Product Name

  • Name

    2-AMINO-6-METHYLHEPTANE

  • EINECS 208-851-1
  • CAS No. 543-82-8
  • Article Data5
  • CAS DataBase
  • Density 0.783 g/cm3
  • Solubility
  • Melting Point 25°C
  • Formula C8H19N
  • Boiling Point 154.999 °C at 760 mmHg
  • Molecular Weight 129.246
  • Flash Point 48.889 °C
  • Transport Information UN 1993 3/PG 3
  • Appearance clear colorless to light yellow liquid
  • Safety 26-36/37/39-16
  • Risk Codes 10-22-36/37/38
  • Molecular Structure Molecular Structure of 543-82-8 (2-AMINO-6-METHYLHEPTANE)
  • Hazard Symbols HarmfulXn
  • Synonyms Hexylamine,1,5-dimethyl- (6CI,7CI,8CI);2-Amino-6-methylheptane;2-Isooctylamine;2-Methyl-6-aminoheptane;6-Amino-2-methylheptane;6-Methyl-2-heptanamine;6-Methyl-2-heptylamine;Amidrine;Isoctaminum;Octodrin;Octodrine;SKF 51;Vaporpac;a,e-Dimethylhexylamine;
  • PSA 26.02000
  • LogP 2.86020

Synthetic route

ammonium formate
540-69-2

ammonium formate

6-methylheptan-2-one
928-68-7

6-methylheptan-2-one

1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

Conditions
ConditionsYield
at 180 - 185℃; Kochen des Reaktionsprodukts mit konz.HCl;
6-methylheptan-2-one
928-68-7

6-methylheptan-2-one

1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

Conditions
ConditionsYield
With ethanol; ammonia; nickel Hydrogenation.unter Druck;
6-methylheptan-2-one
928-68-7

6-methylheptan-2-one

A

1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

B

bis-(1,5-dimethyl-hexyl)-amine
101440-18-0

bis-(1,5-dimethyl-hexyl)-amine

Conditions
ConditionsYield
With hydrazine hydrate anschliessend mit Methanol, wss. Ammoniak und aktiviertem Aluminium;
2-methyl-heptanone-(6)-oxime

2-methyl-heptanone-(6)-oxime

1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

Conditions
ConditionsYield
With nickel Hydrogenation;
With ethanol; sodium
(R)-6-methylheptan-2-amine
70419-11-3

(R)-6-methylheptan-2-amine

1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

Conditions
ConditionsYield
With 2,2,2-trifluoroethanethiol In tetrahydrofuran; 3-methylpentan-3-ol at 22 - 24℃; for 2h; Photolysis;
6-Methyl-hept-5-en-2-on
110-93-0

6-Methyl-hept-5-en-2-on

A

1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

B

6-methylhept-5-en-2-ol
4630-06-2, 1569-60-4

6-methylhept-5-en-2-ol

C

6-methylhept-5-en-2-amine
22462-79-9

6-methylhept-5-en-2-amine

Conditions
ConditionsYield
With ammonia; hydrogen In tert-butyl alcohol at 120℃; for 24h; Autoclave; High pressure;A 5 %Chromat.
B 73 %Chromat.
C 15 %Chromat.
...Expand
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

bis(1H-benzo[d][1,2,3]triazol-1-yl)methanethione
4314-19-6

bis(1H-benzo[d][1,2,3]triazol-1-yl)methanethione

benzotriazole-1-carbothioic acid (1,5-dimethylhexyl)amide
690634-05-0

benzotriazole-1-carbothioic acid (1,5-dimethylhexyl)amide

Conditions
ConditionsYield
In dichloromethane at 20℃; for 18h;99%
In dichloromethane at 20℃; for 18h;87%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

N-tert-butoxycarbonyl-L-leucine
13139-15-6

N-tert-butoxycarbonyl-L-leucine

L-Leucin-(+)-1,5-dimethylhexylamid
13532-69-9

L-Leucin-(+)-1,5-dimethylhexylamid

Conditions
ConditionsYield
Stage #1: N-tert-butoxycarbonyl-L-leucine With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at -15℃; for 0.333333h;
Stage #2: 1,5-dimethylhexylamine In tetrahydrofuran at -15 - 20℃; for 8h;
Stage #3: With trifluoroacetic acid In dichloromethane for 5h;		98%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

N-tert-butoxycarbonyl-L-phenylalanine
13734-34-4

N-tert-butoxycarbonyl-L-phenylalanine

C17H28N2O

C17H28N2O

Conditions
ConditionsYield
Stage #1: N-tert-butoxycarbonyl-L-phenylalanine With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at -15℃; for 0.333333h;
Stage #2: 1,5-dimethylhexylamine In tetrahydrofuran at -15 - 20℃; for 8h;
Stage #3: With trifluoroacetic acid In dichloromethane for 5h;		97%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

pyroglutamic acid sodium salt
54571-67-4

pyroglutamic acid sodium salt

C13H25N2O3(1-)*Na(1+)
1311195-36-4

C13H25N2O3(1-)*Na(1+)

Conditions
ConditionsYield
at 140℃; for 5h;94%
succinic acid anhydride
108-30-5

succinic acid anhydride

1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

4-[(6-methylheptan-2-yl)amino]-4-oxobutanoic acid
897522-18-8

4-[(6-methylheptan-2-yl)amino]-4-oxobutanoic acid

Conditions
ConditionsYield
In acetone at 20℃; Inert atmosphere;93%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

methyl 3,4,6-tri-O-acetyl-2-deoxy-2-(4-nitrophenoxycarbonylamino)-β-D-glucopyranoside
130539-23-0

methyl 3,4,6-tri-O-acetyl-2-deoxy-2-(4-nitrophenoxycarbonylamino)-β-D-glucopyranoside

methyl 3,4,6-tri-O-acetyl-2-deoxy-2-<3-(1,5-dimethylhexyl)ureido>-β-D-glucopyranoside
130539-31-0

methyl 3,4,6-tri-O-acetyl-2-deoxy-2-<3-(1,5-dimethylhexyl)ureido>-β-D-glucopyranoside

Conditions
ConditionsYield
In dichloromethane Ambient temperature;92%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

p-benzyloxybenzaldehyde
4397-53-9

p-benzyloxybenzaldehyde

N-(4-(benzyloxy)benzyl)-6-methylheptan-2-amine

N-(4-(benzyloxy)benzyl)-6-methylheptan-2-amine

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In tetrahydrofuran for 12h; Inert atmosphere;92%
formaldehyd
50-00-0

formaldehyd

1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

N,N',N''-tris(1,5-dimethylhexyl)-1,3,5-triazacyclohexane

N,N',N''-tris(1,5-dimethylhexyl)-1,3,5-triazacyclohexane

Conditions
ConditionsYield
In toluene for 0.5h; Heating;91%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

4-phenoxy benzaldehyde
67-36-7

4-phenoxy benzaldehyde

6-methyl-N-(4-phenoxybenzyl)heptan-2-amine

6-methyl-N-(4-phenoxybenzyl)heptan-2-amine

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In tetrahydrofuran for 12h; Inert atmosphere;91%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

3-Aminophenylboronic acid
30418-59-8

3-Aminophenylboronic acid

3-bromo-4-chloropyrazolo<3,4-d>pyrimidine
90914-41-3

3-bromo-4-chloropyrazolo<3,4-d>pyrimidine

[3-(3-amino-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-(1,5-dimethyl-hexyl)-amine

[3-(3-amino-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-(1,5-dimethyl-hexyl)-amine

Conditions
ConditionsYield
Stage #1: 1,5-dimethylhexylamine; 3-bromo-4-chloropyrazolo<3,4-d>pyrimidine With acetic acid In 1,4-dioxane at 150℃; for 0.166667h; microwave irradiation;
Stage #2: 3-Aminophenylboronic acid With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane at 180℃; for 0.166667h; Suzuki coupling; microwave irradiation;		90%
...Expand
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

(E)-2-hydroxy-2-methyl-5-phenylpent-4-en-3-one
63677-96-3

(E)-2-hydroxy-2-methyl-5-phenylpent-4-en-3-one

N-(6-methylheptan-2-yl)-3-phenylpropanamide
885902-84-1

N-(6-methylheptan-2-yl)-3-phenylpropanamide

Conditions
ConditionsYield
With 1,2,4-Triazole; C6H10N3O2S(1+)*Cl(1-); N-ethyl-N,N-diisopropylamine In dichloromethane at 40℃; for 3h;90%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

N-tert-butoxycarbonyl-D-cyclohexylalanine
127095-92-5

N-tert-butoxycarbonyl-D-cyclohexylalanine

tert-butyl N-[(1R)-1-(cyclohexylmethyl)-2-(1,5-dimethylhexylamino)-2-oxoethyl]carbamate

tert-butyl N-[(1R)-1-(cyclohexylmethyl)-2-(1,5-dimethylhexylamino)-2-oxoethyl]carbamate

Conditions
ConditionsYield
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 10 - 20℃; for 4h;86%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

(±)-3-(1-phenylethoxy)benzaldehyde

(±)-3-(1-phenylethoxy)benzaldehyde

(±)-6-methyl-N-(3-(1-phenylethoxy)benzyl)heptan-2-amine

(±)-6-methyl-N-(3-(1-phenylethoxy)benzyl)heptan-2-amine

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In tetrahydrofuran for 12h; Inert atmosphere;85%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

N-tert-butoxycarbonyl-L-phenylalanine
13734-34-4

N-tert-butoxycarbonyl-L-phenylalanine

C22H36N2O3

C22H36N2O3

Conditions
ConditionsYield
Stage #1: N-tert-butoxycarbonyl-L-phenylalanine With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at -15℃; for 0.333333h;
Stage #2: 1,5-dimethylhexylamine In tetrahydrofuran at -15 - 20℃; for 8h;		85%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

(±)-4-(1-phenylethoxy)benzaldehyde

(±)-4-(1-phenylethoxy)benzaldehyde

(±)-6-methyl-N-(4-(1-phenylethoxy)benzyl)heptan-2-amine

(±)-6-methyl-N-(4-(1-phenylethoxy)benzyl)heptan-2-amine

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In tetrahydrofuran for 12h; Inert atmosphere;83%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

2,4-Toluene diisocyanate
584-84-9

2,4-Toluene diisocyanate

1,5-dimethylhexyl-3-[3-(3-(1,5-dimethylhexyl)ureido)-4-methylphenyl]urea

1,5-dimethylhexyl-3-[3-(3-(1,5-dimethylhexyl)ureido)-4-methylphenyl]urea

Conditions
ConditionsYield
In dichloromethane for 24h;82%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

C26H24N6O12S2

C26H24N6O12S2

C42H58N8O10S2

C42H58N8O10S2

Conditions
ConditionsYield
Stage #1: C26H24N6O12S2 With thionyl chloride In chloroform; N,N-dimethyl-formamide at 50℃; for 5h;
Stage #2: 1,5-dimethylhexylamine With triethylamine In chloroform; N,N-dimethyl-formamide at 20℃;		82%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

2-chloro-5-fluoronicotinic acid
38186-88-8

2-chloro-5-fluoronicotinic acid

2-[(1,5-dimethylhexyl)amino]-5-fluoronicotinic acid
1038827-24-5

2-[(1,5-dimethylhexyl)amino]-5-fluoronicotinic acid

Conditions
ConditionsYield
Stage #1: 1,5-dimethylhexylamine; 2-chloro-5-fluoronicotinic acid With copper; potassium carbonate; copper(I) bromide In N,N-dimethyl-formamide at 120℃; for 2h;
Stage #2: With hydrogenchloride; water		81%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

diisopropylamine
108-18-9

diisopropylamine

6-methyl-N-(1-methylethyl)-2-heptanamine
13946-02-6

6-methyl-N-(1-methylethyl)-2-heptanamine

Conditions
ConditionsYield
With μ-diiodo-di((η5-pentamethylcyclopentadienyl)(iodo)iridium) In 5,5-dimethyl-1,3-cyclohexadiene at 155℃; for 10h; Inert atmosphere;80%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

(2-(4-chlorophenyl)cyclopropyl)(4-fluorophenyl)methanone

(2-(4-chlorophenyl)cyclopropyl)(4-fluorophenyl)methanone

(2-(4-chlorophenyl)cyclopropyl)(4-(6-methylheptan-2-ylamino)phenyl)methanone

(2-(4-chlorophenyl)cyclopropyl)(4-(6-methylheptan-2-ylamino)phenyl)methanone

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100 - 120℃; Inert atmosphere;80%
phthalic anhydride
85-44-9

phthalic anhydride

1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

N-phthaloyl-6-methylheptan-2-amine

N-phthaloyl-6-methylheptan-2-amine

Conditions
ConditionsYield
In toluene for 5h; Reflux;80%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

4-bromo-1,8-naphthalenedicarboxylic anhydride
81-86-7

4-bromo-1,8-naphthalenedicarboxylic anhydride

6-bromo-2-(1,5-dimethylhexyl)benzo[de]isoquinoline-1,3-dione

6-bromo-2-(1,5-dimethylhexyl)benzo[de]isoquinoline-1,3-dione

Conditions
ConditionsYield
In ethanol for 24h; Reflux;80%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

C30H26N8O10S2

C30H26N8O10S2

A

C46H60N10O8S2

C46H60N10O8S2

B

C38H43N9O9S2

C38H43N9O9S2

Conditions
ConditionsYield
Stage #1: C30H26N8O10S2 With thionyl chloride In chloroform; N,N-dimethyl-formamide at 20 - 50℃; for 5h;
Stage #2: 1,5-dimethylhexylamine With triethylamine In chloroform; N,N-dimethyl-formamide at 20℃;		A 80%
B n/a
...Expand
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

N-tert-butoxycarbonyl-L-leucine
13139-15-6

N-tert-butoxycarbonyl-L-leucine

C19H38N2O3

C19H38N2O3

Conditions
ConditionsYield
Stage #1: N-tert-butoxycarbonyl-L-leucine With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran at -15℃; for 0.333333h;
Stage #2: 1,5-dimethylhexylamine In tetrahydrofuran at -15 - 20℃; for 8h;		78%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

levulinic acid
123-76-2

levulinic acid

C13H25NO

C13H25NO

Conditions
ConditionsYield
With hydrogen In neat (no solvent) at 100℃; under 2250.23 Torr; for 20h;77%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

triethylammonium N-tert-butylsulfamate

triethylammonium N-tert-butylsulfamate

N-tert-butyl-N'-(6-methylhept-2-yl)sulfamide

N-tert-butyl-N'-(6-methylhept-2-yl)sulfamide

Conditions
ConditionsYield
Stage #1: triethylammonium N-tert-butylsulfamate With trifluoromethylsulfonic anhydride; Triphenylphosphine oxide In dichloromethane at 0℃; for 0.25h; Inert atmosphere;
Stage #2: With triethylamine In dichloromethane at -78℃; for 0.25h; Inert atmosphere;
Stage #3: 1,5-dimethylhexylamine In dichloromethane at -78 - 22℃; Inert atmosphere;		77%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

p-acetylaminobenzenesulfonyl chloride
121-60-8

p-acetylaminobenzenesulfonyl chloride

N-[4-(1,5-dimethyl-hexylsulfamoyl)-phenyl]-acetamide

N-[4-(1,5-dimethyl-hexylsulfamoyl)-phenyl]-acetamide

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 6h; Substitution;76%
With dmap; triethylamine In dichloromethane at 5 - 20℃; for 6.21h;
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

methyl 3-methoxypropionate
3852-09-3

methyl 3-methoxypropionate

(R)-3-methoxy-N-(6-methylheptan-2-yl) propanamide
1322805-10-6

(R)-3-methoxy-N-(6-methylheptan-2-yl) propanamide

Conditions
ConditionsYield
With Candida antarctica lipase B; Octanethiol; [Ir(2-phenylpyridine)2(4,4′-di-tert-butyl-2,2′-bipyridine)](PF6) In acetonitrile at 38℃; for 48h; Schlenk technique; Molecular sieve; Inert atmosphere; Irradiation; Enzymatic reaction; enantioselective reaction;74%
1,3-propanesultone
1120-71-4

1,3-propanesultone

1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

3-(1,5-dimethyl-hexylamino)-1-propanesulfonic acid

3-(1,5-dimethyl-hexylamino)-1-propanesulfonic acid

Conditions
ConditionsYield
In acetone; toluene at 20℃; Heating / reflux;72%
1,5-dimethylhexylamine
543-82-8

1,5-dimethylhexylamine

benzaldehyde
100-52-7

benzaldehyde

(±)-N-benzyl-6-methylheptan-2-amine

(±)-N-benzyl-6-methylheptan-2-amine

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In tetrahydrofuran for 12h; Inert atmosphere;71%
Stage #1: 1,5-dimethylhexylamine; benzaldehyde In methanol for 3h;
Stage #2: With sodium sulfate In methanol for 0.166667h;
Stage #3: With methanol; sodium tetrahydroborate for 4h;		51%

1,5-Dimethylhexylamine Consensus Reports

Reported in EPA TSCA Inventory.

1,5-Dimethylhexylamine Specification

The 1,5-Dimethylhexylamine, with the CAS registry number 543-82-8, is also known as Octodrine. Its EINECS number is 208-851-1. This chemical's molecular formula is C8H19N and molecular weight is 129.24. What's more, its systematic name is 6-Methyl-2-heptanamine. Its classification codes are: (1)Adrenergic [vasoconstrictor]; (2)Anesthetic [local]; (3)Drug / Therapeutic Agent; (4)Inhibitor [HMG-CoA reductase]. This chemical should be sealed and stored in a cool, ventilated and dry place. Moreover, it should be protected from heat and fire. This chemcial can be prepared by the amination and catalytic hydrogenation of 6-Methyl-2-heptanone. The product can be used as a local anesthetic, vasoconstrictore, but it mainly as an intermediates of octamylamine.

Physical properties of 1,5-Dimethylhexylamine are: (1)ACD/LogP: 2.782; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.32; (4)ACD/LogD (pH 7.4): -0.21; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 26.02 Å2; (13)Index of Refraction: 1.429; (14)Molar Refractivity: 42.564 cm3; (15)Molar Volume: 165.02 cm3; (16)Polarizability: 16.874×10-24cm3; (17)Surface Tension: 26.45 dyne/cm; (18)Density: 0.783 g/cm3; (19)Flash Point: 48.889 °C; (20)Enthalpy of Vaporization: 39.175 kJ/mol; (21)Boiling Point: 154.999 °C at 760 mmHg; (22)Vapour Pressure: 3.09 mmHg at 25°C.

Uses of 1,5-Dimethylhexylamine: it can be used to produce N-[4-(1,5-dimethyl-hexylsulfamoyl)-phenyl]-acetamide at the temperature of 20 °C. It will need reagent Et3N and solvent dimethylformamide with the reaction time of 6 hours. The yield is about 76%.

1,5-Dimethylhexylamine can be used to produce N-[4-(1,5-dimethyl-hexylsulfamoyl)-phenyl]-acetamide at the temperature of 20 °C

When you are using this chemical, please be cautious about it as the following:
This chemical is flammable, so you should keep it away from sources of ignition - No smoking. It is harmful if swallowed. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need to wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)SMILES: NC(C)CCCC(C)C
(2)Std. InChI: InChI=1S/C8H19N/c1-7(2)5-4-6-8(3)9/h7-8H,4-6,9H2,1-3H3
(3)Std. InChIKey: QNIVIMYXGGFTAK-UHFFFAOYSA-N

The toxicity data is as follows:  

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo subcutaneous 100mg/kg (100mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 80, Pg. 1153, 1960.
rat LD50 intramuscular 146mg/kg (146mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Bolletino della Societe Italiana di Biologia Sperimentale. Vol. 27, Pg. 354, 1951.
rat LD50 oral 538mg/kg (538mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Bolletino della Societe Italiana di Biologia Sperimentale. Vol. 27, Pg. 354, 1951.

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