1-(2-Chloroethyl)piperidine hydro-chloride supplier

Name
2-Piperidinoethylchloride hydrochloride
EINECS 217-920-5
CAS No. 2008-75-5
Article Data8
CAS DataBase
Density
Solubility soluble in water
Melting Point 230-232 °C(lit.)
Formula C₇H₁₄ClN^.HCl
Boiling Point 190.3 °C at 760 mmHg
Molecular Weight 184.109
Flash Point 68.9 °C
Transport Information UN 2928 6.1/PG 2
Appearance Colorless to beige crystals
Safety 26-28-36/37/39-45-24/25
Risk Codes 28-34-36/37/38
Molecular Structure
Hazard Symbols T+, Xi
Synonyms Piperidine,1-(2-chloroethyl)-, hydrochloride (6CI,7CI,8CI,9CI);1-(2-Chloroethyl)piperidine hydrochloride;1-(2-Chloroethyl)piperidinemonohydrochloride;1-(2-Chloroethyl)piperidinium chloride;1-Chloro-2-piperidinoethane hydrochloride;2-(1-Piperidinyl)-1-chloroethanehydrochloride;2-(Piperidin-1-yl)ethyl chloride hydrochloride;2-Piperidino-1-chloroethane hydrochloride;N-(2-Chloroethyl)piperidine hydrochloride;N-(b-Chloroethyl)piperidine hydrochloride;1-(2-Chloroethyl) Piperidine hydrochloride;
PSA 3.24000
LogP 2.45100

Synthetic route

: 3040-44-6
1-piperidinoethanol

: 2008-75-5
N-chloroethylpiperidine hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In chloroform for 3h; Cooling with ice; Reflux;	85%
With hydrogenchloride; thionyl chloride In chloroform for 1h; Heating / reflux;	76%
With thionyl chloride In chloroform for 4h; Reflux; Cooling with ice;

: 110-89-4
piperidine

: 107-07-3
2-chloro-ethanol

: 2008-75-5
N-chloroethylpiperidine hydrochloride

Conditions

Conditions	Yield
Stage #1: piperidine; 2-chloro-ethanol In toluene for 3h; Reflux; Stage #2: With thionyl chloride In toluene for 2h; Reflux;	59.2%
Stage #1: piperidine; 2-chloro-ethanol In toluene for 2h; Reflux; Stage #2: With thionyl chloride In toluene at 20℃; for 8h; Cooling with ice;	15.5 g

: trans-4-bromo-N-methyl-N-[4-(2-piperidin-1-yl-ethoxy)-cyclohexyl]-benzenesulfonamide

A: trans-4-Bromo-N-(4-hydroxy-cyclohexyl)-N-methyl-benzenesulfonamide

B: 2008-75-5
N-chloroethylpiperidine hydrochloride

: trans-N-Methyl-N-[4-(2-piperidin-1-yl-ethoxy)-cyclohexyl]-4-trifluoromethyl-benzenesulfonamide

A: trans-N-(4-hydroxy-cyclohexyl)-N-methyl-4-trifluoro-methyl-benzenesulfonamide

B: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 573674-55-2
4-[6-methoxy-2-(3-methoxyphenyl)-1-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]phenol

: 573674-57-4
6-methoxy-2-(3-methoxyphenyl)-1-methyl-1-[4-(2-piperidin-1-yl-ethoxy)phenyl]-1,2,3,4-tetrahydroisoquinoline

Conditions

Conditions	Yield
Stage #1: 4-[6-methoxy-2-(3-methoxyphenyl)-1-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]phenol With sodium hydride In 1,4-dioxane at 20℃; for 0.166667h; Stage #2: N-chloroethylpiperidine hydrochloride With sodium hydride In 1,4-dioxane at 80℃; for 5h;	100%

: 106-41-2
4-bromo-phenol

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 836-58-8
1-[2-(4-bromophenoxy)ethyl]piperidine

Conditions

Conditions	Yield
With caesium carbonate; potassium iodide In N,N-dimethyl-formamide at 25 - 50℃; for 14.5h;	100%
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; water at 20 - 35℃; for 18h;	98.5%
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In dichloromethane at 30 - 35℃; for 18h; Industrial scale;	98.2%

: 710348-61-1
5-methylene-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-2-ol

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 710348-59-7
1-[2-(5-methylene-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-2-yloxy)ethyl]piperidine

Conditions

Conditions	Yield
With sodium hydride In DMF (N,N-dimethyl-formamide) at 20℃;	100%

: 63676-19-7
[6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl](4-hydroxyphenyl)methanone

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 84541-38-8
[6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-Piperidinyl)ethoxy]phenyl] Methanone

Conditions

Conditions	Yield
In dichloromethane; water at 16 - 20℃; for 6.5h; Product distribution / selectivity; Reflux;	100%
With sodium hydroxide In dichloromethane; water at 16 - 20℃; for 6.75h; Product distribution / selectivity; Reflux;	100%
With sodium hydroxide In dichloromethane; water at 16℃; for 6.5h; Product distribution / selectivity; Reflux;	100%

: 17754-90-4
4-(Diethylamino)salicylaldehyde

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 1402729-63-8
4-diethylamino-2-[2-(1-piperidyl)ethoxy]benzaldehyde

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 80℃; for 4h;	100%

: 2491-32-9
1-(4-Hydroxyphenyl)-2-phenylethanone

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 2-phenyl(4-piperidinylethoxyphenyl)ethan-1-one

Conditions

Conditions	Yield
With potassium carbonate In acetone for 6h; Heating;	99%

: 636-93-1
5-nitroguaiacol

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 399579-80-7
1-[2-(2-methoxy-5-nitro-phenoxy)-ethyl]-piperidine

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 72h;	99%
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 72h;	99%
With potassium carbonate In 1,2-dimethoxyethane at 20℃; for 24h;
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 24h;

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 861930-34-9
1-(2-{4-[2-(3-fluoro-phenyl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine

Conditions

Conditions	Yield
Stage #1: 4-[2-(3-fluoro-phenyl)-6-methoxy-naphthalen-1-yloxy]-phenol With sodium hydride In DMF (N,N-dimethyl-formamide) at 20℃; for 0.5h; Stage #2: N-chloroethylpiperidine hydrochloride for 72h;	99%

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 1-(2-{4-[6-benzyloxy-2-(4-fluoro-phenyl)-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine

Conditions

Conditions	Yield
Stage #1: 4-[6-benzyloxy-2-(4-fluoro-phenyl)-naphthalen-1-yloxy]-phenol With sodium hydride In DMF (N,N-dimethyl-formamide) at 20℃; for 0.5h; Stage #2: N-chloroethylpiperidine hydrochloride	99%

: 19932-85-5
6-bromobenzo[d]oxazol-2(3H)-one

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 6-bromo-3-[2-(piperidin-1-yl)ethyl]-1,3-benzoxazol-2-one

Conditions

Conditions	Yield
Stage #1: 6-bromobenzo[d]oxazol-2(3H)-one With potassium carbonate In acetonitrile at 80℃; for 0.5h; Stage #2: N-chloroethylpiperidine hydrochloride In acetonitrile at 80℃; for 12h;	99%

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 2-((3-(2-(piperidin-1-yl)ethoxy)phenyl)amino)-9-cyclopentyl-8-((2-fluorophenyl)amino)-9H-purine

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water at 55℃;	98%

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 54081-76-4
17α-ethynyl-3E-oximino-4-androsten-17β-ol

: 17α-ethynyl-3E-[O-(2-piperidinoethyl)]oximino-4-androsten-17β-ol

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In butanone for 48h; Heating;	97.05%

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 3-[3-chloro-4'-(2-piperidin-1-yl-ethoxy)-biphenyl-4-ylmethyl]-1-cyclohexyl-pyrrolidin-2-one hydrochloride

Conditions

Conditions	Yield
Stage #1: 3-(3-chloro-4'-hydroxy-biphenyl-4-ylmethyl)-1-cyclohexyl-pyrrolidin-2-one With potassium carbonate; caesium carbonate In acetone at 20℃; for 0.0833333h; Stage #2: N-chloroethylpiperidine hydrochloride In acetone at 50℃;	97%

: 362-99-2
(4-fluorophenyl)phenylmethanone oxime

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: (4-fluoro-phenyl)-phenyl-methanone O-(2-piperidin-1-yl-ethyl)-oxime

Conditions

Conditions	Yield
With sodium hydroxide; 18-crown-6 ether In dimethyl sulfoxide at 40℃; for 48h;	96%

: 371757-03-8
9a-butyl-4-(4-hydroxyphenyl)-7-methoxy-1,2,9,9a-tetrahydro-3H-fluoren-3-one

MeOH+1% Et3N: MeOH+1% Et3N

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 371757-04-9
9a-butyl-7-methoxy-4-{4-[2-(1-piperidinyl)ethoxy]phenyl}-1,2,9,9a-tetrahydro-3H-fluoren-3-one

Conditions

Conditions	Yield
With caesium carbonate In ethyl acetate; acetone	96%

...Expand

: 554-84-7
meta-nitrophenol

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 891855-93-9
1-(2-(3-nitrophenoxy)ethyl)piperidine

Conditions

Conditions	Yield
Stage #1: meta-nitrophenol With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 0.0833333h; Stage #2: N-chloroethylpiperidine hydrochloride In N,N-dimethyl-formamide at 80℃; for 0.25h;	96%
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 48h;	54%

: (E)-3-(3,4-bis(methoxymethoxy)phenyl)-1-(4-hydroxyphen-yl)prop-2-en-1-one

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: (E)-3-(3,4-bis(methoxymethoxy)phenyl)-1-(4-(2-(piperidin-1-yl)ethoxy)phenyl)prop-2-en-1-one

Conditions

Conditions	Yield
With potassium carbonate In acetone at 60℃; for 8h;	96%

: tert-butyl 4-(4-hydroxy-2,6-difluoro-phenyl)-piperazine-1-carboxylate

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: tert-butyl 4-(2,6-difluoro-4-(2-(piperidin-1-yl)ethoxy)phenyl)piperazine-1-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50 - 60℃; for 17h;	96%
With potassium carbonate In N,N-dimethyl-formamide at 50 - 60℃; for 17h;	96%
With potassium carbonate In N,N-dimethyl-formamide at 50 - 60℃; for 17h;	390 mg

: 4500-58-7
2-ethylthiophenol

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 1-[2-((2-ethylphenyl)thio)ethyl]piperidine

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 4h; Reflux;	96%

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 135-19-3
β-naphthol

: 1222-85-1
1-(2-(naphthalen-2-yloxy)ethyl)piperidine

Conditions

Conditions	Yield
Stage #1: β-naphthol With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 0.166667h; Stage #2: N-chloroethylpiperidine hydrochloride In N,N-dimethyl-formamide at 100℃; for 0.5h;	96%

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 99-76-3
methyl 4-hydroxylbenzoate

A: 89407-97-6
4-[2-(N-piperidine)-ethoxy]benzoic acid methyl ester

B: 84449-80-9
4-(2-piperidin-1-ylethoxy)benzoic acid hydrochloride

Conditions

Conditions	Yield
With potassium carbonate In Isopropyl acetate; water	A n/a B 95.3%

...Expand

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: (+/-)-cis-4-(4-hydroxyphenyl)-7-methoxy-3-(4-(trifluoromethyl)phenyl)chromane

: (+/-)-cis-7-methoxy-4-(4-(2-piperidinoethoxy)phenyl)-3-(4-(trifluoromethyl)phenyl)chromane

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In acetone at 60℃; for 24h;	95%

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 468096-21-1
3-(4-chlorophenyl)-2-mercaptothieno[2,3-d]pyrimidin-4(3H)-one

: 468096-29-9
3-(4-chlorophenyl)-2-[(2-piperidin-1-ylethyl)thio]thieno[2,3-d]pyrimidin-4(3H)-one

Conditions

Conditions	Yield
With sodium hydroxide In water at 50℃; for 0.5h;	95%

: 897445-88-4
2-[cyclohexyl(phenyl)methyl]-6-methoxy-1H-benzimidazole

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 2-(cyclohexyl-phenyl-methyl)-6-methoxy-1-(2-piperidin-1-yl-ethyl)-1H-benzoimidazole

Conditions

Conditions	Yield
With sodium hydride; potassium iodide In tetrahydrofuran for 6h; Heating;	95%

: 42454-06-8
2-nitro-5-hydroxybenzaldehyde

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 485844-02-8
2-nitro-5-(2-piperidin-1-ylethoxy)benzaldehyde

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 4h;	95%
With potassium carbonate In N,N-dimethyl-formamide at 45℃; for 16h;	85%

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 91221-46-4
1,1-bis(4-hydroxyphenyl)-2-phenyl-1-butene

: 1,1-bis-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-2-phenyl-1-butene

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 50℃; for 0.5h;	95%

: 623-05-2
(4-hydroxyphenyl)methanol

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 223251-13-6
[4-[2-(1-piperidinyl)ethoxy]phenyl]methanol

Conditions

Conditions	Yield
Stage #1: (4-hydroxyphenyl)methanol With sodium hydroxide In water for 0.333333h; Stage #2: N-chloroethylpiperidine hydrochloride With tetrabutylammomium bromide In water; toluene Reflux;	95%
With potassium carbonate; caesium carbonate In acetonitrile at 90℃; for 24h;	44%

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 269409-70-3
4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 710348-58-6
(4-(2-(piperidin-1-yl)ethoxy)phenyl)boronic acid

Conditions

Conditions	Yield
Stage #1: N-chloroethylpiperidine hydrochloride; 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol With potassium carbonate; 18-crown-6 ether In acetonitrile at 180℃; for 0.166667h; Microwave irradiation; Stage #2: With methanol	95%

: 33403-02-0
7-methyl-2,6-dithioxo-1,2,3,6-tetrahydropurine

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 1411565-21-3
2,6-bis(2-piperidinylethylthio)-7-methylpurine

Conditions

Conditions	Yield
Stage #1: 7-methyl-2,6-dithioxo-1,2,3,6-tetrahydropurine With sodium hydroxide In 1,4-dioxane at 20℃; for 1h; Stage #2: N-chloroethylpiperidine hydrochloride In 1,4-dioxane for 2h; Reflux;	95%

: 540-38-5
4-Iodophenol

: 2008-75-5
N-chloroethylpiperidine hydrochloride

: 103808-68-0
4-[2-(piperidin-1-yl)-ethoxy]-iodobenzene

Conditions

Conditions	Yield
With potassium carbonate In acetone at 56℃; for 3h;	95%
With potassium carbonate In N,N-dimethyl-formamide at 110℃; for 6h;	77%
With tetra-(n-butyl)ammonium iodide; potassium carbonate In N,N-dimethyl-formamide at 50℃;

1-(2-Chloroethyl)piperidine hydro-chloride Specification

The IUPAC name of 1-(2-Chloroethyl)piperidine hydro-chloride is 1-(2-chloroethyl)piperidine hydrochloride. With the CAS registry number 2008-75-5, it is also named as Piperidinoethyl chloride, hydrochloride. The product's categories are Piperidines, Piperidones, Piperazines; Piperidine. Besides, it is colorless to beige crystals, which should be stored in tightly sealed container in a cool, dry place. And you should ensure that the workplaces have good ventilation or exhaust devices. In addition, its molecular formula is C₇H₁₄ClN^.HCl and molecular weight is 184.11.

The other characteristics of this product can be summarized as: (1)EINECS: 217-920-5; (2)ACD/LogP: 1.92; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): -0.86; (5)ACD/LogD (pH 7.4): 0.74; (6)ACD/BCF (pH 5.5): 1; (7)ACD/BCF (pH 7.4): 1.11; (8)ACD/KOC (pH 5.5): 1; (9)ACD/KOC (pH 7.4): 17.27; (10)#H bond acceptors: 1; (11)#H bond donors: 0; (12)#Freely Rotating Bonds: 2; (13)Polar Surface Area: 3.24 Å²; (14)Flash Point: 68.9 °C; (15)Melting point: 228-234 °C; (16)Enthalpy of Vaporization: 42.65 kJ/mol; (17)Boiling Point: 190.3 °C at 760 mmHg; (18)Vapour Pressure: 0.545 mmHg at 25 °C.

Uses of 1-(2-Chloroethyl)piperidine hydro-chloride: this chemical is used as intermediate for the syntheses of pharmaceuticals. Additionally, it can react with ethylamine to get ethyl-(2-piperidin-1-yl-ethyl)-amine.

This reaction needs H₂O at temperature of 20 °C for 2 hours. The yield is 87 %.

When you are using this chemical, please be cautious about it as the following: it is very toxic if swallowed. It may also cause burns. And it irritates to eyes, respiratory system and skin. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. Moreover, you should wear suitable protective clothing, gloves and eye/face protection to avoid contact with skin and eyes. After contact with skin, wash immediately with plenty of soap-suds. Furthermore, in case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
(1)SMILES: ClCCN1CCCCC1.Cl
(2)InChI: InChI=1/C7H14ClN.ClH/c8-4-7-9-5-2-1-3-6-9;/h1-7H2;1H
(3)InChIKey: VFLQQZCRHPIGJU-UHFFFAOYAN

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	93mg/kg (93mg/kg)	BEHAVIORAL: ATAXIA	Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 249, 1948.
mouse	LD50	intravenous	56mg/kg (56mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#07326,
mouse	LD50	subcutaneous	125mg/kg (125mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 97, Pg. 25, 1949.

Product Name

2-Piperidinoethylchloride hydrochloride

Synthetic route

1-(2-Chloroethyl)piperidine hydro-chloride Specification

Related Products

Hot Products