(S)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methylpropan-1-one (2R,3R)-O,O'-dibenzoyltartrate
(2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone
Conditions | Yield |
---|---|
With diethylamine In tert-butyl methyl ether at 20 - 25℃; for 1.5h; | 96.5% |
With diethylamine In tert-butyl methyl ether at 20℃; for 3h; Product distribution / selectivity; | |
With ammonia; water In 2-methyltetrahydrofuran for 0.5h; Product distribution / selectivity; | |
With diethylamine In tert-butyl methyl ether |
formaldehyd
1-(3-methoxyphenyl)propan-1-one
N,N-dimethylammonium chloride
(2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone
Conditions | Yield |
---|---|
With hydrogenchloride; L-proline In ethanol; water for 16h; Reflux; Inert atmosphere; | 78% |
3-(dimethylamino)-1-(3-methoxyphenyl)-2-methylpropan-1-one
(2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetone; methanol 2: diethylamine / tert-butyl methyl ether View Scheme |
1-(3-methoxyphenyl)propan-2-one
(2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: trifluoroacetic acid 2: acetone; methanol 3: diethylamine / tert-butyl methyl ether View Scheme |
formaldehyd
1-(3-methoxyphenyl)propan-1-one
dimethyl amine
(2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone
Conditions | Yield |
---|---|
With L-proline In ethanol at 77℃; for 36h; Temperature; Solvent; Mannich Aminomethylation; | 306.2 g |
(2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone
ethylmagnesium bromide
(2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methyl pentan-3-ol
Conditions | Yield |
---|---|
Stage #1: (2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone; ethylmagnesium bromide In tetrahydrofuran at 15℃; for 4h; Grignard Reaction; Stage #2: With ammonium bisulphate; water In tetrahydrofuran at 5℃; Product distribution / selectivity; | 99% |
(2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone
(2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methyl pentan-3-ol
Conditions | Yield |
---|---|
Stage #1: ethyl bromide With magnesium In diethyl ether at 35℃; for 2.5h; Stage #2: (2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone In diethyl ether at 10 - 15℃; for 2h; Grignard Reaction; Stage #3: With ammonium bisulphate; water In diethyl ether at 5℃; Product distribution / selectivity; | 98% |
(2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone
ethylmagnesium bromide
Conditions | Yield |
---|---|
Stage #1: (2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone; ethylmagnesium bromide In tetrahydrofuran; diethyl ether at 10 - 15℃; for 2h; Grignard Reaction; Stage #2: With water; ammonium chloride In tetrahydrofuran; diethyl ether at 5℃; | 71% |
(2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone
ethylmagnesium chloride
(2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methyl pentan-3-ol
Conditions | Yield |
---|---|
Stage #1: (2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone; ethylmagnesium chloride In tetrahydrofuran at 2 - 25℃; for 3.83333h; Grignard Reaction; Stage #2: With water; acetic acid In tetrahydrofuran at 20℃; for 0.5h; Stage #3: With ammonia; water In tetrahydrofuran at 20℃; for 0.166667h; |
(2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: diethyl ether; tetrahydrofuran / 2 h / 10 - 15 °C 1.2: 5 °C 2.1: hydrogenchloride / water / 5 h / 55 °C 2.2: 20 °C / pH 12 3.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 20 °C / Inert atmosphere View Scheme |
(2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: diethyl ether; tetrahydrofuran / 2 h / 10 - 15 °C 1.2: 5 °C 2.1: hydrogenchloride / water / 5 h / 55 °C 2.2: 20 °C / pH 12 3.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 20 °C / Inert atmosphere 4.1: methanesulfonic acid; DL-methionine / 72 h / 80 °C 4.2: pH 10 - 12 5.1: hydrogenchloride / diethyl ether / 4 h View Scheme |
(2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone
tapentadol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: diethyl ether; tetrahydrofuran / 2 h / 10 - 15 °C 1.2: 5 °C 2.1: hydrogenchloride / water / 5 h / 55 °C 2.2: 20 °C / pH 12 3.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 20 °C / Inert atmosphere 4.1: methanesulfonic acid; DL-methionine / 72 h / 80 °C 4.2: pH 10 - 12 View Scheme |
(2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: diethyl ether; tetrahydrofuran / 2 h / 10 - 15 °C 1.2: 5 °C 2.1: hydrogenchloride / water / 5 h / 55 °C 2.2: 20 °C / pH 12 View Scheme |
(2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone
(R,R)-tapentadol-(PABA tert-butyl ester) carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: diethyl ether; tetrahydrofuran / 2 h / 10 - 15 °C 1.2: 5 °C 2.1: hydrogenchloride / water / 5 h / 55 °C 2.2: 20 °C / pH 12 3.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 20 °C / Inert atmosphere 4.1: methanesulfonic acid; DL-methionine / 72 h / 80 °C 4.2: pH 10 - 12 5.1: toluene / Reflux View Scheme |
(2S)-3-dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone
(R,R)-tapentadol-PABA carbamate trifluoroacetate
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: diethyl ether; tetrahydrofuran / 2 h / 10 - 15 °C 1.2: 5 °C 2.1: hydrogenchloride / water / 5 h / 55 °C 2.2: 20 °C / pH 12 3.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 20 °C / Inert atmosphere 4.1: methanesulfonic acid; DL-methionine / 72 h / 80 °C 4.2: pH 10 - 12 5.1: toluene / Reflux 6.1: 1 h / 20 °C View Scheme |
The systematic name of 1-Propanone,3-(dimethylamino)-1-(3-methoxyphenyl)-2-methyl-, (2S)- is (2S)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methyl-propan-1-one. With the CAS registry number 850222-40-1, it is also named as (S)-3-Dimethylamino-1-(3-methoxyphenyl)-2-methyl-1-propanone. In addition, its molecular formula is C13H19NO2 and its molecular weight is 221.30.
The other characteristics of 1-Propanone,3-(dimethylamino)-1-(3-methoxyphenyl)-2-methyl-, (2S)- can be summarized as: (1)ACD/LogP: 2.27; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 7.4): 0.79; (4)#H bond acceptors: 3; (5)#H bond donors: 0; (6)#Freely Rotating Bonds: 5; (7)Polar Surface Area: 29.54 Å2; (8)Index of Refraction: 1.508; (9)Molar Refractivity: 65.17 cm3; (10)Molar Volume: 218.6 cm3; (11)Polarizability: 25.83×10-24cm3; (12)Surface Tension: 34.8 dyne/cm; (13)Density: 1.012 g/cm3; (14)Flash Point: 144.8 °C; (15)Enthalpy of Vaporization: 55.7 kJ/mol; (16)Boiling Point: 315.8 °C at 760 mmHg; (17)Vapour Pressure: 0.000428 mmHg at 25 °C.
People can use the following data to convert to the molecule structure.
(1)SMILES: CC(CN(C)C)C(=O)c1cccc(c1)OC
(2)InChI: InChI=1/C13H19NO2/c1-10(9-14(2)3)13(15)11-6-5-7-12(8-11)16-4/h5-8,10H,9H2,1-4H3/t10-/m0/s1
(3)InChIKey: YHCVGGJYRMYIGG-JTQLQIEIBN
(4)Std. InChI: InChI=1S/C13H19NO2/c1-10(9-14(2)3)13(15)11-6-5-7-12(8-11)16-4/h5-8,10H,9H2,1-4H3/t10-/m0/s1
(5)Std. InChIKey: YHCVGGJYRMYIGG-JTQLQIEISA-N
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