1,3-Bis(4-fluorobenzoyl)benzene supplier

Name
1,3-BIS(4-FLUOROBENZOYL)BENZENE
EINECS 1312995-182-4
CAS No. 108464-88-6
Article Data6
CAS DataBase
Density 1.268 g/cm³
Solubility
Melting Point 181-183 °C(lit.)
Formula C₂₀H₁₂F₂O₂
Boiling Point 476.3 °C at 760 mmHg
Molecular Weight 322.311
Flash Point 178.9 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Methanone,1,3-phenylenebis[(4-fluorophenyl)- (9CI);1,3-Bis(p-fluorobenzoyl)benzene;
PSA 34.14000
LogP 4.42680

Synthetic route

: 462-06-6
fluorobenzene

: 99-63-8
benzene-1,3-dicarbonyl dichloride

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

Conditions

Conditions	Yield
With aluminium trichloride at 23℃; for 4h; Friedel-Crafts acylation;	98%
Stage #1: benzene-1,3-dicarbonyl dichloride With aluminum (III) chloride In dichloromethane for 0.5h; Friedel-Crafts Acylation; Inert atmosphere; Reflux; Stage #2: fluorobenzene In dichloromethane for 12h; Friedel-Crafts Acylation; Inert atmosphere;	56%
Stage #1: benzene-1,3-dicarbonyl dichloride With aluminum (III) chloride In dichloromethane for 0.5h; Reflux; Stage #2: fluorobenzene In dichloromethane for 12h; Reflux;	42%
With aluminum (III) chloride for 8h; Friedel-Crafts Acylation; Inert atmosphere;	3.24 g

: 437-29-6
tris(4-fluorophenyl)bismuthane

: 99-63-8
benzene-1,3-dicarbonyl dichloride

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

Conditions

Conditions	Yield
With triethylamine; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 80℃; for 3h;	76%
With tributyl-amine In 1-methyl-pyrrolidin-2-one at 80℃; for 4h; Schlenk technique; Inert atmosphere;	74%

: 92-88-6
4,4'-Dihydroxybiphenyl

: 135-53-5
2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4.5 mmol; 4,4\-biphenol, 0.5 mmol: Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4.5 mmol; 4,4\-biphenol, 0.5 mmol

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;	100%

...Expand

: 92-88-6
4,4'-Dihydroxybiphenyl

: 135-53-5
2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4 mmol; 4,4\-biphenol, 1 mmol: Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4 mmol; 4,4\-biphenol, 1 mmol

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;	100%

...Expand

: 92-88-6
4,4'-Dihydroxybiphenyl

: 135-53-5
2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 3.5 mmol; 4,4\-biphenol, 1.5 mmol: Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 3.5 mmol; 4,4\-biphenol, 1.5 mmol

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;	100%

...Expand

: 92-88-6
4,4'-Dihydroxybiphenyl

: 135-53-5
2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 3 mmol; 4,4\-biphenol, 2 mmol: Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 3 mmol; 4,4\-biphenol, 2 mmol

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;	100%

...Expand

: 92-88-6
4,4'-Dihydroxybiphenyl

: 135-53-5
2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 2.5 mmol; 4,4\-biphenol, 2.5 mmol: Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 2.5 mmol; 4,4\-biphenol, 2.5 mmol

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;	100%

...Expand

: 135-53-5
2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 4 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4 mmol: Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 4 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4 mmol

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;	100%

: 135-53-5
2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

: 123-31-9
hydroquinone

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4.5 mmol; hydroquinone, 0.5 mmol: Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4.5 mmol; hydroquinone, 0.5 mmol

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;	100%

...Expand

: 135-53-5
2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

: 123-31-9
hydroquinone

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4 mmol; hydroquinone, 1 mmol: Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 4 mmol; hydroquinone, 1 mmol

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;	100%

...Expand

: 135-53-5
2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

: 123-31-9
hydroquinone

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 3.5 mmol; hydroquinone, 1.5 mmol: Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 3.5 mmol; hydroquinone, 1.5 mmol

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;	100%

...Expand

: 135-53-5
2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

: 123-31-9
hydroquinone

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 3 mmol; hydroquinone, 2 mmol: Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 3 mmol; hydroquinone, 2 mmol

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;	100%

...Expand

: 135-53-5
2,3-dihydroxynaphthalene-6-sulphonic acid sodium salt

: 123-31-9
hydroquinone

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 2.5 mmol; hydroquinone, 2.5 mmol: Polymer; Monomer(s): 1,3-bis(4-fluorobenzoyl)benzene, 5 mmol; sodium 6,7-dihydroxy-2-naphthalenesulfonate, 2.5 mmol; hydroquinone, 2.5 mmol

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160 - 170℃;	100%

...Expand

: 120-72-9
indole

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

: 1515716-88-7
C36H24N2O2

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 160℃; for 4h; Schlenk technique; Inert atmosphere;	95%

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

: 1,3-bis(3-nitro-4-fluorobenzoyl)benzene

Conditions

Conditions	Yield
With sulfuric acid; nitric acid In (2S)-N-methyl-1-phenylpropan-2-amine hydrate	87.3%

: 626-04-0
3-mercaptothiophenol

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

: C26H16O2S2

Conditions

Conditions	Yield
With potassium carbonate In hexane; N,N-dimethyl acetamide for 18h; Heating;	75%

: 591-27-5
m-Hydroxyaniline

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

: 110471-15-3
1,3-bis[4-(3-aminophenoxy)benzoyl]benzene

Conditions

Conditions	Yield
Stage #1: m-Hydroxyaniline With potassium carbonate In N,N-dimethyl-formamide; toluene Dean-Stark trap; Reflux; Stage #2: 1,3-bis(4'-fluorobenzoyl)benzene In N,N-dimethyl-formamide; toluene at 130 - 150℃; Inert atmosphere;	64.4%

: 1066-26-8
sodium acetylide

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

: 874365-01-2
1,3-di[1-hydroxy-1-(p-fluorophenyl)-prop-2-ynyl]benzene

Conditions

Conditions	Yield
With acetylene In tetrahydrofuran; dimethyl sulfoxide at 23℃;	64%

: 18531-99-2
(S)-[1,1']-binaphthalenyl-2,2'-diol

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

: C60H36O6F2

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 150℃; for 9h;	64%

: 79-19-6
thiosemicarbazide

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

: 1458033-39-0
1,3-bis-(4-fluorobenzoyl)benzene thiosemicarbazone

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In methanol for 10h; Reflux;	52%
With toluene-4-sulfonic acid In methanol for 10h; Inert atmosphere; Reflux;	52%

: 92-88-6
4,4'-Dihydroxybiphenyl

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

A: C64H40O8

B: TIMEOUT: 5s

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl acetamide; toluene for 8h; Cyclo-condensation; Heating;	A 7.7% B 15%

...Expand

: 86-74-8
9H-carbazole

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

: 1,3-phenylenebis(4-(9H-carbazol-9-yl)phenyl)methanone

Conditions

Conditions	Yield
With potassium tert-butylate In N,N-dimethyl-formamide at 120℃; for 24h; Inert atmosphere;	12%

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

: 599205-75-1
C40H26N4O5

polymer, Mn 16824 by GPC, Mw 36525, ηinh 0.68 dL/g in CHCl3 at 25 deg C; monomer(s): 1,3-bis(4-fluorobenzoyl)benzene; O,O-bis(4-(1,2-dihydro-phthalazin-1-on-4-yl)phenyl)-4,4-dihydroxydiphenyl ether: polymer, Mn 16824 by GPC, Mw 36525, ηinh 0.68 dL/g in CHCl3 at 25 deg C; monomer(s): 1,3-bis(4-fluorobenzoyl)benzene; O,O-bis(4-(1,2-dihydro-phthalazin-1-on-4-yl)phenyl)-4,4-dihydroxydiphenyl ether

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl acetamide; toluene at 145 - 180℃; for 22h;

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

: C40H26N4O3S2

polymer, Mn 63403 by GPC, Mw 151167, ηinh 1.01 dL/g in CHCl3 at 25 deg C; monomer(s): 1,3-bis(4-fluorobenzoyl)benzene; O,O-bis(4-(1,2-dihydro-phthalazin-1-on-4-yl)phenyl)-4,4-oxybis(benzenethiol): polymer, Mn 63403 by GPC, Mw 151167, ηinh 1.01 dL/g in CHCl3 at 25 deg C; monomer(s): 1,3-bis(4-fluorobenzoyl)benzene; O,O-bis(4-(1,2-dihydro-phthalazin-1-on-4-yl)phenyl)-4,4-oxybis(benzenethiol)

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl acetamide; toluene at 145 - 180℃; for 22h;

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

: 599205-73-9
C43H32N4O4

polymer, Mn 37852 by GPC, Mw 93547, ηinh 0.91 dL/g in CHCl3 at 25 deg C; monomer(s): 1,3-bis(4-fluorobenzoyl)benzene; O,O-bis(4-(1,2-dihydro-phthalazin-1-on-4-yl)phenyl)-4,4-isopropylidenebiphenol: polymer, Mn 37852 by GPC, Mw 93547, ηinh 0.91 dL/g in CHCl3 at 25 deg C; monomer(s): 1,3-bis(4-fluorobenzoyl)benzene; O,O-bis(4-(1,2-dihydro-phthalazin-1-on-4-yl)phenyl)-4,4-isopropylidenebiphenol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl acetamide; toluene at 145 - 180℃; for 22h;

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

: 599205-74-0
C43H26F6N4O4

polymer, Mn 31112 by GPC, Mw 55299, ηinh 0.41 dL/g in CHCl3 at 25 deg C; monomer(s): 1,3-bis(4-fluorobenzoyl)benzene; O,O-bis(4-(1,2-dihydro-phthalazin-1-on-4-yl)phenyl)-4,4-(hexafluoroisopropylidene)biphenol: polymer, Mn 31112 by GPC, Mw 55299, ηinh 0.41 dL/g in CHCl3 at 25 deg C; monomer(s): 1,3-bis(4-fluorobenzoyl)benzene; O,O-bis(4-(1,2-dihydro-phthalazin-1-on-4-yl)phenyl)-4,4-(hexafluoroisopropylidene)biphenol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl acetamide; toluene at 145 - 180℃; for 22h;

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

: C80H48O8

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 64 percent / potassium carbonate / dimethylformamide / 9 h / 150 °C 2: 2 percent / potassium carbonate / toluene; dimethylformamide / 108 h / 150 °C View Scheme

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

: 874365-05-6
1,3-di-(3-p-fluorophenyl-[3H]-naphtho[2,1-b]pyran-3-yl)-benzene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 64 percent / acetylene / tetrahydrofuran; dimethylsulfoxide / 23 °C 2: 73 percent / PPTS; trimethyl orthoformate / CH2Cl2 / 6 h / Heating View Scheme

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

: 874365-10-3
1,3-di-(8-bromo-3-p-fluorophenyl-[3H]-naphtho[2,1-b]pyran-3-yl)-benzene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 64 percent / acetylene / tetrahydrofuran; dimethylsulfoxide / 23 °C 2: 86 percent / PPTS; trimethyl orthoformate / CH2Cl2 / 8 h / Heating View Scheme

: 108464-88-6
1,3-bis(4'-fluorobenzoyl)benzene

: 874365-15-8
1,3-di-(2-p-fluorophenyl-6-phenyl-5-ethoxycarbonyl-[2H]-naphtho[2,1-b]pyran-2-yl)-benzene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 64 percent / acetylene / tetrahydrofuran; dimethylsulfoxide / 23 °C 2: 72 percent / PPTS; trimethyl orthoformate / CH2Cl2 / 6 h / Heating View Scheme

1,3-Bis(4-fluorobenzoyl)benzene Specification

The systematic name of 1,3-Bis(4-fluorobenzoyl)benzene is benzene-1,3-diylbis[(4-fluorophenyl)methanone] . With the CAS registry number 108464-88-6, it is also named as 1,3-Phenylenebis[(4-fluorophenyl)methanone] ; methanone, 1,1'-(1,3-phenylene)bis[1-(4-fluorophenyl)- . The product's categories are C15 to C38, carbonyl compounds and ketones. It is used as pharmaceutical intermediates. 1,3-Bis(4-fluorobenzoyl)benzene must be sealed in the container. Keep the container tightly sealed and store in a cool and dry place.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 4.86 ; (2)# of Rule of 5 Violations: 0 ; (3)#H bond acceptors: 2 ; (4)#H bond donors: 0 ; (5)#Freely Rotating Bonds: 4 ; (6)Index of Refraction: 1.59 ; (7)Molar Refractivity: 85.82 cm³ ; (8)Molar Volume: 254 cm³ ; (9)Polarizability: 34.02×10^-24 cm³ ; (10)Surface Tension: 45.7 dyne/cm ; (11)Enthalpy of Vaporization: 74 kJ/mol ; (12)Vapour Pressure: 3.08E-09 mmHg at 25°C.

People can use the following data to convert to the molecule structure. SMILES: O=C(c1ccc(F)cc1)c3cccc(C(=O)c2ccc(F)cc2)c3; InChI: InChI=1/C20H12F2O2/c21-17-8-4-13(5-9-17)19(23)15-2-1-3-16(12-15)20(24)14-6-10-18(22)11-7-14/h1-12H; InChIKey: PISLKPDKKIDMQT-UHFFFAOYAJ. The price of this product changes with the market.

Product Name

1,3-BIS(4-FLUOROBENZOYL)BENZENE

Synthetic route

1,3-Bis(4-fluorobenzoyl)benzene Specification

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