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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Everolimus

Cas:159351-69-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

we are reliable supplier for APIs and intermediates for international markets. we supply good quality with competitive price. Appearance:white powder Storage:2-8℃ Package:1kg/alum.bag Application:pharmaceutical Transportation:cold temperature Port

everolimus

Cas:159351-69-6

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

159351-69-6/Everolimus

Cas:159351-69-6

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

inquiry

SEASONS BIOTECHNOLOGY CO., LTD

1. High-quality products, cost-effective prices, best reputation and professional services. 2. Strong technology team and service team, Professional data management system. 3. Professional synthesis and formulations laboratory and production

Everolimus

Cas:159351-69-6

Min.Order:1 Kilogram

FOB Price: $300.0

Type:

inquiry

Luyunjia Chemistry Xiamen Limited

HK Luyunjia Chemical Industry Co.,Ltd is a high-tech company specializing in R&D and manufacturing of photoinitiators monomers and oligomers, UV absorbers and pharmaceutical intermediates, and pharmaceutical intermediates of generic drug. and ha

Everolimus

Cas:159351-69-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

ACHIEVER SYSTEAM BIOCHEM CO., LTD.

We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our research team of

Everolimus

Cas:159351-69-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Shanghai Biobond Pharmaceutical Co.,Ltd

1, Purity is above 99%. 2, The starting materia,sirolimus is enough.for producing Everolimus 3, The product can be produced in large scale. Application:159351-69-6; used for anticancer and for medicine registering and research.

Everolimus

Cas:159351-69-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Everolimus Manufacturer/High quality/Best price/In stock

Cas:159351-69-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Lower price Everolimus powder 1) USP/EP standard , high quality & high purity 99% up with competitive price 2) GMP certified facrtory, provide GMP/DMF/FDA documents ; 3) Quick delivery & provide free sample in 3 days after your payment App

Lower price Everolimus powder

Cas:159351-69-6

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

Factory supply high quality Everolimus 159351-69-6 Description of Everolimus Everolimus is a macrolide derived from rapamycin (sc-3504) with immunosuppressant properties shown t

CAS:159351-69-6 Everolimus

Cas:159351-69-6

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Everolimus CAS 159351-69-6 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing

Everolimus CAS 159351-69-6

Cas:159351-69-6

Min.Order:1 Gram

FOB Price: $50.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Everolimus

Cas:159351-69-6

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Everolimus 159351-69-6 GMP Manufacturer

Cas:159351-69-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Everolimus

Cas:159351-69-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

everolimus

Cas:159351-69-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

everolimus

Cas:159351-69-6

Min.Order:5 Gram

FOB Price: $200.0

Type:Trading Company

inquiry

Hubei Vanz Pharm Co.,Ltd

Hubei Vanz Pharm Co. Ltd. is located in Wuhan, Hubei province. We are one of the most professional company in pharm/chmecial industry for more than 10 years. We export to many countries and area with very competitive price, high quality, good ser

Everolimus certican manufacture supply best price

Cas:159351-69-6

Min.Order:1 Gram

FOB Price: $10.0 / 12.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Everolimus CAS NO: 159351-69-6 Molecular formula:C53H83NO14 Molecular weight:958.2244 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability

Everolimus/CAS:159351-69-6/Raw material supply

Cas:159351-69-6

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

159351-69-6 Everolimus

Cas:159351-69-6

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Anti-Cancer Drug Everolimus Powder CAS 159351-69-6

Cas:159351-69-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 159351-69-6 with best quality

Cas:159351-69-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Everolimus/ LIDE PHARMA- Factory supply / Best price

Cas:159351-69-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

Everolimus CAS:159351-69-6 Test Items Standards Test Results Character Off-white to white powder conform M.P. 124~130℃ 123.5~124.5℃

Good supply Everolimus Manufacture

Cas:159351-69-6

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 159351-69-6 Everolimus with best price

Cas:159351-69-6

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Rapamycin,42-O-(2-hydroxyethyl)- 159351-69-6

Cas:159351-69-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Shanghai Minstar Chemical Co., Ltd

Everolimus Chemical Properties Melting point NA Boiling point 998.7±75.0 °C(Predicted) density 1.18±0.1 g/cm3(Predicted) Fp 2℃ storage temp. -20°C pka 10.40±0.70(Predicted) Water Solubility Solu

Everolimus

Cas:159351-69-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Anti-cancer Everolimus Powder CAS:159351-69-6

Cas:159351-69-6

Min.Order:1 Kilogram

FOB Price: $140.0 / 180.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Everolimus CAS: 159351-69-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Everolimus CAS: 159351-69-6

Cas:159351-69-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Rapamycin,42-O-(2-hydroxyethyl)-

Cas:159351-69-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

42-O-trityl-everolimus

42-O-trityl-everolimus

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
With hydrogenchloride In methanol; water Solvent; Reagent/catalyst;88%
With 1,1,1,3',3',3'-hexafluoro-propanol at 58℃; for 3.5h;
28-O-TES-42-O-THDMS everolimus

28-O-TES-42-O-THDMS everolimus

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
With sulfuric acid In tetrahydrofuran at 0 - 10℃; for 1h;71%
With sulfuric acid In tetrahydrofuran at 0 - 10℃; for 1h; Reagent/catalyst;3.72 g
28-O-TMS-42-O-TBS everolimus

28-O-TMS-42-O-TBS everolimus

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
With hydrogenchloride In water; acetone at 0 - 5℃; for 1h;68.3%
With hydrogenchloride In water; acetonitrile at -10 - 0℃; for 0.5h;20.4 g
With hydrogenchloride In acetone at 0 - 5℃; for 1h;3.58 g
42-O-[2-(1-methyl-1-methoxyethoxy)ethyl]rapamycin

42-O-[2-(1-methyl-1-methoxyethoxy)ethyl]rapamycin

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 5℃; pH=3 - 4;68%
42-O-[2(tetrahydrofuran-2-oxy)ethyl]rapamycin

42-O-[2(tetrahydrofuran-2-oxy)ethyl]rapamycin

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 5℃;67%
42-O-[2-(1-ethoxyethoxy)ethyl]rapamycin

42-O-[2-(1-ethoxyethoxy)ethyl]rapamycin

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 5℃;65%
42-O-[2(tetrahydro-2H-furan-2-oxy)ethyl]rapamycin

42-O-[2(tetrahydro-2H-furan-2-oxy)ethyl]rapamycin

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 5℃;61%
42-O-[2-(methoxymethoxy)ethyl]rapamycin

42-O-[2-(methoxymethoxy)ethyl]rapamycin

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 5℃;55%
40-O-[2-(t-butyldimethylsilyl)oxy]ethyl rapamycin
159351-68-5

40-O-[2-(t-butyldimethylsilyl)oxy]ethyl rapamycin

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
With triethylamine tris(hydrogen fluoride) In tetrahydrofuran at 20℃; for 2h;54%
With pyridine hydrogenfluoride In tetrahydrofuran at 0 - 45℃; for 1.5h;2.96 g
With hydrogenchloride In methanol; water at 0 - 25℃; for 1h; pH=1-3; pH-value; Time;
40-O-[2-(t-butyldiphenylsilyl)oxy]ethyl-rapamycin
1314705-20-8

40-O-[2-(t-butyldiphenylsilyl)oxy]ethyl-rapamycin

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
With pyridine; hydrogen fluoride In tetrahydrofuran at 0 - 20℃; for 4h;15%
With pyridine hydrogenfluoride In tetrahydrofuran at 0 - 20℃; for 4h;15%
With pyridine hydrogenfluoride In tetrahydrofuran at 0 - 45℃; for 3.5h; Temperature;6.81 g
With hydrogenchloride In water; acetonitrile at -10 - 0℃; for 0.5h;
40-O-[2-((2,3-dimethylbut-2-yl)dimethylsilyloxy)ethyl] rapamycin
1392400-31-5

40-O-[2-((2,3-dimethylbut-2-yl)dimethylsilyloxy)ethyl] rapamycin

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 0℃; for 1.5h;
With hydrogenchloride In methanol; water at -10℃; Inert atmosphere;
C74H101NO16

C74H101NO16

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
With 1,1,1,3',3',3'-hexafluoro-propanol at 50℃; for 1.5h; Reagent/catalyst;621 mg
sirolimus
53123-88-9

sirolimus

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (1-ethylpropyl)diisopropylamine / toluene / 30 °C
2: pyridine hydrogenfluoride / tetrahydrofuran / 3.5 h / 0 - 45 °C
View Scheme
Multi-step reaction with 2 steps
1.1: 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride / dichloromethane / 0.5 h / -40 °C
1.2: -40 - 40 °C
2.1: hydrogenchloride / methanol; water / 1 h / 0 - 25 °C / pH 1-3
View Scheme
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / toluene / 12 h / 60 °C
2: hydrogenchloride / methanol; water / 5 °C
View Scheme
40-O-[2-(triisopropylsilyl)oxy]ethyl-rapamycin

40-O-[2-(triisopropylsilyl)oxy]ethyl-rapamycin

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
With hydrogenchloride; phosphoric acid; water In n-heptane; acetonitrile at 20℃; for 24h;64 %Chromat.
31,42-bis(trimethylsilylether)rapamycin
331810-13-0

31,42-bis(trimethylsilylether)rapamycin

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / tetrahydrofuran / 5 h / Cooling with ice
2: hydrogenchloride / toluene; water / 6 h / 0 - 10 °C
3: hydrogenchloride / water; methanol / 4.5 h / Cooling with ice
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / ethyl acetate; water / Cooling with ice
2: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane; toluene / 4 h / 60 °C
3: hydrogenchloride / water; acetone / 1 h / 0 - 5 °C
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / water / Cooling with ice
2: N-ethyl-N,N-diisopropylamine / toluene; 1,2-dimethoxyethane / 4 h / 60 °C
3: hydrogenchloride / acetone / 1 h / 0 - 5 °C
View Scheme
C56H91NO14Si

C56H91NO14Si

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
With hydrogenchloride In methanol; water for 4.5h; Cooling with ice;3.8 g
oxirane
75-21-8

oxirane

sirolimus
53123-88-9

sirolimus

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In toluene at 70℃; under 7500.75 Torr; for 8h; Reagent/catalyst; Temperature; Pressure; Solvent; Autoclave;6.9 g
ethylene glycol
107-21-1

ethylene glycol

sirolimus
53123-88-9

sirolimus

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
Stage #1: ethylene glycol With trifluoroacetic anhydride In tetrahydrofuran at 10℃; for 1.5h; Inert atmosphere; Large scale;
Stage #2: sirolimus With boron trifluoride diethyl etherate In tetrahydrofuran at 10℃; for 2h; Temperature; Large scale;
5.7 kg
C56H91NO14Si

C56H91NO14Si

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
With hydrogenchloride In water; acetonitrile at -10 - 0℃; for 0.5h;
C59H97NO14Si

C59H97NO14Si

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
With hydrogenchloride In water; acetonitrile at -10 - 0℃; for 0.5h;
31-(trimethylsilylether)rapamycin
331810-10-7

31-(trimethylsilylether)rapamycin

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane; toluene / 4 h / 60 °C
2: hydrogenchloride / water; acetone / 1 h / 0 - 5 °C
View Scheme
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / toluene; 1,2-dimethoxyethane / 4 h / 60 °C
2: hydrogenchloride / acetone / 1 h / 0 - 5 °C
View Scheme
31,42-bis(triethylsilylether)rapamycin
155435-45-3

31,42-bis(triethylsilylether)rapamycin

everolimus
159351-69-6

everolimus

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sulfuric acid / acetone / 0 - 10 °C
2: N-ethyl-N,N-diisopropylamine / toluene / 4 h / 53 °C
3: sulfuric acid / tetrahydrofuran / 1 h / 0 - 10 °C
View Scheme
Multi-step reaction with 3 steps
1: sulfuric acid / acetone / 0 - 10 °C
2: N-ethyl-N,N-diisopropylamine / toluene; hexane / 2 h / 60 °C
3: sulfuric acid / tetrahydrofuran / 1 h / 0 - 10 °C
View Scheme
vinyl bromoacetate
5309-70-6

vinyl bromoacetate

everolimus
159351-69-6

everolimus

everolimus 42-bromoacetate
159351-81-2

everolimus 42-bromoacetate

Conditions
ConditionsYield
Novozym 435TM lipase In tert-butyl methyl ether at 35℃; for 10h; Molecular sieve;96%
at 20℃; for 4h; Enzymatic reaction;
everolimus
159351-69-6

everolimus

42-O-(2-fluoroethyl)rapamycin
1422173-29-2

42-O-(2-fluoroethyl)rapamycin

Conditions
ConditionsYield
With 1,3-bis(2,6-diisopropylphenyl)-2,2-difluoro-2,3-dihydro-1h-imidazole; N-ethyl-N,N-diisopropylamine In dichloromethane at 23℃; for 5h; Inert atmosphere;83%
Iodoacetic acid
64-69-7

Iodoacetic acid

everolimus
159351-69-6

everolimus

SDZ-RAD-iodoacetate ester

SDZ-RAD-iodoacetate ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; Inert atmosphere; Darkness;73%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 2.66667h;
2-{[tert-butyl(diphenyl)silyl]oxy}ethyl trifluoromethansulphonate

2-{[tert-butyl(diphenyl)silyl]oxy}ethyl trifluoromethansulphonate

everolimus
159351-69-6

everolimus

(35E,37E,39E,40E,48R,49S,50R,51R,53S,55S,57S,58S,59R,60R,69R)-58-[(1R)-2-[(1S,3R,4R)-4-[2-[2-[tert-butyl(diphenyl)silyl]oxyethoxy]ethoxy]-3-methoxy-cyclohexyl]-1-methyl-ethyl]-59,69-dihydroxy-57,60-dimethoxy-48,49,50,51,61,62-hexamethyl-79,80-dioxa-71-azatricyclohexatriaconta-35,37,39(61),40(62)-tetraene-63,64,65,66,67-pentone

(35E,37E,39E,40E,48R,49S,50R,51R,53S,55S,57S,58S,59R,60R,69R)-58-[(1R)-2-[(1S,3R,4R)-4-[2-[2-[tert-butyl(diphenyl)silyl]oxyethoxy]ethoxy]-3-methoxy-cyclohexyl]-1-methyl-ethyl]-59,69-dihydroxy-57,60-dimethoxy-48,49,50,51,61,62-hexamethyl-79,80-dioxa-71-azatricyclohexatriaconta-35,37,39(61),40(62)-tetraene-63,64,65,66,67-pentone

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In toluene at 45℃; for 18h;59%
everolimus
159351-69-6

everolimus

C53H83NO14

C53H83NO14

Conditions
ConditionsYield
With zinc(II) chloride In tetrahydrofuran at 60℃; for 2h; Reagent/catalyst;45%
everolimus
159351-69-6

everolimus

(22E,24E,26E,27E,31R,32S,33R,34R,36S,38S,40S,41S,42S,43R,52R)-42,52-dihydroxy-41-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl]-40,43-dimethoxy-31,32,33,34,44,45-hexamethyl-62,63-dioxa-53-azatricyclohexatriaconta-22,24,26(44),27(45)-tetraene-46,47,48,49,50-pentone

(22E,24E,26E,27E,31R,32S,33R,34R,36S,38S,40S,41S,42S,43R,52R)-42,52-dihydroxy-41-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl]-40,43-dimethoxy-31,32,33,34,44,45-hexamethyl-62,63-dioxa-53-azatricyclohexatriaconta-22,24,26(44),27(45)-tetraene-46,47,48,49,50-pentone

Conditions
ConditionsYield
With titanium(IV) isopropylate In dichloromethane at 20℃;38%
everolimus
159351-69-6

everolimus

2,2'-[1,2-ethanediylbis(oxy)]bisethanol
112-27-6

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

(21E,23E,25E,26E,36R,37S,38R,39R,41S,43S,46S,47R,48R,57R)-47,57-dihydroxy-45-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-46-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl]-48-methoxy-36,37,38,39,49,50-hexamethyl-68,69-dioxa-58-azatricyclohexatriaconta-21,23,25(49),26(50)-tetraene-51,52,53,54,55-pentone

(21E,23E,25E,26E,36R,37S,38R,39R,41S,43S,46S,47R,48R,57R)-47,57-dihydroxy-45-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-46-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl]-48-methoxy-36,37,38,39,49,50-hexamethyl-68,69-dioxa-58-azatricyclohexatriaconta-21,23,25(49),26(50)-tetraene-51,52,53,54,55-pentone

Conditions
ConditionsYield
With toluene-4-sulfonic acid In tetrahydrofuran; water at 20℃; for 2h;28%
everolimus
159351-69-6

everolimus

diethylene glycol
111-46-6

diethylene glycol

(21E,23E,25E,26E,34R,35S,36R,37R,39S,41S,44S,45R,46R,55R)-45,55-dihydroxy-43-[2-(2-hydroxyethoxy)ethoxy]-44-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl]-46-methoxy-34,35,36,37,47,48-hexamethyl-66,67-dioxa-56-azatricyclohexatriaconta-21,23,25(47),26(48)-tetraene-49,50,51,52,53-pentone

(21E,23E,25E,26E,34R,35S,36R,37R,39S,41S,44S,45R,46R,55R)-45,55-dihydroxy-43-[2-(2-hydroxyethoxy)ethoxy]-44-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl]-46-methoxy-34,35,36,37,47,48-hexamethyl-66,67-dioxa-56-azatricyclohexatriaconta-21,23,25(47),26(48)-tetraene-49,50,51,52,53-pentone

Conditions
ConditionsYield
With toluene-4-sulfonic acid In tetrahydrofuran; water at 20℃; for 2h;19%
Tetraethylene glycol
112-60-7

Tetraethylene glycol

everolimus
159351-69-6

everolimus

(21E,23E,25E,26E,38R,39S,40R,41R,43S,45S,48S,49R,50R,59R)-49,59-dihydroxy-47-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]-48-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl]-50-methoxy-38,39,40,41,51,52-hexamethyl-70,71-dioxa-60-azatricyclohexatriaconta-21,23,25(51),26(52)-tetraene-53,54,55,56,57-pentone

(21E,23E,25E,26E,38R,39S,40R,41R,43S,45S,48S,49R,50R,59R)-49,59-dihydroxy-47-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]-48-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl]-50-methoxy-38,39,40,41,51,52-hexamethyl-70,71-dioxa-60-azatricyclohexatriaconta-21,23,25(51),26(52)-tetraene-53,54,55,56,57-pentone

Conditions
ConditionsYield
With toluene-4-sulfonic acid In tetrahydrofuran; water at 20℃; for 2h;17%
heptaethylene glycol
5617-32-3

heptaethylene glycol

everolimus
159351-69-6

everolimus

(21E,23E,25E,26E,44R,45S,46R,47R,49S,51S,54S,55R,56R,65R)-55,65-dihydroxy-53-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-54-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl]-56-methoxy-44,45,46,47,57,58-hexamethyl-76,77-dioxa-66-azatricyclohexatriaconta-21,23,25(57),26(58)-tetraene-59,60,61,62,63-pentone

(21E,23E,25E,26E,44R,45S,46R,47R,49S,51S,54S,55R,56R,65R)-55,65-dihydroxy-53-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-54-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxy-cyclohexyl]-1-methyl-ethyl]-56-methoxy-44,45,46,47,57,58-hexamethyl-76,77-dioxa-66-azatricyclohexatriaconta-21,23,25(57),26(58)-tetraene-59,60,61,62,63-pentone

Conditions
ConditionsYield
With toluene-4-sulfonic acid In tetrahydrofuran; water at 22℃; for 18h; Inert atmosphere;14%
everolimus
159351-69-6

everolimus

40-O-(2-hydroxy)ethyl rapamycin

40-O-(2-hydroxy)ethyl rapamycin

Conditions
ConditionsYield
With triethylammonium acetate In 1,4-dioxane; water at 22 - 28℃; for 4h;
1H-benzo[d][1,2,3]triazol-1-yl (2-(pyridin-2-yldisulfaneyl)ethyl) carbonate
913168-10-2

1H-benzo[d][1,2,3]triazol-1-yl (2-(pyridin-2-yldisulfaneyl)ethyl) carbonate

everolimus
159351-69-6

everolimus

everolimus (2'-pyridyldisulfanyl)ethyl carbonate
1312678-90-2

everolimus (2'-pyridyldisulfanyl)ethyl carbonate

Conditions
ConditionsYield
With dmap In dichloromethane for 0.5h; Inert atmosphere;
malonic acid
141-82-2

malonic acid

everolimus
159351-69-6

everolimus

C54H83NO15

C54H83NO15

Conditions
ConditionsYield
In methanol at 20℃; for 10h;
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