(S)-(+)-2-Phenylglycinol supplier

Name
(S)-(+)-2-Phenylglycinol
EINECS 260-287-5
CAS No. 20989-17-7
Article Data156
CAS DataBase
Density 1.104 g/cm³
Solubility Soluble in chloroform, dimethylsulfoxide and methanol. Limited solubility in water.
Melting Point 76-79 °C
Formula C₈H₁₁NO
Boiling Point 261 °C at 760 mmHg
Molecular Weight 137.181
Flash Point 125.3 °C
Transport Information
Appearance white to light yellow crystal powder
Safety 22-24/25-45-36/37/39-26
Risk Codes 34-36/37/38-23/24/25
Molecular Structure
Hazard Symbols C, T
Synonyms S(+)-2-phenylglycinol;Benzeneethanol, beta-amino-, (S)-;(2S)-2-amino-2-phenyl-ethanol;L-phenylglycinol;(S)-(+)-2-Amino-2-phenylethanol;L-(+)-alpha-Phenylglycinol;L-2-Phenylglycinol;(S)-(+)-2-Pheny;(S)-(+)-Phenylglycinol;(S)-(-)-2-Phenylalanine;(S)-2-Phenylglycinol;L-(+)-2-Phenylglycinol;(S)-Phenylglycinol;(S)-2-Phenylglycinol hydrochloride;
PSA 46.25000
LogP 1.37900

Synthetic route

: 118958-06-8
N-<(2R,4E)-2-Methyl-4-hexenoyl>-S-phenylglycinol

A: 20989-17-7
(2S)-2-phenylglycinol

B: 93553-73-2
(2R,4E)-2-Methyl-4-hexenoic acid

Conditions

Conditions	Yield
With sulfuric acid In 1,4-dioxane at 70 - 80℃; for 3h;	A 92% B 99%

: 2935-35-5
(S)-2-phenylglycine

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran Heating;	97%
With lithium aluminium tetrahydride In tetrahydrofuran Heating;	97%
With lithium aluminium tetrahydride In tetrahydrofuran Heating;	95%

: 117049-14-6
tert-butyl N-[(1S)-2-hydroxy-1-phenylethyl]carbamate

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
In acetonitrile at 300℃; under 75007.5 Torr;	93%

: 6591-61-3, 24461-61-8, 26682-99-5, 37760-98-8
(S)-Phenylglycine methyl ester

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran for 1.5h; Reflux;	88%
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 1.5h; Reflux;	88%
Stage #1: (S)-Phenylglycine methyl ester With sodium tetrahydroborate In tetrahydrofuran at 65℃; for 0.25h; Stage #2: With methanol In tetrahydrofuran at 65℃; stereospecific reaction;	73%
With sodium tetrahydroborate In methanol at 20℃; for 1h;
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 1h; Cooling with ice; Inert atmosphere;

: 99395-88-7
(S)-4-phenyl-2-oxazolidinone

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
With 3-azapentane-1,5-diamine at 140℃; for 18h;	85%

: 15028-39-4
L-2-phenylglycine methyl ester hydrochloride

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
With sodium tetrahydroborate In ethanol 1) RT, 9h, b) 5.5h, reflux, c) RT, 8h;	83%
With sodium tetrahydroborate In ethanol; water for 5.5h; Heating;
Stage #1: L-2-phenylglycine methyl ester hydrochloride With triethylamine In methanol; diethyl ether at -10℃; for 1h; Stage #2: With sodium tetrahydroborate In methanol at 0 - 20℃;	4.4 g

: 217650-36-7
N-(2-methoxymethoxy-1-phenyl-ethyl)-acetamide

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
In methanol Hydrolysis; Acid hydrolysis;	81%

: 130406-31-4
benzyl (S)-(2-hydroxy-1-phenylethyl)carbamate

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
With hydrogen; palladium dihydroxide In methanol for 0.25h;	80%

: 20989-17-7, 56613-80-0, 71006-16-1, 7568-92-5, 188586-38-1
Phenylglycinol

A: 56613-80-0
(R)-Phenylglycinol

B: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
With hydrogenchloride; (S)-(+)-3,3′-bis(3,5-bis(trifluoromethyl)phenyl)-1,1′-binaphthyl-2,2′-diyl hydrogenphosphate In dichloromethane; water at 21.84℃; pH=2.32; Centrifugal contactor separators; Resolution of racemate; optical yield given as %ee;	A n/a B 36%
With chiral stationary phase including isopropyl-functionalized CF6 In methanol; acetic acid; triethylamine; acetonitrile at 20℃; Purification / work up;
With 3,3'-bis[3,5-bis(trifluoromethyl)phenyl]-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate In tetrachloromethane at 6℃; pH=3; aq. buffer; enantioselective reaction;

: 2935-35-5
(S)-2-phenylglycine

A: (2S)-(-)-2-amino-2-phenylethanol N-borane

B: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
Stage #1: (S)-2-phenylglycine With sodium tetrahydroborate; sulfuric acid In tetrahydrofuran; diethyl ether at 0 - 20℃; for 20h; Inert atmosphere; Stage #2: With hydrogenchloride In water at 20℃; for 2h;	A 27% B 33%

: 15962-49-9
(S)-phenylglycine ethyl ester

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride

: 126923-25-9
(S)-2-azido-2-phenylethanol

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran Heating; Yield given;

: 127718-96-1
(1S,2S,5S)-3-[(E)-(S)-2-Hydroxy-1-phenyl-ethylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
With hydroxylamine acetate In ethanol for 20h; Ambient temperature; Yield given;

: 20989-17-7, 56613-80-0, 71006-16-1, 7568-92-5, 188586-38-1
Phenylglycinol

: 20989-17-7
(2S)-2-phenylglycinol

: 102089-74-7, 117049-14-6, 138457-46-2, 67341-01-9
tert-butyl 2-hydroxy-1-phenylethylcarbamate

A: 56613-80-0
(R)-Phenylglycinol

B: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane for 1h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

: 126927-38-6
(1S,1'S)-N-2'-hydroxy-1'-phenylethyl-1-phenylethylamine

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
With hydrogen S, Ram, L. D. Spicer Synth. Commun. 1987, 17, 415.;

: 20780-53-4
(R)-Styrene oxide

A: 20989-17-7
(2S)-2-phenylglycinol

B: 2549-14-6
(R)-2-Amino-1-phenylethanol

Conditions

Conditions	Yield
With ammonium hydroxide In water at 130℃; under 9000.72 Torr; microwave irradiation;	A 20 % Chromat. B 80 % Chromat.

: (S)-2-Hydrazino-2-phenyl-ethanol

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
With hydrogen; nickel In methanol at 25℃; under 25857.4 Torr; for 28h;	0.136 g

: 1026035-75-5
C18H26N2O5

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: NaBH4 / methanol 2: TFA / CH2Cl2 / 3 h / 20 °C 3: 0.136 g / H2 / Raney-Ni / methanol / 28 h / 25 °C / 25857.4 Torr View Scheme

: 1027539-12-3
C18H28N2O5

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: TFA / CH2Cl2 / 3 h / 20 °C 2: 0.136 g / H2 / Raney-Ni / methanol / 28 h / 25 °C / 25857.4 Torr View Scheme

: 122-78-1
phenylacetaldehyde

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: D-proline / CH2Cl2 / 3 h / 20 °C 2: NaBH4 / methanol 3: TFA / CH2Cl2 / 3 h / 20 °C 4: 0.136 g / H2 / Raney-Ni / methanol / 28 h / 25 °C / 25857.4 Torr View Scheme

: 131934-09-3, 135765-81-0, 712-41-4
ethyl 2-(hydroxyimino)-2-phenylacetate

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 85 percent / NaBH4; I2 / tetrahydrofuran / 4 h / Heating 2.1: dibenzoyl-L-tartaric acid / acetone / 6 h / 25 °C 2.2: aq. KOH / CH2Cl2 View Scheme

: 121411-08-3
(4-Methoxy-phenyl)-[(S)-1-phenyl-2-((R)-toluene-4-sulfinyl)-ethyl]-amine

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 80 percent / CAN / H2O; acetonitrile / 0.5 h / 0 °C 2: 80 percent / K2CO3 / dioxane; H2O / 0.17 h / Ambient temperature 3: 1.) (CF3CO)2O, sym-collidine, 2.) K2CO3, NaBH4 / 1.) MeCN, 0 deg C, 5 min, 2.) H2O, 0 deg C to room temperature, 15 min 4: 80 percent / H2 / Pd(OH)2/C / methanol / 0.25 h View Scheme

: 100-52-7
benzaldehyde

HI, I2: HI, I2

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 70 percent / DOWEX 50W X8-400 / benzene / Heating 2: LDA / tetrahydrofuran; hexane / -70 °C / 1.) 15 min, 2.) 30 min 3: 80 percent / CAN / H2O; acetonitrile / 0.5 h / 0 °C 4: 80 percent / K2CO3 / dioxane; H2O / 0.17 h / Ambient temperature 5: 1.) (CF3CO)2O, sym-collidine, 2.) K2CO3, NaBH4 / 1.) MeCN, 0 deg C, 5 min, 2.) H2O, 0 deg C to room temperature, 15 min 6: 80 percent / H2 / Pd(OH)2/C / methanol / 0.25 h View Scheme
Multi-step reaction with 3 steps 1: 4 Angstroem mol. sieves / CH2Cl2 2: TiCl4 / 15 °C / Irradiation 3: H2 / S, Ram, L. D. Spicer Synth. Commun. 1987, 17, 415. View Scheme

Yield

Multi-step reaction with 6 steps
1: 70 percent / DOWEX 50W X8-400 / benzene / Heating
2: LDA / tetrahydrofuran; hexane / -70 °C / 1.) 15 min, 2.) 30 min
3: 80 percent / CAN / H2O; acetonitrile / 0.5 h / 0 °C
4: 80 percent / K2CO3 / dioxane; H2O / 0.17 h / Ambient temperature
5: 1.) (CF3CO)2O, sym-collidine, 2.) K2CO3, NaBH4 / 1.) MeCN, 0 deg C, 5 min, 2.) H2O, 0 deg C to room temperature, 15 min
6: 80 percent / H2 / Pd(OH)2/C / methanol / 0.25 h
View Scheme

Multi-step reaction with 3 steps
1: 4 Angstroem mol. sieves / CH2Cl2
2: TiCl4 / 15 °C / Irradiation
3: H2 / S, Ram, L. D. Spicer Synth. Commun. 1987, 17, 415.
View Scheme

: 1613-90-7
4-methoxy-N-[(E)-phenylmethylidene]aniline

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: LDA / tetrahydrofuran; hexane / -70 °C / 1.) 15 min, 2.) 30 min 2: 80 percent / CAN / H2O; acetonitrile / 0.5 h / 0 °C 3: 80 percent / K2CO3 / dioxane; H2O / 0.17 h / Ambient temperature 4: 1.) (CF3CO)2O, sym-collidine, 2.) K2CO3, NaBH4 / 1.) MeCN, 0 deg C, 5 min, 2.) H2O, 0 deg C to room temperature, 15 min 5: 80 percent / H2 / Pd(OH)2/C / methanol / 0.25 h View Scheme

Yield

Multi-step reaction with 5 steps
1: LDA / tetrahydrofuran; hexane / -70 °C / 1.) 15 min, 2.) 30 min
2: 80 percent / CAN / H2O; acetonitrile / 0.5 h / 0 °C
3: 80 percent / K2CO3 / dioxane; H2O / 0.17 h / Ambient temperature
4: 1.) (CF3CO)2O, sym-collidine, 2.) K2CO3, NaBH4 / 1.) MeCN, 0 deg C, 5 min, 2.) H2O, 0 deg C to room temperature, 15 min
5: 80 percent / H2 / Pd(OH)2/C / methanol / 0.25 h
View Scheme

: 224433-92-5
(S)-1-Phenyl-2-((R)-toluene-4-sulfinyl)-ethylamine

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 80 percent / K2CO3 / dioxane; H2O / 0.17 h / Ambient temperature 2: 1.) (CF3CO)2O, sym-collidine, 2.) K2CO3, NaBH4 / 1.) MeCN, 0 deg C, 5 min, 2.) H2O, 0 deg C to room temperature, 15 min 3: 80 percent / H2 / Pd(OH)2/C / methanol / 0.25 h View Scheme

: 224433-96-9
[(S)-1-Phenyl-2-((R)-toluene-4-sulfinyl)-ethyl]-carbamic acid benzyl ester

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) (CF3CO)2O, sym-collidine, 2.) K2CO3, NaBH4 / 1.) MeCN, 0 deg C, 5 min, 2.) H2O, 0 deg C to room temperature, 15 min 2: 80 percent / H2 / Pd(OH)2/C / methanol / 0.25 h View Scheme

: 69350-13-6
N-benzylidene-(S)-α-methylbenzylamine

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: TiCl4 / 15 °C / Irradiation 2: H2 / S, Ram, L. D. Spicer Synth. Commun. 1987, 17, 415. View Scheme

: 582-24-1
1-phenyl-2-hydroxyethanone

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: LiH / dimethylformamide 2: H2NOH*HCl; NaOAc / ethanol; H2O 3: Fe / dimethylformamide 4: 100 percent / H2 / {1,2-bis[(R,R)-2,5-dimethylphospholane]benzene}rhodium(I) / toluene / 20 °C / 7600 Torr 5: 81 percent / methanol / Acid hydrolysis View Scheme
With ω-transaminase from Arthrobacter; isopropylamine In tert-butyl methyl ether at 25℃; for 24h; Enzymatic reaction; enantioselective reaction;	n/a
With (R)-1-phenyl-ethyl-amine; (R)-ω-transaminase from Mycobacterium vanbaalenii; NAD Enzymatic reaction; enantioselective reaction;

: 103548-06-7
2-methoxymethoxy-1-phenyl-ethanone

: 20989-17-7
(2S)-2-phenylglycinol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: H2NOH*HCl; NaOAc / ethanol; H2O 2: Fe / dimethylformamide 3: 100 percent / H2 / {1,2-bis[(R,R)-2,5-dimethylphospholane]benzene}rhodium(I) / toluene / 20 °C / 7600 Torr 4: 81 percent / methanol / Acid hydrolysis View Scheme

: 20989-17-7
(2S)-2-phenylglycinol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 120417-13-2
(S)-2-(tert-butyldimethylsilyloxy)-1-phenylethylamine

Conditions

Conditions	Yield
With dmap; triethylamine In dichloromethane at 20℃; for 41h; Substitution;	100%
With dmap; triethylamine In dichloromethane at 20℃; for 12h;	85%
With dmap; triethylamine In dichloromethane at 20℃;	85%

: 20989-17-7
(2S)-2-phenylglycinol

: 105-45-3
acetoacetic acid methyl ester

: 476187-10-7
(Z)-3-((S)-2-Hydroxy-1-phenyl-ethylamino)-but-2-enoic acid methyl ester

Conditions

Conditions	Yield
In methanol for 24h; Heating;	100%

: 50-00-0
formaldehyd

: 20989-17-7
(2S)-2-phenylglycinol

: 95977-53-0
(S)-2-(N,N-dimethylamino)-2-phenylethanol

Conditions

Conditions	Yield
With HCOOH (98percent) In water for 18h; Heating;	100%

: 3984-34-7
4-(4-chlorophenyl)-4-oxobutanoic acid

: 20989-17-7
(2S)-2-phenylglycinol

: 873577-48-1
(3S,7aS)-7a-(4-Chloro-phenyl)-3-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

Conditions

Conditions	Yield
In toluene for 16h; Heating;	100%

: 20989-17-7
(2S)-2-phenylglycinol

: 58457-57-1
4-(2,4-dichlorophenyl)-4-oxobutanoic acid

: 808186-29-0
(3S,7aS)-7a-(2,4-Dichloro-phenyl)-3-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

Conditions

Conditions	Yield
In toluene for 16h; Heating;	100%

: 20989-17-7
(2S)-2-phenylglycinol

: 110931-77-6
4-(2,4-difluorophenyl)-4-oxobutanoic acid

: 808186-32-5
(3S,7aS)-7a-(2,4-Difluoro-phenyl)-3-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one

Conditions

Conditions	Yield
In toluene for 16h; Heating;	100%

: 89-95-2
2-methyl-benzyl alcohol

: 20989-17-7
(2S)-2-phenylglycinol

: 113866-46-9, 129049-04-3, 129049-05-4
2-{(E)-((1S)-2-hydroxy-1-phenylethylimino)methyl}phenol

Conditions

Conditions	Yield
With sodium sulfate In methanol for 12h; Heating;	100%
In ethanol at 20℃;

: 20989-17-7
(2S)-2-phenylglycinol

: 15431-67-1
ethyl 5-formyl-3-methoxy-4-methyl-1H-pyrrole-2-carboxylate

: ethyl 4-methyl-3-methoxy-5-[(L-phenylglycinolimino)methyl]-1H-pyrrole-2-carboxylate

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane	100%

: (3E,5E)-7-(tert-Butyl-dimethyl-silanyloxy)-2-[2-oxo-eth-(Z)-ylidene]-hepta-3,5-dienoic acid ethyl ester

: 20989-17-7
(2S)-2-phenylglycinol

: 5-[3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-3-phenyl-2,3,6,8a-tetrahydro-5H-oxazolo[3,2-a]pyridine-7-carboxylic acid ethyl ester

Conditions

Conditions	Yield
In chloroform-d1 at 24℃;	100%

: 20989-17-7
(2S)-2-phenylglycinol

: 344907-95-5
ethyl (E,E)-4-oxo-2-styrylbut-2-enoate

: 3,5-diphenyl-2,3,6,8a-tetrahydro-5H-oxazolo[3,2-a]pyridine-7-carboxylic acid ethyl ester

Conditions

Conditions	Yield
In chloroform-d1 at 24℃;	100%

: 20989-17-7
(2S)-2-phenylglycinol

: 107-02-8
acrolein

: 1055874-41-3
(3S,9S)-3,9-diphenyloctahydro-5H,11H-bis[1,3]oxazolo[3,2-a:3',2'-e][1,5]diazocine

Conditions

Conditions	Yield
In chloroform at 20℃; for 0.0833333h;	100%
In toluene at 20℃; for 15h; Molecular sieve;	36%

: 764-59-0
hex-5-en-1-al

: 20989-17-7
(2S)-2-phenylglycinol

: (4S)-2-(pent-4-en-1-yl)-4-phenyloxazolidine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane Inert atmosphere;	100%

: 20989-17-7
(2S)-2-phenylglycinol

: C49H61O2P

: C57H70NO2P

Conditions

Conditions	Yield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; Inert atmosphere; Cooling with ice;	100%

: 24424-99-5
di-tert-butyl dicarbonate

: 20989-17-7
(2S)-2-phenylglycinol

: 117049-14-6
tert-butyl N-[(1S)-2-hydroxy-1-phenylethyl]carbamate

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 3h; Acylation;	99%
In chloroform at 0 - 20℃;	97%
With triethylamine In tetrahydrofuran for 2h;	96%

: 20989-17-7
(2S)-2-phenylglycinol

: 37031-29-1, 6134-82-3, 6135-80-4, 90613-41-5, 116499-08-2, 37031-30-4
(+)-dimethyl-2,3-O-isopropylidene-D-tartrate

: 182966-70-7
(4S,5S)-2,2-Dimethyl-[1,3]dioxolane-4,5-dicarboxylic acid bis-[((S)-2-hydroxy-1-phenyl-ethyl)-amide]

Conditions

Conditions	Yield
at 120℃; for 3h;	99%

: 14371-10-9
(E)-3-phenylpropenal

: 20989-17-7
(2S)-2-phenylglycinol

: (S)-2-Phenyl-2-[(E)-3-phenyl-prop-2-en-(E)-ylideneamino]-ethanol

Conditions

Conditions	Yield
In diethyl ether for 1.33333h; Ambient temperature;	99%

: 75-15-0
carbon disulfide

: 20989-17-7
(2S)-2-phenylglycinol

: 190970-57-1
(S)-4-phenyl-1,3-oxazolidine-2-thione

Conditions

Conditions	Yield
With dihydrogen peroxide; potassium carbonate In ethanol at 50℃;	99%
Stage #1: carbon disulfide; (2S)-2-phenylglycinol With triethylamine In methanol at 20℃; for 0.5h; Stage #2: With dihydrogen peroxide In methanol	95%
With dihydrogen peroxide; potassium carbonate In ethanol at 50℃; for 0.0833333h;	80%

: 54884-55-8
2-methoxy-6-methyl-benzaldehyde

: 20989-17-7
(2S)-2-phenylglycinol

: 702684-35-3
(+)-(βS)-β-{[(1E)-(2-methoxy-6-methylphenyl)methylene]amino}benzeneethanol

Conditions

Conditions	Yield
With 4A MS In ethanol at 20℃; for 26h;	99%

: 920985-42-8, 856407-39-1
(R)-1,1'-spirobiindane-7,7'-dicaboxylic acid

: 20989-17-7
(2S)-2-phenylglycinol

: (Ra,S,S)-N,N'-bis(2-hydroxy-1-phenylethyl)-1,1'-spirobiindane-7,7'-diamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In tetrahydrofuran at -5 - 20℃;	99%

: 6783-05-7
trans-2-phenylvinylboronic acid

: 20989-17-7
(2S)-2-phenylglycinol

: 6000-59-5
glyoxalic acid monohydrate

: 82795-51-5
D-homophenylalanine

Conditions

Conditions	Yield
In dichloromethane	99%

...Expand

: 20989-17-7
(2S)-2-phenylglycinol

: 105-45-3
acetoacetic acid methyl ester

: C14H18O3

Conditions

Conditions	Yield
In toluene at 20℃; for 4h; Molecular sieve;	99%

: 20989-17-7
(2S)-2-phenylglycinol

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 215178-44-2
(2-hydroxy-1-phenylethyl)carbamic acid 9H-fluoren-9-ylmethyl ester

Conditions

Conditions	Yield
In 1,4-dioxane; water at 20℃; for 16h;	99%

: 20989-17-7
(2S)-2-phenylglycinol

: 109-94-4
formic acid ethyl ester

: (+)-(2S)-2-(formylamino)-2-phenylethanol

Conditions

Conditions	Yield
Reflux;	99%

: 4160-82-1
3,3-dimethylglutaric anhydride

: 20989-17-7
(2S)-2-phenylglycinol

: 1327278-20-5
3-(((S)-2-hydroxy-1-phenylethyl-carbamoyl)methyl)-3-methylbutanoic acid

Conditions

Conditions	Yield
In dichloromethane; toluene at 20 - 60℃; for 5.5h;	99%

: 586-76-5
4-Bromobenzoic acid

: 20989-17-7
(2S)-2-phenylglycinol

: (S)-4-bromo-N-(2-hydroxy-1-phenylethyl)benzamide

Conditions

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1,2-dichloro-ethane In N,N-dimethyl-formamide at 25℃; for 20h; Solvent; chemoselective reaction;	99%
With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate In tetrahydrofuran at 20℃; for 20h;	60%

: 24517-64-4
2-amino-3-pyridinecarbonitrile

: 20989-17-7
(2S)-2-phenylglycinol

: 3-[(4S)-4-phenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridine-2-amine

Conditions

Conditions	Yield
With zinc(II) chloride In chlorobenzene at 60℃; for 96h; Inert atmosphere;	99%

(S)-(+)-2-Phenylglycinol Chemical Properties

Molecular Structure of (S)-(+)-2-Phenylglycinol (CAS NO.20989-17-7):

IUPAC Name: (2S)-2-amino-2-phenylethanol
Empirical Formula: C₈H₁₁NO
Molecular Weight: 137.179
H bond acceptors: 2
H bond donors: 3
Freely Rotating Bonds: 4
Polar Surface Area: 12.47 Å²
Index of Refraction: 1.572
Molar Refractivity: 40.87 cm³
Molar Volume: 124.1 cm³
Surface Tension: 48.8 dyne/cm
Density: 1.104 g/cm³
Flash Point: 125.3 °C
Enthalpy of Vaporization: 52.69 kJ/mol
Boiling Point: 261 °C at 760 mmHg
Vapour Pressure: 0.00601 mmHg at 25°C
Melting point: 76-79 °C
Storage temp: Store at 0-5°C
Sensitive: Air Sensitive
InChI
InChI=1/C8H11NO/c9-8(6-10)7-4-2-1-3-5-7/h1-5,8,10H,6,9H2/t8-/m1/s1
Smiles
c1(ccccc1)[C@@H](CO)N
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage: Store in a cool, dry place. Store in a tightly closed container. Corrosives area. Store under nitrogen.
Product Categories: Pharmaceutical Intermediates; Alcohols and Derivatives; chiral; Chiral Reagent; Phenylglycine [Phg]; Amino Acids 13C, 2H, 15N; Amino Alcohols (Chiral); Asymmetric Synthesis; Chiral Building Blocks; Synthetic Organic Chemistry; Amino alcohols; Amino Acids & Derivatives

(S)-(+)-2-Phenylglycinol Safety Profile

Risk Statements: 34-36/37/38-23/24/25
R34:Causes burns.
R36/37/38:Irritating to eyes, respiratory system and skin.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-24/25-45-36/37/39-26
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Hazard Codes: Corrosive C, Toxic T
WGK Germany: 3
F: 2-10

(S)-(+)-2-Phenylglycinol Specification

(S)-(+)-2-Phenylglycinol , with CAS number of 20989-17-7, can be called (R)/(S)-Phenylglycinol ; 2-Amino-2-pheynlethanol ; Benzeneethanol, beta-amino-, (S)- ; (2S)-2-amino-2-phenyl-ethanol ; (S)-(+)-2-Amino-2-phenylethanol ; (S)-(+)-2-Pheny ; S-(+)-2-Phenylglycinol (>=99%) ; (S)-(-)-2-Phenylalanine ; L-(+)-2-Phenylglycinol ; (S)-(+)-2-Amino-2-Phenylethanol; (S)-(+)-2- . It is a white to light yellow crystal powde.

Product Name

(S)-(+)-2-Phenylglycinol

Synthetic route

(S)-(+)-2-Phenylglycinol Chemical Properties

(S)-(+)-2-Phenylglycinol Safety Profile

(S)-(+)-2-Phenylglycinol Specification

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