1-Methyl-4-piperidone
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
With ammonium formate; palladium on carbon In methanol | 100% |
With ammonium formate; palladium on activated charcoal In methanol; water at 20℃; | 75% |
With ammonium formate; palladium on activated charcoal In methanol; water at 20℃; | 37% |
1-methylpiperidin-4-one hydrochloride
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
Stage #1: 1-methylpiperidin-4-one hydrochloride With ammonium acetate In methanol for 0.166667h; Stage #2: With sodium cyanoborohydride In methanol for 1h; | 88% |
With ammonium acetate; sodium cyanoborohydride In methanol for 1.16667h; | 88% |
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
With sodium tetrahydroborate at 5℃; for 12h; Reflux; Large scale; | 85.3% |
N-((4-methylphenyl)methyl)-N-(1-piperidin-4-yl)-4-chlorophenylacetamide
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
With formic acid; palladium 10% on activated carbon In methanol for 24h; Heating / reflux; | 51% |
4-(4-methoxybenzylamino)-1-methylpiperidine
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
With formic acid; palladium 10% on activated carbon In methanol for 24h; Inert atmosphere; Reflux; | 51% |
1-methyl-piperidin-4-one oxime ; hydrochloride
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
With ethanol; sodium Heating; | 50% |
Conditions | Yield |
---|---|
With sodium |
1-methyl-4-piperidinone oxime
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
With i-Amyl alcohol; sodium |
N-(1-methyl-[4]piperidyl)-acetamide
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
With hydrogenchloride |
1-methylpiperidine-4-carboxamide
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
With potassium hydroxide; bromine |
1-methyl-4-oxo-piperidine-3-carboxylic acid methyl ester
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: water; hydrochloric acid 3: isopentyl alcohol; sodium View Scheme |
Conditions | Yield |
---|---|
With hydrogenchloride; NaCNBH3; silica gel In methanol; diethyl ether | 3.88 g (88%) |
With hydrogenchloride; NaCNBH3; silica gel In methanol; diethyl ether | 3.88 g (88%) |
4-chlorocarbonyl-4,9-dihydro-1-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one
A
1-methyl-4-aminopiperidine
4-(chlorocarbonyl)-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one
A
1-methyl-4-aminopiperidine
4-(chlorocarbonyl)-4,9-dihydro-1,3-dimethyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one
A
1-methyl-4-aminopiperidine
1-(trifluoroacetyl)-4-piperidone
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium cyanoborohydride; acetic acid / methanol / 20 h / pH ~ 5 1.2: pH ~ 10 2.1: triethylamine / dichloromethane / 0.17 h / 0 °C 2.2: 1.25 h / 0 °C 3.1: potassium carbonate / methanol / 24 h / 40 °C 4.1: formic acid / palladium 10% on activated carbon / methanol / 24 h / Heating / reflux View Scheme |
4-(4-methylbenzylamino)-1-(trifluoroacetyl)piperidine
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / 0.17 h / 0 °C 1.2: 1.25 h / 0 °C 2.1: potassium carbonate / methanol / 24 h / 40 °C 3.1: formic acid / palladium 10% on activated carbon / methanol / 24 h / Heating / reflux View Scheme |
2-(4-chlorophenyl)-N-(4-methylbenzyl)-N-(1-trifluoroacetylpiperidin-4-yl)acetamide
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / methanol / 24 h / 40 °C 2: formic acid / palladium 10% on activated carbon / methanol / 24 h / Heating / reflux View Scheme |
tert-butyl 4-((4-methylphenyl)methyl)aminopiperidine carboxylate
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C 1.2: 2 h 2.1: hydrogenchloride / 1,4-dioxane; diethyl ether / 2 h / 20 °C 3.1: formic acid / palladium 10% on activated carbon / methanol / 24 h / Heating / reflux View Scheme |
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / 1,4-dioxane; diethyl ether / 2 h / 20 °C 2: formic acid / palladium 10% on activated carbon / methanol / 24 h / Heating / reflux View Scheme |
4-piperidone hydrochloride
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triethylamine / dichloromethane / 0.17 h / 0 °C 1.2: 2 h / 20 °C 2.1: sodium cyanoborohydride; acetic acid / methanol / 20 h / pH ~ 5 2.2: pH ~ 10 3.1: triethylamine / dichloromethane / 0.17 h / 0 °C 3.2: 1.25 h / 0 °C 4.1: potassium carbonate / methanol / 24 h / 40 °C 5.1: formic acid / palladium 10% on activated carbon / methanol / 24 h / Heating / reflux View Scheme |
N-tert-butyloxycarbonylpiperidin-4-one
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium cyanoborohydride; acetic acid / methanol / 20 h / 20 °C 1.2: 1 h 2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C 2.2: 2 h 3.1: hydrogenchloride / 1,4-dioxane; diethyl ether / 2 h / 20 °C 4.1: formic acid / palladium 10% on activated carbon / methanol / 24 h / Heating / reflux View Scheme |
1-methyl-4-aminopiperidine
2‐fluoro‐5‐methoxy‐4‐nitrobenzoic acid
2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)-4-nitrobenzamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In ISOPROPYLAMIDE at 18 - 25℃; for 1h; | 100% |
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl acetamide at 18 - 25℃; for 1h; | 100% |
1-methyl-4-aminopiperidine
4-amino-3-fluorobenzoic acid
4-amino-3-fluoro-N-(1-methylpiperidin-4-yl)benzamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 18 - 25℃; for 18h; | 100% |
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl acetamide at 18 - 25℃; for 18h; | 100% |
1-methyl-4-aminopiperidine
2-fluoro-4-bromobenzoic acid
4-bromo-2-fluoro-N-(1-methylpiperidin-4-yl)benzamide
Conditions | Yield |
---|---|
Stage #1: 4-Amino-1-methylpiperidine; 2-fluoro-4-bromobenzoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1.5h; Stage #2: With sodium hydroxide In water at 20℃; | 100% |
With triethylamine; HATU In N,N-dimethyl-formamide |
1-methyl-4-aminopiperidine
7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline
7-(benzyloxy)-2-chloro-6-methoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; | 100% |
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; | 100% |
at 20℃; |
1-methyl-4-aminopiperidine
5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid
5-amino-4-methyl-N-(1-methylpiperidin-4-yl)-1-phenyl-1H-pyrazole-3-carboxamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 5.5h; | 100% |
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
With potassium fluoride In dimethyl sulfoxide at 120℃; for 1h; | 100% |
1-methyl-4-aminopiperidine
N-(5-bromo-4-chloropyridin-2-yl)pivalamide
N-(5-bromo-4-(1-methylpiperidin-4-ylamino)pyridin-2-yl)pivalamide
Conditions | Yield |
---|---|
In 1-methyl-pyrrolidin-2-one at 220℃; for 3h; Microwave irradiation; | 99% |
1-methyl-4-aminopiperidine
1-bromo-3-nitro-5-(trifluoromethyl)benzene
1-methyl-N-[3-nitro-5-(trifluoromethyl)phenyl]piperidin-4-amine
Conditions | Yield |
---|---|
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,4-dioxane at 120℃; Inert atmosphere; | 99% |
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,4-dioxane at 120℃; Inert atmosphere; | 99% |
1-methyl-4-aminopiperidine
4-Bromo-1-fluoro-2-nitrobenzene
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 0 - 20℃; Inert atmosphere; | 99% |
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 8h; |
1-methyl-4-aminopiperidine
6-bromo-4-chloro-3-quinolinecarbonitrile
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 100℃; for 0.5h; Microwave irradiation; | 99% |
1-methyl-4-aminopiperidine
N-(1-methyl-piperidin-4-yl)-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)-phenyl]-urea
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 5h; | 98% |
In 1,2-dimethoxyethane |
1-methyl-4-aminopiperidine
3-methyl-4-nitrobenzoic acid
3-methyl-N-(1-methyl-4-piperidyI)-4-nitro-benzamide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 18 - 25℃; for 18h; | 98% |
1-methyl-4-aminopiperidine
3-chloro-5-hydroxybenzaldehyde
Conditions | Yield |
---|---|
With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 18.5h; | 97% |
1-methyl-4-aminopiperidine
ortho-nitrofluorobenzene
N-(1-methyl-piperidin-4-yl)-benzene-1,2-diamine
Conditions | Yield |
---|---|
96% |
1-methyl-4-aminopiperidine
5-(1,1-difluoroethyl)-2-methyl-2H-pyrazole-3-carboxylic acid
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In 1-methyl-pyrrolidin-2-one at 90℃; for 0.166667h; Microwave irradiation; | 96% |
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere; | 96% |
1-methyl-4-aminopiperidine
methyl 2-isothiocyanatobenzoate
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 150℃; for 0.75h; Microwave irradiation; | 96% |
1-methyl-4-aminopiperidine
2-Fluoro-5-nitrobenzotrifluoride
(1-methyl-piperidin-4-yl)-(4-nitro-2-trifluoromethyl-phenyl)-amine
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 4h; | 95% |
1-methyl-4-aminopiperidine
5-bromo-2-methoxypyridine-3-carboxaldehyde
Conditions | Yield |
---|---|
With sodium cyanoborohydride; acetic acid In methanol at 20℃; for 22h; | 94% |
1-methyl-4-aminopiperidine
3-fluoro-4-nitrobenzoic acid
Conditions | Yield |
---|---|
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere; | 94% |
1-methyl-4-aminopiperidine
3,4,5-Trimethoxybenzoyl chloride
Conditions | Yield |
---|---|
In benzene Ambient temperature; | 93% |
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 0 - 20℃; for 4h; Inert atmosphere; | 92.4% |
1-methyl-4-aminopiperidine
4-methyl-benzoyl chloride
Conditions | Yield |
---|---|
In benzene Ambient temperature; | 92% |
1-methyl-4-aminopiperidine
2-chloro-6,7-dimethoxy-3H-quinazolin-4-one
2-chloro-6,7-dimethoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 2h; | 92% |
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 2h; | 92% |
With potassium carbonate In N,N-dimethyl-formamide at 20℃; | 90% |
1-methyl-4-aminopiperidine
4-nitro-benzoic acid
N-(1-methylpiperidin-4-yl)-4-nitrobenzamide
Conditions | Yield |
---|---|
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere; | 92% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; | 17.39% |
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 35℃; for 4h; |
1-methyl-4-aminopiperidine
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In 1,4-dioxane at 20℃; for 24h; | 92% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In 1,4-dioxane at 20℃; for 24h; Inert atmosphere; | 92% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 70℃; for 16h; | 92% |
cyclohexanylcarbonyl chloride
Conditions | Yield |
---|---|
In benzene Ambient temperature; | 91% |
1-methyl-4-aminopiperidine
3',4',5'-trimethoxycinnamoyl chloride
Conditions | Yield |
---|---|
In benzene Ambient temperature; | 91% |
IUPAC Name: 1-Methylpiperidin-4-amine
Molecular Formula: C6H14N2
Molecular Weight: 114.19 g/mol
Canonical SMILES: CN1CCC(CC1)N
InChI: InChI=1S/C6H14N2/c1-8-4-2-6(7)3-5-8/h6H,2-5,7H2,1H3
Product Categories: Pyridine; API intermediates
XLogP3-AA: -0.1
H-Bond Donor: 1
H-Bond Acceptor: 2
Index of Refraction: 1.469
Molar Refractivity: 34.88 cm3
Molar Volume: 125 cm3
Polarizability: 13.82×10-24 cm3
Surface Tension: 30.8 dyne/cm
Density: 0.912 g/cm3
Flash Point: 39.2 °C
Enthalpy of Vaporization: 37.82 kJ/mol
Boiling Point: 141 °C at 760 mmHg
Melting Point: 203-207 °C
Vapour Pressure of 1-Methylpiperidin-4-amine (CAS NO.41838-46-4): 5.97 mmHg at 25 °C
Hazard Codes: Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
Hazard Note: Irritant
HazardClass of 1-Methylpiperidin-4-amine (CAS NO.41838-46-4): Irritant
1-Methylpiperidin-4-amine (CAS NO.41838-46-4), its Synonyms are 4-Amino-1-methylpiperidine ; 1-Methyl-4-Amino Piperidine ; N-Methyl-4-aminopiperidine ; 1-(5-Bromopyrimidin-2-yl)[1,4]diazepane ; 4-Amino-1-methyl-piperidine ; 4-Amino-1-methylpiperidine 97% ; 4-Piperidinamine, 1-methyl- .
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View