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inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
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inquiry(betaR,gammaR)-gamma-Ethyl-3-methoxy-N,N,beta-trimethylbenzenepropanamine Basic information Product Name: (betaR,gammaR)-gamma-Ethyl-3-methoxy-N,N,beta-trimethylbenzenepropanamine Synonyms: (2R,3R)-3-(3-Methoxyphenyl)-N,N-2-trimethylpentanamine;(
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inquiryHANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exp
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inquiryProduct Name: (betaR,gammaR)-gamma-Ethyl-3-methoxy-N,N,beta-trimethylbenzenepropanamine Synonyms: (2R,3R)-3-(3-Methoxyphenyl)-N,N-2-trimethylpentanam…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton
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inquirySuperior quality, moderate price & quick delivery. Storage:Stored in cool, dry and ventilation place; Away from fire and heat; Package:as per your request Application:Used as Pharmaceutical Intermediates Transportation:as per your request Port
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inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
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inquiryJ&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals
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inquiryOur own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin
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inquirygood quality, competitive price, thoughtful after sale serviceAppearance:White to Off-White Solid Storage:Keep it in dry,shady and cool place Package:as your requirement Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by Sea
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inquiry(2R,3R)-3-(3-Methoxyphenyl)-N,N-2-trimethylpentanamine cas 175591-22-7Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China
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inquirybulk?production Application:Pharmaceutical intermediates
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inquirymolecular formula:C15H25NO2
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inquiry(2R,3R)-3-(3-methoxyphenyl)-N,N,2-trimethylpent-4-en-1-amine
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen In ethanol at 24℃; under 3750.38 Torr; for 22h; | 99% |
With hydrogen; 5%-palladium/activated carbon In methanol at 20℃; under 3375.34 Torr; for 16h; |
(R),(R)-toluene-4-sulfonic acid 3-(3-methoxy-phenyl)-2-methyl-pentyl ester
N,N-dimethylammonium chloride
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Stage #1: N,N-dimethylammonium chloride With sodium hydroxide In dimethyl sulfoxide at 20 - 25℃; for 0.166667h; Stage #2: (R),(R)-toluene-4-sulfonic acid 3-(3-methoxy-phenyl)-2-methyl-pentyl ester In dimethyl sulfoxide at 50 - 55℃; for 2h; | 95% |
(2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methyl pentan-3-ol
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Stage #1: (2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methyl pentan-3-ol With methanesulfonic acid; sulfuric acid In tetrahydrofuran; cyclohexane at 25 - 78℃; for 3h; Stage #2: With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; cyclohexane at 25 - 30℃; Autoclave; Inert atmosphere; | 93.62% |
Multi-step reaction with 2 steps 1.1: sulfuric acid / cyclohexane; tetrahydrofuran / 3 h / 25 - 80 °C 1.2: pH 8 - 9 2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 25 - 30 °C / in an autoclave; Inert atmosphere 2.2: 0 - 5 °C / pH 9 - 10 View Scheme | |
Multi-step reaction with 2 steps 1: sulfuric acid / tetrahydrofuran; cyclohexane / 3 h / 25 - 78 °C 2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 25 - 30 °C / Autoclave; Inert atmosphere View Scheme |
(2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan-3-yl 4-methylsulfonate
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Stage #1: (2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methylpentan-3-yl 4-methylsulfonate With hydrogen; palladium 10% on activated carbon In tetrahydrofuran at 25 - 30℃; in an autoclave; Inert atmosphere; Stage #2: With sodium hydroxide In water at 0 - 5℃; pH=9 - 10; Product distribution / selectivity; | 91% |
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran at 25 - 30℃; Autoclave; Inert atmosphere; | 91% |
(βR,γR)-γ-ethyl-3-methoxy-β-methylbenzenepropanol
N,N-dimethylammonium chloride
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Stage #1: (βR,γR)-γ-ethyl-3-methoxy-β-methylbenzenepropanol With methanesulfonyl chloride; triethylamine In dichloromethane at 0℃; for 1h; Stage #2: N,N-dimethylammonium chloride In dichloromethane at 30℃; for 2h; | 91% |
(αR,βR)-β-ethyl-3-methoxy-N,N,α-trimethyl benzenepropanamide
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran for 2h; Cooling with ice; | 90% |
Stage #1: (αR,βR)-β-ethyl-3-methoxy-N,N,α-trimethyl benzenepropanamide With lithium aluminium tetrahydride In tetrahydrofuran for 2h; Cooling with ice; Stage #2: With water; sodium hydroxide In tetrahydrofuran | 90% |
Stage #1: (αR,βR)-β-ethyl-3-methoxy-N,N,α-trimethyl benzenepropanamide With sodium bis(2-methoxyethoxy)aluminium dihydride In toluene for 1h; Inert atmosphere; Reflux; Stage #2: With sodium hydroxide In water; toluene at 20℃; for 0.5h; Cooling with ice; | 84% |
Stage #1: (αR,βR)-β-ethyl-3-methoxy-N,N,α-trimethyl benzenepropanamide With dimethylsulfide borane complex In tetrahydrofuran at 20 - 80℃; for 3h; Inert atmosphere; Stage #2: With methanol In tetrahydrofuran at 0 - 5℃; for 0.5h; |
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
With hydrogenchloride; hydrogen; palladium 10% on activated carbon In ethanol; water at 20℃; Inert atmosphere; | 72% |
formaldehyd
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
With formic acid In water at 85℃; for 3h; | 70% |
A
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Stage #1: (R)-3-(3-methoxyphenyl)-N,N,2-trimethylpent-3-en-1-amine With hydrogenchloride; hydrogen; 5%-palladium/activated carbon In ethanol; water under 750.075 - 3750.38 Torr; Stage #2: With sodium hydroxide; water In ethanol at 20℃; pH=10 - 12; |
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Stage #1: C17H24F3NO3 With hydrogen; palladium 10% on activated carbon at 40℃; under 1520.1 Torr; for 4h; Stage #2: With sodium hydroxide; water at 20℃; for 0.166667h; Product distribution / selectivity; |
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Stage #1: C17H27NO3 With hydrogen; palladium 10% on activated carbon at 40℃; under 1520.1 Torr; for 4h; Stage #2: With sodium hydroxide; water at 20℃; for 0.166667h; Product distribution / selectivity; |
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Stage #1: C19H29NO5 With hydrogen; palladium 10% on activated carbon at 40℃; under 1520.1 Torr; for 4h; Stage #2: With sodium hydroxide; water at 20℃; for 0.166667h; Product distribution / selectivity; |
(E)-(RS)-[3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethylamine hydrochloride
A
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Stage #1: (Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethyl-amine hydrochloride; (E)-(RS)-[3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethylamine hydrochloride With hydrogen; 5%-palladium/activated carbon In water at 45℃; under 750.075 - 3750.38 Torr; Stage #2: With sodium hydroxide In water Product distribution / selectivity; |
(E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethyl-amine
(Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethyl-amine
A
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
With hydrogen; 5%-palladium/activated carbon In ethanol at 25℃; under 750.075 - 3750.38 Torr; Product distribution / selectivity; | |
With hydrogen; palladium 10% on activated carbon In ethanol; water at 25℃; under 750.075 - 3750.38 Torr; Product distribution / selectivity; | |
With hydrogen; 5%-palladium/activated carbon In ethanol; water at 25℃; under 750.075 - 3750.38 Torr; Product distribution / selectivity; | |
With hydrogen; 1% Pd/C In ethanol; water at 25℃; under 750.075 - 3750.38 Torr; Product distribution / selectivity; | |
Stage #1: (E)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethyl-amine; (Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethyl-amine With hydrogenchloride; hydrogen; 5%-palladium/activated carbon In ethanol; water at 25℃; under 750.075 - 3750.38 Torr; Stage #2: With sodium hydroxide In water; ethyl acetate at 20℃; pH=10 - 12; Product distribution / selectivity; |
(2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methyl pentan-3-ol
A
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Stage #1: (2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methyl pentan-3-ol With hydrogenchloride In water at 20 - 70℃; for 1.66667h; Stage #2: With sodium hydroxide; sodium chloride In water at 20℃; Stage #3: With sodium hydroxide; hydrogen; 1% Pd/C Product distribution / selectivity; more than 3 stages; | |
Stage #1: (2S,3R)-1-(dimethylamino)-3-(3-methoxyphenyl)-2-methyl pentan-3-ol With hydrogenchloride In water at 20 - 70℃; for 1.66667h; Stage #2: With sodium hydroxide; sodium chloride In water at 20℃; Stage #3: With sodium hydroxide; hydrogen; palladium dichloride Product distribution / selectivity; more than 3 stages; |
(Z)-(2R)-[3-(3-methoxy-phenyl)-2-methyl-pent-3-enyl]-dimethyl-amine
A
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
With methanesulfonic acid; hydrogen; bis(norbornadiene)rhodium(l)tetrafluoroborate; (S)-Solphos In ethanol at 0 - 25℃; under 7500.75 - 15001.5 Torr; for 16.5 - 67.5h; Product distribution / selectivity; | |
With methanesulfonic acid; hydrogen; bis(norbornadiene)rhodium(l)tetrafluoroborate; 2,2'-bis(dicyclohexylphosphino)-6,6'-dimethyl-1,1'-biphenyl In ethanol at 0 - 25℃; under 15001.5 Torr; for 20h; Product distribution / selectivity; | |
With methanesulfonic acid; hydrogen; bis(norbornadiene)rhodium(l)tetrafluoroborate; 4,12-bis(diphenylphosphino)-[2.2]-paracyclophane In ethanol at 0 - 25℃; under 15001.5 Torr; for 20h; Product distribution / selectivity; |
2-(3-methoxybenzylidene)malononitrile
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: tetrahydrofuran / -15 - 25 °C / Inert atmosphere 1.2: 0 - 5 °C 2.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 25 °C 2.2: 1 h / 25 °C 3.1: tri-n-butyl-tin hydride / 2,2'-azobis(isobutyronitrile) / toluene / 10 h / Reflux 3.2: 20 °C 4.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 4.2: pH 1 5.1: di-isopropyl ether / 6 h / 20 - 75 °C 6.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 7.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 8.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 9.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 9.2: 0.5 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 8 steps 1.1: tetrahydrofuran / -15 - 25 °C / Inert atmosphere 1.2: 0 - 5 °C 2.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 25 °C 2.2: 1 h / 25 °C 3.1: sodium hydroxide; ethylene glycol / 4 h / 170 - 180 °C 3.2: pH 1 4.1: di-isopropyl ether / 6 h / 20 - 75 °C 5.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 6.1: borane-dimethyl sulfide complex / tetrahydrofuran / 1 h / 50 - 55 °C / Inert atmosphere 6.2: 0 - 5 °C 7.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 8.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 8.2: 2 h / 50 - 55 °C View Scheme | |
Multi-step reaction with 9 steps 1.1: tetrahydrofuran / -15 - 25 °C / Inert atmosphere 1.2: 0 - 5 °C 2.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 25 °C 2.2: 1 h / 25 °C 3.1: sodium hydroxide; ethylene glycol / 4 h / 170 - 180 °C 3.2: pH 1 4.1: di-isopropyl ether / 6 h / 20 - 75 °C 5.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 6.1: sulfuric acid / 5 h / 50 - 55 °C 7.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 4 h / 50 - 55 °C 8.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 9.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 9.2: 2 h / 50 - 55 °C View Scheme | |
Multi-step reaction with 9 steps 1.1: tetrahydrofuran / -15 - 25 °C / Inert atmosphere 1.2: 0 - 5 °C 2.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 25 °C 2.2: 1 h / 25 °C 3.1: sodium hydroxide; ethylene glycol / 4 h / 170 - 180 °C 3.2: pH 1 4.1: di-isopropyl ether / 6 h / 20 - 75 °C 5.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 6.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 7.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 55 °C 7.2: 0 - 5 °C 8.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 9.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 9.2: 2 h / 50 - 55 °C View Scheme |
3-methoxy-benzaldehyde
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 6 h / 50 - 60 °C 2.1: tetrahydrofuran / -15 - 25 °C / Inert atmosphere 2.2: 0 - 5 °C 3.1: sodium hydride / toluene / 1 h / 20 °C / Inert atmosphere 3.2: 4 h / 45 - 50 °C 3.3: 0 - 5 °C / pH 1 4.1: lithium chloride / dimethyl sulfoxide / 15 h / 150 - 160 °C 5.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 5.2: pH 1 6.1: di-isopropyl ether / 6 h / 20 - 75 °C 7.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 8.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 9.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 10.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 10.2: 0.5 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 10 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 6 h / 50 - 60 °C 2.1: tetrahydrofuran / -15 - 25 °C / Inert atmosphere 2.2: 0 - 5 °C 3.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 25 °C 3.2: 1 h / 25 °C 4.1: tri-n-butyl-tin hydride / 2,2'-azobis(isobutyronitrile) / toluene / 10 h / Reflux 4.2: 20 °C 5.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 5.2: pH 1 6.1: di-isopropyl ether / 6 h / 20 - 75 °C 7.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 8.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 9.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 10.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 10.2: 0.5 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 9 steps 1.1: tetrahydrofuran / -5 °C / Inert atmosphere 1.2: 0 °C 2.1: phosphorus tribromide / 0 - 25 °C 3.1: sodium hydride / dimethyl sulfoxide / 1 h / 25 °C 3.2: 5 h 4.1: sodium hydroxide; ethylene glycol / 4 h / 170 - 180 °C 4.2: pH 1 5.1: di-isopropyl ether / 6 h / 20 - 75 °C 6.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 7.1: borane-dimethyl sulfide complex / tetrahydrofuran / 1 h / 50 - 55 °C / Inert atmosphere 7.2: 0 - 5 °C 8.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 9.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 9.2: 2 h / 50 - 55 °C View Scheme |
2-cyano-3-(3-methoxyphenyl)acrylic acid ethyl ester
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: tetrahydrofuran / -15 - 25 °C / Inert atmosphere 1.2: 0 - 5 °C 2.1: sodium hydride / toluene / 1 h / 20 °C / Inert atmosphere 2.2: 4 h / 45 - 50 °C 2.3: 0 - 5 °C / pH 1 3.1: lithium chloride / dimethyl sulfoxide / 15 h / 150 - 160 °C 4.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 4.2: pH 1 5.1: di-isopropyl ether / 6 h / 20 - 75 °C 6.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 7.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 8.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 9.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 9.2: 0.5 h / 0 - 5 °C View Scheme |
2-[1-(3-methoxy-phenyl)-propyl]-malononitrile
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 25 °C 1.2: 1 h / 25 °C 2.1: tri-n-butyl-tin hydride / 2,2'-azobis(isobutyronitrile) / toluene / 10 h / Reflux 2.2: 20 °C 3.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 3.2: pH 1 4.1: di-isopropyl ether / 6 h / 20 - 75 °C 5.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 6.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 7.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 8.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 8.2: 0.5 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 25 °C 1.2: 1 h / 25 °C 2.1: sodium hydroxide; ethylene glycol / 4 h / 170 - 180 °C 2.2: pH 1 3.1: di-isopropyl ether / 6 h / 20 - 75 °C 4.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 5.1: borane-dimethyl sulfide complex / tetrahydrofuran / 1 h / 50 - 55 °C / Inert atmosphere 5.2: 0 - 5 °C 6.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 7.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 7.2: 2 h / 50 - 55 °C View Scheme | |
Multi-step reaction with 8 steps 1.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 25 °C 1.2: 1 h / 25 °C 2.1: sodium hydroxide; ethylene glycol / 4 h / 170 - 180 °C 2.2: pH 1 3.1: di-isopropyl ether / 6 h / 20 - 75 °C 4.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 5.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 55 °C 6.2: 0 - 5 °C 7.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 8.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 8.2: 2 h / 50 - 55 °C View Scheme | |
Multi-step reaction with 8 steps 1.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 25 °C 1.2: 1 h / 25 °C 2.1: sodium hydroxide; ethylene glycol / 4 h / 170 - 180 °C 2.2: pH 1 3.1: di-isopropyl ether / 6 h / 20 - 75 °C 4.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 5.1: sulfuric acid / 5 h / 50 - 55 °C 6.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 4 h / 50 - 55 °C 7.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 8.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 8.2: 2 h / 50 - 55 °C View Scheme |
3-(1-bromopropyl)anisole
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 3 h / 25 °C 2.1: sodium hydride / toluene / 1 h / 20 °C / Inert atmosphere 2.2: 4 h / 45 - 50 °C 2.3: 0 - 5 °C / pH 1 3.1: lithium chloride / dimethyl sulfoxide / 15 h / 150 - 160 °C 4.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 4.2: pH 1 5.1: di-isopropyl ether / 6 h / 20 - 75 °C 6.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 7.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 8.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 9.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 9.2: 0.5 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 10 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 3 h / 25 °C 2.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 25 °C 2.2: 1 h / 25 °C 3.1: sodium amalgam / ethanol / 25 - 30 °C 4.1: sodium amide / toluene / 4 h / 20 °C / Reflux 4.2: Reflux 5.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 5.2: pH 1 6.1: di-isopropyl ether / 6 h / 20 - 75 °C 7.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 8.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 9.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 10.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 10.2: 0.5 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 9 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 3 h / 25 °C 2.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 25 °C 2.2: 1 h / 25 °C 3.1: sodium amalgam / methanol / 25 - 30 °C 4.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 4.2: pH 1 5.1: di-isopropyl ether / 6 h / 20 - 75 °C 6.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 7.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 8.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 9.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 9.2: 0.5 h / 0 - 5 °C View Scheme |
3-(3-methoxy-phenyl)-2-(toluene-4-sulfonyl)-pentanoic acid ethyl ester
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 25 °C 1.2: 1 h / 25 °C 2.1: sodium amalgam / ethanol / 25 - 30 °C 3.1: sodium amide / toluene / 4 h / 20 °C / Reflux 3.2: Reflux 4.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 4.2: pH 1 5.1: di-isopropyl ether / 6 h / 20 - 75 °C 6.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 7.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 8.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 9.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 9.2: 0.5 h / 0 - 5 °C View Scheme |
3-(3-methoxy-phenyl)-2-(toluene-4-sulfonyl)-pentanenitrile
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 25 °C 1.2: 1 h / 25 °C 2.1: sodium amalgam / methanol / 25 - 30 °C 3.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 3.2: pH 1 4.1: di-isopropyl ether / 6 h / 20 - 75 °C 5.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 6.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 7.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 8.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 8.2: 0.5 h / 0 - 5 °C View Scheme |
2-[1-(3-methoxy-phenyl)-propyl]-2-methyl-malononitrile
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: tri-n-butyl-tin hydride / 2,2'-azobis(isobutyronitrile) / toluene / 10 h / Reflux 1.2: 20 °C 2.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 2.2: pH 1 3.1: di-isopropyl ether / 6 h / 20 - 75 °C 4.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 5.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 6.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 7.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 7.2: 0.5 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: sodium hydroxide; ethylene glycol / 4 h / 170 - 180 °C 1.2: pH 1 2.1: di-isopropyl ether / 6 h / 20 - 75 °C 3.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 4.1: borane-dimethyl sulfide complex / tetrahydrofuran / 1 h / 50 - 55 °C / Inert atmosphere 4.2: 0 - 5 °C 5.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 6.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 6.2: 2 h / 50 - 55 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: sodium hydroxide; ethylene glycol / 4 h / 170 - 180 °C 1.2: pH 1 2.1: di-isopropyl ether / 6 h / 20 - 75 °C 3.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 4.1: sulfuric acid / 5 h / 50 - 55 °C 5.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 4 h / 50 - 55 °C 6.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 7.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 7.2: 2 h / 50 - 55 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: sodium hydroxide; ethylene glycol / 4 h / 170 - 180 °C 1.2: pH 1 2.1: di-isopropyl ether / 6 h / 20 - 75 °C 3.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 4.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 5.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 55 °C 5.2: 0 - 5 °C 6.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 7.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 7.2: 2 h / 50 - 55 °C View Scheme |
3-(3-methoxy-phenyl)-2-methyl-2-(toluene-4-sulfonyl)-pentanoic acid ethyl ester
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: sodium amalgam / ethanol / 25 - 30 °C 2.1: sodium amide / toluene / 4 h / 20 °C / Reflux 2.2: Reflux 3.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 3.2: pH 1 4.1: di-isopropyl ether / 6 h / 20 - 75 °C 5.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 6.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 7.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 8.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 8.2: 0.5 h / 0 - 5 °C View Scheme |
3-(3-methoxy-phenyl)-2-methyl-2-(toluene-4-sulfonyl)-pentanenitrile
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: sodium amalgam / methanol / 25 - 30 °C 2.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 2.2: pH 1 3.1: di-isopropyl ether / 6 h / 20 - 75 °C 4.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 5.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 6.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 7.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 7.2: 0.5 h / 0 - 5 °C View Scheme |
2-methyl-3-(3-methoxyphenyl)pentanenitrile
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 1.2: pH 1 2.1: di-isopropyl ether / 6 h / 20 - 75 °C 3.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 4.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 5.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 6.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 6.2: 0.5 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: sodium hydroxide; ethylene glycol / 4 h / 170 - 180 °C 1.2: pH 1 2.1: di-isopropyl ether / 6 h / 20 - 75 °C 3.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 4.1: borane-dimethyl sulfide complex / tetrahydrofuran / 1 h / 50 - 55 °C / Inert atmosphere 4.2: 0 - 5 °C 5.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 6.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 6.2: 2 h / 50 - 55 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: sodium hydroxide; ethylene glycol / 4 h / 170 - 180 °C 1.2: pH 1 2.1: di-isopropyl ether / 6 h / 20 - 75 °C 3.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 4.1: sulfuric acid / 5 h / 50 - 55 °C 5.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 4 h / 50 - 55 °C 6.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 7.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 7.2: 2 h / 50 - 55 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: sodium hydroxide; ethylene glycol / 4 h / 170 - 180 °C 1.2: pH 1 2.1: di-isopropyl ether / 6 h / 20 - 75 °C 3.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 4.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 5.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 55 °C 5.2: 0 - 5 °C 6.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 7.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 7.2: 2 h / 50 - 55 °C View Scheme |
2-cyano-3-(3-methoxy-phenyl)-2-methyl-pentanoic acid
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: lithium chloride / dimethyl sulfoxide / 15 h / 150 - 160 °C 2.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 2.2: pH 1 3.1: di-isopropyl ether / 6 h / 20 - 75 °C 4.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 5.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 6.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 7.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 7.2: 0.5 h / 0 - 5 °C View Scheme |
2-methyl-3-(3-methoxyphenyl)valeric acid
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: di-isopropyl ether / 6 h / 20 - 75 °C 2.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 3.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 4.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 5.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 5.2: 0.5 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: di-isopropyl ether / 6 h / 20 - 75 °C 2.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 3.1: borane-dimethyl sulfide complex / tetrahydrofuran / 1 h / 50 - 55 °C / Inert atmosphere 3.2: 0 - 5 °C 4.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 5.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 5.2: 2 h / 50 - 55 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: di-isopropyl ether / 6 h / 20 - 75 °C 2.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 3.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 55 °C 4.2: 0 - 5 °C 5.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 6.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 6.2: 2 h / 50 - 55 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: di-isopropyl ether / 6 h / 20 - 75 °C 2.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 3.1: sulfuric acid / 5 h / 50 - 55 °C 4.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 4 h / 50 - 55 °C 5.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 6.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 6.2: 2 h / 50 - 55 °C View Scheme |
diethyl 1-(3-methoxyphenyl)propylmethylmalonate
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: sodium hydroxide / ethylene glycol / 4 h / 170 - 180 °C 1.2: pH 1 2.1: di-isopropyl ether / 6 h / 20 - 75 °C 3.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 4.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 5.1: sodium carbonate / toluene; water / 1 h / 0 - 5 °C 6.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 20 - 80 °C / Inert atmosphere 6.2: 0.5 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: sodium hydroxide; ethylene glycol / 4 h / 170 - 180 °C 1.2: pH 1 2.1: di-isopropyl ether / 6 h / 20 - 75 °C 3.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 4.1: borane-dimethyl sulfide complex / tetrahydrofuran / 1 h / 50 - 55 °C / Inert atmosphere 4.2: 0 - 5 °C 5.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 6.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 6.2: 2 h / 50 - 55 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: sodium hydroxide; ethylene glycol / 4 h / 170 - 180 °C 1.2: pH 1 2.1: di-isopropyl ether / 6 h / 20 - 75 °C 3.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 4.1: sulfuric acid / 5 h / 50 - 55 °C 5.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 4 h / 50 - 55 °C 6.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 7.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 7.2: 2 h / 50 - 55 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: sodium hydroxide; ethylene glycol / 4 h / 170 - 180 °C 1.2: pH 1 2.1: di-isopropyl ether / 6 h / 20 - 75 °C 3.1: hydrogenchloride / water; tert-butyl methyl ether / 0.5 h / 20 - 25 °C 4.1: thionyl chloride / toluene / 3 h / 75 - 80 °C 5.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 55 °C 5.2: 0 - 5 °C 6.1: triethylamine / dmap / dichloromethane / 6 h / 25 - 30 °C 7.1: sodium hydroxide / dimethyl sulfoxide / 0.17 h / 20 - 25 °C 7.2: 2 h / 50 - 55 °C View Scheme |
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
tapentadol
Conditions | Yield |
---|---|
With hydrogen bromide In water at 100 - 110℃; for 3h; | 98% |
Stage #1: (βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine With dimethylsulfide In methanesulfonic acid at 5 - 60℃; for 2.16667h; Stage #2: With sodium hydroxide In water at 5℃; pH=9 - 10; | 88.62% |
With methanesulfonic acid; DL-methionine at 80℃; for 16h; | 81% |
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Stage #1: (βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine With boron tribromide In dichloromethane at 20℃; for 15h; Cooling with ice; Stage #2: With hydrogenchloride In water | 90% |
Stage #1: (βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine With boron tribromide In dichloromethane at 20℃; for 15h; Cooling with ice; Stage #2: With methanol In dichloromethane Cooling with ice; Stage #3: With hydrogenchloride In water | 90% |
Stage #1: (βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine With methanesulfonic acid; DL-methionine at 80℃; for 12h; Stage #2: With hydrogenchloride In ethyl acetate at 0℃; | 88% |
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
With hydrogenchloride In di-isopropyl ether at 25 - 30℃; for 2h; | 87% |
With hydrogenchloride In isopropyl alcohol at 0 - 20℃; for 4.08333h; |
(βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine
Conditions | Yield |
---|---|
Stage #1: (βR,γR)-γ-ethyl-N,N,β-trimethyl-3-methoxybenzenepropanamine With methanesulfonic acid; dimethylsulfide at 0 - 45℃; for 7h; Stage #2: With hydrogenchloride In water; butanone at 20 - 25℃; for 2h; pH=6.5 - 7; Temperature; | 54% |
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