1,1,3,3-Tetramethyldisilazane supplier

Name
1,1,3,3-Tetramethyldisilazane
EINECS 240-072-2
CAS No. 15933-59-2
Article Data11
CAS DataBase
Density 0.752 g/mL at 25 °C(lit.)
Solubility
Melting Point 99-100 °C
Formula C₄H₁₅NSi₂
Boiling Point 91.1 °C at 760 mmHg
Molecular Weight 133.341
Flash Point 17 °F
Transport Information
Appearance Clear colorless to faintly yellow liquid
Safety 16-26-36
Risk Codes 11-36/37/38
Molecular Structure
Hazard Symbols F; Xi
Synonyms Disilazane,1,1,3,3-tetramethyl- (6CI,7CI,8CI);1,1,3,3-Tetramethyldisilazane;1,3-Dihydrido-1,1,3,3-tetramethyldisilazane;Bis(dimethylsilyl)amine;LS 7050;NSC 139849;TMDS;Tetramethyldisilazane;
PSA 12.03000
LogP 0.93370

Synthetic route

: 1066-35-9
dimethylmonochlorosilane

: 15933-59-2
1,1,3,3-tetramethyldisilazane

Conditions

Conditions	Yield
With ammonia In hexane at -30 - 20℃; for 6h; Inert atmosphere; Schlenk technique;	90%
With ammonia In hexane at -30 - 20℃; for 6h; Inert atmosphere; Schlenk technique;	90%
With ammonia
With ammonia
With ammonia In pentane at -25 - 20℃; for 6h; Schlenk technique; Inert atmosphere;	197 g

: tetramethyldisilazane

: 99892-23-6
N,N',N''-trimethyl-1,4,7,10-tetraazacyclododecane

: C15H39MgN5Si2

B: 15933-59-2
1,1,3,3-tetramethyldisilazane

Conditions

Conditions	Yield
In pentane at 25℃; for 0.5h; Inert atmosphere; Schlenk technique; Glovebox;	A 86% B n/a

...Expand

: 1066-35-9
dimethylmonochlorosilane

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

A: 75-77-4
chloro-trimethyl-silane

B: 15933-59-2
1,1,3,3-tetramethyldisilazane

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride Heating;	A n/a B 70%

...Expand

: C22H30F12NO3S2Si2Y

: 67-63-0
isopropyl alcohol

A: C21H23F12O4S2Y

B: 15933-59-2
1,1,3,3-tetramethyldisilazane

Conditions

Conditions	Yield
In dichloromethane-d2 Inert atmosphere;

...Expand

: 67-51-6
3,5-dimethyl-1H-pyrazole

: 1414380-27-0
tris(tetramethyldisilazanido)bis(tetrahydrofuran)cerium

A: Ce(3,5-dimethylpyrazolato)3

B: 15933-59-2
1,1,3,3-tetramethyldisilazane

Conditions

Conditions	Yield
In tetrahydrofuran-d8; benzene-d6 Inert atmosphere;

...Expand

: 67-51-6
3,5-dimethyl-1H-pyrazole

: tetramethyldisilazane

A: [Ce(Me2pz)4(Me2pzH)]

B: 15933-59-2
1,1,3,3-tetramethyldisilazane

Conditions

Conditions	Yield
In benzene-d6 at 20℃; Inert atmosphere;

...Expand

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 108-95-2
phenol

: 18246-19-0
dimethylphenoxysilane

Conditions

Conditions	Yield
	100%
With dimethylmonochlorosilane; triethylamine for 1h; temp.: below 40 deg C;	57%
With dimethylmonochlorosilane Heating;
at 20 - 160℃; for 2h; Inert atmosphere;

: 106-48-9
4-chloro-phenol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 30342-25-7
(4-Chloro-phenoxy)-dimethyl-silane

Conditions

Conditions	Yield
	100%
at 20 - 160℃; for 2h; Inert atmosphere;

: 100-02-7
4-nitro-phenol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 79516-20-4
Dimethyl-(4-nitro-phenoxy)-silane

Conditions

Conditions	Yield
	100%
at 20 - 160℃; for 2h; Inert atmosphere;

: 106-44-5
p-cresol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 76058-60-1
Dimethyl-p-tolyloxy-silane

Conditions

Conditions	Yield
	100%
at 20 - 160℃; for 2h; Inert atmosphere;

: 371-41-5
4-Fluorophenol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 79516-17-9
(4-Fluoro-phenoxy)-dimethyl-silane

Conditions

Conditions	Yield
	100%
at 20 - 160℃; for 2h; Inert atmosphere;

: 106-41-2
4-bromo-phenol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 33324-34-4
4-bromophenoxydimethylsilane

Conditions

Conditions	Yield
	100%

: 540-38-5
4-Iodophenol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 79516-18-0
(4-Iodo-phenoxy)-dimethyl-silane

Conditions

Conditions	Yield
	100%

: 554-84-7
meta-nitrophenol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 79516-19-1
Dimethyl-(3-nitro-phenoxy)-silane

Conditions

Conditions	Yield
	100%

: 42052-51-7
3-hydroxy-1,3-diphenylpropan-1-one

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 116596-13-5
3-(dimethylsiloxy)-1,3-diphenyl-1-propanone

Conditions

Conditions	Yield
for 3h;	100%

: 140170-12-3
(Z,3R,8R,9S)-8-tert-butyldiphenylsilanyloxy-9-ethyl-3-hydroxy-2-methylene-2,3,4,7,8,9-hexahydrooxonine

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 140170-11-2
(Z)-(2S,3R,8R)-3-(tert-Butyl-diphenyl-silanyloxy)-8-dimethylsilanyloxy-2-ethyl-9-methylene-2,3,4,7,8,9-hexahydro-oxonine

Conditions

Conditions	Yield
With ammonium chloride at 60℃;	100%

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: (Z,3S,8S)-3-hydroxy-2-methylene-8-triisopropylsilyloxymethyl-3,4,7,8-tetrahydro-2H-oxocine

: (Z,3S,8S)-3-dimethylsilyloxy-2-methylene-8-triisopropylsilyloxymethyl-3,4,7,8-tetrahydro-2H-oxocine

Conditions

Conditions	Yield
With ammonium chloride at 60℃; for 18h; Etherification;	100%
With ammonium chloride at 60℃;	99%

: 2-methyl-1-o-tolyl-hex-4-yn-1-ol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 2,2,3,6-tetramethyl-7-o-tolyl-2,5,6,7-tetrahydro-[1,2]oxasilepine

Conditions

Conditions	Yield
Stage #1: 2-methyl-1-o-tolyl-hex-4-yn-1-ol; 1,1,3,3-tetramethyldisilazane at 50℃; for 2h; Stage #2: With tris(acetonitrile)pentamethylcyclopentadienylruthenium(II) hexafluorophosphate In dichloromethane at 0 - 20℃;	100%

: 140170-12-3
(Z,3R,8R,9S)-8-tert-butyldiphenylsilanyloxy-9-ethyl-3-hydroxy-2-methylene-2,3,4,7,8,9-hexahydrooxonine

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 140170-11-2
(Z,2S,3R,8R)-3-tert-butyldiphenylsilanyloxy-8-dimethylsilanyloxy-2-ethyl-9-methylene-2,3,4,7,8,9-hexahydrooxonine

Conditions

Conditions	Yield
With ammonium chloride	100%
With ammonium chloride at 60℃; for 18h;	100%

: 1017581-24-6
(Z,3S,8S,9R)-benzyloxy-9-tbutyldiphenylsilyloxymethyl-3-hydroxy-2-methylene-4,7,8,9-tetrahydro-3H-oxonine

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 1017581-25-7
(Z,3S,8S,9R)-benzyloxy-9-tbutyldiphenylsilyloxymethyl-3-dimethylsilyloxy-2-methylene-4,7,8,9-tetrahydro-3H-oxonine

Conditions

Conditions	Yield
With ammonium chloride at 60℃;	100%

: 1172121-69-5
(3S,5Z,8S,9R)-2-methylene-3-hydroxy-8-(tert-butyldiphenylsilanyloxy)-9-vinyl-2,3,4,7,8,9-hexahydrooxonine

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 1172121-72-0
(3S,5Z,8S,9R)-2-methylene-3-(dimethylsilanyloxy)-8-(tert-butyldiphenylsilanyloxy)-9-vinyl-2,3,4,7,8,9-hexahydrooxonine

Conditions

Conditions	Yield
With ammonium chloride at 60℃; for 18h; Inert atmosphere;	100%

: 1167535-08-1
(3R,5Z,7S)-7-{[tert-butyl(dimethyl)silyl]oxy}-2-methyl-7-phenylhept-5-en-3-ol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: C22H40O2Si2

Conditions

Conditions	Yield
at 20℃; for 18h;	100%

: 1167535-33-2
(3S,5E,7S)-7-{[tert-butyl(dimethyl)silyl]oxy}-2-methyl-7-phenylhept-5-en-3-ol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: C22H40O2Si2

Conditions

Conditions	Yield
at 20℃; for 18h;	100%

: 123-31-9
hydroquinone

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 70939-99-0
1,4-bis(dimethylsilyloxy)benzene

Conditions

Conditions	Yield
With dimethylmonochlorosilane In tetrahydrofuran Reflux;	100%

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 108-46-3
recorcinol

: 138219-50-8
1,3-bis(dimethylsilyloxy)benzene

Conditions

Conditions	Yield
With dimethylmonochlorosilane In tetrahydrofuran Reflux;	100%

: 1428671-98-0
(5S,6S,7R,9Z,11R)-11-{2-[bis(4-methoxyphenyl)(phenyl)methoxy]ethyl}-5-{2-[(3,4-dimethoxybenzyl)oxy]ethyl}-2,2,3,3,6,13,13,14,14-nonamethyl-4,12-dioxa-3,13-disilapentadec-9-en-7-ol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 1428671-99-1
C56H86O9Si3

Conditions

Conditions	Yield
at 20℃;	100%

: 3(R),8(R)-8-[[(tert-butyldiphenylsilyl)oxy]methyl]-3-hydroxy-2-methylene-3,4,7,8-tetrahydro-(2H)-oxocin

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 3(R),8(R)-8-[[(tert-butyldiphenylsilyl)oxy]methyl]-3-[(dimethylsilyl)oxy]-2-methylene-3,4,7,8-tetrahydro-(2H)-oxocin

Conditions

Conditions	Yield
With ammonium chloride at 60℃; silylation;	99%
With ammonium chloride at 60℃; Yield given;

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: (Z,3R,7R,8S)-8-((1R)-2-benzyloxy-1-methyl-ethyl)-5,7-dimethyl-3-hydroxy-2-methylene-3,4,7,8-tetrahydro-2H-oxocine

: (Z,3R,7R,8S)-8-((1R)-2-benzyloxy-1-methyl-ethyl)-5,7-dimethyl-3-dimethylsilanyloxy-2-methylene-3,4,7,8-tetrahydro-2H-oxocine

Conditions

Conditions	Yield
With ammonium chloride at 60℃; for 18h; Etherification;	99%
With ammonium chloride at 60℃; for 9h;	99%

: borane tetrahydrofuran

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 187281-89-6
(BH3)HN(Si2H2(CH3)4)

Conditions

Conditions	Yield
In tetrahydrofuran (N2); room temp.; evapn.;	99%

: 97-99-4
Tetrahydrofurfuryl alcohol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 1333319-95-1
1,1,3,3-tetramethyl-1,3-bis[(tetrahydrofuran-2-yl)methoxy]disiloxane

Conditions

Conditions	Yield
With 1.2% Pd/C at 20℃; for 20h; Inert atmosphere;	99%

: 317374-14-4
triisobutylsilanol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 1,1,1-triisobutyl-3,3-dimethyldisiloxane

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 0.5h;	99%

: 36408-37-4
1,1,3,3-tetraisopropyl-1,3-dihydroxydisiloxane

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 1,1,7,7-tetramethyl-3,3,5,5-tetraisopropyltetrasiloxane

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 0.5h;	99%

: 3,5,7,9,11,13,15-hepta(isobutyl)pentacyclo[9.5.1.13,9.15,15.17,13]octasiloxan-1-ol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 1-dimethylosiloxy-3,5,7,9,11,13,15-heptacyclohexylpentacyclo[9.5.113,9.15,15.17,13]octasiloxane

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate In toluene at 20℃; for 1h; Catalytic behavior;	99%

: 307531-92-6
1,3,5,7,9,11,14-heptaisobutyltricyclo[7.3.3.15,11]heptasiloxane-endo-3,7,14-triol

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: 625417-05-2
3,7,14-tris[dimethylsiloxy]-1,3,5,7,9,11,14-heptaisobutyltricyclo[7.3.3.15,11]heptasiloxane

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate In toluene at 20℃; for 1h;	99%

: 140170-18-9
(Z,3R,8R,9S)-8-tert-butyldiphenylsilanyloxy-9-ethyl-3-hydroxy-4,7,8,9-tetrahydro-3H-oxonin-2-one

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: (Z)-(3R,8R,9S)-8-(tert-Butyl-diphenyl-silanyloxy)-3-dimethylsilanyloxy-9-ethyl-4,7,8,9-tetrahydro-3H-oxonin-2-one

Conditions

Conditions	Yield
With ammonium chloride at 60℃;	98%

: 15933-59-2
1,1,3,3-tetramethyldisilazane

: (Z,3R,4S,8S)-8-((1R)-2-benzyloxy-1-methyl-ethyl)-3-hydroxy-4-methyl-2-methylene-3,4,7,8-tetrahydro-2H-oxocine

: (Z,3R,4S,8S)-8-((1R)-2-benzyloxy-1-methyl-ethyl)-3-dimethylsilanyloxy-4-methyl-2-methylene-3,4,7,8-tetrahydro-2H-oxocine

Conditions

Conditions	Yield
With ammonium chloride at 60℃; for 18h; Etherification;	98%
With ammonium chloride at 60℃; for 18h;	98%

1,1,3,3-Tetramethyldisilazane Specification

The 1,1,3,3-Tetramethyldisilazane, with the CAS registry number 15933-59-2 and EINECS registry number 240-072-2, has the systematic name of N-(dimethylsilyl)-1,1-dimethylsilanamine. It is a kind of clear colorless to faintly yellow liquid which is moisture Sensitive, and it belongs to the following product categories: Analytical Chemistry; Dimethylsilylation (GC Derivatizing Reagents); GC Derivatizing Reagents; Si (Classes of Silicon Compounds); Si-H Compounds; Silazanes; Silylation (GC Derivatizing Reagents); Si-N Compounds. The molecular formula of the chemical is C₄H₁₅NSi₂.

The characteristics of 1,1,3,3-Tetramethyldisilazane as followings: (1)ACD/LogP: 3.49; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.41; (4)ACD/LogD (pH 7.4): 1.16; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1.25; (7)ACD/KOC (pH 5.5): 1.59; (8)ACD/KOC (pH 7.4): 8.93; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 3.24 Å²; (13)Enthalpy of Vaporization: 33.11 kJ/mol; (14)Boiling Point: 91.1 °C at 760 mmHg; (15)Vapour Pressure: 54.6 mmHg at 25°C.

Uses of 1,1,3,3-Tetramethyldisilazane: It can react with phenol to produce dimethylphenoxysilane. This reaction will need reagent triethylamine and dimethylchlorosilane. The reaction time is 1 hour with temperature below 40°C, and the yield is about 57%.

You should be cautious while dealing with this chemical. It is a kind of highly flammable chemical which irritates to eyes, respiratory system and skin. Therefore, you had better take the following instructions: Keep away from sources of ignition - No smoking; Wear suitable protective clothing; In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

Addtionally, the following datas could be converted into the molecular structure:
(1)SMILES: N([SiH](C)C)[SiH](C)C
(2)InChI: InChI=1/C4H15NSi2/c1-6(2)5-7(3)4/h5-7H,1-4H3
(3)InChIKey: NQCZAYQXPJEPDS-UHFFFAOYAW

Product Name

1,1,3,3-Tetramethyldisilazane

Synthetic route

1,1,3,3-Tetramethyldisilazane Specification

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