Product Name

  • Name

    1,3,5-Tris[(3,3,3-trifluoropropyl)methyl]cyclotrisiloxane

  • EINECS 219-154-7
  • CAS No. 2374-14-3
  • Density 1.23 g/cm3
  • Solubility 1.3ng/L at 20℃
  • Melting Point 35 °C
  • Formula C12H21F9O3Si3
  • Boiling Point 253.5 °C at 760 mmHg
  • Molecular Weight 468.539
  • Flash Point 107.1 °C
  • Transport Information UN 2811
  • Appearance Translucent to white waxy solid
  • Safety 26-36/37/39-45
  • Risk Codes 25-36/37/38
  • Molecular Structure Molecular Structure of 2374-14-3 (1,3,5-Tris[(3,3,3-trifluoropropyl)methyl]cyclotrisiloxane)
  • Hazard Symbols FlammableF
  • Synonyms (3,3,3-Trifluoropropyl)methylsiloxanecyclic trimer;1,3,5-Trimethyl-1,3,5-tris(3,3,3-trifluoropropyl)cyclotrisiloxane;1,3,5-Tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane;2,4,6-Trimethyl-2,4,6-tris(3,3,3-trifluoropropyl)cyclotrisiloxane;Tris-3,3,3-trifluoropropyltrimethylcyclotrisiloxane;
  • PSA 27.69000
  • LogP 6.12300

Synthetic route

methyl(3,3,3-trifluoropropyl)dichlorosilane
675-62-7

methyl(3,3,3-trifluoropropyl)dichlorosilane

A

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane
2374-14-3

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

B

2,4,6,8-tetramethyl-2,4,6,8-tetrakis-(3,3,3-trifluoro-propyl)-cyclotetrasiloxane
429-67-4

2,4,6,8-tetramethyl-2,4,6,8-tetrakis-(3,3,3-trifluoro-propyl)-cyclotetrasiloxane

Conditions
ConditionsYield
With diethyl ether; water
methyl(3,3,3-trifluoropropyl)dichlorosilane
675-62-7

methyl(3,3,3-trifluoropropyl)dichlorosilane

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane
2374-14-3

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

Conditions
ConditionsYield
hydrolysis;
1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane
2374-14-3

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethyltrisiloxane-1,5-diol
2802-54-2

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethyltrisiloxane-1,5-diol

Conditions
ConditionsYield
With palladium on activated carbon; water; hydrogen In tetrahydrofuran at 25℃; for 144h;90.2%
1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane
2374-14-3

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

dimethylsilicon dichloride
75-78-5

dimethylsilicon dichloride

C14H28F9NO3Si4
1342892-55-0

C14H28F9NO3Si4

Conditions
ConditionsYield
Stage #1: 1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane; dimethylsilicon dichloride; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone at 20℃; for 12h; Inert atmosphere;
Stage #2: With ammonia In toluene at 5℃; for 6h; Cooling with ice;		89.1%
1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane
2374-14-3

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

phenyllithium
591-51-5

phenyllithium

methyl(phenyl)(3,3,3-trifluoropropyl)silanol
242808-84-0

methyl(phenyl)(3,3,3-trifluoropropyl)silanol

Conditions
ConditionsYield
In diethyl ether at 0 - 20℃; Alkylation;84%
1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane
2374-14-3

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

bis<4-(methacryloyloxy)butyl>tetramethyldisiloxane
70877-11-1

bis<4-(methacryloyloxy)butyl>tetramethyldisiloxane

C60H108F30O15Si12

C60H108F30O15Si12

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In chloroform at 25℃; for 24h;81.5%
1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane
2374-14-3

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

1,3-bis(3-(acryloxymethyl)phenylethyl)tetramethyldisiloxane

1,3-bis(3-(acryloxymethyl)phenylethyl)tetramethyldisiloxane

C68H108F30O15Si12

C68H108F30O15Si12

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In chloroform at 25℃; for 24h;80.3%
1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane
2374-14-3

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

p-tolyllithium
2417-95-0

p-tolyllithium

methyl(4-methylphenyl)(3,3,3-trifluoropropyl)silanol
267012-06-6

methyl(4-methylphenyl)(3,3,3-trifluoropropyl)silanol

Conditions
ConditionsYield
In diethyl ether Arylation;76%
1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane
2374-14-3

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

(E)-1-iodohept-1-ene
60595-37-1

(E)-1-iodohept-1-ene

(E)-(3,3,3-trifluoropropyl)-methyl-(1-heptenyl)silanol

(E)-(3,3,3-trifluoropropyl)-methyl-(1-heptenyl)silanol

Conditions
ConditionsYield
Stage #1: (E)-1-iodohept-1-ene With n-butyllithium In diethyl ether; hexane at -78℃; for 1h;
Stage #2: 1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane In diethyl ether at -78 - 20℃;		75%
1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane
2374-14-3

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

2-naphthyllithium
4541-70-2

2-naphthyllithium

methyl-naphthalen-2-yl-(3,3,3-trifluoro-propyl)-silanol

methyl-naphthalen-2-yl-(3,3,3-trifluoro-propyl)-silanol

Conditions
ConditionsYield
In diethyl ether at 0 - 20℃; Alkylation;74%
1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane
2374-14-3

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

(E)-2-phenylethenyllithium
4843-72-5, 6160-69-6, 62839-69-4

(E)-2-phenylethenyllithium

methyl(E)-2-phenylethenyl(3,3,3-trifluoropropyl)silanol
242808-86-2

methyl(E)-2-phenylethenyl(3,3,3-trifluoropropyl)silanol

Conditions
ConditionsYield
70%
1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane
2374-14-3

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

p-methoxyphenyllithium
14774-77-7

p-methoxyphenyllithium

4-methoxyphenyl(methyl)(3,3,3-trifluoropropyl)silanol
267012-05-5

4-methoxyphenyl(methyl)(3,3,3-trifluoropropyl)silanol

Conditions
ConditionsYield
In diethyl ether Arylation;69%
1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane
2374-14-3

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

naphthalen-1-yl-lithium
14474-59-0

naphthalen-1-yl-lithium

methyl-naphthalen-1-yl-(3,3,3-trifluoro-propyl)-silanol

methyl-naphthalen-1-yl-(3,3,3-trifluoro-propyl)-silanol

Conditions
ConditionsYield
In diethyl ether at 0 - 20℃; Alkylation;66%
1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane
2374-14-3

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

α-phenyl vinyllithium
4843-72-5, 6160-69-6, 62839-69-4

α-phenyl vinyllithium

phenyllithium
591-51-5

phenyllithium

methyl(E)-2-phenylethenyl(3,3,3-trifluoropropyl)silanol
242808-86-2

methyl(E)-2-phenylethenyl(3,3,3-trifluoropropyl)silanol

Conditions
ConditionsYield
In diethyl ether at 0 - 20℃; Alkylation;55%
...Expand
n-butyllithium
109-72-8, 29786-93-4

n-butyllithium

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane
2374-14-3

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

dimethylsilicon dichloride
75-78-5

dimethylsilicon dichloride

C22H44F12O4Si5

C22H44F12O4Si5

Conditions
ConditionsYield
Stage #1: n-butyllithium; 1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane In tetrahydrofuran; toluene at 0 - 25℃; for 8h;
Stage #2: dimethylsilicon dichloride With triethylamine In tetrahydrofuran; toluene at 20 - 25℃; for 3h;
Stage #3: With water In tetrahydrofuran; toluene for 0.0833333h;		47.8%
Stage #1: n-butyllithium; 1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane In toluene at 0 - 25℃; for 8h;
Stage #2: dimethylsilicon dichloride With triethylamine In toluene at 20 - 25℃; for 3h;		47.8%
Stage #1: n-butyllithium; 1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane In tetrahydrofuran; toluene at 0 - 25℃; for 8h;
Stage #2: dimethylsilicon dichloride With triethylamine In tetrahydrofuran; toluene at 20 - 25℃; for 3h;		47.8%
...Expand
1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane
2374-14-3

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

acetic anhydride
108-24-7

acetic anhydride

1,5-Diacetoxy-1,3,5-trimethyl-1,3,5-tris-(3,3,3-trifluor-propyl)-trisiloxan
23174-00-7

1,5-Diacetoxy-1,3,5-trimethyl-1,3,5-tris-(3,3,3-trifluor-propyl)-trisiloxan

Conditions
ConditionsYield
With iron(III) chloride at 150℃;
methyl(3,3,3-trifluoropropyl)dichlorosilane
675-62-7

methyl(3,3,3-trifluoropropyl)dichlorosilane

A

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

B

2,4,6,8-tetramethyl-2,4,6,8-tetrakis-(3,3,3-trifluoro-propyl)-cyclotetrasiloxane
429-67-4

2,4,6,8-tetramethyl-2,4,6,8-tetrakis-(3,3,3-trifluoro-propyl)-cyclotetrasiloxane

Conditions
ConditionsYield
With diethyl ether; water
methyl(3,3,3-trifluoropropyl)dichlorosilane
675-62-7

methyl(3,3,3-trifluoropropyl)dichlorosilane

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane
2374-14-3

1,3,5-tris(3,3,3-trifluoropropyl)-1,3,5-trimethylcyclotrisiloxane

Conditions
ConditionsYield
hydrolysis;

1,3,5-Tris[(3,3,3-trifluoropropyl)methyl]cyclotrisiloxane Chemical Properties

Chemistry informtion about Fluorosilicone Trimer (CAS NO.2374-14-3) is:
IUPAC Name: 2,4,6-trimethyl-2,4,6-tris(3,3,3-trifluoropropyl)-1,3,5,2,4,6-trioxatrisilinane
Synonyms: (3,3,3-Trifluoropropyl)Methylcyclic Siloxanes ; (3,3,3-Trifluoropropyl)Methylcyclosiloxanes ; (3,3,3-Trifluoropropyl)Methylcyclotrisiloxane ; (3,3,3-Trifluoropropyl)Methylsiloxanes ; 1,3,5-Trimethyl-1,3,5-Tris(3,3,3-Trifluoropropyl)Cyclotrisiloxane ; 1,3,5-Tri[(3,3,3-Trifluoropropyl)Methyl] Cyclotrisiloxane ; 1,3,5-Tris[(3,3,3-Trifluoropropyl)Methyl]Cyclotrisiloxane ; (3,3,3-Trifluoropropyl)Methylsiloxanecyclictrimer
Product Categories: Fluoro ; Organics ; Fluoro Silanes ; Siloxanes 
MF: C12H21F9O3Si3
MW: 468.54
EINECS: 219-154-7 
Density: 1.23 g/cm3
Melting Point: 35°C
Flash Point: 107.1 °C
Boiling Point: 253.5 °C at 760 mmHg
Vapour Pressure: 0.0291 mmHg at 25°C 
Enthalpy of Vaporization: 47.1 kJ/mol
Refractive Index: 1.38
BRN: 1809096
Following is the molecular structure of Fluorosilicone Trimer (CAS NO.2374-14-3) is:

1,3,5-Tris[(3,3,3-trifluoropropyl)methyl]cyclotrisiloxane Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rabbit LD50 skin 25400mg/kg (25400mg/kg) behavioral: somnolence (general depressed activity) lungs, thorax, or respiration: dyspnea liver: other changes National Technical Information Service. Vol. OTS0572679,
rat LD50 oral 180mg/kg (180mg/kg)   National Technical Information Service. Vol. OTS0557552,

1,3,5-Tris[(3,3,3-trifluoropropyl)methyl]cyclotrisiloxane Consensus Reports

Reported in EPA TSCA Inventory.

1,3,5-Tris[(3,3,3-trifluoropropyl)methyl]cyclotrisiloxane Safety Profile

Low toxicity by skin contact. When heated to decomposition it emits toxic vapors of F−. 
Hazard Codes:
FlammableF
Risk Statements:
R25 :Toxic if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: 2811
RTECS: GZ4818000
Hazard Note: Flammable
TSCA: Yes
HazardClass: 6.1
PackingGroup: II

1,3,5-Tris[(3,3,3-trifluoropropyl)methyl]cyclotrisiloxane Specification

Fluorosilicone Trimer (CAS NO.2374-14-3) is a translucent to white waxy solid.
First Aid Measures:
Ingestion: Seek medical assistance.
Inhalation: Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult.
Skin: Remove and isolate contaminated clothing and shoes. Immediately flush with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin.
Eyes: Immediately flush with running water for at least 20 minutes.

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