Conditions | Yield |
---|---|
With Ipc2BOH In pentane at 25℃; for 6h; | 100% |
With Ca2>2*THF In hexane at 20℃; for 0.5h; other carbonyl compounds, var. calcium tetrakis(alkoxy)alanates, solvents, times, temp.; | 99% |
With hydrogen; aluminum oxide; copper at 150℃; | 99% |
Conditions | Yield |
---|---|
With hydrogenchloride In acetone at 20℃; for 0.25h; Product distribution; other alkyl formates; | 100% |
dodecacarbonyl-triangulo-triruthenium; P(C4H9)3 In pyridine at 180℃; for 8h; | 75% |
With water; tetraphenylphosphonium bromide; triphenylphosphine; potassium hydroxide In dibutyl ether at 25℃; for 0.166667h; | 11% |
Conditions | Yield |
---|---|
With lithium dihydrido borata-bicyclo[3.3.0]nonane In tetrahydrofuran at 15℃; for 0.25h; Product distribution; with other oxiranes; | A 99% B 1% |
With zeolite supported zinc borohydride In tetrahydrofuran at 20℃; for 12h; Yield given. Yields of byproduct given; |
Conditions | Yield |
---|---|
With methanol; DOWEX 50 W-X2 cation exchange resin at 40℃; for 1.13333h; | A n/a B 99% |
Conditions | Yield |
---|---|
With hydrogen; copper-palladium; silica gel In ethanol at 25℃; under 760 Torr; Kinetics; | A 99% B n/a |
Tributoxyoxovanadium
(3bR,4aR)-2-(3,4,4-trime-3b,4,4a,5-tetrahydrocyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)-ethanol
17O-water
B
butan-1-ol
Conditions | Yield |
---|---|
In dichloromethane compd. prepd. by react. VO(On-Bu)3 with ligand in CH2Cl2; H2(17)O added to soln.; detn. by NMR; | A 99% B n/a |
Conditions | Yield |
---|---|
With 0.5%Pd/TiO2; isopropyl alcohol In water at 24.84℃; for 2h; Inert atmosphere; Sealed tube; Irradiation; | A 99% B 99% |
Conditions | Yield |
---|---|
With hydrogen; Cu-based catalyst at 190℃; Product distribution; Further Variations:; Temperatures; reaction in vapour phase, fixed bed reactor; | A 98.8% B 0.8% |
maleic acid
A
tetrahydrofuran
B
4-butanolide
C
methanol
D
Butane-1,4-diol
E
malic acid
F
succinic acid
G
acetic acid
H
butan-1-ol
Conditions | Yield |
---|---|
With hydrogen; 0.5percent Pd on Rutile TiO2 at 110℃; Product distribution / selectivity; | A 0.45% B 0.06% C 0% D 0.21% E 0.36% F 98.73% G 0.04% H 0.08% |
Conditions | Yield |
---|---|
With hydrogen at 265℃; for 3480h; Reagent/catalyst; Time; | 98% |
With water In aq. phosphate buffer at 20℃; pH=7.4; Electrolysis; Inert atmosphere; Enzymatic reaction; | 98.5% |
With diphenylamine borane In tetrahydrofuran 1.) 0 deg C, 1 h, 2.) 20 deg C, 1 h; | 61% |
maleic acid
A
tetrahydrofuran
B
4-butanolide
C
Butane-1,4-diol
D
4-hydroxybutanoic acid
E
succinic acid
F
acetic acid
G
butan-1-ol
Conditions | Yield |
---|---|
With hydrogen; 0.5percent Pd on Rutile TiO2 at 110℃; Product distribution / selectivity; | A 0.77% B 0.38% C 0.24% D 0.05% E 98.28% F 0.02% G 0.26% |
(R)-(+)-1,2-epoxybutane
A
(S)-2-butanol
B
butan-1-ol
Conditions | Yield |
---|---|
With hydrogen; 10percentPd/C; 1,2-diaminoethane; mixture of at 25℃; under 37503.8 Torr; for 24h; Conversion of starting material; | A 98.21% B 0.99% |
With hydrogen; 10percentPd/C; 1,2-diaminoethane; mixture of at 25 - 50℃; under 3750.38 - 7500.75 Torr; for 24h; | A 89% B 0.958% |
With hydrogen; palladium 10% on activated carbon In methanol at 25℃; under 3750.38 Torr; for 24h; Conversion of starting material; | A 81.752% B 11.148% |
With hydrogen; carbon; Na2PdCl4; sodium hydroxide; 1,2-diaminoethane; mixture of at 25℃; under 3750.38 Torr; for 24h; Conversion of starting material; | A 71.379% B 0.721% |
With hydrogen; carbon; Na2PdCl4; sodium hydroxide; 1,2-diaminoethane; mixture of In methanol at 25℃; under 3750.38 Torr; for 24h; Conversion of starting material; | A 41.58% B 0.42% |
Conditions | Yield |
---|---|
With 2,6-bis[1-(2,6-diisopropylphenylimino)ethyl]pyridine cobalt(II) dichloride; diethoxymethylane; sodium triethylborohydride In toluene at -78 - 20℃; for 5h; | 98% |
With hydrogen; ruthenium palladium In propan-1-ol at 89.9℃; Rate constant; | |
With (bis(mesityl-benzimidazol-2-ylidene)phenyl)Co(N2)(PPh3); hydrogen In benzene-d6 at -196.16 - 19.84℃; under 3040.2 Torr; for 2h; | |
With hydrogen In dichloromethane at 20℃; under 3000.3 Torr; for 24h; Time; |
dimethyl cis-but-2-ene-1,4-dioate
A
tetrahydrofuran
B
2-methoxytetrahydrofuran
C
4-butanolide
D
propan-1-ol
E
2-(4'-hydroxybutoxy)-tetrahydrofuran
F
Butane-1,4-diol
G
butan-1-ol
Conditions | Yield |
---|---|
With hydrogen; copper catalyst, T 4489, Sud-Chemie AG, Munich at 150 - 280℃; under 187519 Torr; Neat liquid(s) and gas(es)/vapour(s); | A 1% B n/a C 0.4% D n/a E n/a F 98% G 0.5% |
Conditions | Yield |
---|---|
In xylene at reflux 140-106°C for 165 h, then distilling butanol-borane azeotrop; | A 98% B n/a |
catechol butyl borate
N-(salicylidene)aniline N-oxide
B
butan-1-ol
Conditions | Yield |
---|---|
In benzene to benzene soln. of nitrone of salicylaldehyde added (C6H4O2)BOC4H9 (molar ratio 1:1), refluxed for 30 min; concd. in vac., added petroleum ether, ppt. washed with ether, dried, elem. anal.; | A 98% B n/a |
Conditions | Yield |
---|---|
With C30H34Cl2N2P2Ru; potassium methanolate; hydrogen In tetrahydrofuran at 100℃; under 38002.6 - 76005.1 Torr; for 15h; Glovebox; Autoclave; | 98% |
With hydrogen at 223.84℃; under 5625.56 Torr; Kinetics; Thermodynamic data; Concentration; Pressure; Temperature; neat (no solvent, gas phase); | |
With [RuH(η2-BH4)(2-di-tert-butylphosphinomethyl-6-diethylaminomethylpyridine)]; hydrogen In tetrahydrofuran at 110℃; under 7600.51 Torr; for 12h; Autoclave; | 97 %Chromat. |
Conditions | Yield |
---|---|
In benzene to benzene soln. of nitrone of salicylaldehyde added (C6H4O2)BOC4H9 (molar ratio 1:1), refluxed for 30 min; concd. in vac., added petroleum ether, ppt. recrystd. from THF/petroleum ether, elem. anal.; | A 97% B n/a |
B
butan-1-ol
Conditions | Yield |
---|---|
In benzene refluxed in benzene for 30 min; | A 96% B n/a |
Conditions | Yield |
---|---|
With 2,6-bis[1-(2,6-diisopropylphenylimino)ethyl]pyridine cobalt(II) dichloride; diethoxymethylane; sodium triethylborohydride In neat (no solvent) at -78 - 40℃; for 2h; | 96% |
With hydrogen In ethanol at 27℃; under 2250.23 Torr; for 0.416667h; Kinetics; Solvent; Time; Green chemistry; |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene at 110℃; for 3h; High pressure; | A 96% B n/a |
Conditions | Yield |
---|---|
With crosslinked polystirene anion exchange resin in BH4- form In ethanol for 2h; Ambient temperature; | 95% |
With C54H60N6O6Pd(2+)*2Br(1-); hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene In 1,4-dioxane at 75℃; under 7500.75 Torr; for 6h; | 30% |
bei der elektrolytischen Reduktion; |
catechol butyl borate
α-(2-hydroxy-1-phenyl)-N-methylnitrone
B
butan-1-ol
Conditions | Yield |
---|---|
In benzene to benzene soln. of nitrone of salicylaldehyde added (C6H4O2)BOC4H9 (molar ratio 1:1), refluxed for 30 min; concd. in vac., added petroleum ether, ppt. washed with ether, dried, elem. anal.; | A 95% B n/a |
4-benzyloxycarbonylaminobutyric acid butyl ester
A
4-(benzyloxycarbonylamino)butyric acid
B
butan-1-ol
Conditions | Yield |
---|---|
With methanol; recombinant Bacillus subtilis esterase double mutant E188W/M193C In hexane at 37℃; for 0.5h; pH=7.4; Kinetics; Reagent/catalyst; Time; aq. phosphate buffer; Enzymatic reaction; | A 95% B n/a |
butyl levulinate
A
γ-hydroxy butyl pentanoate
B
5-methyl-dihydro-furan-2-one
C
butan-1-ol
Conditions | Yield |
---|---|
With n-butyl formate; water at 170℃; under 7500.75 Torr; for 6h; Inert atmosphere; chemoselective reaction; | A n/a B 95% C n/a |
benzaldehyde
N-butylamine
acetophenone
A
2,4,6-triphenylpyridine
B
butan-1-ol
Conditions | Yield |
---|---|
With diphenylammonium trifluoromethanesulfonate at 120℃; for 4h; Neat (no solvent); regioselective reaction; | A 95% B 91 %Chromat. |
urethane
methyloxirane
A
4-methyl-2-oxazolidone
B
5-methyl-1,3-oxazolidin-2-one
C
butan-1-ol
Conditions | Yield |
---|---|
With basic molar 1:1 Mg-Fe oxide calcined at 400 °C at 140℃; for 8h; Reagent/catalyst; Temperature; Autoclave; | A n/a B 95% C n/a |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In methanol at 25℃; for 4h; | 94.4% |
1-(t-butyldiphenylsilyloxy)butane
butan-1-ol
Conditions | Yield |
---|---|
With Selectfluor In acetonitrile at 150℃; for 0.166667h; Microwave irradiation; | 94% |
With methanol; trimethylsilyl bromide at 20℃; for 9h; chemoselective reaction; | 90% |
Conditions | Yield |
---|---|
With 2Al(3+)*HO(1-)*5CH3O3S(1-) In dichloromethane at 20℃; for 0.75h; Reagent/catalyst; | 100% |
With ruthenium(III) acetate at 20℃; for 0.5h; | 99% |
With aminosulfonic acid at 15℃; for 3h; | 98% |
Conditions | Yield |
---|---|
With cucurbit[7]uril at 55℃; for 4h; Time; | 100% |
at 20℃; for 4h; | 99% |
With zirconyl(IV) nitrate hydrate at 45℃; for 0.333333h; | 97% |
Conditions | Yield |
---|---|
With diacidic ionic liquid supported on magnetic-silica nanoparticles In neat (no solvent) at 118℃; for 2h; Temperature; Dean-Stark; | 100% |
With sulfuric acid; acetonitrile at 80 - 85℃; for 16 - 18h; | 99% |
With phosphotungstic acid; bis(acetylacetonato)dioxomolybdenum(VI); potassium tetranitroplatinate at 95 - 105℃; under 540.054 Torr; for 1h; | 99.4% |
Conditions | Yield |
---|---|
chlorodi-(n-butyl)tin acetate In chloroform for 0.833333h; Product distribution; Mechanism; Ambient temperature; catalytic activity, various tin(IV) catalysts; | 100% |
chlorodi-(n-butyl)tin acetate In chloroform for 0.833333h; Ambient temperature; | 100% |
With diallyltin(IV)di(2-ethyl hexanoate) In dichloromethane for 0.0833333h; Product distribution; Heating; other alcohols and isocyanates; var. temp. and time; | 93% |
Conditions | Yield |
---|---|
With crosslinked sulphonated polystyrene at 80℃; for 2h; Product distribution; other acids and solvents; var. catalysts, temp. and time; | 100% |
zirconium(IV) oxide for 2h; Heating; | 100% |
phosphomolybdic acid hydrate at 65 - 70℃; for 1h; Product distribution; Further Variations:; Catalysts; Reaction partners; | 100% |
Conditions | Yield |
---|---|
Stage #1: butan-1-ol With triethylamine In dichloromethane at 25℃; Stage #2: methanesulfonyl chloride In dichloromethane at 0 - 20℃; | 100% |
With triethylamine In dichloromethane at -15℃; for 1h; Green chemistry; | 100% |
With sodium hydroxide; potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate In benzene at 15 - 20℃; for 1h; | 99% |
Conditions | Yield |
---|---|
Stage #1: butan-1-ol With RuCpCl(o-EtOdppe); silver(I) 4-methylbenzenesulfonate In toluene for 0.0833333h; Inert atmosphere; Stage #2: allyl alcohol In toluene at 100℃; for 2h; Inert atmosphere; regioselective reaction; | 100% |
With boron fluoride ether; mercury(II) diacetate; benzene | |
With ammonium chloride; copper; copper(l) chloride Reagens 4: wss. Salzsaeure; |
Conditions | Yield |
---|---|
With [Al(H2O)6][MS]3 In cyclohexane for 1h; Reagent/catalyst; Dean-Stark; Reflux; | 100% |
With Candida antarctica B lipase In 2,2,4-trimethylpentane at 40℃; for 3h; Enzymatic reaction; | 98% |
With DOOl-AlCl3 superacid resin for 1.5h; Heating; | 97% |
Conditions | Yield |
---|---|
With 3,3′-(2,2-bis(hydroxymethyl)propane-1,3-diyl)bis(1-methyl-1H-imidazol-3-ium) hydrogen sulfate for 2h; Dean-Stark; Reflux; | 100% |
With [3-(1-methylimidazolium-3-yl)propane-1-sulfonate]3PW12O40 at 130℃; for 3h; | 98.6% |
With Candida antarctica lipase B In cyclohexane at 45℃; for 3h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; | 92% |
Conditions | Yield |
---|---|
With N-nitro-2,4,6-trimethylpyridinium tetrafluoroborate In acetonitrile at 0℃; for 2h; | 100% |
With carbon dioxide; dinitrogen pentoxide at 0℃; under 45004.5 - 60006 Torr; for 0.5h; Autoclave; | 94% |
With nitric acid; urea; europium(III) trifluoromethanesulfonate In cyclohexane at 80℃; for 10h; Schlenk technique; | 90% |
Conditions | Yield |
---|---|
With boric acid In toluene Reflux; | 100% |
With aluminum oxide; sodium borate; carbon dioxide at 80℃; under 1034.32 Torr; for 4h; | 38% |
With boron trichloride; pentane |
Conditions | Yield |
---|---|
With oxygen; phosphan; copper dichloride at 24.9℃; Rate constant; Product distribution; other acohols and reagents, var. concentration of reagents and temperatures; | 100% |
With oxygen; phosphan; copper dichloride at 24.9℃; | 100% |
With oxygen; copper dichloride at 59.9℃; | 100% |
Conditions | Yield |
---|---|
With C29H44Cl2N2Ru; potassium tert-butylate In toluene for 15h; Reagent/catalyst; Time; Reflux; | 100% |
Ru complex at 118℃; for 12h; Inert atmosphere; | 99% |
With dihydrogen peroxide; bromine In dichloromethane; water at 20℃; for 2h; | 99% |
Conditions | Yield |
---|---|
With oxidase In water at 40℃; for 1.5h; Reformatsky Reaction; Enzymatic reaction; | 100% |
With tetramethylammonium monofluorochromate(VI) In dichloromethane at 20℃; for 2h; | 98% |
With DIQCC In dichloromethane at 20℃; for 0.5h; | 98% |
Conditions | Yield |
---|---|
With ammonium cerium (IV) nitrate; sodium trimethylsilylpropionate-d4; C18H22N4O2Ru(2+)*2F6P(1-); water at 20℃; for 0.5h; | 100% |
With oxygen In water at 80℃; under 760.051 Torr; for 24h; | 99.7% |
With potassium hydroxide at 50℃; electrolysis; | 98.8% |
Conditions | Yield |
---|---|
With tetrachloromethane; bis(acetylacetonate)oxovanadium; triethylamine at 175℃; for 5h; Inert atmosphere; Autoclave; | 100% |
With sodium hydroxide; 1,5-bis-(N-benzyl-N,N-diethylammonium)diethylether dichloride at 50 - 60℃; for 4h; | 90% |
With potassium hydroxide; tetrabutylammomium bromide; potassium carbonate at 122℃; for 0.0152778h; | 86% |
Conditions | Yield |
---|---|
With 1-chloro-3-hydroxy-1,1,3,3-tetrabutyldistannoxane at 120℃; for 24h; Esterification; | 100% |
Zn4O (OCOCF3)6(CF3COOH)n In di-isopropyl ether for 18h; Product distribution / selectivity; Inert atmosphere; Reflux; | 100% |
With di-tert-butyl dicarbonate; magnesium chloride at 20℃; | 97% |
Conditions | Yield |
---|---|
With Amano P at 25℃; for 6h; | 100% |
In toluene at 90℃; Inert atmosphere; | 90% |
at 127℃; for 2h; | 85% |
Conditions | Yield |
---|---|
With Amano P at 25℃; for 6h; | 100% |
Heating; |
1,4-diisocyanatobenzene
butan-1-ol
(4-Butoxycarbonylamino-phenyl)-carbamic acid butyl ester
Conditions | Yield |
---|---|
for 4h; Heating; | 100% |
N,N'-dibenzyl-2,3,5,6-piperazinetetraone
butan-1-ol
1,3-Dibenzyl-2-hydroxy-4,5-dioxo-imidazolidine-2-carboxylic acid butyl ester
Conditions | Yield |
---|---|
for 6h; Heating; | 100% |
Conditions | Yield |
---|---|
for 24h; | 100% |
With sulfuric acid for 16h; Heating; | 78% |
1,3-Phenylene diisocyanate
butan-1-ol
(3-Butoxycarbonylamino-phenyl)-carbamic acid butyl ester
Conditions | Yield |
---|---|
for 4h; Heating; | 100% |
di(4-isocyanatophenyl)methane
butan-1-ol
dibutyl diphenyl methane-4,4’-dicarbamate
Conditions | Yield |
---|---|
for 4h; Heating; | 100% |
In tetrahydrofuran at 20℃; for 2h; | 84% |
ethyl 2-hydroxypyrrolidine-1-carboxylate
butan-1-ol
2-Butoxy-pyrrolidine-1-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With acetic acid | 100% |
sec-Butyl acetate
butan-1-ol
A
acetic acid butyl ester
B
iso-butanol
Conditions | Yield |
---|---|
With water; sodium butanolate at 30℃; for 0.0833333h; carried out in a reaction-distillation unit, industrial preparation; | A n/a B 100% |
Conditions | Yield |
---|---|
With chloro-trimethyl-silane at 25℃; for 24h; | 100% |
With hydrogenchloride Heating; | |
With chloro-trimethyl-silane at 25℃; for 24h; |
3-(2-vinyloxyethoxy)-1,2-propylene carbonate
butan-1-ol
4-[2-(1-Butoxy-ethoxy)-ethoxymethyl]-[1,3]dioxolan-2-one
Conditions | Yield |
---|---|
With heptafluorobutyric Acid at 20 - 45℃; for 0.333333h; | 100% |
1-Butanol, also known as butyl alcohol, is a colourless, flammable, volatile liquid with a strong alcoholic odor. It is a four carbon straight chain alcohol. 1-Butanol is slightly soluble in water, miscible with alcohol, ether, benzene and other organic solvents, so it can dissolve alkaloids, camphor, dyes, rubber, ethyl cellulose, grease, wax and a variety of natural and synthetic resins. Naturally, 1-Butanol occurs as a minor product of the fermentation of sugars and other carbohydrates. And it is also present in many foods and beverages.
Preparation of 1-Butanol:
There are three industry factures of 1-butanol: fermentation, propylene carbonyl synthesis and acetaldehyde aldol condensation.
Fermentation: The grain, cereals, potato or molasses and other raw materials are crushed and adding water to obtain fermentation liquor. After high pressure steam sterilization process, cooled and put in pure acetone - butanol bacteria. Then ferment at 36-37 °C. Fermentation genetates gas containing carbon dioxide and hydrogen generation. The fermentation liquor contains ethanol, butanol and acetone with the ratio of 6:3:1. People can seperate butanol, acetone and ethanol by rectification.
Propylene carbonyl synthesis: The carbon monoxide and hydrogen which are made from coke and propylene go through carbonyl synthesis reaction at high pressure in the presence of cobalt-based or rhodium-based catalyst to get n-butanal and isobutyraldehyde. Then, after hydrogenation and fractionation, 1-butanol can be obtained.
Acetaldehyde aldol condensation: The condensation and dehydration of two molecules of acetaldehyde can obtain crotonaldehyde. Crotonaldehyde can be hydrogenated to produce 1-butanol in the presence of nickel-chromium catalyst at 180 °C and 0.29MPa.
Uses of 1-Butanol:
1-Butanol is used as solvent for paints, coatings, resins, gums, dyes, varnishes, vegetable oils, waxes, dyes, fats, rubbers, resins, shellac, camphor, and alkaloids. It is also used as dehydrating agent, anticreaming agent, extractant of drugs (such as antibiotics, hormones and vitamins) and spices, additive of alkyd paint, etc. As a solvent, 1-butanol is used to separate potassium perchlorate and sodium perchlorate, and sodium chloride and lithium chloride. What's more, it is mainly used in the manufacture of phthalic acid, aliphatic dicarboxylic acid and phosphoric acid butyl acetate plasticizers which are widely used in a variety of plastic and rubber products. Besides, it is also used as a diluent/reactant in the manufacture of urea–formaldehyde and melamine–formaldehyde resins. In addition, it is allowed as artificial flavorant in the United States, used in ice cream and ices, cream, fruit, rum, baked goods, whiskey, candy, butter, and cordials.
Safty informaition of 1-Butanol:
1-Butanol is not only harmful if swallowed, but also irritating to respiratory system and skin. It also has risk of serious damage to the eyes. Vapours may cause drowsiness and dizziness. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If swallowed, seek medical advice immediately and show this container or label. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) But no deaths were reported at an inhaled concentration of 8000 ppm (4-hour exposure, rats). Keep 1-butanol away from food, drink and animal foodstuffs.
Structure Descriptors:
1. Smiles:C(CC)CO
2. InChI:InChI=1/C4H10O/c1-2-3-4-5/h5H,2-4H2,1H3
Toxicity of 1-Butanol are as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - wild | LD50 | oral | 2500mg/kg (2500mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. | |
cat | LDLo | intravenous | 243mg/kg (243mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 16, Pg. 1, 1920. | |
dog | LDLo | oral | 1760mg/kg (1760mg/kg) | GASTROINTESTINAL: OTHER CHANGES BLOOD: HEMORRHAGE | Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 81, Pg. 192, 1875. |
dog | LDLo | subcutaneous | 2gm/kg (2000mg/kg) | GASTROINTESTINAL: OTHER CHANGES BLOOD: HEMORRHAGE | Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 81, Pg. 192, 1875. |
human | TCLo | inhalation | 25ppm (25ppm) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 282, 1943. |
mammal (species unspecified) | LC50 | inhalation | 28400mg/m3 (28400mg/m3) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(5), Pg. 61, 1986. | |
mouse | LD50 | intraperitoneal | 254mg/kg (254mg/kg) | LIVER: OTHER CHANGES | Research Communications in Chemical Pathology and Pharmacology. Vol. 26, Pg. 75, 1979. |
mouse | LD50 | intravenous | 377mg/kg (377mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 135, Pg. 330, 1962. | |
mouse | LD50 | oral | 2680mg/kg (2680mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(11), Pg. 57, 1981. | |
mouse | LD50 | subcutaneous | 3200mg/kg (3200mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. | |
rabbit | LD50 | oral | 3484mg/kg (3484mg/kg) | SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE LUNGS, THORAX, OR RESPIRATION: DYSPNEA CARDIAC: PULSE RATE | Industrial Medicine and Surgery. Vol. 41, Pg. 31, 1972. |
rabbit | LD50 | skin | 3400mg/kg (3400mg/kg) | Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 10, 1974. | |
rabbit | LDLo | unreported | 3500mg/kg (3500mg/kg) | Therapeutische Monatshefte. Vol. 6, Pg. 327, 1892. | |
rat | LC50 | inhalation | 8000ppm/4H (8000ppm) | Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 10, 1974. | |
rat | LD50 | intraperitoneal | 1122mg/kg (1122mg/kg) | EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985. | |
rat | LD50 | intravenous | 310mg/kg (310mg/kg) | EHP, Environmental Health Perspectives. Vol. 61, Pg. 321, 1985. | |
rat | LD50 | oral | 790mg/kg (790mg/kg) | LIVER: FATTY LIVER DEGERATION KIDNEY, URETER, AND BLADDER: OTHER CHANGES BLOOD: OTHER CHANGES | South African Medical Journal. Vol. 43, Pg. 795, 1969. |
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