1-Methylsilatrane supplier | CasNO.2288-13-3

Name
METHYLSILATRANE
EINECS 218-928-1
CAS No. 2288-13-3
Article Data15
CAS DataBase
Density 1.12 g/cm³
Solubility Insoluble in water
Melting Point 152 °C
Formula C7H15 N O3 Si
Boiling Point 228.1 °C at 760 mmHg
Molecular Weight 189.286
Flash Point 91.7 °C
Transport Information
Appearance White powder
Safety Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic vapors of NO_x.
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols
Synonyms 1-Methylsilatrane;Methylsilatrane
PSA 30.93000
LogP -0.12800

Synthetic route

: 2031-67-6
Methyltriethoxysilan

: 135718-12-6
2,2-dimethyl-6-<2-(trimethylsiloxy)ethyl>-1,3,6,2-dioxazasilocane

: 2288-13-3
1-methylsilatrane

Conditions

Conditions	Yield
With sodium isopropylate In isopropyl alcohol for 20h;	85%

: 2031-67-6
Methyltriethoxysilan

: 144967-53-3
2-Methyl-6-(2-trimethylsilanyloxy-ethyl)-2-vinyl-[1,3,6,2]dioxazasilocane

: 2288-13-3
1-methylsilatrane

Conditions

Conditions	Yield
With sodium isopropylate In isopropyl alcohol for 20h;	80%

: 2031-67-6
Methyltriethoxysilan

: 118162-82-6
2-methyl-2-phenyl-6-(2-hydroxyethyl)-1,3,6,2-dioxazasilocane

: 2288-13-3
1-methylsilatrane

Conditions

Conditions	Yield
With sodium isopropylate In isopropyl alcohol for 10h;	78%

: 144967-54-4
2-methyl-2-phenyl-6-<2-(trimethylsiloxy)ethyl>-1,3,6,2-dioxazasilocane

: 2288-13-3
1-methylsilatrane

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane at 80℃; for 1h;	78%

: 75-79-6
Methyltrichlorosilane

: 20836-42-4
2,2',2''-tris(trimethylsiloxy)triethylamine

A: 75-77-4
chloro-trimethyl-silane

B: 2288-13-3
1-methylsilatrane

Conditions

Conditions	Yield
at 140 - 150℃; Yields of byproduct given;	A n/a B 77%

...Expand

: 102-71-6
triethanolamine

: C13H33O9P3Si

: 2288-13-3
1-methylsilatrane

Conditions

Conditions	Yield
In diethyl ether at 135℃; for 2h;	60%

: 102-71-6
triethanolamine

: 2031-67-6
Methyltriethoxysilan

: 2288-13-3
1-methylsilatrane

Conditions

Conditions	Yield
In xylene for 2h; Heating;	59%
at 130℃; for 4h;	14.4 g

: 2031-67-6
Methyltriethoxysilan

: 283-56-7
2,8,9-trioxa-5-aza-1-borabicyclo[3.3.3]undecane

: 2288-13-3
1-methylsilatrane

Conditions

Conditions	Yield
With sodium ethanolate In N,N-dimethyl-formamide at 140℃; for 22h;	50%

: 75-79-6
Methyltrichlorosilane

: 102-71-6
triethanolamine

: 2288-13-3
1-methylsilatrane

Conditions

Conditions	Yield
In chloroform at 0 - 20℃; Inert atmosphere;	50%

: 1185-55-3
Methyltrimethoxysilan

: 74630-95-8
tris(2-hydroxyethyl)ammonium fluoride

: 2288-13-3
1-methylsilatrane

Conditions

Conditions	Yield
Heating;	40%

: 102-71-6
triethanolamine

: 18001-76-8
1,1,2,2-tetraethoxydimethyldisilane

A: 2288-13-3
1-methylsilatrane

B: 2-Ethoxy-1,2-dimethyl-3,9,10-trioxa-6-aza-1,2-disila-bicyclo[4.3.3]dodecane

Conditions

Conditions	Yield
In acetonitrile; xylene for 10h; Heating;	A n/a B 21.7%

...Expand

: 102-71-6
triethanolamine

: 1185-55-3
Methyltrimethoxysilan

: 2288-13-3
1-methylsilatrane

: 102-71-6
triethanolamine

: 681-84-5
tetramethylorthosilicate

: 2288-13-3
1-methylsilatrane

Conditions

Conditions	Yield
In benzene for 3h; Heating;

: 102-71-6
triethanolamine

polymethylsesquisiloxane: polymethylsesquisiloxane

: 2288-13-3
1-methylsilatrane

Conditions

Conditions	Yield
With potassium hydroxide In xylene

: 102-71-6
triethanolamine

: 2288-13-3
1-methylsilatrane

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 60 percent / EtONa / ethanol; diethylamine / Heating 2: 20 percent / conc. aq. H2SO4 / 70 °C 3: 78 percent / KOH / dioxane / 1 h / 80 °C View Scheme

: 775-56-4
diethoxy-methyl-phenyl-silane

: 2288-13-3
1-methylsilatrane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 40 percent / ZnCl2 / Heating 2: 78 percent / KOH / dioxane / 1 h / 80 °C View Scheme

: 118162-82-6
2-methyl-2-phenyl-6-(2-hydroxyethyl)-1,3,6,2-dioxazasilocane

: 2288-13-3
1-methylsilatrane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 20 percent / conc. aq. H2SO4 / 70 °C 2: 78 percent / KOH / dioxane / 1 h / 80 °C View Scheme

: 2288-13-3
1-methylsilatrane

: 33446-81-0
1-chlorosilatrane

Conditions

Conditions	Yield
With Iodine monochloride In dichloromethane at 20℃; Chlorination;	38%

: 2288-13-3
1-methylsilatrane

: 33446-82-1
1-bromosilatrane

Conditions

Conditions	Yield
With bromine In dichloromethane at -5℃; Bromination;	30.1%

: 4390-10-7
2,2′-dithiobis(1-propylamine)

: 2288-13-3
1-methylsilatrane

: 124187-01-5
2-(2,8,9-Trioxa-5-aza-1-sila-bicyclo[3.3.3]undec-1-ylsulfanyl)-propylamine

Conditions

Conditions	Yield
In benzene for 3h; Heating;

: 1072-22-6
cystamine hydrochloride

: 2288-13-3
1-methylsilatrane

: 124186-99-8
2-(2,8,9-Trioxa-5-aza-1-sila-bicyclo[3.3.3]undec-1-ylsulfanyl)-ethylamine; hydrochloride

Conditions

Conditions	Yield
In benzene for 3h; Heating;

: 2288-13-3
1-methylsilatrane

A: 102-71-6
triethanolamine

B: 2445-53-6
methylsilanetriol

Conditions

Conditions	Yield
With disodium hydrogenphosphate; potassium dihydrogenphosphate at 40 - 70℃; Kinetics; Thermodynamic data; Mechanism; hydrolysis in neutral medium;

: 2288-13-3
1-methylsilatrane

: 2-(2-Chloro-2-methyl-[1,3,6,2]dioxazasilocan-6-yl)-ethanol; hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In benzene further solvents chloroform, methylene chloride;

: 2288-13-3
1-methylsilatrane

: mercury(II) iodide

: 143-36-2
methylmercury(II) iodide

Conditions

Conditions	Yield
In [(2)H6]acetone Kinetics; byproducts: ISi(OCH2CH2)3N; not isolated, reaction followed by (1)H-NMR spectroscopy;

: 2288-13-3
1-methylsilatrane

: mercury dichloride

: 115-09-3
methylmercury(II) chloride

Conditions

Conditions	Yield
In [(2)H6]acetone Kinetics; byproducts: ClSi(OCH2CH2)3N; not isolated, reaction followed by (1)H-NMR spectroscopy;
In water-d2 Kinetics; byproducts: ClSi(OCH2CH2)3N; not isolated, reaction followed by (1)H-NMR spectroscopy;
In d(4)-methanol Kinetics; byproducts: ClSi(OCH2CH2)3N; 35°C; not isolated, reaction followed by (1)H-NMR spectroscopy;

: 1878-49-5
o-methylphenoxyacetic acid

: 2288-13-3
1-methylsilatrane

: 1219360-09-4
C7H17NO4Si*C9H10O3

Conditions

Conditions	Yield
With methanol for 6h; Reflux;

1-Methylsilatrane Chemical Properties

Molecular Structure of 1-Methylsilatrane (CAS NO.2288-13-3):

IUPAC: 5-Methyl-4,6,11-trioxa-1-aza-5-silabicyclo[3.3.3]undecane
Molecular Formula:C₇H₁₅NO₃Si
Molecular Weight:189.28
EINECS:218-928-1
Density:1.12 g/cm³
Melting point:152^oC
Flash Point:110^oC
Boiling Point:174^oC
SMILES:O1CCN2CCO[Si]1(OCC2)C
InChI:InChI=1/C7H15NO3Si/c1-12-9-5-2-8(3-6-10-12)4-7-11-12/h2-7H2,1H3
InChIKey:DZLQWMNVOBAZGC-UHFFFAOYAM
Index of Refraction:1.484
Molar Volume:168.3 cm³
Surface Tension:31.4 dyne/cm
Molar Refractivity:48.23 cm³
Enthalpy of Vaporization:46.46 kJ/mol
Vapour Pressure:0.0749 mmHg at 25^oC

1-Methylsilatrane Toxicity Data With Reference

1.		orl-mus LD50:1800 mg/kg		PHARAT Pharmazie. 26 (1970),224.
2.		ipr-mus LD50:840 mg/kg		PHARAT Pharmazie. 26 (1970),224.

1-Methylsilatrane Consensus Reports

Reported in EPA TSCA Inventory.

1-Methylsilatrane Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic vapors of NO_x.

Safty informations about 1-Methylsilatrane (CAS NO.2288-13-3):
Risk Statements:22-36/37/38
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements:26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
TSCA:Yes

1-Methylsilatrane Specification

1-Methylsilatrane with cas registry number of 2288-13-3 is also known as Methylsilatrane ; 1-Methyl-2,8,9-trioxa-5-aza-1-silabicyclo(3.3.3)undecane ; 1-Methyl-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane ; 1-Methyl-2,8,9-trioxo-5-aza-1-silabicyclo(3.3.3)undecane ; 1-Methylsilatrane ; 2,8,9-Trioxa-5-aza-1-silabicyclo[3.3.3]undecane,1-methyl- ; 8,9-Trioxa-5-aza-1-silabicyclo[3.3.3]undecane,1-methyl-2 ; 9-Trioxa-5-aza-1-silabicyclo(3.3.3)undecane,1-methyl-8 . It is a compound with the appearance of white crystals or granular solid with a slight odor and it is insoluble in water. 1-Methylsilatrane is incompatible with strong oxidizing materials and probably combustible, so it should be stored in a tightly closed container when not in use and kept away from fire. 1-Methylsilatrane is used as a silane reagent in physical chemistry research.

Product Name

METHYLSILATRANE

Synthetic route

1-Methylsilatrane Chemical Properties

1-Methylsilatrane Toxicity Data With Reference

1-Methylsilatrane Consensus Reports

1-Methylsilatrane Safety Profile

1-Methylsilatrane Specification

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