• Name

  1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride

• EINECS 258-038-0
• CAS No. 52605-52-4
• Article Data4
• CAS DataBase
• Density
• Solubility 3.9g/L at 28℃
• Melting Point 198-203 °C(lit.)
• Formula C₁₃H₁₈Cl₂N₂^.HCl
• Boiling Point 395.8 °C at 760 mmHg
• Molecular Weight 309.666
• Flash Point 193.2 °C
• Transport Information
• Appearance off-white solid
• Safety 26-37/39-24/25
• Risk Codes 36/37/38-20/21/22
• Molecular Structure
• Hazard Symbols Xi,Xn
• Synonyms Piperazine,1-(3-chlorophenyl)-4-(3-chloropropyl)-, monohydrochloride (9CI);
• PSA 6.48000
• LogP 3.89580

Synthetic route

13078-15-4

1-(3-chlorophenyl)piperazine hydrochloride

109-70-6

1,3-chlorobromopropane

52605-52-4

1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride

Conditions

Conditions	Yield
Stage #1: 1-(3-chlorophenyl)piperazine hydrochloride; 1.3-chlorobromopropane With tetrabutylammomium bromide; potassium carbonate In acetonitrile for 0.0111111h; Microwave irradiation; Stage #2: With hydrogenchloride In 1,4-dioxane; acetone Solvent;	88%

ice-H2 O

ice-H2 O

13078-15-4

1-(3-chlorophenyl)piperazine hydrochloride

109-70-6

1,3-chlorobromopropane

52605-52-4

1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride

Conditions

Conditions	Yield
With sodium hydroxide In hydrogenchloride; water; acetone	55.6%

...Expand

19434-65-2

3-chloropropanaldehyde

13078-15-4

1-(3-chlorophenyl)piperazine hydrochloride

52605-52-4

1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride

Conditions

Conditions	Yield
Stage #1: 3-chloropropanaldehyde; 1-(3-chlorophenyl)piperazine hydrochloride In dichloromethane for 0.25h; Inert atmosphere; Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane Inert atmosphere;

52605-52-4

1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride

6969-71-7

[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

19794-93-5

trazodone

Conditions

Conditions	Yield
With sodium hydroxide In isopropyl alcohol for 26h; Reagent/catalyst; Inert atmosphere; Reflux;	92%
With tetrabutylammomium bromide; potassium carbonate In acetonitrile for 0.0222222h; Time; Microwave irradiation;	92%

52605-52-4

1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride

1-(3-chlorophenyl)-4-(3-hydrazinopropyl)piperazine

Conditions

Conditions	Yield
With hydrazine In isopropyl alcohol	85%

95885-13-5

5-ethyl-4-(2-phenoxyethyl)-2H-1,2,4-triazol-3(4H)-one

52605-52-4

1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride

83366-66-9

nefazadone

Conditions

Conditions	Yield
With sodium hydroxide In isopropyl alcohol for 7h; Heating;	84%

52605-52-4

1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride

1,2,4-triazolo<4,3-a>pyridin-3(2H)-one sodium salt

25332-39-2

trazodone hydrochloride

Conditions

Conditions	Yield
With tetrabutylammomium bromide; sodium carbonate In isopropyl alcohol at 80 - 85℃; for 12h; Reagent/catalyst;	83%

486-66-8

daidzein

52605-52-4

1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride

640275-96-3

daidzein 7-ω-(3"-chlorophenylpiperozine)-4-N-propyl ether

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 80℃; for 4h;	68.2%

13754-86-4

1,5,6,7-tetrahydro-indol-4-one

52605-52-4

1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride

496921-70-1

1-{3-[4-(3-chlorophenyl)piperazine-1-yl]propyl}-1,5,6,7-tetrahydroindol-4-one

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide In 1,4-dioxane; dichloromethane; dimethyl sulfoxide
With hydrogenchloride; sodium hydroxide In 1,4-dioxane; dichloromethane; dimethyl sulfoxide
Stage #1: 1,5,6,7-tetrahydro-indol-4-one With sodium hydroxide In dimethyl sulfoxide at 25℃; for 0.25h; Stage #2: 1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride In dimethyl sulfoxide
With hydrogenchloride; sodium hydroxide In 1,4-dioxane; dichloromethane; dimethyl sulfoxide

5-(2Methyl-1,4-dixolan-2yl)-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

5-(2Methyl-1,4-dixolan-2yl)-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

584-08-7

potassium carbonate

52605-52-4

1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride

2-(3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl)-5-(2-methyl-1,4-dioxolan-2-yl)-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one

Conditions

Conditions	Yield
With sodium hydroxide; Ki In acetonitrile

...Expand

52605-52-4

1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride

153707-87-0

2-(3-[4-(3-chlorophenyl)-1-piperazinyl]propyl)-4-(2-phenoxyethyl)-4H-1,2,4-triazole-3,5(1H,2H)-dione hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide In methanol; water; isopropyl alcohol	10.21 g (47%)

52605-52-4

1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride

13078-15-4

1-(3-chlorophenyl)piperazine hydrochloride

109-70-6

1,3-chlorobromopropane

4-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-3H-1,2,4-triazol-3-one

Conditions

Conditions	Yield
With sodium hydroxide In hydrogenchloride; water; acetone

...Expand

58-55-9

theophylline

52605-52-4

1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride

58215-79-5

C20H25ClN6O2

Conditions

Conditions	Yield
With sodium carbonate In tetrahydrofuran for 2h; Reflux;

22246-18-0

7-hydroxy-3,4-dihydro-2-(1H)-quinolinone

52605-52-4

1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride

72722-66-8

7-{3-[4-(3-chlorophenyl)-1-piperazinyl]propoxy}-3,4-dihydrocarbostyril

Conditions

Conditions	Yield
With sodium methylate In methanol Reflux;

1569-69-3

Cyclohexanethiol

52605-52-4

1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride

ClH*C19H29ClN2S

Conditions

Conditions	Yield
Stage #1: Cyclohexanethiol With sodium hydroxide In tetrahydrofuran for 1h; Inert atmosphere; Reflux; Stage #2: 1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride In tetrahydrofuran for 4h; Reflux; Inert atmosphere;

23974-72-3

sodium phenylselenide

52605-52-4

1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride

1-(3-chlorophenyl)-4-(3-phenylseleno propyl)piperazine hydrochloride

Conditions

Conditions	Yield
at 20℃;

52605-52-4

1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride

6969-71-7

[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

25332-39-2

trazodone hydrochloride

Conditions

Conditions	Yield
Stage #1: 1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine hydrochloride; [1,2,4]triazolo[4,3-a]pyridin-3(2H)-one With tetrabutylammomium bromide; potassium carbonate In acetonitrile Microwave irradiation; Stage #2: With hydrogenchloride In 1,4-dioxane; acetone

1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride Chemical Properties

1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride Safety Profile

1-(3-Chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride Specification