1-(4-Fluorophenyl)piperazine supplier

Name
1-(4-Fluorophenyl)piperazine
EINECS 218-846-6
CAS No. 2252-63-3
Article Data30
CAS DataBase
Density 1.112 g/cm³
Solubility Insoluble in water.
Melting Point 30-33 °C
Formula C₁₀H₁₃FN₂
Boiling Point 363.6 °C at 760 mmHg
Molecular Weight 180.225
Flash Point 137.8 °C
Transport Information
Appearance clear yellowish liquid after melting
Safety 26
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn,T,C
Synonyms Piperazine,1-(p-fluorophenyl)- (6CI,7CI,8CI);1-(p-Fluorophenyl)piperazine;N-(4-Fluorophenyl)piperazine;N-(p-Fluorophenyl)piperazine;p-Fluorophenylpiperazine;
PSA 15.27000
LogP 1.62910

Synthetic route

: 110-85-0
piperazine

NaOBut: NaOBut

: 13716-12-6
tri-tert-butyl phosphine

: 460-00-4
1-Bromo-4-fluorobenzene

: 2252-63-3
1-(4-Fluorophenyl)piperazine

Conditions

Conditions	Yield
palladium diacetate In o-xylene; water	95%

...Expand

: 110-85-0
piperazine

: 352-33-0
1-Chloro-4-fluorobenzene

: 2252-63-3
1-(4-Fluorophenyl)piperazine

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); 2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl; sodium t-butanolate In 1,4-dioxane at 100℃; for 0.166667h; Temperature;	88%
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; ruphos In 1,4-dioxane at 100℃; for 1h; Buchwald-Hartwig Coupling;	81.1%

: 821-48-7
bis-(2-chloroethyl)amine hydrochloride

: 371-40-4
4-fluoroaniline

: 2252-63-3
1-(4-Fluorophenyl)piperazine

Conditions

Conditions	Yield
In various solvent(s) at 150℃;	87%
With toluene-4-sulfonic acid at 145℃;
With potassium iodide at 150℃; Inert atmosphere;

: 141940-39-8
tert-butyl 4-(4-fluorophenyl)piperazine-1-carboxylate

: 2252-63-3
1-(4-Fluorophenyl)piperazine

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane at 20℃; for 2h;	83%

: 4004-97-1
4-(4-fluorophenyl)-1-toluene-p-sulfonylpiperazine

: 2252-63-3
1-(4-Fluorophenyl)piperazine

Conditions

Conditions	Yield
With hydrogen bromide; phenol for 0.5h; Heating;	66%

: 77697-11-1
2-bromo-N(2-bromoethyl)-N-carbethoxy-ethanamine

: 371-40-4
4-fluoroaniline

: 2252-63-3
1-(4-Fluorophenyl)piperazine

Conditions

Conditions	Yield
With methanol; basic alumina (Waters Sep-Pak cartridge 51820) at 150℃; for 0.666667h;	75 % Chromat.
With methanol; aluminum oxide at 150℃; for 0.666667h; Product distribution; reaction of aniline derivatives with bis(2-bromoethyl)-N-(ethoxycarbonyl)amine on solid support;	75 % Chromat.

: 110-85-0
piperazine

: 460-00-4
1-Bromo-4-fluorobenzene

A: 462-06-6
fluorobenzene

B: 2252-63-3
1-(4-Fluorophenyl)piperazine

C: 21598-27-6
1,4-bis-(4-fluoro-phenyl)-piperazine

Conditions

Conditions	Yield
With sodium t-butanolate; palladium bis(dibenzylideneacetone)palladium(0); tri-tert-butyl phosphine In o-xylene at 120℃; Yield given. Yields of byproduct given;

...Expand

: 460-00-4
1-Bromo-4-fluorobenzene

A: 462-06-6
fluorobenzene

B: 2252-63-3
1-(4-Fluorophenyl)piperazine

C: 21598-27-6
1,4-bis-(4-fluoro-phenyl)-piperazine

Conditions

Conditions	Yield
With piperazine; sodium t-butanolate; palladium diacetate; tri-tert-butyl phosphine In o-xylene at 120℃; Yield given. Yields of byproduct given;

...Expand

: 110-85-0
piperazine

: 460-00-4
1-Bromo-4-fluorobenzene

: 2252-63-3
1-(4-Fluorophenyl)piperazine

Conditions

Conditions	Yield
With dichlorobis(tri-O-tolylphosphine)palladium; sodium t-butanolate In toluene Heating;
Buchwald-Hartwig amination;
With palladium diacetate; Tri(p-tolyl)phosphine; sodium t-butanolate In toluene at 110℃;
Stage #1: piperazine With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 20℃; for 0.25h; Buchwald-Hartwig Coupling; Inert atmosphere; Stage #2: 1-Bromo-4-fluorobenzene In toluene for 20h; Buchwald-Hartwig Coupling; Inert atmosphere; Reflux;

VersabeadsTM VO400-bound bis(chloroethyl)amine: VersabeadsTM VO400-bound bis(chloroethyl)amine

: 371-40-4
4-fluoroaniline

: 2252-63-3
1-(4-Fluorophenyl)piperazine

Conditions

Conditions	Yield
Stage #1: VersabeadsTM VO400-bound bis(chloroethyl)amine; 4-fluoroaniline With pyridine; potassium iodide at 100℃; for 66h; Stage #2: With potassium tert-butylate In 1,2-dimethoxyethane for 3h; Heating;

: 371-40-4
4-fluoroaniline

alkali thiocyanate: alkali thiocyanate

: 2252-63-3
1-(4-Fluorophenyl)piperazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 58 percent / NaHCO3, HMPA / 1 h / 130 °C 2: 66 percent / 48percent aq. HBr, phenol / 0.5 h / Heating View Scheme

: 6163-58-2
tris-(o-tolyl)phosphine

: 460-00-4
1-Bromo-4-fluorobenzene

: 2252-63-3
1-(4-Fluorophenyl)piperazine

Conditions

Conditions	Yield
tris-(dibenzylideneacetone)dipalladium(0)

: 2033-24-1
cycl-isopropylidene malonate

: 5768-55-8
2,3,4,6,7,8,9,10-octahydropyrimido<1,2-a>azepino

A: 3-(3-(4-(4-fluorophenyl)piperazin-1-yl)propyl)-6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepine

B: 2252-63-3
1-(4-Fluorophenyl)piperazine

...Expand

: 57260-71-6
1-t-Butoxycarbonylpiperazine

1-halide-4-fluorobenzene: 1-halide-4-fluorobenzene

: 2252-63-3
1-(4-Fluorophenyl)piperazine

Conditions

Conditions	Yield
Stage #1: 1-t-Butoxycarbonylpiperazine; 1-halide-4-fluorobenzene Buchwald-Hartwig cross coupling; Stage #2: With hydrogenchloride In 1,4-dioxane

: 462-06-6
fluorobenzene

: 140681-55-6
Selectfluor

: 2252-63-3
1-(4-Fluorophenyl)piperazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: C20H28N4O2Pd(2+)*2BF4(1-); tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate / acetonitrile / 24 h 2: sodium thiosulfate; water / acetonitrile / 2 h / Sealed tube View Scheme

: C13H18ClFN2(2+)*2BF4(1-)

: 2252-63-3
1-(4-Fluorophenyl)piperazine

Conditions

Conditions	Yield
With water; sodium thiosulfate In acetonitrile for 2h; Sealed tube;

: 460-00-4
1-Bromo-4-fluorobenzene

: 2252-63-3
1-(4-Fluorophenyl)piperazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; sodium t-butanolate / toluene / 8.83 h / 100 °C / Inert atmosphere 2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C View Scheme

: 127167-47-9
(E)-11-(2-chloroethylidene)-6,11-dihydrodibenzoxepin-2-carboxylic acid methyl ester

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 11-[2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-eth-(E)-ylidene]-6,11-dihydro-dibenzo[b,e]oxepine-2-carboxylic acid methyl ester

Conditions

Conditions	Yield
In ethanol	100%

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: N-(4-bromobutyl)-dibenzobicyclo<2.2.2>octane-2,3-dicarboximide

: C32H32FN3O2

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetonitrile for 30h; Heating;	100%

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 191591-69-2
5-(3-chloropropyl)-1-methyl-1,4,5,6,7,8-hexahydro-pyrrolo[3,2-c]azepine-4,8-dione

: 191591-86-3
5-[3-[4-(4-fluorophenyl)piperazin-1-yl]propyl]-1-methyl-1,4,5,6,7,8-hexahydropyrrolo[3,2-c]azepine-4,8-dione

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In acetonitrile for 38h; Alkylation; Heating;	100%
With sodium iodide; sodium chloride; potassium carbonate In acetonitrile	99%
With sodium iodide; sodium chloride; potassium carbonate In acetonitrile	99%
With sodium iodide; potassium carbonate In acetonitrile	99%

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 150159-17-4
7-(4-bromobutyl)-1-methyl-1,4,5,6,7,8-hexahydropyrrolo[2,3-c]azepine-4,8-dione

: 7-[4-[4-(4-fluorophenyl)piperazin-1-yl]butyl]-1-methyl-1,4,5,6,7,8-hexahydropyrrolo[2,3-c]azepine-4,8-dione

Conditions

Conditions	Yield
With potassium carbonate; sodium iodide In acetonitrile for 14h; Heating;	100%

: 920490-05-7
6-(2-hydroxyethyl)-2-(methylthio)-4-pyrimidinyl 4-methyl-1-benzenesulfonate

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: C17H21FN4OS

Conditions

Conditions	Yield
In tetrahydrofuran at 70℃; for 48h;	100%

: 215595-66-7
N6-Boc-N2-Cbz-lysine

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: C29H39FN4O5

Conditions

Conditions	Yield
With triethylamine	100%

: 865626-86-4
(R)-3-(7-methyl-1H-indazol-5-yl)-2-(4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carbonyloxy)propanoic acid

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: (R)-1-(4-(4-Fluorophenyl)piperazin-1-yl)-3-(7-methyl-1H-indazol-5-yl)-1-oxopropan-2-yl 4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxylate

Conditions

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethyl-formamide); dichloromethane at 0℃; for 4h;	100%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide

: 232619-87-3
2-(3-chloropropyl)-6-methyl-3,4,5,6-tetrahydro-2H-pyrrolo[2,3-f][1,2]thiazepin-5-one 1,1-dioxide

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 2-[3-[4-(4-fluorophenyl)piperazin-1-yl]propyl]-6-methyl-3,4,5,6-tetrahydro-2H-pyrrolo[2,3-f][1,2]thiazepin-5-one 1,1-dioxide

Conditions

Conditions	Yield
With sodium iodide; potassium carbonate In acetonitrile	100%

: 50-00-0
formaldehyd

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 1-(4-fluorophenyl)-4-methylpiperazine

Conditions

Conditions	Yield
Heating;	99%

: 2-(3-bromopropyl)-4,4-dimethoxy-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 2-[3-[4-(4-fluorophenyl)piperazin-1-yl]propyl]-4,4-dimethoxy-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane	99%

: 1179358-18-9
7-(dimethylamino)methyl-3-methyl-2-pyrrolidin-1-yl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 1179358-24-7
7-{[4-(4-fluorophenyl)piperazin-1-yl]methyl}-3-methyl-2-pyrrolidin-1-yl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

Conditions

Conditions	Yield
In toluene at 110℃; for 3h;	99%

: (1R,4R)-7,7-dimethyl-1-((R)-oxiran-2-yl)bicyclo[2.2.1]heptan-2-one

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 1615687-82-5
(1R,4R)-1-((R)-2-(4-(4-fluorophenyl)piperazin-1-yl)-1-hydroxyethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one

Conditions

Conditions	Yield
With lithium perchlorate In acetonitrile at 20 - 50℃;	99%

: C12H22N2O2

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: C22H35FN4O

Conditions

Conditions	Yield
With sodium cyanoborohydride; zinc(II) chloride In methanol at 75℃; for 27h;	98.99%

: C10H18N2O2

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: C20H31FN4O

Conditions

Conditions	Yield
With sodium cyanoborohydride; zinc(II) chloride In methanol at 75℃; for 96h;	98.01%

: 134336-95-1
3-(2-bromoethyl)oxazolo<4,5-b>pyridin-2(3H)-one

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 3-<2-<4-(4-fluorophenyl)-1-piperazinyl>ethyl>oxazolo<4,5-b>pyridin-2(3H)-one

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 60℃; for 12h;	98%

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 62062-74-2
α-hydroxymethylenedeoxyvasicin-4-one

: 3-[4-(4-fluoro-phenyl)-piperazin-1-ylmethylene]-2,3-dihydro-1H-pyrrolo[2,1-b]quinazolin-9-one

Conditions

Conditions	Yield
In chloroform Heating; various conditions;	98%

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 7,8-difluoro-1-methyl-4-oxo-1,4,5,10-tetrahydro-benzo[b][1,8]naphthyridine-3-carboxylic acid

: 7-fluoro-8-[4-(4-fluoro-phenyl)-piperazin-1-yl]-1-methyl-4-oxo-1,4,5,10-tetrahydro-benzo[b][1,8]naphthyridine-3-carboxylic acid

Conditions

Conditions	Yield
In dimethyl sulfoxide at 90℃; for 4h;	98%

: 37743-18-3
N-(dihydro-3,3-diphenyl-2(3H)-furanylidene)-N-methylmethanaminium bromide

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 4-[4-(4-fluoro-phenyl)-piperazin-1-yl]-N,N-dimethyl-2,2-diphenyl-butyramide

Conditions

Conditions	Yield
With sodium carbonate In N,N-dimethyl-formamide at 100℃; for 4h;	98%

: 369-34-6
3,4-difluoronitrobenzene

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 1-(2-fluoro-4-nitrophenyl)-4-(4-fluorophenyl)-piperazine

Conditions

Conditions	Yield
Stage #1: 1-(4-Fluorophenyl)piperazine With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.5h; Inert atmosphere; Stage #2: 3,4-difluoronitrobenzene In acetonitrile Inert atmosphere; Reflux;	98%
With sodium hydrogencarbonate at 125℃; for 0.5h; Temperature; Microwave irradiation;	90%
With sodium hydrogencarbonate In neat (no solvent) at 125℃; for 0.5h; Microwave irradiation; Sealed tube;	90%
With N-ethyl-N,N-diisopropylamine

: 186491-71-4
2-(3-chloropropyl)-5-methoxy-3,4-dihydro-2H-1,2-benzothiazin-4-one 1,1-dioxide ethylene acetal

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 186491-82-7
2-[3-[4-(4-fluorophenyl)piperazin-1-yl]propyl]-5-methoxy-3,4-dihydro-2H-1,2-benzothiazin-4-one 1,1-dioxide ethylene acetal

Conditions

Conditions	Yield
With sodium iodide; sodium hydrogencarbonate In acetonitrile	98%

: 186491-72-5
5-chloro-2-(3-chloropropyl)-3,4-dihydro-2H-1,2-benzothiazin-4-one 1,1-dioxide ethylene acetal

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 186491-85-0
5-chloro-2-[3-[4-(4-fluorophenyl)piperazin-1-yl]propyl]-3,4-dihydro-2H-1,2-benzothiazin-4-one 1,1-dioxide ethylene acetal

Conditions

Conditions	Yield
With sodium iodide; sodium hydrogencarbonate In acetonitrile	98%

: (1R,4R)-7,7-dimethyl-1-((S)-oxiran-2-yl)bicyclo[2.2.1]heptan-2-one

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 1615687-99-4
(1R,4R)-1-((S)-2-(4-(4-fluorophenyl)piperazin-1-yl)-1-hydroxyethyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one

Conditions

Conditions	Yield
With lithium perchlorate In acetonitrile at 20 - 50℃;	98%

: methyl 4-((((4-nitrophenoxy)carbonyl)(pyridine-2-yl)amino)methyl)benzoate

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: methyl 4-((4-(4-fluorophenyl)-N-(pyridin-2-yl)piperazine-1-carboxamido)methyl)benzoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 55℃; for 12h;	98%

: 142714-73-6
1-(3-bromopropyl)oxazolo<5,4-b>pyridin-2(1H)-one

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 1-<3-<4-(4-fluorophenyl)-1-piperazinyl>propyl>oxazolo<5,4-b>pyridin-2(1H)-one

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 85℃; for 12h;	97%

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 212578-60-4
3-(4-benzyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl)propionic acid

: 212578-62-6
3-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-1-[4-(4-fluoro-phenyl)-piperazin-1-yl]-propan-1-one

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 5h; Ambient temperature;	97%

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: (2R,3S,8R,9S,10S,13S,14S,17S)-10,13-Dimethyl-hexadecahydro-20-oxa-cyclopropa[2,3]cyclopenta[a]phenanthren-17-ol

: (2S,3S,8R,9S,10S,13S,14S,17S)-2-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-3,17-diol

Conditions

Conditions	Yield
With gadolinium(III) trifluoromethanesulfonate In toluene at 150 - 190℃;	97%

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 22525-95-7
1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one

: 1-<2-<3-<4-(4-fluorophenyl)-1-piperazinyl>-2-hydroxypropoxy>phenyl>-3-phenyl-1-propanone hydrochloride

Conditions

Conditions	Yield
Stage #1: 1-(4-Fluorophenyl)piperazine; 1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one In ethanol at 160℃; for 0.25h; Microwave irradiation; Stage #2: With hydrogenchloride In methanol	97%

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 5437-45-6
Benzyl bromoacetate

: 486457-27-6
C19H21FN2O2

Conditions

Conditions	Yield
With triethylamine; potassium iodide In tetrahydrofuran Reflux;	97%

: 107-19-7
propargyl alcohol

: 143321-89-5
2,2,2-trifluoro-N-(2-iodophenyl)acetamide

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 2-((4-(4-fluorophenyl)piperazine-1-yl)methyl)-1H-indole

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h; Inert atmosphere;	97%

...Expand

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 3958-57-4
1-bromomethyl-3-nitrobenzene

: 1-(4-fluorophenyl)-4-(3-nitrobenzyl)piperazine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃;	97%

1-(4-Fluorophenyl)piperazine Specification

The 4-Fluoro-phenylpiperazine, with the CAS registry number 2252-63-3 and EINECS registry number 218-846-6, has the systematic name of 1-(4-fluorophenyl)piperazine. It is a kind of clear yellowish liquid after melting, and belongs to the following product categories: Nitrogen cyclic compounds; Piperidines, Piperidones, Piperazines; Piperaizine; API intermediates; Building Blocks; Heterocyclic Building Blocks. And the molecular formula of the chemical is C₁₀H₁₃FN₂. What's more, it is always used as a catalyst and intermediate.

The physical properties of 4-Fluoro-phenylpiperazine are as followings: (1)ACD/LogP: 1.20; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.6; (4)ACD/LogD (pH 7.4): -0.02; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 6.44; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 6.48 Å²; (13)Index of Refraction: 1.527; (14)Molar Refractivity: 49.79 cm³; (15)Molar Volume: 161.9 cm³; (16)Polarizability: 19.74×10^-24cm³; (17)Surface Tension: 35.8 dyne/cm; (18)Density: 1.112 g/cm³; (19)Flash Point: 137.8 °C; (20)Enthalpy of Vaporization: 60.97 kJ/mol; (21)Boiling Point: 363.6 °C at 760 mmHg; (22)Vapour Pressure: 1.78E-05 mmHg at 25°C.

You should be cautious while dealing with this chemical. It irritates to eyes, respiratory system and skin, and it is also harmful by inhalation, in contact with skin and if swallowed. Therefore, you had better take the following instructions: Wear suitable protective clothing, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: Fc1ccc(cc1)N2CCNCC2
(2)InChI: InChI=1/C10H13FN2/c11-9-1-3-10(4-2-9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
(3)InChIKey: AVJKDKWRVSSJPK-UHFFFAOYAS

Product Name

1-(4-Fluorophenyl)piperazine

Synthetic route

1-(4-Fluorophenyl)piperazine Specification

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