; 1.) CH3CN, H2O, 25 deg C; Yield given. Multistep reaction;

: 4254-15-3
(S)-1,2-Propanediol

: tris{2-[1-(dimethylamino)ethyl]phenyl}boroxine

: 2-(2-[(1R,S)-1-(dimethylamino)ethyl]phenyl)-(4S)-4-methyl-1,3,2-dioxaborolane

Conditions

Conditions	Yield
In toluene byproducts: H2O; heating equimolar amts. of the boroxine and (S)-1,2-propanediol in toluene;; concn.; distn.; elem. anal.;;	89%

: 4254-15-3
(S)-1,2-Propanediol

: C16H16I(1+)*C2F3O2(1-)

: (S)-1-(((R)-2'-iodo-4,4',6,6'-tetramethyl-[1,1'-biphenyl]-2-yl)oxy)propan-2-ol

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate); triethylamine; 2,6-bis[(4R)-5,5-dihydro-4-phenyl-2-oxazolyl]pyridine; 10-hydroxy-4a,10a-dihydrobenzo[b][1,4]benzoxaborinine In 1,2-dichloro-ethane at 40℃; for 24h; Inert atmosphere; Schlenk technique; diastereoselective reaction;	89%

: 4254-15-3
(S)-1,2-Propanediol

: 64-19-7
acetic acid

: 10299-39-5
acetoxy bromide of S-(+)-propane-1,2-diol

Conditions

Conditions	Yield
With hydrogen bromide	88%

: 4254-15-3
(S)-1,2-Propanediol

: 64-19-7
acetic acid

: 153904-73-5
(S)-2-Acetoxypropanol

Conditions

Conditions	Yield
With hydrogen bromide	87%

: 4254-15-3
(S)-1,2-Propanediol

: 64-19-7
acetic acid

A: 39968-99-5
(S)-(-)-2-acetoxy-1-bromopropane

B: 1-Acetoxy-2-brompropan

Conditions

Conditions	Yield
With hydrogen bromide at 0 - 20℃; for 1h;	A 87% B n/a

...Expand

: 4254-15-3
(S)-1,2-Propanediol

: 124-63-0
methanesulfonyl chloride

: 270577-16-7
(S)-methylethylene bis(methanesulfonate)

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 1h; Mesylation;	86%
With triethylamine In dichloromethane

: 4254-15-3
(S)-1,2-Propanediol

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 161106-18-9
(S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)propan-2-ol

Conditions

Conditions	Yield
With diethylamine In dichloromethane	85%
With dmap In pyridine Ambient temperature;	79%

: 4254-15-3
(S)-1,2-Propanediol

: 1396842-55-9
8-nitro-2-(4-oxopiperidin-1-yl)-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one

: 1161233-85-7
2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one

Conditions

Conditions	Yield
Stage #1: (S)-1,2-Propanediol With trimethylsilyl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.25h; Inert atmosphere; Stage #2: 8-nitro-2-(4-oxopiperidin-1-yl)-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one In dichloromethane for 0.333333h; Inert atmosphere;	85%

: 4254-15-3
(S)-1,2-Propanediol

: 39968-99-5
(S)-(-)-2-acetoxy-1-bromopropane

Conditions

Conditions	Yield
With hydrogen bromide; acetic acid at 20℃; for 0.75h;	85%

: 4254-15-3
(S)-1,2-Propanediol

: C14H12I(1+)*C2F3O2(1-)

: (S)-1-(((S)-2'-iodo-6,6'-dimethyl-[1,1'-biphenyl]-2-yl)oxy)propan-2-ol

Conditions

Conditions	Yield
With copper(II) bis(trifluoromethanesulfonate); triethylamine; 2,6-bis[(4R)-5,5-dihydro-4-phenyl-2-oxazolyl]pyridine; 10-hydroxy-4a,10a-dihydrobenzo[b][1,4]benzoxaborinine In 1,2-dichloro-ethane at 40℃; for 24h; Inert atmosphere; Schlenk technique; enantioselective reaction;	85%

: 4254-15-3
(S)-1,2-Propanediol

: 95753-24-5
2-[(diethylamino)methyl]phenyl boronic acid

: 2-(2-[(diethylamino)methyl]phenyl)-(4S)-4-methyl-1,3,2-dioxaborolane

Conditions

Conditions	Yield
In toluene byproducts: H2O; heating equimolar amts. of the boronic acid and (S)-1,2-propanediol in toluene;; concn.; distn.; elem. anal.;;	84%

: tert-butyl (1-phenylprop-2-yn-1-yl) carbonate

: 4254-15-3
(S)-1,2-Propanediol

: (S)-1-(((S)-1-phenylprop-2-yn-1-yl)oxy)propan-2-ol

Conditions

Conditions	Yield
Stage #1: tert-butyl (1-phenylprop-2-yn-1-yl) carbonate With 2,6-bis[(4S)-4-methyl-4,5-dihydrooxazol-2-yl]pyridine; tetrakis(acetonitrile)copper(I)tetrafluoroborate In tetrahydrofuran at 20℃; for 0.166667h; Sealed tube; Stage #2: (S)-1,2-Propanediol With triethylamine; 10-hydroxy-4a,10a-dihydrobenzo[b][1,4]benzoxaborinine In tetrahydrofuran at -20℃; for 24h; Sealed tube; stereoselective reaction;	84%

Yield

Stage #1: tert-butyl (1-phenylprop-2-yn-1-yl) carbonate With 2,6-bis[(4S)-4-methyl-4,5-dihydrooxazol-2-yl]pyridine; tetrakis(acetonitrile)copper(I)tetrafluoroborate In tetrahydrofuran at 20℃; for 0.166667h; Sealed tube;
Stage #2: (S)-1,2-Propanediol With triethylamine; 10-hydroxy-4a,10a-dihydrobenzo[b][1,4]benzoxaborinine In tetrahydrofuran at -20℃; for 24h; Sealed tube; stereoselective reaction;

84%

: 95753-26-7
2-[(N,N-diisopropylamino)methyl]phenylboronic acid

: 4254-15-3
(S)-1,2-Propanediol

: 2-(2-[(diisopropylamino)methyl]phenyl)-(4S)-4-methyl-1,3,2-dioxaborolane

Conditions

Conditions	Yield
In toluene byproducts: H2O; heating equimolar amts. of the boronic acid and (S)-1,2-propanediol in toluene;; concn.; distn.; elem. anal.;;	83%

: 4254-15-3
(S)-1,2-Propanediol

: 2,4,6-tris(2-(trifluoromethyl)-phenyl)-1,3,5,2,4,6-trioxatriborinane

: (4S)-4-methyl-2-[2-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane

Conditions

Conditions	Yield
In toluene byproducts: H2O; heating equimolar amts. of the boroxine and (S)-1,2-propanediol in toluene;; concn.; distn.; elem. anal.;;	83%

: 879545-38-7
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethylbenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

: 4254-15-3
(S)-1,2-Propanediol

: C3H8O2*C21H25ClO5

Conditions

Conditions	Yield
In tert-butyl methyl ether at 20℃; for 24h;	83%

: 4254-15-3
(S)-1,2-Propanediol

: 95753-07-4
2,4,6-tris[2-(methoxymethyl)phenyl]boroxine

: 2-[2-(methoxymethyl)phenyl]-(4S)-4-methyl-1,3,2-dioxaborolane

Conditions

Conditions	Yield
In toluene byproducts: H2O; heating equimolar amts. of the boroxine and (S)-1,2-propanediol in toluene;; concn.; distn.; elem. anal.;;	81%

: 2033-24-1
cycl-isopropylidene malonate

: 24523-45-3, 41097-38-5
bis-(4-bromo-benzylidene)-hydrazine

: 4254-15-3
(S)-1,2-Propanediol

: 7,14-bis(4-bromophenyl)-2,11,11-trimethyl-1,4,10,12-tetraoxadispiro[4.2.5.2]pentadecane-9,13-dione

Conditions

Conditions	Yield
With acetic acid at 80℃; for 8h;	81%

...Expand

(S)-(+)-1,2-Propanediol Chemical Properties

IUPAC Name:propane-1,2-diol
Molecular Formula:C₃H₈O₂
Molecular Weight:76.094420 g/mol
Appearance:clear colorless liquid
Melting Point:-59 °C
Boiling Point:186-188 °C at 765 mm Hg(lit.)
Flash Point:225 °F
Solubility:water
alpha:16 °(c=neat)
density:1.036 g/mL at 20 °C(lit.)
refractive index:n20/D 1.432(lit.)
Sensitive:Hygroscopic
Merck:14,7855
BRN:1718871
Synonyms of S-1,2-Propanediol(4254-15-3):
(S)-(+)-Propane-1,2-diol;(S)-Propane-1,2-diol;L-(+)-PROPYLENE GLYCOL;(S)-(+)-PROPANEDIOL;(S)-(+)-PROPYLENE GLYCEROL;(S)-(+)-PROPYLENE GLYCOL;(S)-(+)-1,2-DIHYDROXYPROPANE;(S)-(+)-1,2-PROPANEDIOL;(S)-(+)-1,2-Propanediol
Categories of S-1,2-Propanediol(4254-15-3):
Chiral Compounds;Diols;chiral;Chiral Building Blocks;Simple Alcohols (Chiral);Synthetic Organic Chemistry;Chiral Compound

(S)-(+)-1,2-Propanediol Uses

S-1,2-Propanediol(4254-15-3) is used for the synthesis of chiral drugs.

(S)-(+)-1,2-Propanediol Safety Profile

Safety Information of S-1,2-Propanediol(4254-15-3):
Hazard Codes:Xn

Risk Statements:36/37/38-22
36/37/38:Irritating to eyes, respiratory system and skin
22:Harmful if swallowed
Safety Statements:24/25-36/37/39-26
24/25:Avoid contact with skin and eyes
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany:1

(S)-(+)-1,2-Propanediol Specification

First Aid Measures of S-1,2-Propanediol(4254-15-3):
Eyes:Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:Get medical aid. Wash mouth out with water.
Inhalation:Remove from exposure and move to fresh air immediately.

Storage of S-1,2-Propanediol(4254-15-3):
Store in a cool, dry place. Store in a tightly closed container.

Product Name

(S)-(+)-1,2-Propanediol

Synthetic route

(S)-(+)-1,2-Propanediol Chemical Properties

(S)-(+)-1,2-Propanediol Uses

(S)-(+)-1,2-Propanediol Safety Profile

(S)-(+)-1,2-Propanediol Specification

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