• Name

  4-FLUORO-1-BUTANOL

• EINECS
• CAS No. 372-93-0
• Article Data8
• CAS DataBase
• Density 0.944 g/cm³
• Solubility
• Melting Point
• Formula C₄H₉FO
• Boiling Point 101.5 °C at 760 mmHg
• Molecular Weight 92.1133
• Flash Point 45.4 °C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 4-Fluoro-1-butanol;
• PSA 20.23000
• LogP 0.72840

Synthetic route

373-09-1

4-fluorobutyl acetate

372-93-0

1-fluoro-4-hydroxybutane

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether at 0 - 20℃; for 4h;	98%
With sulfuric acid In ethanol for 13.5h; Heating;	43%

326-49-8

benzoic acid-(4-fluoro-butyl ester)

372-93-0

1-fluoro-4-hydroxybutane

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

3153-36-4

4-chloro-butyric acid ethyl ester

372-93-0

1-fluoro-4-hydroxybutane

Conditions

Conditions	Yield
(i) NaI, acetone, (ii) KF, ethane-1,2-diol, (iii) LiAlH4, Et2O; Multistep reaction;

110-63-4

Butane-1,4-diol

A

109-99-9

tetrahydrofuran

B

5732-45-6

cyclic sulfite of 1,4-butanediol

C

372-93-0

1-fluoro-4-hydroxybutane

Conditions

Conditions	Yield
With sulfur tetrafluoride In diethyl ether at 20℃; for 45h; stainless-steel autoclave; Yield given;
With sulfur tetrafluoride In diethyl ether at 25℃; for 12h; stainless-steel autoclave; Yield given;
With sulfur tetrafluoride at 20℃; for 45h; Product distribution; solvent; other reaction time; other temperature.;	A 60 % Chromat. B 10 % Chromat. C 30 % Chromat.
With sulfur tetrafluoride at 20℃; for 45h; stainless-steel autoclave; Yield given;

...Expand

124536-08-9

C4H8FO4S(1-)*Na(1+)

372-93-0

1-fluoro-4-hydroxybutane

Conditions

Conditions	Yield
With hydrogenchloride at 80℃;

<4-fluoro-butyl>-acetate

<4-fluoro-butyl>-acetate

372-93-0

1-fluoro-4-hydroxybutane

Conditions

Conditions	Yield
With sulfuric acid

1-benzyloxy-4-fluorobutane

372-93-0

1-fluoro-4-hydroxybutane

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In dichloromethane at 20℃; for 1.5h; Inert atmosphere;

286946-77-8

5-bromo-2-chloro-3-hydroxypyridine

372-93-0

1-fluoro-4-hydroxybutane

1202796-36-8

5-bromo-2-chloro-3-(4-fluorobutoxy)pyridine

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃;	98%

2-methoxy-5-(prop-1-yn-1-yl)pyrimidine

372-93-0

1-fluoro-4-hydroxybutane

(3R,4R)-7-fluoro-3-(2-methoxypyrimidin-5-yl)hept-1-en-4-ol

Conditions

Conditions	Yield
With carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II); (R)-1-[(SP)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; p-nitrobenzenesulfonic acid; tetra-(n-butyl)ammonium iodide In 1,2-dimethoxyethane at 80℃; for 48h; Inert atmosphere; Sealed tube; stereoselective reaction;	73%

372-93-0

1-fluoro-4-hydroxybutane

potassium 4-fluorobutyrate

Conditions

Conditions	Yield
With ruthenium trichloride; sodium periodate In tetrachloromethane; acetonitrile at 20℃; for 24h;	70%

372-93-0

1-fluoro-4-hydroxybutane

2-(3,4-dichlorophenyl)-1-[(4aSR,8SR,8aSR)-8-(pyrrolidin-1-yl)-3,4,4a,5,6,7,8,8aoctahydroquinoxaline-1(2H)-yl]ethan-1-one

2-(3,4-dichlorophenyl)-1-[(4aRS,8RS,8aSR)-4-(4-fluorobutyl)-8-(pyrrolidin-1-yl)-3,4,4a,5,6,7,8,8a-octahydroquinoxalin-1(2H)-yl]ethan-1-one

Conditions

Conditions	Yield
Stage #1: 1-fluoro-4-hydroxybutane With Dess-Martin periodane In dichloromethane at 20℃; Inert atmosphere; Stage #2: 2-(3,4-dichlorophenyl)-1-[(4aSR,8SR,8aSR)-8-(pyrrolidin-1-yl)-3,4,4a,5,6,7,8,8aoctahydroquinoxaline-1(2H)-yl]ethan-1-one In dichloromethane at 20℃; for 0.5h; Stage #3: With sodium tris(acetoxy)borohydride In dichloromethane at 20℃;	51%

372-93-0

1-fluoro-4-hydroxybutane

C36H40Br2N4O4

7,12-bis(1-(4-fluorobutoxy)ethyl)-3,8,13,17-tetramethylporphyrin-2,18-dipropionic acid

Conditions

Conditions	Yield
Stage #1: 1-fluoro-4-hydroxybutane; C36H40Br2N4O4 at 20℃; for 4h; Stage #2: In tetrahydrofuran at 20℃; Alkaline conditions;	31%

372-93-0

1-fluoro-4-hydroxybutane

462-72-6

4-bromo-1-fluorobutane

Conditions

Conditions	Yield
With phosphorus tribromide

372-93-0

1-fluoro-4-hydroxybutane

462-23-7

4-fluorobutanoic acid

Conditions

Conditions	Yield
With chromium(III) oxide; sulfuric acid

372-93-0

1-fluoro-4-hydroxybutane

98-74-8

4-Nitrobenzenesulfonyl chloride

34198-13-5

4-fluorobutyl 4-nitrobenzenesulfonate

Conditions

Conditions	Yield
In pyridine
With dmap; triethylamine In dichloromethane at 20℃; for 2h; Inert atmosphere;	0.67 mg

372-93-0

1-fluoro-4-hydroxybutane

10035-10-6, 12258-64-9

hydrogen bromide

110-52-1

1,4-dibromo-butane

Conditions

Conditions	Yield
at 120℃;

372-93-0

1-fluoro-4-hydroxybutane

A

109-99-9

tetrahydrofuran

B

7664-39-3

hydrogen fluoride

Conditions

Conditions	Yield
zersetzt sich sehr leicht;

PEG 4000-sulfonyl chloride

372-93-0

1-fluoro-4-hydroxybutane

C4H8FO3PolS

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran; dichloromethane at 20℃; for 24h; solid phase reaction;

2-methoxy-5-(prop-1-yn-1-yl)pyrimidine

372-93-0

1-fluoro-4-hydroxybutane

7-fluoro-3-(2-methoxypyrimidin-5-yl)hept-1-en-4-ol

Conditions

Conditions	Yield
With carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II); 1,1'-bis(diisopropylphosphino)ferrocene; p-nitrobenzenesulfonic acid; tetra-(n-butyl)ammonium iodide In 1,2-dimethoxyethane at 80℃; for 48h; Inert atmosphere; Sealed tube; diastereoselective reaction;	n/a

1-Butanol, 4-fluoro- Specification