methanesulfonyl chloride
cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
Conditions | Yield |
---|---|
With pyridine | 87% |
(+/-)-cis-[2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-yl]methyl benzoate
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) NaH, 3.) aq. NaOH 2: 87 percent / pyridine View Scheme |
4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1-methyl-1H-1,2,4-triazol-5(4H)-one
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2-methyl-2,4-dihydro-[1,2,4]triazol-3-one
Conditions | Yield |
---|---|
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction; |
1-ethyl-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2-ethyl-2,4-dihydro-[1,2,4]triazol-3-one
Conditions | Yield |
---|---|
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction; |
4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-2-propyl-2,4-dihydro-3H-1,2,4-triazol-3-one
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2-propyl-2,4-dihydro-[1,2,4]triazol-3-one
Conditions | Yield |
---|---|
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction; |
4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1-isopropyl-1H-1,2,4-triazol-5(4H)-one
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
cis-4-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>-2,4-dihydro-2-(1-methylethyl)-3H-1,2,4-triazol-3-one
Conditions | Yield |
---|---|
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction; |
4-{4-[4-(4-Hydroxy-phenyl)-piperazin-1-yl]-phenyl}-2,5-dimethyl-2,4-dihydro-[1,2,4]triazol-3-one
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,5-dimethyl-2,4-dihydro-[1,2,4]triazol-3-one
Conditions | Yield |
---|---|
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction; |
4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1-isobutyl-1H-1,2,4-triazol-5(4H)-one
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2-isobutyl-2,4-dihydro-[1,2,4]triazol-3-one
Conditions | Yield |
---|---|
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction; |
1-butyl-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
2-Butyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2,4-dihydro-[1,2,4]triazol-3-one
Conditions | Yield |
---|---|
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction; |
2-Ethyl-4-{4-[4-(4-hydroxy-phenyl)-piperazin-1-yl]-phenyl}-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2-ethyl-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one
Conditions | Yield |
---|---|
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction; |
4-{4-[4-(4-Hydroxy-phenyl)-piperazin-1-yl]-phenyl}-2-isopropyl-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2-isopropyl-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one
Conditions | Yield |
---|---|
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction; |
4-{4-[4-(4-Hydroxy-phenyl)-piperazin-1-yl]-phenyl}-5-methyl-2-propyl-2,4-dihydro-[1,2,4]triazol-3-one
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2-propyl-2,4-dihydro-[1,2,4]triazol-3-one
Conditions | Yield |
---|---|
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction; |
4-{4-[4-(4-Hydroxy-phenyl)-piperazin-1-yl]-phenyl}-2-isobutyl-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-2-isobutyl-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one
Conditions | Yield |
---|---|
With sodium hydride 1.) Me2SO, 50 deg C, 1 h, 2.) Me2SO, 100 deg C, 3 h; Yield given. Multistep reaction; |
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
4-(4-hydroxyphenyl)-1-(1-methylethyl)piperazine
(+/-)-Terconazole
Conditions | Yield |
---|---|
With sodium hydride 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 4 h; Yield given. Multistep reaction; |
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
N-acetyl-N'-(4-hydroxyphenyl)piperazine
cis-1-acetyl-4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>-methoxy>phenyl>piperazine
Conditions | Yield |
---|---|
With sodium hydride 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 5 h; Yield given. Multistep reaction; |
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
Conditions | Yield |
---|---|
With sodium hydride 1.) DMSO, 30 min, 2.) DMSO, from 60 deg C to 70 deg C, 2 h; Yield given. Multistep reaction; |
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
cis-1-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>piperazine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 5 h 2: 70 percent / NaOH / butan-1-ol / Heating View Scheme |
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
cis-1-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>benzenamine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 5 h 2: 70 percent / NaOH / butan-1-ol / Heating 3: 50 percent / K2CO3 / dimethylsulfoxide / 120 °C 4: 80 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating View Scheme |
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
cis-1-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-4-(4-nitrophenyl)piperazine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 5 h 2: 70 percent / NaOH / butan-1-ol / Heating 3: 50 percent / K2CO3 / dimethylsulfoxide / 120 °C View Scheme |
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
cis-1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>hydrazinecarboxamide
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 5 h 2: 70 percent / NaOH / butan-1-ol / Heating 3: 50 percent / K2CO3 / dimethylsulfoxide / 120 °C 4: 80 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating 5: 86 percent / pyridine / CHCl3 / 3 h 6: 99 percent / hydrazine hydrate / dioxane / 3 h / Heating View Scheme |
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
4-[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 5 h 2: 70 percent / NaOH / butan-1-ol / Heating 3: 50 percent / K2CO3 / dimethylsulfoxide / 120 °C 4: 80 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating 5: 86 percent / pyridine / CHCl3 / 3 h 6: 99 percent / hydrazine hydrate / dioxane / 3 h / Heating 7: 38 percent / NaOAc / butan-1-ol View Scheme |
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
cis-phenyl 1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>carbamate
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 5 h 2: 70 percent / NaOH / butan-1-ol / Heating 3: 50 percent / K2CO3 / dimethylsulfoxide / 120 °C 4: 80 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating 5: 86 percent / pyridine / CHCl3 / 3 h View Scheme |
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
2-sec-Butyl-4-[4-(4-{4-[(2R,4S)-2-(2,4-dichloro-phenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-5-methyl-2,4-dihydro-[1,2,4]triazol-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 5 h 2: 70 percent / NaOH / butan-1-ol / Heating 3: 50 percent / K2CO3 / dimethylsulfoxide / 120 °C 4: 80 percent / H2, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating 5: 86 percent / pyridine / CHCl3 / 3 h 6: 99 percent / hydrazine hydrate / dioxane / 3 h / Heating 7: 38 percent / NaOAc / butan-1-ol 8: 68 percent / KOH / dimethylsulfoxide View Scheme |
The 1,3-Dioxolane-4-methanol,2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-, 4-methanesulfonate,(2R,4R)-rel-, with the CAS registry number 67914-86-7, is also known as cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate. It belongs to the product categories of Pharmaceutical Intermediates; Intermediatesofitraconazole; Intermediates & Fine Chemicals; Pharmaceuticals. Its EINECS registry number is 267-749-5. This chemical's molecular formula is C14H15Cl2N3O5S and molecular weight is 408.26. Its IUPAC name is called [(2S,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate. This chemical which is white-to-off-white powder can be used as an intermediate in the synthesis of itraconazole.
Physical properties of 1,3-Dioxolane-4-methanol,2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-, 4-methanesulfonate,(2R,4R)-rel-: (1)ACD/LogP: 1.79; (2)ACD/LogD (pH 5.5): 1.79; (3)ACD/LogD (pH 7.4): 1.79; (4)ACD/BCF (pH 5.5): 13.38; (5)ACD/BCF (pH 7.4): 13.46; (6)ACD/KOC (pH 5.5): 222.37; (7)ACD/KOC (pH 7.4): 223.75; (8)#H bond acceptors: 8; (9)#Freely Rotating Bonds: 6; (10)Index of Refraction: 1.647; (11)Molar Refractivity: 92.95 cm3; (12)Molar Volume: 255.5 cm3; (13)Surface Tension: 58.8 dyne/cm; (14)Density: 1.59 g/cm3; (15)Flash Point: 326 °C; (16)Enthalpy of Vaporization: 91.31 kJ/mol; (17)Boiling Point: 615.5 °C at 760 mmHg; (18)Vapour Pressure: 4.42E-15 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CS(=O)(=O)OCC1COC(O1)(CN2C=NC=N2)C3=C(C=C(C=C3)Cl)Cl
(2)Isomeric SMILES: CS(=O)(=O)OC[C@@H]1CO[C@@](O1)(CN2C=NC=N2)C3=C(C=C(C=C3)Cl)Cl
(3)InChI: InChI=1S/C14H15Cl2N3O5S/c1-25(20,21)23-6-11-5-22-14(24-11,7-19-9-17-8-18-19)12-3-2-10(15)4-13(12)16/h2-4,8-9,11H,5-7H2,1H3/t11-,14+/m0/s1
(4)InChIKey: QIMASXGTWQEFGS-SMDDNHRTSA-N
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