1-Methoxy-2-propanol supplier

Name
1-Methoxy-2-propanol
EINECS 203-539-1
CAS No. 107-98-2
Article Data103
CAS DataBase
Density 0.912 g/cm³
Solubility soluble in water
Melting Point - 97 °C
Formula C₄H₁₀O₂
Boiling Point 118.5 °C at 760 mmHg
Molecular Weight 90.1222
Flash Point 33.9 °C
Transport Information UN 3092 3/PG 3
Appearance colourless liquid
Safety 26-24/25
Risk Codes 10
Molecular Structure
Hazard Symbols R10:;
Synonyms 1-Methoxy-2-hydroxypropane;Dowtherm 209;Propylene glycol methyl ether;Propylenglykol-monomethylaether;Dowanol-33B;1-methoxypropan-2-ol;.alpha.-Propylene glycol monomethyl ether;2-Methoxy-1-methylethanol;2-Propanol,1-methoxy-;2-Propanol, 1-methoxy-;Propylene Glycol Monomethyl Ether(PM):;Propylene Glycol Monomethyl Ether;Methoxyisopropanol;
PSA 29.46000
LogP 0.01360

Synthetic route

: 187737-37-7
propene

A: 107-98-2
1-methoxy-2-propanol

B: 75-56-9, 16033-71-9
methyloxirane

Conditions

Conditions	Yield
With pyridine N-oxide; dihydrogen peroxide; methyltrioxorhenium(VII) In methanol; water at 40℃; under 11894.7 - 36201.3 Torr; for 3h;	A 1.02% B 98%
With pyridine; carbon dioxide; dihydrogen peroxide; methyltrioxorhenium(VII) In methanol; water at 25 - 40℃; under 36201.3 Torr; for 3h;	A n/a B 60.25%
With pyridine N-oxide; carbon dioxide; dihydrogen peroxide; methyltrioxorhenium(VII) In methanol; water at 25 - 40℃; under 36201.3 Torr; for 3 - 9h;	A n/a B 51.1%
With pyridine N-oxide; urea hydrogen peroxide adduct; methyltrioxorhenium(VII) In methanol; water at 30℃; under 12929 Torr;

: 67-56-1
methanol

: 75-56-9, 16033-71-9
methyloxirane

: 107-98-2
1-methoxy-2-propanol

Conditions

Conditions	Yield
With sodium hydroxide at 120℃; for 0.116667h; Concentration; Temperature; Reagent/catalyst; Flow reactor;	93%
With sodium methylate	78%
With Al2O3/MgO composite at 120℃; Inert atmosphere;	37.4%

: 67-56-1
methanol

: 75-56-9, 16033-71-9
methyloxirane

A: 107-98-2
1-methoxy-2-propanol

B: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With MCM-41-encapsulated cetyltrimethylammonium hydroxide at 110℃; for 3h; regioselective reaction;	A 92% B n/a
With boron trifluoride diethyl etherate	A 36% B 39%
at 200℃;

...Expand

: 187737-37-7
propene

A: 57-55-6
propylene glycol

B: 107-98-2
1-methoxy-2-propanol

C: 1589-47-5
2-methoxypropanol

D: 75-56-9, 16033-71-9
methyloxirane

Conditions

Conditions	Yield
With dihydrogen peroxide; titanium-silicate In methanol at 40℃;	A n/a B n/a C n/a D 92%
With dihydrogen peroxide; titanium-silicate In methanol at 40℃;	A n/a B n/a C n/a D 78%
With dihydrogen peroxide; titanium-silicate In water at 30 - 80℃; under 18751.9 Torr; pH=4.5;	A n/a B n/a C n/a D 61%

...Expand

: 57-55-6
propylene glycol

: 74-88-4
methyl iodide

: 107-98-2
1-methoxy-2-propanol

Conditions

Conditions	Yield
With iron(III) perchlorate at 20℃; for 24h; neat (no solvent);	85%
With potassium In tetrahydrofuran for 2h; Heating;	58%

: 930-37-0
glycidyl methyl ether

: 107-98-2
1-methoxy-2-propanol

Conditions

Conditions	Yield
With Bu3Sn(HMPA)I; tri-n-butyl-tin hydride In tetrahydrofuran at 40℃; for 24h;	75%

: 187737-37-7
propene

A: 57-55-6
propylene glycol

B: 107-98-2
1-methoxy-2-propanol

C: 75-56-9, 16033-71-9
methyloxirane

Conditions

Conditions	Yield
With pyridine N-oxide; dihydrogen peroxide; methyltrioxorhenium(VII) In methanol; water at 40℃; under 36201.3 Torr; for 3h;	A 0.59% B 1.85% C 72.73%
With dihydrogen peroxide In methanol at 49.84℃; under 5250.53 Torr; Green chemistry;

...Expand

: 67-56-1
methanol

: 124-38-9
carbon dioxide

: 75-56-9, 16033-71-9
methyloxirane

A: 108-32-7
1,2-propylene cyclic carbonate

B: 57-55-6
propylene glycol

C: 107-98-2
1-methoxy-2-propanol

D: 1589-47-5
2-methoxypropanol

E: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With 6,7,9,10,12,13,20,21-octahydrodibenzo[b,h][1,4,7,10,13,16]hexaoxacyclooctadecine; potassium chloride at 130℃; under 15001.5 Torr; for 8h; Reagent/catalyst; Autoclave; High pressure;	A 69.2% B 12.5% C n/a D n/a E 13.2%
With 6,7,9,10,12,13,20,21-octahydrodibenzo[b,h][1,4,7,10,13,16]hexaoxacyclooctadecine; potassium bromide at 130℃; under 15001.5 Torr; for 8h; Reagent/catalyst; Autoclave; High pressure;	A 62.9% B 14.4% C n/a D n/a E 12.5%
With potassium bromide at 130℃; under 15001.5 Torr; for 8h; Autoclave; High pressure;	A 44.1% B 6.7% C n/a D n/a E 5.8%

...Expand

: 67-56-1
methanol

: 75-56-9, 16033-71-9
methyloxirane

A: 107-98-2
1-methoxy-2-propanol

B: 1589-47-5
2-methoxypropanol

C: 127-00-4
1-Chloro-2-propanol

Conditions

Conditions	Yield
With Cu(L-Asp)(1,2-bis(4-pyridyl)ethylene)0.5(H2O)0.5(MeOH)0.5 at 25℃;	A 56% B 40% C 4%
With Cu(L-Asp)(1,2-bis(4-pyridyl)ethylene)0.5(H2O)0.5(MeOH)0.5 at 60℃;	A 49% B 47% C 4%

...Expand

: 67-56-1
methanol

: 124-38-9
carbon dioxide

: 75-56-9, 16033-71-9
methyloxirane

A: 108-32-7
1,2-propylene cyclic carbonate

B: 107-98-2
1-methoxy-2-propanol

C: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With lithium iodide at 130℃; under 15001.5 Torr; for 8h; Reagent/catalyst; Autoclave; High pressure;	A 54.8% B n/a C n/a
With potassium carbonate at 100℃; for 6h; Supercritical conditions; Green chemistry;	A 35.6% B n/a C n/a

...Expand

: 67-56-1
methanol

: 124-38-9
carbon dioxide

: 75-56-9, 16033-71-9
methyloxirane

A: 108-32-7
1,2-propylene cyclic carbonate

B: 57-55-6
propylene glycol

C: 107-98-2
1-methoxy-2-propanol

D: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With lithium bromide at 130℃; under 15001.5 Torr; for 8h; Autoclave; High pressure;	A 52.4% B 5.7% C n/a D n/a

...Expand

: 186581-53-3, 908094-01-9
diazomethane

: 57-55-6
propylene glycol

A: 107-98-2
1-methoxy-2-propanol

B: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With H(+)-zeolite-X In benzene at 25℃; for 0.5h; Product distribution; further alcohols, thiols, aminoalcohols; further catalyst;	A 51% B 33%
With H(+)-zeolite-X In benzene at 25℃; for 0.5h;	A 51 % Chromat. B 33 % Chromat.
With sulfuric acid In benzene at 25℃; for 0.5h;	A 37 % Chromat. B 38 % Chromat.

...Expand

: 5878-19-3
Methoxyacetone

: 107-98-2
1-methoxy-2-propanol

Conditions

Conditions	Yield
With nickel at 140℃; under 294203 Torr; Hydrogenation;
With hydrogen; In diethylene glycol dimethyl ether; water at 30℃; under 735.5 Torr; for 20h;

: 124-41-4
sodium methylate

: 75-56-9, 16033-71-9
methyloxirane

: 107-98-2
1-methoxy-2-propanol

: 1072-47-5
4-methyl-1,3-dioxolane

A: 107-98-2
1-methoxy-2-propanol

B: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; boron trichloride 1.) CH2Cl2, 10 min, 2.) Et2O, 30 min; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

: 627-40-7
methylallylether

A: 71-23-8
propan-1-ol

B: 107-98-2
1-methoxy-2-propanol

C: 1589-49-7
methoxypropanol

Conditions

Conditions	Yield
With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide Product distribution; 1) THF, 25 deg C, 2 h;	A 1.5 % Chromat. B n/a C 94 % Chromat.

...Expand

: 627-40-7
methylallylether

A: 107-98-2
1-methoxy-2-propanol

B: 1589-49-7
methoxypropanol

Conditions

Conditions	Yield
With sodium hydroxide; sodium tetrahydroborate; mercury(II) diacetate 1) water, THF, 30 min, 2) ca. 0.5 h; Yield given. Multistep reaction. Yields of byproduct given;
With sodium hydroxide; mercury(II) diacetate In tetrahydrofuran; water Product distribution; 1) 30 min, 2) ca. 0.5 h;

: 67-56-1
methanol

: 75-56-9, 16033-71-9
methyloxirane

A: 107-98-2
1-methoxy-2-propanol

B: 20324-32-7
propylene glycol monomethyl ether dimer

Conditions

Conditions	Yield
With sodium hydroxide at 85℃; Heating; Yield given. Yields of byproduct given;
With sodium hydroxide at 85℃; Heating; Yield given. Yields of byproduct given;

...Expand

: 23465-33-0
1-bromo-2-methoxypropane

: 7732-18-5
water

A: 107-98-2
1-methoxy-2-propanol

B: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
at 100℃;

...Expand

Reaxys ID: 11354065: Reaxys ID: 11354065

A: 107-98-2
1-methoxy-2-propanol

B: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
Purification / work up; Industry scale;

: 187737-37-7
propene

A: 57-55-6
propylene glycol

B: 107-98-2
1-methoxy-2-propanol

C: 74-98-6
propane

D: 1589-47-5
2-methoxypropanol

E: 75-56-9, 16033-71-9
methyloxirane

Conditions

Conditions	Yield
With dihydrogen peroxide; titanium silicate In methanol at 59℃; under 18751.9 Torr; Product distribution / selectivity;

...Expand

: 67-56-1
methanol

: 187737-37-7
propene

A: 57-55-6
propylene glycol

B: 107-98-2
1-methoxy-2-propanol

C: 74-98-6
propane

D: 1589-47-5
2-methoxypropanol

E: 75-56-9, 16033-71-9
methyloxirane

Conditions

Conditions	Yield
With ammonia; dihydrogen peroxide; titanium-silicate catalyst In water at 41 - 59℃; under 18751.9 Torr; pH=4.5; Product distribution / selectivity; Continuously procces;
With water; hydrogen; oxygen; Pd-Bi/TiO2; tegafur at 60℃; under 16274.9 Torr; for 18h; pH=6; Product distribution / selectivity; aqueous ammonium phosphate buffer;
With water; hydrogen; oxygen; Pd-Au/TiO2; tegafur at 60℃; under 16274.9 Torr; for 18h; pH=6; Product distribution / selectivity; aqueous ammonium phosphate buffer;
With water; hydrogen; oxygen; Pd-Bi-Au/TiO2; tegafur at 60℃; under 16274.9 Torr; for 18h; pH=6; Product distribution / selectivity; aqueous ammonium phosphate buffer;
With ammonium acetate; hydrogen; oxygen at 60℃; under 56255.6 Torr; for 12h; Catalytic behavior; Reagent/catalyst; Temperature; Autoclave; Supercritical conditions;	A n/a B n/a C n/a D n/a E 11.8 %Chromat.

...Expand

: 7440-32-6
titanium

: 187737-37-7
propene

: 98-85-1, 13323-81-4
1-Phenylethanol

A: 107-98-2
1-methoxy-2-propanol

B: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With dihydrogen peroxide In methanol

...Expand

: 67-56-1
methanol

: 187737-37-7
propene

A: 3,6-dioxa-2,4-dimethyl-1-heptanol

B: 57-55-6
propylene glycol

C: 108-61-2
2,2'-oxydipropanol

D: 107-98-2
1-methoxy-2-propanol

E: 74-98-6
propane

F: 1589-47-5
2-methoxypropanol

G: 75-56-9, 16033-71-9
methyloxirane

Conditions

Conditions	Yield
With hydrogen; oxygen; Pd/TS-1 In water at 60℃; under 16274.9 Torr; pH=6; Product distribution / selectivity; ammonium phosphate buffer;

...Expand

: 5878-19-3
Methoxyacetone

: 67-63-0
isopropyl alcohol

A: 107-98-2
1-methoxy-2-propanol

B: 67-64-1
acetone

Conditions

Conditions	Yield
With Tri-tert-butylaluminium; trifluoroacetic acid In toluene at 60℃; for 24h; Meerwein-Ponndorf-Verley reduction; Inert atmosphere;

...Expand

: 7778-85-0
1,2-dimethoxypropane

A: 74-87-3
methylene chloride

B: 26198-63-0, 78-87-5
1,2-Dichloropropane

C: 107-98-2
1-methoxy-2-propanol

D: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
Stage #1: 1,2-dimethoxypropane With dichloromethane; tungsten(VI) chloride In Chloroform-D at 100℃; for 3h; Stage #2: With water In Chloroform-D at -20℃;

...Expand

: 67-56-1
methanol

: 124-38-9
carbon dioxide

: 75-56-9, 16033-71-9
methyloxirane

A: 108-32-7
1,2-propylene cyclic carbonate

B: 107-98-2
1-methoxy-2-propanol

C: 616-38-6
carbonic acid dimethyl ester

Conditions

Conditions	Yield
With Br(1-)*C14H33N2(1+) at 170℃; under 15001.5 - 37503.8 Torr; for 8h; Autoclave;

...Expand

: 75-56-9, 16033-71-9
methyloxirane

A: 57-55-6
propylene glycol

B: 107-98-2
1-methoxy-2-propanol

C: 1589-47-5
2-methoxypropanol

Conditions

Conditions	Yield
With 0.5% Pt/Al2O3; dihydrogen peroxide at 59.84℃; under 3750.38 Torr; for 2h; Inert atmosphere; Autoclave;

...Expand

: 107-98-2
1-methoxy-2-propanol

: 124-63-0
methanesulfonyl chloride

: 24590-51-0
(+/-)-(methoxyprop-2-yl) methanesulphonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 1h;	100%
With pyridine at -5℃;

: 936247-35-7
5-chloro-2-nitropyridin-3-ol

: 107-98-2
1-methoxy-2-propanol

: 1144110-19-9
5-chloro-3-(2-methoxy-1-methyl-ethoxy)-2-nitro-pyridine

Conditions

Conditions	Yield
With di-tert-butyl-diazodicarboxylate; triphenylphosphine In tetrahydrofuran at 0℃; for 5h;	100%

: 107-98-2
1-methoxy-2-propanol

: 700-36-7
2-bromo-4-fluoronitrobenzene

: 943247-79-8
2-bromo-4-(2-methoxy-1-methylethoxy)-1-nitrobenzene

Conditions

Conditions	Yield
Stage #1: 1-methoxy-2-propanol With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: 2-bromo-4-fluoronitrobenzene In N,N-dimethyl-formamide at 0 - 20℃; for 1h;	100%

: 17464-88-9
1,3,4,6-tetrakis(methoxymethyl)glycoluril

: 107-98-2
1-methoxy-2-propanol

: 1,3,4,6-tetrakis(1'-methyl-2'-methoxy)ethoxymethylglycoluril

Conditions

Conditions	Yield
With Amberlyst 15 resin at 60℃; for 17h; Catalytic behavior; Reagent/catalyst;	99.8%
With AMBERLYST at 25 - 60℃; under 80 - 100 Torr; for 7h;

: 107-98-2
1-methoxy-2-propanol

: 5878-19-3
Methoxyacetone

Conditions

Conditions	Yield
	99.4%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; sodium hydrogencarbonate In dichloromethane at 0 - 10℃; for 3.5h; Temperature;	97.8%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; chlorine; sodium carbonate In dichloromethane at 0 - 10℃; for 3.5h; Reagent/catalyst; Temperature;	97.6%

: 107-98-2
1-methoxy-2-propanol

: 61706-54-5
N-(chloromethyl)-N-(2,6-dimethylphenyl)-α-chloroacetamide

: 83447-95-4
2',6'-Dimethyl-N-(2-Methoxy-1-Methylethoxymethyl) 2-Chloroacetanilide

Conditions

Conditions	Yield
In 1,2-dichloro-ethane	99.1%

(S,S)-Co(salen): (S,S)-Co(salen)

: 107-98-2
1-methoxy-2-propanol

: 106-89-8
epichlorohydrin

: 62-23-7
4-nitro-benzoic acid

: 60827-45-4
(S)-3-chloropropan-1,2-diol

Conditions

Conditions	Yield
In water	99%

...Expand

: 107-98-2
1-methoxy-2-propanol

: N-(2-ethyl-6-methylphenyl)-4-nitrobenzenesulfonamide

: C18H22N2O5S

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In toluene at 50℃; for 2h; Temperature; Cooling with ice;	99%
With di-isopropyl azodicarboxylate; triphenylphosphine In toluene at 50℃; for 2h; Cooling with ice;	62 %Chromat.
With di-isopropyl azodicarboxylate; triphenylphosphine In toluene at 50℃; for 2h; Cooling with ice;	62 %Chromat.

: 107-98-2
1-methoxy-2-propanol

: 589-18-4
4-Methylbenzyl alcohol

: 1-(2-methoxy-1-methyl-ethoxymethyl)-4-methyl-benzene

Conditions

Conditions	Yield
With ytterbium(III) triflate at 140℃; for 20h;	97%

: 107-98-2
1-methoxy-2-propanol

: 627-40-7
methylallylether

Conditions

Conditions	Yield
With zirconium(IV) oxide at 100℃; for 3h; Temperature; Reagent/catalyst;	96.6%

: 85-44-9
phthalic anhydride

: 107-98-2
1-methoxy-2-propanol

: C12H14O5

Conditions

Conditions	Yield
With dmap In 2-methoxy-ethanol	96%

1-methoxy-2-propanol (propylene glycol monomethylether): 1-methoxy-2-propanol (propylene glycol monomethylether)

: 107-98-2
1-methoxy-2-propanol

: 37721-75-8
tetrabromo-p-cresol

: 74-95-3
1,2-dibromomethane

: bis(tetrabromo-4-methylphenoxy)-methane

Conditions

Conditions	Yield
With sodium hydroxide In water	95.3%

...Expand

: 107-98-2
1-methoxy-2-propanol

: 179898-34-1
3-bromo-5-fluorobenzonitrile

: 883907-45-7
3-bromo-5-(2-methoxy-1-methylethoxy)benzonitrile

Conditions

Conditions	Yield
Stage #1: 1-methoxy-2-propanol With sodium hexamethyldisilazane In N,N-dimethyl-formamide at 25℃; for 0.25h; Stage #2: 3-bromo-5-fluorobenzonitrile In N,N-dimethyl-formamide at 23 - 27℃; for 0.583333h;	95%

: trimethylaluminium dimer

: 107-98-2
1-methoxy-2-propanol

: [(CH3)2Al(μ-O-CH(CH3)CH2-OCH3)]2

Conditions

Conditions	Yield
In pentane byproducts: CH4; Ar-atmosphere; dropwise addn. of ligand to AlMe3 at -78°C, stirring for 2 h, then at room temp. for 12 h; solvent removal (vac.), sublimation (110°C/0.1 mbar); elem. anal.;	94%

: 13734-41-3
t-Boc-L-valine

: 107-98-2
1-methoxy-2-propanol

: (2S)-1-methoxypropan-2-yl 2-((tert-butoxycarbonyl)amino)-3-methylbutanoate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	94%

: 107-98-2
1-methoxy-2-propanol

: N-(2-acetyl-6-methylphenyl)-2-nitrobenzenesulfonamide

: N-(2-acetyl-6-methylphenyl)-N-(1-methoxypropan-2-yl)-2-nitrobenzenesulfonamide

Conditions

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; dichloromethane at 0 - 20℃; Mitsunobu Displacement; Inert atmosphere;	90%

: 107-98-2
1-methoxy-2-propanol

: 1445-79-0
trimethyl gallium

: [(CH3)2Ga(μ-O-CH(CH3)CH2-OCH3)]2

Conditions

Conditions	Yield
In pentane byproducts: CH4; Ar-atmosphere; dropwise addn. of ligand to GaMe3 at room temp., stirringovernight; distn. off of solvent, sublimation (74°C/0.1 mbar), then distn. (50°C/0.1 mbar) and crystn. on standing at -30°C for 1 h; elem. anal.;	89%

: 17228-64-7
6-chloro-2-methoxypyridine

: 107-98-2
1-methoxy-2-propanol

: 2-methoxy-6-((1-methoxypropan-2-yl)oxy)pyridine

Conditions

Conditions	Yield
With C34H47ClNiO3P2; sodium t-butanolate In toluene at 110℃; for 18h; Inert atmosphere; Sealed tube;	89%

: 107-98-2
1-methoxy-2-propanol

: 34306-42-8
Boc-Abu

: (2S)-1-methoxypropan-2-yl 2-((tert-butoxycarbonyl)amino)butanoate

Conditions

Conditions	Yield
With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	88%

: 107-98-2
1-methoxy-2-propanol

: 1191102-65-4
ethyl 7-hydroxy-5-[4-(methylsulfonyl)phenoxy]-1H-indole-2-carboxylate

: 1191103-54-4
ethyl 7-(2-methoxy-1-methylethoxy)-5-[4-(methylsulfonyl)phenoxy]-1H-indole-2-carboxylate

Conditions

Conditions	Yield
With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine In tetrahydrofuran at 50℃;	87%

: 292638-84-7
styrene

: 107-98-2
1-methoxy-2-propanol

: Umemoto's reagent

: 3,3,3-trifluoro-1-phenylpropyl 1-methoxy-2-propyl ether

Conditions

Conditions	Yield
With tris[2-phenylpyridinato-C2,N]iridium(III) In dichloromethane at 20℃; for 2.5h; Schlenk technique; Inert atmosphere; Irradiation; regioselective reaction;	87%

...Expand

: 107-98-2
1-methoxy-2-propanol

: 372-09-8
cyanoacetic acid

: 32804-79-8
1-methoxypropan-2-yl 2-cyanoacetate

Conditions

Conditions	Yield
With sulfuric acid In benzene for 2.5h; Fischer esterification; Heating;	85%

: 107-98-2
1-methoxy-2-propanol

: 89-86-1
4-hydroxysalicylic acid

Conditions

Conditions	Yield
With hydrogenchloride; CO2; potassium carbonate In water	85%

: 107-98-2
1-methoxy-2-propanol

: 77111-77-4
2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

: 1050495-05-0
2-([1-methyl-2-(methoxy)ethyl]oxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

Conditions

Conditions	Yield
With potassium tert-butylate at 80 - 90℃; for 2h;	84.7%

1-Methoxy-2-propanol Specification

The CAS registry number of Methoxy propanol is 107-98-2. The IUPAC name is 1-methoxypropan-2-ol. In addition, the molecular formula is C₄H₁₀O₂. What's more, it is a kind of colourless liquid and incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, water. It is mainly used as a solvent, dispersant and diluent. Besides, it is also used as antifreeze agent for the fuel, extraction solvent.

Physical properties about this chemical are: (1)ACD/LogP: -0.45; (2)ACD/LogD (pH 5.5): -0.45; (3)ACD/LogD (pH 7.4): -0.45; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 13.56; (7)ACD/KOC (pH 7.4): 13.56; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 3; (11)Polar Surface Area: 18.46 Å²; (12)Index of Refraction: 1.397; (13)Molar Refractivity: 23.81 cm³; (14)Molar Volume: 98.8 cm³; (15)Polarizability: 9.44 ×10^-24cm³; (16)Surface Tension: 26.9 dyne/cm; (17)Density: 0.912 g/cm³; (18)Flash Point: 33.9 °C; (19)Enthalpy of Vaporization: 41.58 kJ/mol; (20)Boiling Point: 118.5 °C at 760 mmHg; (21)Vapour Pressure: 8.15 mmHg at 25°C.

Preparation of Methoxy propanol: it can be prepared by methyloxirane and methanol. This reaction will need reagent NaOCH₃. The yield is about 78%.

Methoxy propanol can be prepared by methyloxirane and methanol

Uses of Methoxy propanol: it can react with oxirane to get 4-methyl-2,5-dioxaheptan-7-ol. This reaction will need reagent BF₃*Et₂O. The yield is about 53%.

Methoxy propanol can react with oxirane to get 4-methyl-2,5-dioxaheptan-7-ol

When you are using this chemical, please be cautious about it as the following:
This chemical is flammable. During using it, you should avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: OC(C)COC
(2)InChI: InChI=1/C4H10O2/c1-4(5)3-6-2/h4-5H,3H2,1-2H3
(3)InChIKey: ARXJGSRGQADJSQ-UHFFFAOYAJ

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	2gm/kg (2000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.
dog	LD50	oral	5gm/kg (5000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.
guinea pig	LCLo	inhalation	15000ppm/7H (15000ppm)	BEHAVIORAL: SLEEP	AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 9, Pg. 509, 1954.
human	TCLo	inhalation	3000ppm (3000ppm)	SENSE ORGANS AND SPECIAL SENSES: TUMORS: OLFACTION BEHAVIORAL: GENERAL ANESTHETIC GASTROINTESTINAL: NAUSEA OR VOMITING	Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 105, 1974.
mouse	LD	intraperitoneal	> 500mg/kg (500mg/kg)		"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 4, Pg. 110, 1952.
mouse	LD50	intravenous	5300mg/kg (5300mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.
mouse	LD50	oral	11700mg/kg (11700mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.
rabbit	LCLo	inhalation	15000ppm/7H (15000ppm)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 9, Pg. 509, 1954.
rabbit	LD50	intravenous	1200mg/kg (1200mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.
rabbit	LD50	oral	5700mg/kg (5700mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.
rabbit	LD50	skin	13gm/kg (13000mg/kg)		Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 105, 1974.
rabbit	LD50	subcutaneous	5gm/kg (5000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.
rat	LC50	inhalation	10000ppm/5H (10000ppm)		Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 105, 1974.
rat	LD50	intraperitoneal	3720mg/kg (3720mg/kg)		"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3977, 1982.
rat	LD50	intravenous	4200mg/kg (4200mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.
rat	LD50	subcutaneous	7800mg/kg (7800mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.
rat	LDLo	oral	3739mg/kg (3739mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	National Technical Information Service. Vol. OTS0520402,

Product Name

1-Methoxy-2-propanol

Synthetic route

1-Methoxy-2-propanol Specification

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