1-Bromo-4-chlorobutane supplier

Name
1-Bromo-4-chlorobutane
EINECS 230-089-3
CAS No. 6940-78-9
Article Data25
CAS DataBase
Density 1.439 g/cm³
Solubility slightly soluble in water
Melting Point 96-97 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6))
Formula C₄H₈BrCl
Boiling Point 164.3 °C at 760 mmHg
Molecular Weight 171.465
Flash Point 60 °C
Transport Information UN 1993 3/PG 3
Appearance clear liquid
Safety 23-24/25-37/39-26
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 1-Chloro-4-bromobutane;4-Bromo-1-chlorobutane;4-Bromobutyl chloride;4-Chloro-1-bromobutane;4-Chlorobutyl bromide;NSC 60193;Tetramethylenechlorobromide;
PSA 0.00000
LogP 2.40030

Synthetic route

: 928-51-8
4-Chloro-1-butanol

: 6940-78-9
4-chlorobutyl bromide

Conditions

Conditions	Yield
With phosphorus tribromide In pyridine 0 deg C, 1 h; r.t., 3 h;	44%
With phosphorus; bromine
With sulfuric acid; water; sodium bromide

: 30379-55-6
benzyloxyacetic acid

: 109-70-6
1,3-chlorobromopropane

: 6940-78-9
4-chlorobutyl bromide

Conditions

Conditions	Yield
Stage #1: benzyloxyacetic acid With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -70 - -30℃; for 1h; Stage #2: 1.3-chlorobromopropane In tetrahydrofuran; hexane at -70 - 20℃; for 2.5h;	32%

: 109-99-9
tetrahydrofuran

A: 110-52-1
1,4-dibromo-butane

B: 6940-78-9
4-chlorobutyl bromide

Conditions

Conditions	Yield
With water; sodium bromide; sodium chloride anschliessenden Erwaermen des Reaktionsprodukts mit Schwefelsaeure;

: 109-65-9
1-bromo-butane

: 6940-78-9
4-chlorobutyl bromide

Conditions

Conditions	Yield
With chlorine im Licht;
With sulfuryl dichloride; dibenzoyl peroxide

: 6334-96-9
bis-(4-chlorobutyl)ether

: 6940-78-9
4-chlorobutyl bromide

Conditions

Conditions	Yield
With sulfuric acid; water; hydrogen bromide at 150℃;

: 110-56-5
1,4-dichlorobutane

: 6940-78-9
4-chlorobutyl bromide

Conditions

Conditions	Yield
With 1,4-dibromo-butane; tetrabutylammomium bromide at 100℃; for 19.5h;	49.7 % Chromat.

: 109-65-9
1-bromo-butane

: 7782-50-5
chlorine

: 6940-78-9
4-chlorobutyl bromide

Conditions

Conditions	Yield
unter Belichtung;

: 109-65-9
1-bromo-butane

: 7791-25-5
sulfuryl dichloride

: 94-36-0
dibenzoyl peroxide

: 6940-78-9
4-chlorobutyl bromide

...Expand

: 109-69-3
n-Butyl chloride

A: 6940-78-9
4-chlorobutyl bromide

B: 514206-33-8
1-bromo-1-chlorobutane

C: 141507-40-6
2-bromo-4-chloro-butane

D: 79504-01-1
2-bromo-1-chlorobutane

Conditions

Conditions	Yield
With carbon tetrabromide; {[PhSiO1.5]2CuO}n at 150℃; for 10h; Product distribution; Further Variations:; Catalysts;

...Expand

: 109-65-9
1-bromo-butane

A: 6940-78-9
4-chlorobutyl bromide

B: 56481-42-6
1-bromo-3-chlorobutane

C: 108200-18-6
1-bromo-2-chlorobutane

Conditions

Conditions	Yield
With perchloric acid; 1-chloro-cis-2,6-dimethylpiperidine In dichloromethane; water at 0℃; for 2h; Irradiation; Sealed tube; Inert atmosphere; Overall yield = 53 percent;

...Expand

: 6940-78-9
4-chlorobutyl bromide

: 2923-28-6
silver trifluoromethanesulfonate

: 103935-55-3
4-chlorobutanol-1-trifluoromethanesulfonate

Conditions

Conditions	Yield
In tetrachloromethane for 0.166667h;	100%

: 6940-78-9
4-chlorobutyl bromide

: 232945-10-7
2-methyl-2,3,4,5-tetrahydropyrrolo[2,3-e][1,2]thiazin-4-one 1,1-dioxide

: 232945-13-0
5-(4-chlorobutyl)-2-methyl-2,3,4,5-tetrahydropyrrolo[2,3-e][1,2]thiazin-4-one 1,1-dioxide

Conditions

Conditions	Yield
With potassium carbonate In butanone	100%

: 6940-78-9
4-chlorobutyl bromide

: 5-phenylpentanoic acid-methoxy-methyl-amide

: 1032445-82-1
C15H21ClO

Conditions

Conditions	Yield
Stage #1: 4-chlorobutyl bromide With magnesium In tetrahydrofuran; diethyl ether for 0.5h; Heating / reflux; Stage #2: 5-phenylpentanoic acid-methoxy-methyl-amide In tetrahydrofuran; diethyl ether at 5 - 55℃; for 3.5h;	100%
Stage #1: 4-chlorobutyl bromide With magnesium In tetrahydrofuran Inert atmosphere; Reflux; Stage #2: In tetrahydrofuran; diethyl ether for 0.5h; Stage #3: 5-phenylpentanoic acid-methoxy-methyl-amide In tetrahydrofuran; diethyl ether at 5 - 55℃; for 3.5h;	100%

: 6940-78-9
4-chlorobutyl bromide

: 177756-65-9
N-methoxy-N-methyl-4-phenylbutanamide

: 78429-24-0
8-Chloro-1-phenyl-octan-4-one

Conditions

Conditions	Yield
Stage #1: 4-chlorobutyl bromide With magnesium In diethyl ether at 20℃; for 1h; Heating / reflux; Stage #2: N-methoxy-N-methyl-4-phenylbutyramide In tetrahydrofuran; diethyl ether at 0 - 50℃; for 4.25h;	100%
Stage #1: 4-chlorobutyl bromide With magnesium In diethyl ether at 20℃; for 1h; Reflux; Stage #2: N-methoxy-N-methyl-4-phenylbutyramide In tetrahydrofuran; diethyl ether at 0 - 50℃;	100%

: 6940-78-9
4-chlorobutyl bromide

: 1111643-45-8
N(1)-ethyl-N(1),N(3)-bis(2-nitrobenzenesulfonyl)propane-1,3-diamine

: 1111643-57-2
N(1)-(4-chlorobutyl)-N(3)-ethyl-N(1),N(3)-bis(2-nitrobenzenesulfonyl)propane-1,3-diamine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 65h;	100%

: 6940-78-9
4-chlorobutyl bromide

: 524-38-9
N-hydroxyphthalimide

: 59376-94-2
2-(2-chlorobutoxy)isoindoline-1,3-dione

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃;	100%

: 6940-78-9
4-chlorobutyl bromide

: 1370520-18-5
C120H176O16

: 1350521-16-2
C152H232Cl8O16

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 60℃; Inert atmosphere;	100%

: 6940-78-9
4-chlorobutyl bromide

: 59942-87-9
2-hydroxypyrazolo<1,5-α>pyridine

: 1451182-03-8
2-(4-chlorobutoxy)pyrazolo[1,5-a]pyridine

Conditions

Conditions	Yield
With sodium iodide In N,N-dimethyl-formamide at 20℃; for 18h;	100%
With potassium carbonate; sodium iodide In N,N-dimethyl-formamide at 20℃; for 18h;	100%

: 6940-78-9
4-chlorobutyl bromide

: 90101-20-5
tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate

: tert-butyl (4-azidobutyl)(4-methylpyridin-2-yl)carbamate

Conditions

Conditions	Yield
Stage #1: tert-Butyl N-(4-methyl-pyridin-2-yl)carbamate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; Inert atmosphere; Stage #2: 4-chlorobutyl bromide In N,N-dimethyl-formamide; mineral oil at 20℃; Inert atmosphere; Stage #3: With sodium azide In N,N-dimethyl-formamide at 50℃; Inert atmosphere;	100%

: 6940-78-9
4-chlorobutyl bromide

: C14H16N2O4

: 2-(4-(4-chlorobutoxy)-5-(cyclopropylmethoxy)-2-nitrophenyl)-2-methylpropanenitrile

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 80℃;	100%

: 6940-78-9
4-chlorobutyl bromide

: 671821-46-8
1-azido-4-chloro-butane

Conditions

Conditions	Yield
With sodium azide In N,N-dimethyl-formamide at 20℃;	99%
With sodium azide In N,N-dimethyl-formamide at 20℃; for 24h;	95%
With sodium azide In N,N-dimethyl-formamide at 20℃; for 20h;	94%

: 6940-78-9
4-chlorobutyl bromide

: 4630-80-2
methyl cyclopentane carboxylate

: 182886-55-1
1-(4-Chlorobutyl)cyclopentanecarboxylic acid, methyl ester

Conditions

Conditions	Yield
With N,N,N,N,N,N-hexamethylphosphoric triamide; ammonium chloride; lithium diisopropyl amide	99%
Stage #1: methyl cyclopentane carboxylate With lithium diisopropyl amide In tetrahydrofuran at -70 - -50℃; for 1h; Stage #2: 4-chlorobutyl bromide at -70 - 20℃; for 15h;	64%
	64%

: 6940-78-9
4-chlorobutyl bromide

: 9-bromo-9,10-dihydro-9,10-[3,4]epipyrroloanthracene-12,14-dione

: N-(4-chlorobutyl)-1-bromo-dibenzo[e,h]bicyclo[2.2.2]octane-2,3-dicarboximide

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 51h; Heating;	99%

: 6940-78-9
4-chlorobutyl bromide

: 91012-53-2
N‐methoxy‐N‐methyl‐2‐phenoxyacetamide

: 1032357-38-2
C12H15ClO2

Conditions

Conditions	Yield
Stage #1: 4-chlorobutyl bromide With magnesium In tetrahydrofuran; diethyl ether at 20℃; for 0.5h; Heating / reflux; Stage #2: N‐methoxy‐N‐methyl‐2‐phenoxyacetamide In tetrahydrofuran; diethyl ether at 5 - 50℃; for 4h;	99%

: 6940-78-9
4-chlorobutyl bromide

: 240423-18-1
N-(tert-butoxycarbonyl)-N'-(2-nitrobenzenesulfonyl)-1,3-propanediamine

: 1111643-42-5
{3-[(4-chlorobutyl)(2-nitrobenzenesulfonyl)amino]propyl}carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 65℃; for 20h;	99%

: 6940-78-9
4-chlorobutyl bromide

: 108-98-5
thiophenol

: 14633-31-9
1-chloro-4-(phenylthio)butane

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 1h;	98%
With potassium carbonate In dimethyl sulfoxide at 20 - 50℃; for 2.16667h; Inert atmosphere;	94%
Stage #1: thiophenol With sodium hydroxide In ethanol; water at 20℃; for 0.166667h; Stage #2: 4-chlorobutyl bromide In ethanol; water at 25℃; for 8h;	92%

: 6940-78-9
4-chlorobutyl bromide

: 135-19-3
β-naphthol

: 653573-32-1
4-(2-naphthyloxy)-1-chlorobutane

Conditions

Conditions	Yield
With potassium carbonate In acetone for 6h; Heating / reflux;	98%
With potassium carbonate In acetone for 6h; Heating / reflux;	98%
With potassium carbonate In acetone Heating;	98%

: 6940-78-9
4-chlorobutyl bromide

: 952402-42-5
1-(3-chloro-propyl)-5-pyridin-3-yl-1H-pyrimidine-2,4-dione

: 952402-43-6
3-benzoyl-1-(4-chloro-butyl)-5-iodo-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃;	98%

: 6940-78-9
4-chlorobutyl bromide

: 252061-66-8
5-hydroxy-1,3-dihydro-1-isoindolone

: 1007455-38-0
5-(4-chloro-butoxy)-2,3-dihydro-isoindol-1-one

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In acetonitrile for 18h; Heating / reflux;	98%

: 6940-78-9
4-chlorobutyl bromide

: 2-ethylhept-6-enenitrile

: 1256484-04-4
C13H22ClN

Conditions

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran at -78℃;	98%

: 6940-78-9
4-chlorobutyl bromide

: 1008798-50-2
3-(4-((benzyl(ethyl)amino)methyl)phenyl)-7-hydroxy-2H-chromen-2-one

: 3-(4-{[benzyl(ethyl)amino]methyl}phenyl)-7-(4-chlorobutoxy)-2H-chromen-2-one

Conditions

Conditions	Yield
With potassium carbonate In acetone for 20h; Reflux;	98%

: 6940-78-9
4-chlorobutyl bromide

: 5763-44-0
4,5,6,6a-tetrahydro-3aH-cyclopenta[c]pyrrole-1,3-dione

: 2-(4-chlorobutyl)tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃;	98%

1-Bromo-4-chlorobutane Chemical Properties

Product Name: 1-Bromo-4-chlorobutane (CAS NO.6940-78-9)

Molecular Formula: C₄H₈BrCl
Molecular Weight: 171.46g/mol
Mol File: 6940-78-9.mol
EINECS: 230-089-3
Appearance: clear liquid
Boiling point: 164.3 °C at 760 mmHg
Flash Point: 60 °C
Density: 1.439 g/cm³
Refractive index: n20/D 1.4875(lit.)
Water Solubility: SLIGHTLY SOLUBLE
Index of Refraction: 1.468
Molar Refractivity: 33.16 cm³
Molar Volume: 119.1 cm³
Surface Tension: 31.3 dyne/cm
Enthalpy of Vaporization: 38.44 kJ/mol
Vapour Pressure: 2.59 mmHg at 25°CXLogP3-AA: 2.3
H-Bond Donor: 0
H-Bond Acceptor: 0
Structure Descriptors of 1-Bromo-4-chlorobutane (CAS NO.6940-78-9):
IUPAC Name: 1-bromo-4-chlorobutane
Canonical SMILES: C(CCBr)CCl
InChI: InChI=1S/C4H8BrCl/c5-3-1-2-4-6/h1-4H2
InChIKey: NIDSRGCVYOEDFW-UHFFFAOYSA-N
Product Categories: Drug Intermediates; BROMO CHLORO; omega-Functional Alkanols, Carboxylic Acids, Amines & Halides; omega-Haloalkyl Chlorides

1-Bromo-4-chlorobutane Safety Profile

Safety Information of 1-Bromo-4-chlorobutane (CAS NO.6940-78-9):
Hazard Codes: Xi Irritant
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 23-24/25-37/39-26
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
S37/39:Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
HazardClass: 3
PackingGroup: III
HS Code: 29034980

1-Bromo-4-chlorobutane Specification

1-Bromo-4-chlorobutane , its CAS NO. is 6940-78-9, the synonyms are 1-Chloro-4-bromobutane ; 4-Bromo-1-chlorobutane ; Tetramethylene chlorobromide ; Butane, 1-bromo-4-chloro- .

Product Name

1-Bromo-4-chlorobutane

Synthetic route

1-Bromo-4-chlorobutane Chemical Properties

1-Bromo-4-chlorobutane Safety Profile

1-Bromo-4-chlorobutane Specification

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