1-Ethoxy-2-propanol supplier

Name
1-Ethoxy-2-propanol
EINECS 216-374-5
CAS No. 1569-02-4
Article Data31
CAS DataBase
Density 0.903 g/cm³
Solubility soluble
Melting Point -100 °C
Formula C₅H₁₂O₂
Boiling Point 131 °C at 760 mmHg
Molecular Weight 104.149
Flash Point 45.9 °C
Transport Information
Appearance Clear colorless liquid
Safety 24
Risk Codes 67-10
Molecular Structure
Hazard Symbols R10:; R67:;
Synonyms Ethyl Proxitol;NSC 2404;
PSA 29.46000
LogP 0.40370

Synthetic route

: 64-17-5
ethanol

: 75-56-9, 16033-71-9
methyloxirane

: 1569-02-4
propylene glycol monoethyl ether

Conditions

Conditions	Yield
With Al2O3/MgO composite at 120℃; Inert atmosphere;	37.2%
With sodium ethanolate
With sodium hydroxide

: 64-67-5
diethyl sulfate

: 57-55-6
propylene glycol

: 1569-02-4
propylene glycol monoethyl ether

Conditions

Conditions	Yield
at 90 - 100℃; in alkal.Loesung;
With sodium hydroxide at 100℃;
With sodium hydroxide at 100℃;

: 64-17-5
ethanol

: 75-56-9, 16033-71-9
methyloxirane

A: 19089-47-5
2-ethoxy-1-propanol

B: 1569-02-4
propylene glycol monoethyl ether

Conditions

Conditions	Yield
With H+-Zeolite X at 35℃; for 24h; Product distribution; Mechanism; other 2-substituted epoxides; other alcohols, thiols and amine as nucleophiles; var. solid-catalysts; also H2SO4 as catalyst; var. temp.;
With sulfuric acid
With boron trifluoride

...Expand

: 64-17-5
ethanol

: 141-52-6
sodium ethanolate

: 75-56-9, 16033-71-9
methyloxirane

: 1569-02-4
propylene glycol monoethyl ether

...Expand

: 141-52-6
sodium ethanolate

: 75-56-9, 16033-71-9
methyloxirane

: 1569-02-4
propylene glycol monoethyl ether

Conditions

Conditions	Yield
In ethanol

: 3054-95-3
acrylaldehyde diethyl acetal

A: 16777-87-0
3,3-diethoxypropan-1-ol

B: 1569-02-4
propylene glycol monoethyl ether

Conditions

Conditions	Yield
With sodium hydroxide; dihydrogen peroxide; bis-(1,2-dimethylpropyl)borane Product distribution; 1)THF, 0 deg C, 7 h;	A 90.5 % Chromat. B 1 % Chromat.

: 64-17-5
ethanol

: 75-56-9, 16033-71-9
methyloxirane

A: 1569-02-4
propylene glycol monoethyl ether

B: 58797-30-1
di(propylene glycol) ethyl ether

Conditions

Conditions	Yield
With sodium hydroxide Heating; Yield given. Yields of byproduct given;

...Expand

: 64-17-5
ethanol

: 75-56-9, 16033-71-9
methyloxirane

sodium hydroxide: sodium hydroxide

: 1569-02-4
propylene glycol monoethyl ether

...Expand

: 64-67-5
diethyl sulfate

: 57-55-6
propylene glycol

A: 1569-02-4
propylene glycol monoethyl ether

B propylene glycol-diethyl ether: propylene glycol-diethyl ether

...Expand

: 23465-32-9
1-bromo-2-ethoxy-propane

: 7732-18-5
water

A: 19089-47-5
2-ethoxy-1-propanol

B: 1569-02-4
propylene glycol monoethyl ether

Conditions

Conditions	Yield
at 100℃;

...Expand

: 64-17-5
ethanol

: 67-63-0
isopropyl alcohol

: 75-56-9, 16033-71-9
methyloxirane

: 75-65-0
tert-butyl alcohol

A: 1569-02-4
propylene glycol monoethyl ether

B: 3944-36-3
1-isopropoxy-2-propanol

C: 57018-52-7
1-tert-butoxy-2-propanol

Conditions

Conditions	Yield
Trimethyl borate; hydrogen fluoride In water for 0.5h;

...Expand

: 1-ethoxy-2-propanyl formate

A: 64-18-6
formic acid

B: 1569-02-4
propylene glycol monoethyl ether

Conditions

Conditions	Yield
With water at 80℃; for 24h; Equilibrium constant; Sealed tube;

: 1569-02-4
propylene glycol monoethyl ether

: 14869-34-2
ethoxy-2-propanone

Conditions

Conditions	Yield
With dihydrogen peroxide In water at 80℃; for 7h; Green chemistry;	72.1%
With pyridinium chlorochromate In dichloromethane at 20℃; for 40h;	60%
With sodium dichromate; sulfuric acid at 4 - 5℃;

: 1569-02-4
propylene glycol monoethyl ether

: 98-88-4
benzoyl chloride

: 1-Methyl-2-ethoxyethylbenzoat

Conditions

Conditions	Yield
With pyridine 1.) 60 deg C, 2 h, 2.) 12 h, r.t.;	57%

: 1569-02-4
propylene glycol monoethyl ether

: N-(6-methylquinolin-8-yl)benzamide

: 2-[(1-ethoxypropan-2-yl)oxy]-N-(6-methylquinolin-8-yl)benzamide

Conditions

Conditions	Yield
With (1,2-dimethoxyethane)dichloronickel(II); 1-Adamantanecarboxylic acid; tetrabutylammonium perchlorate; sodium 1-adamantanecarboxylate In N,N-dimethyl acetamide at 130℃; for 12h; Inert atmosphere; Electrochemical reaction;	54%

: 1569-02-4
propylene glycol monoethyl ether

: 51779-32-9
iminodicarboxylic acid di-tert-butyl ester

: 947184-87-4
di-tert-butyl (2-ethoxy-1-methylethyl)imidodicarbonate

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃;	45%

: 1569-02-4
propylene glycol monoethyl ether

: 660851-11-6
N-[5-chloro-2-(2-ethoxy-1-methylethoxy)phenyl]-N'-(5-cyano-2-pyrazinyl)urea

Conditions

Conditions	Yield
	31%

: 1569-02-4
propylene glycol monoethyl ether

: 210563-62-5
(-)-O,21-dihydrocamptothecin

: 1412740-33-0
C25H28N2O5

Conditions

Conditions	Yield
With hydrogenchloride In water at 50℃; for 3h;	21.6%

: 108-05-4
vinyl acetate

: 1569-02-4
propylene glycol monoethyl ether

: 54839-24-6
2-acetoxy-1-ethoxypropane

Conditions

Conditions	Yield
With sulfuric acid at 110℃;

: 1569-02-4
propylene glycol monoethyl ether

: phosphonic acid bis-(β-ethoxy-isopropyl ester)

Conditions

Conditions	Yield
With phosphorus trichloride

: 1569-02-4
propylene glycol monoethyl ether

: phosphoric acid tris-(β-ethoxy-isopropyl ester)

Conditions

Conditions	Yield
With N,N-dimethyl-aniline; phosphorus trichloride

: 1569-02-4
propylene glycol monoethyl ether

: 71385-98-3
1-ethoxy-2-bromo-propane

Conditions

Conditions	Yield
With phosphorus tribromide

: 2523-94-6
methyl phosphorodichloridothionate

: 1569-02-4
propylene glycol monoethyl ether

: 28244-15-7
thiophosphorochloridic acid O-(2-ethoxy-1-methyl-ethyl) ester O'-methyl ester

: 1569-02-4
propylene glycol monoethyl ether

: 28256-34-0
thiophosphorodichloridic acid O-(2-ethoxy-1-methyl-ethyl) ester

Conditions

Conditions	Yield
With trichlorophosphate

: 1569-02-4
propylene glycol monoethyl ether

: 7732-18-5
water

Na2Cr2O7: Na2Cr2O7

: 14869-34-2
ethoxy-2-propanone

Conditions

Conditions	Yield
at 4 - 5℃;

...Expand

: 1569-02-4
propylene glycol monoethyl ether

: 7664-93-9
sulfuric acid

: 108-24-7
acetic anhydride

: 54839-24-6
2-acetoxy-1-ethoxypropane

...Expand

: 70125-16-5
2-amino-8-quinolinol

: 1569-02-4
propylene glycol monoethyl ether

: 8-(2-ethoxy-1-methylethoxy)quinolin-2-amine

Conditions

Conditions	Yield
With PS-PPh3; dibenzyl azodicarboxylate In tetrahydrofuran Mitsunobu reaction;

: 658085-52-0
5-(6-(azidocarbonyl)-5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-2,4-difluoro-N-methoxybenzamide

: 1569-02-4
propylene glycol monoethyl ether

: [4-(2,4-difluoro-5-methoxycarbamoyl-phenylamino)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid 2-ethoxy-1-methyl-ethyl ester

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 85℃; for 2h; Curtius rearrangement;

: 1569-02-4
propylene glycol monoethyl ether

: 32315-10-9
bis(trichloromethyl) carbonate

: carbonic acid bis-(2-ethoxy-1-methyl-ethyl) ester

Conditions

Conditions	Yield
With pyridine In benzene at 60℃; for 12h;

: 1569-02-4
propylene glycol monoethyl ether

: 2365-48-2
Methyl thioglycolate

: 2-ethoxy-1-methylethyl thioglycolate

Conditions

Conditions	Yield
With sulfuric acid at 80℃; for 7h;

: 1569-02-4
propylene glycol monoethyl ether

: 79-42-5
2-mercaptopropanoic acid

: 2-ethoxy-1-methylethyl thiolactate

Conditions

Conditions	Yield
With sulfuric acid at 100℃; for 3h;

1-Ethoxy-2-propanol Chemical Properties

Structure of 2-Propanol, 1-ethoxy- (CAS NO.1569-02-4):

IUPAC Name: 1-ethoxypropan-2-ol
Empirical Formula: C₅H₁₂O₂
Molecular Weight: 104.1476
EINECS: 216-374-5
Index of Refraction: 1.408
Molar Refractivity: 28.45 cm³
Molar Volume: 115.3 cm³
Polarizability: 11.27×10^-24cm³
Surface Tension: 27.8 dyne/cm
Density: 0.903 g/cm³
Flash Point: 45.9 °C
Enthalpy of Vaporization: 42.95 kJ/mol
Melting Point: -100 °C
Boiling Point: 131 °C at 760 mmHg
Vapour Pressure: 4.21 mmHg at 25°C
Water Solubility: soluble
Physical Appearance: Clear colorless liquid
Synonyms of 2-Propanol, 1-ethoxy- (CAS NO.1569-02-4): 1-Ethoxy-2-propanol ; 4-01-00-02471 (Beilstein Handbook Reference) ; Propylene glycol ethyl ether

1-Ethoxy-2-propanol Uses

2-Propanol, 1-ethoxy- (CAS NO.1569-02-4) is used in coatings, inks, photosensitive plastic etc.

1-Ethoxy-2-propanol Toxicity Data With Reference

1.		orl-rat LD50:4400 mg/kg		NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. 1 (1974),104.
2.		skn-rbt LD50:8100 mg/kg		NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. 1 (1974),104.

1-Ethoxy-2-propanol Consensus Reports

Glycol ether compounds are on the Community Right-To-Know List.

1-Ethoxy-2-propanol Safety Profile

Mildly toxic by ingestion and skin contact. A combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also GLYCOL ETHERS.
Risk Statements: 67-10
R67:Vapours may cause drowsiness and dizziness.
R10:Flammable.
Safety Statements: 24
S24:Avoid contact with skin.
RIDADR: 1987
RTECS: UB5250000
HazardClass: 3
PackingGroup: III

Product Name

1-Ethoxy-2-propanol

Synthetic route

1-Ethoxy-2-propanol Chemical Properties

1-Ethoxy-2-propanol Uses

1-Ethoxy-2-propanol Toxicity Data With Reference

1-Ethoxy-2-propanol Consensus Reports

1-Ethoxy-2-propanol Safety Profile

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