1,3-Diphenylurea supplier | CasNO.102-07-8

Name
N,N'-Diphenylurea
EINECS 203-003-7
CAS No. 102-07-8
Article Data837
CAS DataBase
Density 1.25 g/cm³
Solubility 150.3mg/L(temperature not stated)
Melting Point 239-241 °C(lit.)
Formula C₁₃H₁₂N₂O
Boiling Point 262 °C at 760 mmHg
Molecular Weight 212.251
Flash Point 91.147 °C
Transport Information UN 2811
Appearance solid
Safety 22-24/25
Risk Codes R22
Molecular Structure
Hazard Symbols R22:Harmful if swallowed.;
Synonyms Carbanilide(7CI,8CI);1,3-Diphenylcarbamide;AD 30;DPU;N,N'-Diphenylurea;N-Phenyl-N'-phenylurea;NSC 227401;NSC 8485;s-Diphenylurea;sym-Diphenylurea;
PSA 41.13000
LogP 3.47660

Synthetic route

: 103-71-9
phenyl isocyanate

: 62-53-3
aniline

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With triethylamine In dichloromethane	100%
In acetic acid for 0.0833333h;	98%
In hexane	95%

: 102-08-9
N,N-diphenylthiourea

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With sodium hydroxide; copper(l) chloride In water; acetonitrile at 25℃; for 0.333333h;	100%
With quinolinium monofluorochromate(VI) In acetonitrile for 3.5h; Heating;	98%
With trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane; water; potassium hydroxide In acetonitrile at 20℃; for 0.0166667h;	98%

: 495-18-1
Benzohydroxamic acid

: 77219-88-6
bis(trimethylsilyl)benzohydroxamic acid

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
at 100℃; for 1.5h;	100%

: 622-16-2
1,3-Diphenylcarbodiimide

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
Ambient temperature; prolonged holding in air;	100%
With air (H2O)	100%
With hydrogenchloride In dichloromethane at 0℃; for 0.5h; Yield given;
With water

: 103-71-9
phenyl isocyanate

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With C24H28N8PrS4(1-)*Li(1+) In acetonitrile at 60℃; for 12h; Inert atmosphere;	99%
With water; triethylamine In 1,4-dioxane at 20℃; for 0.05h;	98%
at 20 - 50℃; Product distribution / selectivity;	95%

: 124-38-9
carbon dioxide

: 3768-55-6
N-trimethylsilylaniline

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With pyridine at 120℃; under 3800.26 Torr; for 18h;	99%
With pyridine; C14H34Cl2InNO2Si2 In toluene at 110℃; under 2280.15 Torr; for 24h; Catalytic behavior; Pressure;	70%
dodecacarbonyl-triangulo-triruthenium at 150℃; under 10343 Torr; for 20h;	48%

: 201230-82-2
carbon monoxide

: 62-53-3
aniline

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With 1-butyl-3-methyl-1H-imidazole-2(3H)-selenone; oxygen at 90℃; under 9750.98 Torr; for 6h; Catalytic behavior; Reagent/catalyst; Temperature; Ionic liquid; Autoclave;	99%
With palladium; oxygen; potassium iodide In 1,4-dioxane at 130℃; under 30003 Torr; for 24h; Autoclave; Green chemistry;	99%
With potassium tetraiodopalladate(II) at 90℃; under 37503.8 Torr; for 24h; Neat (no solvent); Autoclave;	96%

: 495-18-1
Benzohydroxamic acid

: 62-53-3
aniline

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
Stage #1: Benzohydroxamic acid With 4-methyl-morpholine; 1,3,5-trichloro-2,4,6-triazine In dichloroethane at 0℃; for 1.5h; Lossen rearrangement; Inert atmosphere; Stage #2: aniline In dichloroethane at 0 - 84℃; for 15h; Lossen rearrangement; Inert atmosphere;	99%
Stage #1: Benzohydroxamic acid With ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0℃; for 1.5h; Lossen Rearrangement; Stage #2: aniline In tetrahydrofuran at 20℃; for 4h; Lossen Rearrangement;	83%
Stage #1: Benzohydroxamic acid With ethyl 2-(tert-butoxycarbonyloxyimino)-2-cyanoacetate; N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 0.25h; Green chemistry; Stage #2: aniline In dichloromethane for 6h; Lossen Rearrangement; Green chemistry; chemoselective reaction;	82%
Stage #1: Benzohydroxamic acid With 2-chloro-1,3-dimethylimidazolinium chloride; triethylamine In dichloromethane at 20℃; for 15h; Rearrangement; Stage #2: aniline In dichloromethane at 20℃; for 4h; Addition;	66%

: 1202047-15-1
1-tert-butyl-1-ethyl-3-phenylurea

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With water In toluene at 70℃; for 1h;	99%

: 32315-10-9
bis(trichloromethyl) carbonate

: 62-53-3
aniline

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
Stage #1: bis(trichloromethyl) carbonate; aniline In acetonitrile at 0 - 5℃; for 1h; Stage #2: With ETS-10 molecular sieve catalyst In acetonitrile at 80℃; for 4h; Solvent; Temperature;	99%
In acetonitrile at 20℃; for 4h; Sealed tube;	38 %Chromat.

: 62-53-3
aniline

: 19226-36-9
3-phenyl-5H-1,4,2-dioxazol-5-one

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With sodium acetate In methanol at 60℃; for 2h; Solvent; Reagent/catalyst; Temperature; Concentration;	99%

: 4231-62-3
1-benzoyl-1H-benzotriazole

: 62-53-3
aniline

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With trimethylsilylazide; triethylamine In toluene at 110℃; for 1h; Sealed tube;	99%
With diphenyl phosphoryl azide; triethylamine In toluene at 110℃; Curtius Rearrangement; Sealed tube;	96%

: 62-53-3
aniline

: 57-13-6
urea

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With iodine at 90 - 95℃; for 0.0833333h;	98%
With zinc(II) chloride at 80 - 85℃; for 0.0833333h; Neat (no solvent);	98%
With PEG-400; cerium(III) chloride; potassium iodide In water for 0.266667h; microwave irradiation;	97%

: 64-17-5
ethanol

: 201230-82-2
carbon monoxide

: 62-53-3
aniline

A: 101-99-5
N-carboethoxyaniline

B: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With oxygen; sodium iodide; Pd-Se/Al2)3 at 170℃; under 49505 Torr; for 3h; Product distribution; Further Variations:; Catalysts;	A 97% B n/a
With oxygen; tertamethylammonium iodide; silica gel; palladium at 160 - 170℃; further catalyst systems;	A 94% B 0.5%
With selenium; oxygen; triethylamine at 180℃; under 15001.5 Torr; for 6h; Autoclave;	A 85% B 8%
With selenium; oxygen; triethylamine at 120℃; under 15001.5 Torr; for 6h; Autoclave;	A 35% B 46%
With oxygen; palladium on activated charcoal; tertamethylammonium iodide at 160 - 170℃; further catalyst systems;	A 42% B 11%

...Expand

: 1274701-95-9
2-tert-butoxy-6-hydroxy-N-phenylpiperidine-1-carboxamide

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With water at 80℃;	97%

: 64-10-8
phenyl carbamate

: 62-53-3
aniline

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With benzoic acid In para-xylene at 130℃; for 8h; Inert atmosphere; Schlenk technique;	96%
With graphene oxide In neat (no solvent) at 80℃; for 4h; Sealed tube;	94%
With sulfated polyborate at 120℃; for 1h;	93%

: 628-05-7
1-nitropentane

: 5-allyl-3-isobutoxy-2-methyl-4-<7-(α-tetrahydropyranyl)oxyheptyl>-2-cyclopenten-1-one

: 3-isobutoxy-2-methyl-5-(3-butyl-4,5-dihydroisoxazolin-5-yl)methyl-4-<7-(α-tetrahydropyranyl)oxyheptyl>-2-cyclopenten-1-one

B: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With phenyl isocyanate; triethylamine In benzene	A 96% B n/a

...Expand

: 124-38-9
carbon dioxide

: 62-53-3
aniline

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With iron(III) chloride; phenylsilane; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine In tetrahydrofuran at 110℃; under 760.051 - 3040.2 Torr; for 24h; Sealed tube;	96%
With diethylene glycol dimethyl ether; cesium fluoride at 100℃; for 20h; Schlenk technique; Glovebox;	96%
With iron(III) chloride; phenylsilane; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine In tetrahydrofuran at 110℃; under 760.051 Torr; for 24h; Reagent/catalyst; Solvent; Temperature; Sealed tube;	92%

: 1152-32-5
1-benzoyl-4-phenylsemicarbazide

: 62-53-3
aniline

A: 613-94-5
benzoic acid hydrazide

B: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
In various solvent(s) at 150℃; for 1h;	A 94% B 96%

...Expand

: 62-53-3
aniline

: 65-85-0
benzoic acid

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With diphenyl phosphoryl azide; triethylamine In toluene at 100℃; for 0.0166667h; Curtius Rearrangement; Microwave irradiation;	96%
With phenyl N-phenylphosphoramidoazidate; triethylamine In acetonitrile for 1.5h; Heating;	94%
Stage #1: benzoic acid With sodium azide; phenyl chloroformate; sodium t-butanolate In 1,2-dimethoxyethane at 25℃; for 8h; Stage #2: aniline In 1,2-dimethoxyethane at 75℃; for 16h;	89%

: 62-53-3
aniline

: 122350-19-0
3,3'-carbonylbis<5-phenyl-1,3,4-oxadiazole-2(3H)-thione>

A: 3004-42-0
5-phenyl-1,3,4-oxadiazole-2(3H)-thione

B: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
In various solvent(s) for 1h; Ambient temperature;	A n/a B 96%

...Expand

: 940-38-5
phenylcarbamoyl azide

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With sodium acetate In acetonitrile at 80℃; for 12h; Inert atmosphere;	96%
With sodium acetate In acetonitrile at 80℃; under 760.051 Torr; for 12h; Schlenk technique; Inert atmosphere;	95%
With sodium acetate In ethyl acetate at 75℃; for 24h;	95%
With silver hexafluoroantimonate; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; N-t-butylbenzamide In 1,2-dichloro-ethane at 90℃; for 24h; Curtius Rearrangement;	35%

: 3768-55-6
N-trimethylsilylaniline

: 103-71-9
phenyl isocyanate

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
dodecacarbonyl-triangulo-triruthenium at 100℃; under 15514.4 Torr; for 20h;	95%

: 591-50-4
iodobenzene

: 64-10-8
phenyl carbamate

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine In N,N-dimethyl-formamide at 85℃; for 24h;	95%
With potassium phosphate In N,N-dimethyl-formamide at 20 - 120℃; for 1h; Microwave irradiation; Sealed tube; Inert atmosphere;	94%
With copper(I) oxide; potassium phosphate monohydrate at 120℃; for 0.666667h; Microwave irradiation; Inert atmosphere; Neat (no solvent);	90%

: 98-88-4
benzoyl chloride

: 62-53-3
aniline

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
Stage #1: benzoyl chloride With pyridine; trimethylsilylazide In N,N-dimethyl-formamide at 20℃; Curtius rearrangement; Microflow reaction; Inert atmosphere; Stage #2: aniline With acetic acid In N,N-dimethyl-formamide at 110℃; Microflow reaction; Inert atmosphere;	95%
Stage #1: benzoyl chloride With N-ethyl-N,N-diisopropylamine; hydroxylamine-O-sulfonic acid In dichloromethane Lossen Rearrangement; Inert atmosphere; Green chemistry; Stage #2: aniline In dichloromethane at 100℃; for 0.0833333h; Solvent; Reagent/catalyst; Microwave irradiation; Inert atmosphere; Green chemistry;	80%

: 501-82-6
N-phenylcarbamic acid

: 62-53-3
aniline

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With trichloroisocyanuric acid; triphenylphosphine In 1,4-dioxane at 80℃; for 4h;	95%

: 61650-22-4
N-(pivaloyloxy)benzamide

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With [RhCl2(p-cymene)]2; silver(I) acetate In 1,4-dioxane at 80℃; for 12h; Catalytic behavior;	95%

: 21251-12-7
N-benzoyl-O-acetylhydroxylamine

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
With [RhCl2(p-cymene)]2; silver(I) acetate In 1,4-dioxane at 80℃; for 12h;	94%
With potassium carbonate

: 2963-12-4
O-Phenylcarbamyl benzohydroxamic acid

: 62-53-3
aniline

: 102-07-8
bis(diphenyl)urea

Conditions

Conditions	Yield
triethylamine In dichloromethane for 0.5h; Heating;	94%

: 13987-61-6
N-methylene-tert-butylamine

: 102-07-8
bis(diphenyl)urea

: 140367-33-5
5-tert-Butyl-1,3-diphenyl-[1,3,5]triazinan-2-one

Conditions

Conditions	Yield
for 4h; Heating;	100%

: 485-47-2
indan-1,2,3-trione hydrate

: 102-07-8
bis(diphenyl)urea

: 58137-72-7
3a,8a-dihydroxy-1,3-diphenyl-1,3,3a,8a-tetrahydro-indeno[1,2-d]imidazole-2,8-dione

Conditions

Conditions	Yield
In acetic acid for 0.25h; Heating;	100%
In water at 50 - 60℃;	64%
In benzene Reflux; regioselective reaction;

: 102-07-8
bis(diphenyl)urea

: 101-99-5
N-carboethoxyaniline

Conditions

Conditions	Yield
	100%
	98%
With iodine; triethylamine	98%

: 79-37-8
oxalyl dichloride

: 102-07-8
bis(diphenyl)urea

: 6488-59-1
diphenylparabanic acid

Conditions

Conditions	Yield
In dichloromethane for 1.5h; Reflux;	99%
In toluene at 50 - 85℃; for 2h; Temperature;	91%

: 64-17-5
ethanol

: 201230-82-2
carbon monoxide

: 102-07-8
bis(diphenyl)urea

: 101-99-5
N-carboethoxyaniline

Conditions

Conditions	Yield
With isocyanate de chlorosulfonyle; oxygen; palladium at 160 - 170℃;	98%
With oxygen; rhodium contaminated with carbon at 160 - 170℃; under 63253.7 Torr; for 3h;

...Expand

: 102-07-8
bis(diphenyl)urea

: 864131-95-3
N,N'-diphenylformamidine

Conditions

Conditions	Yield
With iron(II) acetylacetonate; phenylsilane; tris(2-diphenylphosphinoethyl)phosphine In tetrahydrofuran at 100℃; for 24h; Reagent/catalyst; Inert atmosphere; Glovebox; Schlenk technique;	98%
Stage #1: bis(diphenyl)urea With phenylsilane; tris(2-diphenylphosphinoethyl)phosphine; iron(II) diacetylacetonate In tetrahydrofuran at 100℃; for 24h; Stage #2: With water at 20℃; Reagent/catalyst; Solvent;	98 %Chromat.

: 98-95-3
nitrobenzene

: 102-07-8
bis(diphenyl)urea

: 156-10-5
p-nitrosodiphenylamine

Conditions

Conditions	Yield
With oxygen; sodium hydroxide In dimethyl sulfoxide at 60℃; for 4h; Reagent/catalyst;	97.3%

: 64-67-5
diethyl sulfate

: 102-07-8
bis(diphenyl)urea

: 85-98-3
ethyl centralite

Conditions

Conditions	Yield
With sodium hydroxide; potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate In toluene for 3h; Alkylation; Heating;	97%

: 102-07-8
bis(diphenyl)urea

: 60285-31-6
N,N'-diphenyl-N-nitroso-urea

Conditions

Conditions	Yield
With nitrosylchloride In N,N-dimethyl-formamide at 0℃; for 2h;	96%
With cis-nitrous acid; acetic acid

1,3-Diphenylurea Chemical Properties

Molecular Structure of CARBANILIDE(102-07-8):

IUPAC Name:1,3-diphenylurea
Molecular Formula:C₁₃H₁₂N₂O
Molecular Weight:212.247180 g/mol
Appearance:white crystalline solid
Melting Point:239-241 °C(lit.)
Density:1.249 g/cm³
Flash Point:91.1 °C
Enthalpy of Vaporization:49.98 kJ/mol
Boiling Point:262 °C at 760 mmHg
Vapour Pressure:0.0112 mmHg at 25 °C
Water Solubility:103.7 mg/L at 25 °C
BRN:782650
EINECS:203-003-7
Synonyms of CARBANILIDE(102-07-8):
CARBANILIDE;CARBANILLIDE;DIPHENYLCARBAMIDE;1,3-DIPHENYLUREA;AKOS B028830;PROXIMPHAM;N,N'-DIPHENYLUREA;N,N'-Diphenylurea
Categories of CARBANILIDE(102-07-8):
Biochemistry;Cytokinins;Plant Growth Regulators

1,3-Diphenylurea Uses

CARBANILIDE(102-07-8) is an intermediate for the synthesis of ammonia benzene sulfonamide.

1,3-Diphenylurea Toxicity Data With Reference

1.		orl-rat LDLo:500 mg/kg		JPETAB Journal of Pharmacology and Experimental Therapeutics. 90 (1947),260.
2.		ipr-mus LD50:200 mg/kg		NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD277-689 .

1,3-Diphenylurea Consensus Reports

Reported in EPA TSCA Inventory.

1,3-Diphenylurea Safety Profile

The safety information of CARBANILIDE(102-07-8) is as follows:
Safety Statements:22-24/25
22:Do not breathe dust
24/25:Avoid contact with skin and eyes
RIDADR:2811
WGK Germany:3
RTECS:FD9800000
HazardClass:6.1(b)
PackingGroup:III
Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NO_x.

1,3-Diphenylurea Specification

Storage information of CARBANILIDE(102-07-8):
Keep in a tightly closed container, in a cool dry location. Store only with compatible chemicals.

Product Name

N,N'-Diphenylurea

Synthetic route

1,3-Diphenylurea Chemical Properties

1,3-Diphenylurea Uses

1,3-Diphenylurea Toxicity Data With Reference

1,3-Diphenylurea Consensus Reports

1,3-Diphenylurea Safety Profile

1,3-Diphenylurea Specification

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