Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:159351-69-6
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirywe are reliable supplier for APIs and intermediates for international markets. we supply good quality with competitive price. Appearance:white powder Storage:2-8℃ Package:1kg/alum.bag Application:pharmaceutical Transportation:cold temperature Port
Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
Cas:159351-69-6
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Manufacturers
inquiry1. High-quality products, cost-effective prices, best reputation and professional services. 2. Strong technology team and service team, Professional data management system. 3. Professional synthesis and formulations laboratory and production
HK Luyunjia Chemical Industry Co.,Ltd is a high-tech company specializing in R&D and manufacturing of photoinitiators monomers and oligomers, UV absorbers and pharmaceutical intermediates, and pharmaceutical intermediates of generic drug. and ha
We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our research team of
1, Purity is above 99%. 2, The starting materia,sirolimus is enough.for producing Everolimus 3, The product can be produced in large scale. Application:159351-69-6; used for anticancer and for medicine registering and research.
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:159351-69-6
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryLower price Everolimus powder 1) USP/EP standard , high quality & high purity 99% up with competitive price 2) GMP certified facrtory, provide GMP/DMF/FDA documents ; 3) Quick delivery & provide free sample in 3 days after your payment App
Cas:159351-69-6
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryFactory supply high quality Everolimus 159351-69-6 Description of Everolimus Everolimus is a macrolide derived from rapamycin (sc-3504) with immunosuppressant properties shown t
Everolimus CAS 159351-69-6 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing
Cas:159351-69-6
Min.Order:1 Gram
FOB Price: $50.0
Type:Trading Company
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:159351-69-6
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:159351-69-6
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res
Hubei Vanz Pharm Co. Ltd. is located in Wuhan, Hubei province. We are one of the most professional company in pharm/chmecial industry for more than 10 years. We export to many countries and area with very competitive price, high quality, good ser
Cas:159351-69-6
Min.Order:1 Gram
FOB Price: $10.0 / 12.0
Type:Manufacturers
inquiryName:Everolimus CAS NO: 159351-69-6 Molecular formula:C53H83NO14 Molecular weight:958.2244 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability
Cas:159351-69-6
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:159351-69-6
Min.Order:1 Kilogram
FOB Price: $1000.0
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:159351-69-6
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:159351-69-6
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:159351-69-6
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryEverolimus CAS:159351-69-6 Test Items Standards Test Results Character Off-white to white powder conform M.P. 124~130℃ 123.5~124.5℃
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:159351-69-6
Min.Order:10 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:159351-69-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:159351-69-6
Min.Order:10 Gram
FOB Price: $3.5
Type:Trading Company
inquiryEverolimus Chemical Properties Melting point NA Boiling point 998.7±75.0 °C(Predicted) density 1.18±0.1 g/cm3(Predicted) Fp 2℃ storage temp. -20°C pka 10.40±0.70(Predicted) Water Solubility Solu
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:159351-69-6
Min.Order:1 Kilogram
FOB Price: $140.0 / 180.0
Type:Trading Company
inquiryEverolimus CAS: 159351-69-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
Cas:159351-69-6
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:159351-69-6
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryeverolimus
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water Solvent; Reagent/catalyst; | 88% |
With 1,1,1,3',3',3'-hexafluoro-propanol at 58℃; for 3.5h; |
everolimus
Conditions | Yield |
---|---|
With sulfuric acid In tetrahydrofuran at 0 - 10℃; for 1h; | 71% |
With sulfuric acid In tetrahydrofuran at 0 - 10℃; for 1h; Reagent/catalyst; | 3.72 g |
everolimus
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetone at 0 - 5℃; for 1h; | 68.3% |
With hydrogenchloride In water; acetonitrile at -10 - 0℃; for 0.5h; | 20.4 g |
With hydrogenchloride In acetone at 0 - 5℃; for 1h; | 3.58 g |
everolimus
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 5℃; pH=3 - 4; | 68% |
everolimus
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 5℃; | 67% |
everolimus
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 5℃; | 65% |
everolimus
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 5℃; | 61% |
everolimus
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 5℃; | 55% |
40-O-[2-(t-butyldimethylsilyl)oxy]ethyl rapamycin
everolimus
Conditions | Yield |
---|---|
With triethylamine tris(hydrogen fluoride) In tetrahydrofuran at 20℃; for 2h; | 54% |
With pyridine hydrogenfluoride In tetrahydrofuran at 0 - 45℃; for 1.5h; | 2.96 g |
With hydrogenchloride In methanol; water at 0 - 25℃; for 1h; pH=1-3; pH-value; Time; |
40-O-[2-(t-butyldiphenylsilyl)oxy]ethyl-rapamycin
everolimus
Conditions | Yield |
---|---|
With pyridine; hydrogen fluoride In tetrahydrofuran at 0 - 20℃; for 4h; | 15% |
With pyridine hydrogenfluoride In tetrahydrofuran at 0 - 20℃; for 4h; | 15% |
With pyridine hydrogenfluoride In tetrahydrofuran at 0 - 45℃; for 3.5h; Temperature; | 6.81 g |
With hydrogenchloride In water; acetonitrile at -10 - 0℃; for 0.5h; |
40-O-[2-((2,3-dimethylbut-2-yl)dimethylsilyloxy)ethyl] rapamycin
everolimus
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 0℃; for 1.5h; | |
With hydrogenchloride In methanol; water at -10℃; Inert atmosphere; |
everolimus
Conditions | Yield |
---|---|
With 1,1,1,3',3',3'-hexafluoro-propanol at 50℃; for 1.5h; Reagent/catalyst; | 621 mg |
sirolimus
everolimus
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: (1-ethylpropyl)diisopropylamine / toluene / 30 °C 2: pyridine hydrogenfluoride / tetrahydrofuran / 3.5 h / 0 - 45 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride / dichloromethane / 0.5 h / -40 °C 1.2: -40 - 40 °C 2.1: hydrogenchloride / methanol; water / 1 h / 0 - 25 °C / pH 1-3 View Scheme | |
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / toluene / 12 h / 60 °C 2: hydrogenchloride / methanol; water / 5 °C View Scheme |
everolimus
Conditions | Yield |
---|---|
With hydrogenchloride; phosphoric acid; water In n-heptane; acetonitrile at 20℃; for 24h; | 64 %Chromat. |
31,42-bis(trimethylsilylether)rapamycin
everolimus
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride / tetrahydrofuran / 5 h / Cooling with ice 2: hydrogenchloride / toluene; water / 6 h / 0 - 10 °C 3: hydrogenchloride / water; methanol / 4.5 h / Cooling with ice View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / ethyl acetate; water / Cooling with ice 2: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane; toluene / 4 h / 60 °C 3: hydrogenchloride / water; acetone / 1 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / water / Cooling with ice 2: N-ethyl-N,N-diisopropylamine / toluene; 1,2-dimethoxyethane / 4 h / 60 °C 3: hydrogenchloride / acetone / 1 h / 0 - 5 °C View Scheme |
everolimus
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water for 4.5h; Cooling with ice; | 3.8 g |
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid In toluene at 70℃; under 7500.75 Torr; for 8h; Reagent/catalyst; Temperature; Pressure; Solvent; Autoclave; | 6.9 g |
Conditions | Yield |
---|---|
Stage #1: ethylene glycol With trifluoroacetic anhydride In tetrahydrofuran at 10℃; for 1.5h; Inert atmosphere; Large scale; Stage #2: sirolimus With boron trifluoride diethyl etherate In tetrahydrofuran at 10℃; for 2h; Temperature; Large scale; | 5.7 kg |
everolimus
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetonitrile at -10 - 0℃; for 0.5h; |
everolimus
Conditions | Yield |
---|---|
With hydrogenchloride In water; acetonitrile at -10 - 0℃; for 0.5h; |
31-(trimethylsilylether)rapamycin
everolimus
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane; toluene / 4 h / 60 °C 2: hydrogenchloride / water; acetone / 1 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / toluene; 1,2-dimethoxyethane / 4 h / 60 °C 2: hydrogenchloride / acetone / 1 h / 0 - 5 °C View Scheme |
31,42-bis(triethylsilylether)rapamycin
everolimus
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sulfuric acid / acetone / 0 - 10 °C 2: N-ethyl-N,N-diisopropylamine / toluene / 4 h / 53 °C 3: sulfuric acid / tetrahydrofuran / 1 h / 0 - 10 °C View Scheme | |
Multi-step reaction with 3 steps 1: sulfuric acid / acetone / 0 - 10 °C 2: N-ethyl-N,N-diisopropylamine / toluene; hexane / 2 h / 60 °C 3: sulfuric acid / tetrahydrofuran / 1 h / 0 - 10 °C View Scheme |
Conditions | Yield |
---|---|
Novozym 435TM lipase In tert-butyl methyl ether at 35℃; for 10h; Molecular sieve; | 96% |
at 20℃; for 4h; Enzymatic reaction; |
everolimus
42-O-(2-fluoroethyl)rapamycin
Conditions | Yield |
---|---|
With 1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1h-imidazole; N-ethyl-N,N-diisopropylamine In dichloromethane at 23℃; for 5h; Inert atmosphere; | 83% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; Inert atmosphere; Darkness; | 73% |
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 2.66667h; |
everolimus
(35E,37E,39E,40E,48R,49S,50R,51R,53S,55S,57S,58S,59R,60R,69R)-58-[(1R)-2-[(1S,3R,4R)-4-[2-[2-[tert-butyl(diphenyl)silyl]oxyethoxy]ethoxy]-3-methoxy-cyclohexyl]-1-methyl-ethyl]-59,69-dihydroxy-57,60-dimethoxy-48,49,50,51,61,62-hexamethyl-79,80-dioxa-71-azatricyclohexatriaconta-35,37,39(61),40(62)-tetraene-63,64,65,66,67-pentone
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In toluene at 45℃; for 18h; | 59% |
everolimus
Conditions | Yield |
---|---|
With zinc(II) chloride In tetrahydrofuran at 60℃; for 2h; Reagent/catalyst; | 45% |
everolimus
Conditions | Yield |
---|---|
With titanium(IV) isopropylate In dichloromethane at 20℃; | 38% |
everolimus
2,2'-[1,2-ethanediylbis(oxy)]bisethanol
(21E,23E,25E,26E,36R,37S,38R,39R,41S,43S,46S,47R,48R,57R)-47,57-dihydroxy-45-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-46-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl]-48-methoxy-36,37,38,39,49,50-hexamethyl-68,69-dioxa-58-azatricyclohexatriaconta-21,23,25(49),26(50)-tetraene-51,52,53,54,55-pentone
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In tetrahydrofuran; water at 20℃; for 2h; | 28% |
everolimus
diethylene glycol
(21E,23E,25E,26E,34R,35S,36R,37R,39S,41S,44S,45R,46R,55R)-45,55-dihydroxy-43-[2-(2-hydroxyethoxy)ethoxy]-44-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl]-46-methoxy-34,35,36,37,47,48-hexamethyl-66,67-dioxa-56-azatricyclohexatriaconta-21,23,25(47),26(48)-tetraene-49,50,51,52,53-pentone
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In tetrahydrofuran; water at 20℃; for 2h; | 19% |
Tetraethylene glycol
everolimus
(21E,23E,25E,26E,38R,39S,40R,41R,43S,45S,48S,49R,50R,59R)-49,59-dihydroxy-47-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]-48-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl]-50-methoxy-38,39,40,41,51,52-hexamethyl-70,71-dioxa-60-azatricyclohexatriaconta-21,23,25(51),26(52)-tetraene-53,54,55,56,57-pentone
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In tetrahydrofuran; water at 20℃; for 2h; | 17% |
heptaethylene glycol
everolimus
(21E,23E,25E,26E,44R,45S,46R,47R,49S,51S,54S,55R,56R,65R)-55,65-dihydroxy-53-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-54-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl]-56-methoxy-44,45,46,47,57,58-hexamethyl-76,77-dioxa-66-azatricyclohexatriaconta-21,23,25(57),26(58)-tetraene-59,60,61,62,63-pentone
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In tetrahydrofuran; water at 22℃; for 18h; Inert atmosphere; | 14% |
everolimus
Conditions | Yield |
---|---|
With triethylammonium acetate In 1,4-dioxane; water at 22 - 28℃; for 4h; |
1H-benzo[d][1,2,3]triazol-1-yl (2-(pyridin-2-yldisulfaneyl)ethyl) carbonate
everolimus
everolimus (2'-pyridyldisulfanyl)ethyl carbonate
Conditions | Yield |
---|---|
With dmap In dichloromethane for 0.5h; Inert atmosphere; |
Conditions | Yield |
---|---|
In methanol at 20℃; for 10h; |
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