1-Acetyl-2-imidazolidinone supplier

Name
1-Acetyl-2-imidazolidinone
EINECS 226-388-3
CAS No. 5391-39-9
Article Data20
CAS DataBase
Density 1.237 g/cm³
Solubility soluble in methanol
Melting Point 173-175 °C
Formula C₅H₈N₂O₂
Boiling Point
Molecular Weight 128.131
Flash Point
Transport Information
Appearance White to off-white powder
Safety
Risk Codes R38
Molecular Structure
Hazard Symbols Xi
Synonyms N-Acetyl-2-imidazolidinone;
PSA 49.41000
LogP -0.17520

Synthetic route

: 120-93-4
imidazolidone

: 108-24-7
acetic anhydride

: 5391-39-9
1-acetylimidazolidin-2-one

Conditions

Conditions	Yield
With water for 0.5h; Heating;	88%
at 150℃; for 1h;	64.1%
for 0.5h; Reflux;	63%

: 120-93-4
imidazolidone

: 18773-93-8
1-acetyl-1H-benzotriazole

: 5391-39-9
1-acetylimidazolidin-2-one

Conditions

Conditions	Yield
Stage #1: imidazolidone With potassium carbonate In toluene at 20℃; for 0.5h; Stage #2: 1-acetyl-1H-benzotriazole In toluene at 80℃; for 2h;	87%

: 120-93-4
imidazolidone

: 88333-03-3, 10340-91-7
Benzyl isocyanide

: 75-36-5
acetyl chloride

A: 5391-39-9
1-acetylimidazolidin-2-one

B: 1-(benzyliminomethyl)imidazolin-2-one hydrochloride

Conditions

Conditions	Yield
In acetonitrile at 20℃; for 9h;	A n/a B 77%

...Expand

: 65118-65-2
imidazol-2-one

: 75-36-5
acetyl chloride

: 5391-39-9
1-acetylimidazolidin-2-one

Conditions

Conditions	Yield
In tetrahydrofuran	52%
In tetrahydrofuran	52%
In tetrahydrofuran	52%
In tetrahydrofuran	52%

: 1001-53-2
monoacetylaminoethylamine

: 124-38-9
carbon dioxide

: 5391-39-9
1-acetylimidazolidin-2-one

Conditions

Conditions	Yield
With cerium(IV) oxide In ethanol at 160℃; for 8h;	9%

: 5391-39-9
1-acetylimidazolidin-2-one

: 593-60-2
Vinyl bromide

: 1-acetyl-3-vinyl-2-imidazolidone

Conditions

Conditions	Yield
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In tetrahydrofuran at 80℃; for 9h; Inert atmosphere; Schlenk technique;	94.4%

: 5391-39-9
1-acetylimidazolidin-2-one

: 32315-10-9
bis(trichloromethyl) carbonate

: 41730-71-6
1-chlorocarbonyl-2-oxo-3-methylcarbonyl-imidazolidine

Conditions

Conditions	Yield
In benzene at 55 - 60℃; for 3h; chloroformylation;	93.8%

: 5391-39-9
1-acetylimidazolidin-2-one

: 30536-19-7
4-amino-5-chloro-2,1,3-benzothiadiazole

: 5-chloro-N-(1-acetyl-4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazole-4-amine

Conditions

Conditions	Yield
With trichlorophosphate In acetone at 50 - 55℃; for 20h; Temperature; Solvent;	93.6%
With thionyl chloride In toluene at 65℃; Reagent/catalyst; Solvent;	67%

: 5391-39-9
1-acetylimidazolidin-2-one

: 503-38-8
trichloromethyl chloroformate

: 41730-71-6
1-chlorocarbonyl-2-oxo-3-methylcarbonyl-imidazolidine

Conditions

Conditions	Yield
With pyridine In benzene at 50 - 55℃; for 2h; Addition;	92%

: 5391-39-9
1-acetylimidazolidin-2-one

: 30536-19-7
4-amino-5-chloro-2,1,3-benzothiadiazole

: 64461-82-1, 74113-36-3
tizanidine hydrochloride

Conditions

Conditions	Yield
Stage #1: 1-acetylimidazolidin-2-one; 4-amino-5-chloro-2,1,3-benzothiadiazole With trichlorophosphate at 60 - 65℃; for 36h; Stage #2: With methanol for 4h; Reflux; Stage #3: With hydrogenchloride In ethanol at 20℃; for 1h;	85%

: 5391-39-9
1-acetylimidazolidin-2-one

: 1075-34-9
5-bromo-2-methyl-1H-indole

: 227801-59-4
5-Bromo-3-(4,5-dihydroimidazol-2-yl)-2-methyl-1H-indole

Conditions

Conditions	Yield
Stage #1: 1-acetylimidazolidin-2-one; 5-bromo-2-methyl-1H-indole With trichlorophosphate at 50℃; Stage #2: With ethanol Heating;	80%
Stage #1: 1-acetylimidazolidin-2-one; 5-bromo-2-methyl-1H-indole With trichlorophosphate at 50℃; Stage #2: With ethanol Heating / reflux;

: 5391-39-9
1-acetylimidazolidin-2-one

: 1075-34-9
5-bromo-2-methyl-1H-indole

: 5-bromo-3-(4,5-dihydro-1H-imidazol-2-yl)-2-methyl-1H-indole hydrochloride

Conditions

Conditions	Yield
	80%

: 5391-39-9
1-acetylimidazolidin-2-one

: C5H6Cl4N2OP(1+)*Cl6P(1-)

Conditions

Conditions	Yield
With phosphorus pentachloride In chloroform at 20℃; for 24h;	79%

: 6298-19-7
2-chloro-3-aminopyridine

: 5391-39-9
1-acetylimidazolidin-2-one

: 1-acetyl-2-[3-(2-chloropyridinyl)]iminoimidazolidine

Conditions

Conditions	Yield
With trichlorophosphate for 3h; Condensation; Heating;	74%

: 5391-39-9
1-acetylimidazolidin-2-one

: 32202-61-2
4-aminoindan

: 67356-94-9
N-(1-Acetyl-2-imidazolin-2-yl)-N-(4-indanyl)amin

Conditions

Conditions	Yield
With trichlorophosphate at 50℃; for 40h;	73.1%

: 5-chloro-2-(2-tolyl)indole

: 5391-39-9
1-acetylimidazolidin-2-one

: 5-chloro-3-(4,5-dihydro-1H-imidazol-2-yl)-2-(2-methylphenyl)-1H-indole

Conditions

Conditions	Yield
	73%
	15.8%

: 5391-39-9
1-acetylimidazolidin-2-one

sodium sulfate anhydride: sodium sulfate anhydride

: 30536-19-7
4-amino-5-chloro-2,1,3-benzothiadiazole

: 51322-75-9
tizanidine

Conditions

Conditions	Yield
With trichlorophosphate In methanol; sodium hydroxide; water	73%

...Expand

: 5391-39-9
1-acetylimidazolidin-2-one

: 227803-32-9
2-(4-methylphenyl)-5-trifluoromethoxy-1H-indole

: 3-(4,5-dihydroimidazol-2-yl)-2-(4-methylphenyl)-5-trifluoromethoxy-1H-indole hydrochloride

Conditions

Conditions	Yield
Stage #1: 1-acetylimidazolidin-2-one; 2-(4-methylphenyl)-5-trifluoromethoxy-1H-indole With trichlorophosphate at 60℃; for 20h; Stage #2: In ethanol at 60℃; for 5h;	70%

: 5391-39-9
1-acetylimidazolidin-2-one

: 30536-19-7
4-amino-5-chloro-2,1,3-benzothiadiazole

: 51322-75-9
tizanidine

Conditions

Conditions	Yield
Stage #1: 1-acetylimidazolidin-2-one; 4-amino-5-chloro-2,1,3-benzothiadiazole With trichlorophosphate at 60 - 65℃; for 36h; Stage #2: With methanol; sodium hydroxide for 4h; Reflux;	70%

: 5391-39-9
1-acetylimidazolidin-2-one

: 579-66-8
2,6-diethylaniline

: 86861-31-6
1-acetyl-N-(2,6-diethylphenyl)-4,5-dihydro-1H-imidazol-2(3H)-imine

Conditions

Conditions	Yield
With trichlorophosphate for 3h; Heating;	69.9%

: 5-chloro-2-m-tolyl-1H-indole

: 5391-39-9
1-acetylimidazolidin-2-one

: 3-(4,5-dihydro-1H-imidazol-2-yl)-5-chloro-2-(3-methylphenyl)-1H-indole hydrochloride

Conditions

Conditions	Yield
	68%

: 5391-39-9
1-acetylimidazolidin-2-one

: 66866-07-7
2-(4-methylphenyl)-5-chloro-1H-indole

: 5-Chloro-3-(4,5-dihydroimidazol-2-yl)-2-(4-methylphenyl)-1H-indole

Conditions

Conditions	Yield
Stage #1: 1-acetylimidazolidin-2-one; 2-(4-methylphenyl)-5-chloro-1H-indole With trichlorophosphate at 50℃; Stage #2: With ethanol Heating;	67%

: 5391-39-9
1-acetylimidazolidin-2-one

: 366448-75-1
2-ethyl-5-chloro-1H-indole

: 5-chloro-3-(4,5-dihydro-1-H-imidazol-2-yl)-2-ethyl-1H-indole

Conditions

Conditions	Yield
Stage #1: 1-acetylimidazolidin-2-one; 2-ethyl-5-chloro-1H-indole With trichlorophosphate at 50℃; Stage #2: With ethanol Heating;	67%
	7.1%

: 5391-39-9
1-acetylimidazolidin-2-one

: 4-(4-(chloromethyl)phenyl)-2-(2,6-difluorophenyl)-4,5-dihydrooxazole

: 1-acetyl-3-(4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzyl)imidazolidin-2-one

Conditions

Conditions	Yield
With tetrabutylammomium bromide; sodium hydroxide In toluene at 20℃; for 5h;	67%

: 5391-39-9
1-acetylimidazolidin-2-one

: 6127-16-8
4-chloro-2-methyl-1H-indole

: 4-chloro-3-(4,5-dihydro-1H-imidazol-2-yl)-2-methyl-1H-indole hydrochloride

Conditions

Conditions	Yield
	66%

: C14H9Cl2N

: 5391-39-9
1-acetylimidazolidin-2-one

: 3-(4,5-dihydro-1H-imidazol-2-yl)-5-chloro-2-(2-chlorophenyl)-1H-indole hydrochloride

Conditions

Conditions	Yield
	66%

: 5391-39-9
1-acetylimidazolidin-2-one

: 3-amino-2-methylchromone hydrochloride

: 1-acetyl-2-(2-methyl-4-oxo-4H-benzopyran-3-yl)iminoimidazolidine

Conditions

Conditions	Yield
With trichlorophosphate Condensation;	65%

: C15H11Cl2N

: 5391-39-9
1-acetylimidazolidin-2-one

: 3-(4,5-dihydro-1H-imidazol-2-yl)-5-chloro-2-(3-methyl-4-chlorophenyl)-1H-indole hydrochloride

Conditions

Conditions	Yield
	65%

: 2-(4-methoxyphenyl)-5-chloro-1H-indole

: 5391-39-9
1-acetylimidazolidin-2-one

: 5-chloro-3-(4,5-dihydro-1H-imidazol-2-yl)-2-(4-methoxyphenyl)-1H-indole hydrochloride

Conditions

Conditions	Yield
	64.8%
	45%

: 5391-39-9
1-acetylimidazolidin-2-one

: 1076-74-0
5-methoxy-2-methyl-1H-indole

: 5-methoxy-2-methyl-3-(4,5-dihydro-1H-imidazol-2-yl)-1H-indole

Conditions

Conditions	Yield
Stage #1: 1-acetylimidazolidin-2-one; 5-methoxy-2-methyl-1H-indole With trichlorophosphate at 50℃; Stage #2: With ethanol Heating;	64%
	14.6%

: 5391-39-9
1-acetylimidazolidin-2-one

: 1809-20-7
diisopropyl hydrogenphosphonate

: 1417780-53-0
diisopropyl(3-acetyl-2-oxoimidazolidin-1-yl)phosphonate

Conditions

Conditions	Yield
With 6,6'-dimethyl-2,2'-bipyridine; copper diacetate In toluene at 80℃; under 760.051 Torr; for 1.5h; Reagent/catalyst; Molecular sieve;	64%

: 5391-39-9
1-acetylimidazolidin-2-one

: 948-65-2
2-phenyl-indole

: 2-phenyl-3-(4,5-dihydro-1H-imidazol-2-yl)-1H-indole hydrochloride

Conditions

Conditions	Yield
	63.9%

1-Acetyl-2-imidazolidinone Chemical Properties

Product Name: 1-Acetyl-2-imidazolidinone (CAS NO.5391-39-9)

Molecular Formula: C₅H₈N₂O₂
Molecular Weight: 128.13g/mol
Mol File: 5391-39-9.mol
EINECS: 226-388-3
Melting Point: 173-175°C
Density: 1.237 g/cm³
Index of Refraction: 1.492 Molar Refractivity: 30.08 cm³
Molar Volume: 103.5 cm³
Surface Tension: 43.2 dyne/cm
XLogP3-AA: -0.9
H-Bond Donor: 1
H-Bond Acceptor: 2
Structure Descriptors of 1-Acetyl-2-imidazolidinone (CAS NO.5391-39-9):
IUPAC Name: 1-acetylimidazolidin-2-one
Canonical SMILES: CC(=O)N1CCNC1=O
InChI: InChI=1S/C5H8N2O2/c1-4(8)7-3-2-6-5(7)9/h2-3H2,1H3,(H,6,9)
InChIKey: JJWACYUTERPMBM-UHFFFAOYSA-N
Product Categories: Imidazol&Benzimidazole; (intermediate of moxonidine hcl)

1-Acetyl-2-imidazolidinone Specification

1-Acetyl-2-imidazolidinone , its CAS NO. is 5391-39-9, the synonym is 1-Acetyl-2-imidazolidinone .

Product Name

1-Acetyl-2-imidazolidinone

Synthetic route

1-Acetyl-2-imidazolidinone Chemical Properties

1-Acetyl-2-imidazolidinone Specification

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