Product Name

  • Name

    1-Methylpiperidin-4-amine

  • EINECS
  • CAS No. 41838-46-4
  • Article Data27
  • CAS DataBase
  • Density 0.913 g/cm3
  • Solubility
  • Melting Point 203-207 °C
  • Formula C6H14N2
  • Boiling Point 141.015 °C at 760 mmHg
  • Molecular Weight 114.191
  • Flash Point 39.197 °C
  • Transport Information
  • Appearance colorless to light-yellow liquid
  • Safety 26-36/37/39
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 41838-46-4 (1-Methylpiperidin-4-amine)
  • Hazard Symbols IrritantXi
  • Synonyms Piperidine,4-amino-1-methyl- (6CI,7CI);1-Methyl-4-aminopiperidine;1-Methyl-4-piperidinamine;4-Amino-1-methylpiperidine;N-Methyl-4-aminopiperidine;4-Piperidinamine,1-methyl-;
  • PSA 29.26000
  • LogP 0.67750

Synthetic route

1-Methyl-4-piperidone
1445-73-4

1-Methyl-4-piperidone

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
With ammonium formate; palladium on carbon In methanol100%
With ammonium formate; palladium on activated charcoal In methanol; water at 20℃;75%
With ammonium formate; palladium on activated charcoal In methanol; water at 20℃;37%
1-methylpiperidin-4-one hydrochloride
34737-83-2

1-methylpiperidin-4-one hydrochloride

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
Stage #1: 1-methylpiperidin-4-one hydrochloride With ammonium acetate In methanol for 0.166667h;
Stage #2: With sodium cyanoborohydride In methanol for 1h;
88%
With ammonium acetate; sodium cyanoborohydride In methanol for 1.16667h;88%
C6H12N2

C6H12N2

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
With sodium tetrahydroborate at 5℃; for 12h; Reflux; Large scale;85.3%
N-((4-methylphenyl)methyl)-N-(1-piperidin-4-yl)-4-chlorophenylacetamide
359878-09-4

N-((4-methylphenyl)methyl)-N-(1-piperidin-4-yl)-4-chlorophenylacetamide

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
With formic acid; palladium 10% on activated carbon In methanol for 24h; Heating / reflux;51%
4-(4-methoxybenzylamino)-1-methylpiperidine
359878-55-0

4-(4-methoxybenzylamino)-1-methylpiperidine

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
With formic acid; palladium 10% on activated carbon In methanol for 24h; Inert atmosphere; Reflux;51%
1-methyl-piperidin-4-one oxime ; hydrochloride
84540-61-4

1-methyl-piperidin-4-one oxime ; hydrochloride

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
With ethanol; sodium Heating;50%
1-methyl-4-piperidinone oxime
1515-27-1

1-methyl-4-piperidinone oxime

ethanol
64-17-5

ethanol

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
With sodium
1-methyl-4-piperidinone oxime
1515-27-1

1-methyl-4-piperidinone oxime

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
With i-Amyl alcohol; sodium
N-(1-methyl-[4]piperidyl)-acetamide
145344-76-9

N-(1-methyl-[4]piperidyl)-acetamide

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
With hydrogenchloride
1-methylpiperidine-4-carboxamide
62718-28-9

1-methylpiperidine-4-carboxamide

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
With potassium hydroxide; bromine
1-methyl-4-oxo-piperidine-3-carboxylic acid methyl ester
13221-89-1, 56026-45-0

1-methyl-4-oxo-piperidine-3-carboxylic acid methyl ester

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water; hydrochloric acid
3: isopentyl alcohol; sodium
View Scheme
1-Methyl-4-piperidone
1445-73-4

1-Methyl-4-piperidone

NH4 OAc

NH4 OAc

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
With hydrogenchloride; NaCNBH3; silica gel In methanol; diethyl ether3.88 g (88%)
With hydrogenchloride; NaCNBH3; silica gel In methanol; diethyl ether3.88 g (88%)
4-chlorocarbonyl-4,9-dihydro-1-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one
118306-22-2

4-chlorocarbonyl-4,9-dihydro-1-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

A

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

B

4,9-dihydro-1-methyl-4-{[(1-methyl-4-piperidinyl)amino]carbonyl}-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

4,9-dihydro-1-methyl-4-{[(1-methyl-4-piperidinyl)amino]carbonyl}-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

4-(chlorocarbonyl)-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one
118306-21-1

4-(chlorocarbonyl)-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

A

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

B

4,9-Dihydro-3-methyl-4-{[(1-methyl-4-piperidinyl)amino]carbonyl}-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

4,9-Dihydro-3-methyl-4-{[(1-methyl-4-piperidinyl)amino]carbonyl}-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

4-(chlorocarbonyl)-4,9-dihydro-1,3-dimethyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one
118306-23-3

4-(chlorocarbonyl)-4,9-dihydro-1,3-dimethyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

A

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

B

4,9-dihydro-1,3-dimethyl-4-{[(1-methyl-4-piperidinyl)amino]carbonyl}-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

4,9-dihydro-1,3-dimethyl-4-{[(1-methyl-4-piperidinyl)amino]carbonyl}-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

1-(trifluoroacetyl)-4-piperidone
65220-86-2

1-(trifluoroacetyl)-4-piperidone

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium cyanoborohydride; acetic acid / methanol / 20 h / pH ~ 5
1.2: pH ~ 10
2.1: triethylamine / dichloromethane / 0.17 h / 0 °C
2.2: 1.25 h / 0 °C
3.1: potassium carbonate / methanol / 24 h / 40 °C
4.1: formic acid / palladium 10% on activated carbon / methanol / 24 h / Heating / reflux
View Scheme
4-(4-methylbenzylamino)-1-(trifluoroacetyl)piperidine
359878-15-2

4-(4-methylbenzylamino)-1-(trifluoroacetyl)piperidine

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 0.17 h / 0 °C
1.2: 1.25 h / 0 °C
2.1: potassium carbonate / methanol / 24 h / 40 °C
3.1: formic acid / palladium 10% on activated carbon / methanol / 24 h / Heating / reflux
View Scheme
2-(4-chlorophenyl)-N-(4-methylbenzyl)-N-(1-trifluoroacetylpiperidin-4-yl)acetamide
359879-83-7

2-(4-chlorophenyl)-N-(4-methylbenzyl)-N-(1-trifluoroacetylpiperidin-4-yl)acetamide

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / methanol / 24 h / 40 °C
2: formic acid / palladium 10% on activated carbon / methanol / 24 h / Heating / reflux
View Scheme
tert-butyl 4-((4-methylphenyl)methyl)aminopiperidine carboxylate
359877-52-4

tert-butyl 4-((4-methylphenyl)methyl)aminopiperidine carboxylate

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C
1.2: 2 h
2.1: hydrogenchloride / 1,4-dioxane; diethyl ether / 2 h / 20 °C
3.1: formic acid / palladium 10% on activated carbon / methanol / 24 h / Heating / reflux
View Scheme
C26H33ClN2O3

C26H33ClN2O3

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / 1,4-dioxane; diethyl ether / 2 h / 20 °C
2: formic acid / palladium 10% on activated carbon / methanol / 24 h / Heating / reflux
View Scheme
4-piperidone hydrochloride
41979-39-9

4-piperidone hydrochloride

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / dichloromethane / 0.17 h / 0 °C
1.2: 2 h / 20 °C
2.1: sodium cyanoborohydride; acetic acid / methanol / 20 h / pH ~ 5
2.2: pH ~ 10
3.1: triethylamine / dichloromethane / 0.17 h / 0 °C
3.2: 1.25 h / 0 °C
4.1: potassium carbonate / methanol / 24 h / 40 °C
5.1: formic acid / palladium 10% on activated carbon / methanol / 24 h / Heating / reflux
View Scheme
N-tert-butyloxycarbonylpiperidin-4-one
79099-07-3

N-tert-butyloxycarbonylpiperidin-4-one

1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium cyanoborohydride; acetic acid / methanol / 20 h / 20 °C
1.2: 1 h
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C
2.2: 2 h
3.1: hydrogenchloride / 1,4-dioxane; diethyl ether / 2 h / 20 °C
4.1: formic acid / palladium 10% on activated carbon / methanol / 24 h / Heating / reflux
View Scheme
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

2‐fluoro‐5‐methoxy‐4‐nitrobenzoic acid
1001345-80-7

2‐fluoro‐5‐methoxy‐4‐nitrobenzoic acid

2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)-4-nitrobenzamide
1001345-79-4

2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)-4-nitrobenzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In ISOPROPYLAMIDE at 18 - 25℃; for 1h;100%
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl acetamide at 18 - 25℃; for 1h;100%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

4-amino-3-fluorobenzoic acid
455-87-8

4-amino-3-fluorobenzoic acid

4-amino-3-fluoro-N-(1-methylpiperidin-4-yl)benzamide
1001345-97-6

4-amino-3-fluoro-N-(1-methylpiperidin-4-yl)benzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 18 - 25℃; for 18h;100%
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl acetamide at 18 - 25℃; for 18h;100%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

2-fluoro-4-bromobenzoic acid
112704-79-7

2-fluoro-4-bromobenzoic acid

4-bromo-2-fluoro-N-(1-methylpiperidin-4-yl)benzamide
893420-55-8

4-bromo-2-fluoro-N-(1-methylpiperidin-4-yl)benzamide

Conditions
ConditionsYield
Stage #1: 4-Amino-1-methylpiperidine; 2-fluoro-4-bromobenzoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 1.5h;
Stage #2: With sodium hydroxide In water at 20℃;
100%
With triethylamine; HATU In N,N-dimethyl-formamide
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline
60771-18-8

7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline

7-(benzyloxy)-2-chloro-6-methoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
1197196-50-1

7-(benzyloxy)-2-chloro-6-methoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;100%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;100%
at 20℃;
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid
1367870-32-3

5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid

5-amino-4-methyl-N-(1-methylpiperidin-4-yl)-1-phenyl-1H-pyrazole-3-carboxamide
1610455-25-8

5-amino-4-methyl-N-(1-methylpiperidin-4-yl)-1-phenyl-1H-pyrazole-3-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 5.5h;100%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

4-(7-bromo-2,6-dichloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylic acid tert-butyl ester

4-(7-bromo-2,6-dichloro-8-fluoroquinazolin-4-yl)piperazine-1-carboxylic acid tert-butyl ester

tert-butyl 4-(7-bromo-6-chloro-8-fluoro-2-((1-methylpiperidin-yl)amino)quinazolin-4-yl)piperazine-1-carboxylate

tert-butyl 4-(7-bromo-6-chloro-8-fluoro-2-((1-methylpiperidin-yl)amino)quinazolin-4-yl)piperazine-1-carboxylate

Conditions
ConditionsYield
With potassium fluoride In dimethyl sulfoxide at 120℃; for 1h;100%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

N-(5-bromo-4-chloropyridin-2-yl)pivalamide
1137477-51-0

N-(5-bromo-4-chloropyridin-2-yl)pivalamide

N-(5-bromo-4-(1-methylpiperidin-4-ylamino)pyridin-2-yl)pivalamide
1137477-53-2

N-(5-bromo-4-(1-methylpiperidin-4-ylamino)pyridin-2-yl)pivalamide

Conditions
ConditionsYield
In 1-methyl-pyrrolidin-2-one at 220℃; for 3h; Microwave irradiation;99%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

1-bromo-3-nitro-5-(trifluoromethyl)benzene
630125-49-4

1-bromo-3-nitro-5-(trifluoromethyl)benzene

1-methyl-N-[3-nitro-5-(trifluoromethyl)phenyl]piperidin-4-amine
1529769-59-2

1-methyl-N-[3-nitro-5-(trifluoromethyl)phenyl]piperidin-4-amine

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,4-dioxane at 120℃; Inert atmosphere;99%
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In 1,4-dioxane at 120℃; Inert atmosphere;99%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

4-Bromo-1-fluoro-2-nitrobenzene
364-73-8

4-Bromo-1-fluoro-2-nitrobenzene

N-(4-bromo-2-nitrophenyl)-1-methylpiperidin-4-amine

N-(4-bromo-2-nitrophenyl)-1-methylpiperidin-4-amine

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0 - 20℃; Inert atmosphere;99%
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 8h;
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

6-bromo-4-chloro-3-quinolinecarbonitrile
364793-54-4

6-bromo-4-chloro-3-quinolinecarbonitrile

6-bromo-4-[(1-methylpiperidin-4-yl)amino]quinoline-3-carbonitrile

6-bromo-4-[(1-methylpiperidin-4-yl)amino]quinoline-3-carbonitrile

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 100℃; for 0.5h; Microwave irradiation;99%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

2-(4-isocyanatophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-(4-isocyanatophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

N-(1-methyl-piperidin-4-yl)-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)-phenyl]-urea
879486-87-0

N-(1-methyl-piperidin-4-yl)-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)-phenyl]-urea

Conditions
ConditionsYield
In dichloromethane at 20℃; for 5h;98%
In 1,2-dimethoxyethane
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

3-methyl-4-nitrobenzoic acid
3113-71-1

3-methyl-4-nitrobenzoic acid

3-methyl-N-(1-methyl-4-piperidyI)-4-nitro-benzamide
1001345-96-5

3-methyl-N-(1-methyl-4-piperidyI)-4-nitro-benzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 18 - 25℃; for 18h;98%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

3-chloro-5-hydroxybenzaldehyde
1829-33-0

3-chloro-5-hydroxybenzaldehyde

3-chloro-5-{[(1-methylpiperidin-4-yl)amino]methyl}phenol

3-chloro-5-{[(1-methylpiperidin-4-yl)amino]methyl}phenol

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 18.5h;97%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

N-(1-methyl-piperidin-4-yl)-benzene-1,2-diamine
600725-12-0

N-(1-methyl-piperidin-4-yl)-benzene-1,2-diamine

Conditions
ConditionsYield
96%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

5-(1,1-difluoroethyl)-2-methyl-2H-pyrazole-3-carboxylic acid
1024599-54-9

5-(1,1-difluoroethyl)-2-methyl-2H-pyrazole-3-carboxylic acid

C13H20F2N4O

C13H20F2N4O

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In 1-methyl-pyrrolidin-2-one at 90℃; for 0.166667h; Microwave irradiation;96%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

3-(cyclopentyloxy)-4-nitrobenzoic acid

3-(cyclopentyloxy)-4-nitrobenzoic acid

3-(cyclopentyloxy)-N-(1-methylpiperidin-4-yl)-4-nitrobenzamide

3-(cyclopentyloxy)-N-(1-methylpiperidin-4-yl)-4-nitrobenzamide

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;96%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

methyl 2-isothiocyanatobenzoate
16024-82-1

methyl 2-isothiocyanatobenzoate

3-(1-methyl-4-piperidyl)-2-thioxo-1H-quinazolin-4-one

3-(1-methyl-4-piperidyl)-2-thioxo-1H-quinazolin-4-one

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 150℃; for 0.75h; Microwave irradiation;96%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

2-Fluoro-5-nitrobenzotrifluoride
400-74-8

2-Fluoro-5-nitrobenzotrifluoride

(1-methyl-piperidin-4-yl)-(4-nitro-2-trifluoromethyl-phenyl)-amine
1183289-25-9

(1-methyl-piperidin-4-yl)-(4-nitro-2-trifluoromethyl-phenyl)-amine

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 4h;95%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

5-bromo-2-methoxypyridine-3-carboxaldehyde
103058-87-3

5-bromo-2-methoxypyridine-3-carboxaldehyde

N-((5-bromo-2-methoxypyridin-3-yl)methyl)-1-methylpiperidin-4-amine

N-((5-bromo-2-methoxypyridin-3-yl)methyl)-1-methylpiperidin-4-amine

Conditions
ConditionsYield
With sodium cyanoborohydride; acetic acid In methanol at 20℃; for 22h;94%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

3-fluoro-4-nitrobenzoic acid
403-21-4

3-fluoro-4-nitrobenzoic acid

3-fluoro-N-(1-methylpiperidin-4-yl)-4-nitrobenzamide

3-fluoro-N-(1-methylpiperidin-4-yl)-4-nitrobenzamide

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;94%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

3,4,5-Trimethoxybenzoyl chloride
4521-61-3

3,4,5-Trimethoxybenzoyl chloride

3,4,5-Trimethoxy-N-(1-methyl-piperidin-4-yl)-benzamide

3,4,5-Trimethoxy-N-(1-methyl-piperidin-4-yl)-benzamide

Conditions
ConditionsYield
In benzene Ambient temperature;93%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

4-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylic acid

4-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylic acid

4-bromo-N-(1-methylpiperidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxamide

4-bromo-N-(1-methylpiperidin-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 0 - 20℃; for 4h; Inert atmosphere;92.4%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

4-methyl-benzoyl chloride
874-60-2

4-methyl-benzoyl chloride

N-(1-methyl-[4]piperidyl)-p-toluamide

N-(1-methyl-[4]piperidyl)-p-toluamide

Conditions
ConditionsYield
In benzene Ambient temperature;92%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

2-chloro-6,7-dimethoxy-3H-quinazolin-4-one
27631-29-4

2-chloro-6,7-dimethoxy-3H-quinazolin-4-one

2-chloro-6,7-dimethoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
1197196-66-9

2-chloro-6,7-dimethoxy-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 2h;92%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 2h;92%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;90%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

4-nitro-benzoic acid
62-23-7

4-nitro-benzoic acid

N-(1-methylpiperidin-4-yl)-4-nitrobenzamide
210643-97-3

N-(1-methylpiperidin-4-yl)-4-nitrobenzamide

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;92%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃;17.39%
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 35℃; for 4h;
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

3‐{[8‐(1‐methyl‐1H‐indol‐6‐yl)quinoxalin‐6‐yl]amino}pyridine‐4‐carboxylic acid

3‐{[8‐(1‐methyl‐1H‐indol‐6‐yl)quinoxalin‐6‐yl]amino}pyridine‐4‐carboxylic acid

3‐{[8‐(1‐methyl‐1H‐indol‐6‐yl)quinoxalin‐6‐yl]amino}‐N‐(1‐methylpiperidin‐4‐yl)pyridine‐4‐carboxamide

3‐{[8‐(1‐methyl‐1H‐indol‐6‐yl)quinoxalin‐6‐yl]amino}‐N‐(1‐methylpiperidin‐4‐yl)pyridine‐4‐carboxamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In 1,4-dioxane at 20℃; for 24h;92%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In 1,4-dioxane at 20℃; for 24h; Inert atmosphere;92%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

ethyl 4-chloro-3-nitrobenzoate
16588-16-2

ethyl 4-chloro-3-nitrobenzoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 70℃; for 16h;92%
1-methyl-4-aminopiperidine

1-methyl-4-aminopiperidine

cyclohexanylcarbonyl chloride
2719-27-9

cyclohexanylcarbonyl chloride

Cyclohexanecarboxylic acid (1-methyl-piperidin-4-yl)-amide

Cyclohexanecarboxylic acid (1-methyl-piperidin-4-yl)-amide

Conditions
ConditionsYield
In benzene Ambient temperature;91%
1-methyl-4-aminopiperidine
41838-46-4

1-methyl-4-aminopiperidine

3',4',5'-trimethoxycinnamoyl chloride
10263-19-1

3',4',5'-trimethoxycinnamoyl chloride

(E)-N-(1-Methyl-piperidin-4-yl)-3-(3,4,5-trimethoxy-phenyl)-acrylamide

(E)-N-(1-Methyl-piperidin-4-yl)-3-(3,4,5-trimethoxy-phenyl)-acrylamide

Conditions
ConditionsYield
In benzene Ambient temperature;91%

1-Methylpiperidin-4-amine Chemical Properties

 
IUPAC Name: 1-Methylpiperidin-4-amine
Molecular Formula: C6H14N2
Molecular Weight: 114.19 g/mol
Canonical SMILES: CN1CCC(CC1)N
InChI: InChI=1S/C6H14N2/c1-8-4-2-6(7)3-5-8/h6H,2-5,7H2,1H3
Product Categories: Pyridine; API intermediates
XLogP3-AA: -0.1  
H-Bond Donor: 1  
H-Bond Acceptor: 2
Index of Refraction: 1.469 
Molar Refractivity: 34.88 cm3 
Molar Volume: 125 cm3 
Polarizability: 13.82×10-24 cm3 
Surface Tension: 30.8 dyne/cm 
Density: 0.912 g/cm
Flash Point: 39.2 °C 
Enthalpy of Vaporization: 37.82 kJ/mol 
Boiling Point: 141 °C at 760 mmHg 
Melting Point: 203-207 °C
Vapour Pressure of 1-Methylpiperidin-4-amine (CAS NO.41838-46-4): 5.97 mmHg at 25 °C

1-Methylpiperidin-4-amine Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
Hazard Note: Irritant
HazardClass of 1-Methylpiperidin-4-amine (CAS NO.41838-46-4): Irritant

1-Methylpiperidin-4-amine Specification

 1-Methylpiperidin-4-amine (CAS NO.41838-46-4), its Synonyms are 4-Amino-1-methylpiperidine ; 1-Methyl-4-Amino Piperidine ; N-Methyl-4-aminopiperidine ; 1-(5-Bromopyrimidin-2-yl)[1,4]diazepane ; 4-Amino-1-methyl-piperidine ; 4-Amino-1-methylpiperidine 97% ; 4-Piperidinamine, 1-methyl- .

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