Product Name

  • Name

    1-PROPOXY-2-PROPANOL

  • EINECS 250-069-8
  • CAS No. 1569-01-3
  • Article Data22
  • CAS DataBase
  • Density 0.885 g/mL at 25 °C(lit.)
  • Solubility miscible
  • Melting Point -80 C
  • Formula C6H14 O2
  • Boiling Point 140 - 160 C
  • Molecular Weight 118.176
  • Flash Point 48 C
  • Transport Information HAZARD
  • Appearance clear liquid
  • Safety
  • Risk Codes R10; R36/37/38
  • Molecular Structure Molecular Structure of 1569-01-3 (1-PROPOXY-2-PROPANOL)
  • Hazard Symbols UN NO.
  • Synonyms 1,2-Propyleneglycol 1-propyl ether; 1-Propoxy-2-propanol; Arcosolv PNP
  • PSA 29.46000
  • LogP 0.79380

Synthetic route

propan-1-ol
71-23-8

propan-1-ol

methyloxirane
75-56-9, 16033-71-9

methyloxirane

1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

Conditions
ConditionsYield
With Al2O3/MgO composite at 120℃; Inert atmosphere;34.4%
With KAcMIMOH at 60℃; for 4h;
With hematite at 160℃; for 8h; Autoclave;
propan-1-ol
71-23-8

propan-1-ol

methyloxirane
75-56-9, 16033-71-9

methyloxirane

A

2-propoxy-1-propanol
10215-30-2

2-propoxy-1-propanol

B

1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

Conditions
ConditionsYield
at 100 - 200℃;
at 180 - 205℃;
With sulfuric acid Yield given. Yields of byproduct given;
...Expand
sodium n-propoxide
6819-41-6

sodium n-propoxide

methyloxirane
75-56-9, 16033-71-9

methyloxirane

1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

Allyl glycidyl ether
106-92-3

Allyl glycidyl ether

A

3-Propoxy-1,2-epoxypropan
3126-95-2

3-Propoxy-1,2-epoxypropan

B

1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

Conditions
ConditionsYield
With hydrogen; 5percent Pd/C(en) In tetrahydrofuran at 20℃; for 2.5h; Catalytic hydrogenation; Title compound not separated from byproducts.;
propylene glycol
57-55-6

propylene glycol

A

propan-1-ol
71-23-8

propan-1-ol

B

Dipropyl ether
111-43-3

Dipropyl ether

C

2-propoxy-1-propanol
10215-30-2

2-propoxy-1-propanol

D

1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; hydrogen; [{CpRu(CO)2}2(μ-H)](+)*OTf(-); cyclopenta-1,3-diene In sulfolane at 110℃; under 39003.1 Torr; for 30h; Product distribution;A 54 % Chromat.
B 15 % Chromat.
C n/a
D n/a
...Expand
propylene glycol
57-55-6

propylene glycol

A

propan-1-ol
71-23-8

propan-1-ol

B

2-ethyl-4-methyl-1,3-dioxolane
4359-46-0

2-ethyl-4-methyl-1,3-dioxolane

C

Dipropyl ether
111-43-3

Dipropyl ether

D

2-propoxy-1-propanol
10215-30-2

2-propoxy-1-propanol

E

1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

F

propionaldehyde
123-38-6

propionaldehyde

Conditions
ConditionsYield
With bis(dicarbonyl)(μ-hydrido)(pentamethylcyclopentadiene)ruthenium trifluoromethanesulfonate; trifluorormethanesulfonic acid; hydrogen In sulfolane at 110℃; under 38787.1 Torr; for 30h; Mechanism; Kinetics; Solvent; Pressure; Concentration; Temperature; Time; regioselective reaction;A 54 %Chromat.
B n/a
C n/a
D n/a
E n/a
F n/a
...Expand
propylene glycol
57-55-6

propylene glycol

A

propan-1-ol
71-23-8

propan-1-ol

B

propyl propionate
106-36-5

propyl propionate

C

propane
74-98-6

propane

D

2-propoxy-1-propanol
10215-30-2

2-propoxy-1-propanol

E

1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

F

propionic acid
802294-64-0

propionic acid

G

1,3,5-trimethyl-benzene
108-67-8

1,3,5-trimethyl-benzene

Conditions
ConditionsYield
With [C6H3-2,6-(OP(tBu)2)2]IrH2; trifluorormethanesulfonic acid; hydrogen In 1,4-dioxane at 125℃; under 5171.62 Torr; Autoclave;
...Expand
1-propoxy-2-propanyl formate

1-propoxy-2-propanyl formate

A

formic acid
64-18-6

formic acid

B

1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

Conditions
ConditionsYield
With water at 80℃; for 24h; Equilibrium constant; Sealed tube;
1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

N’-(5-bromo-6-hydroxy-2-methyl-3-pyridyl)-N-ethyl-N-methyl-formamidine
1056233-21-6

N’-(5-bromo-6-hydroxy-2-methyl-3-pyridyl)-N-ethyl-N-methyl-formamidine

N’-[5-bromo-2-methyl-6-[1-methyl-2-propoxy-ethoxy]-3-pyridyl]-N-ethyl-N-methyl-formamidine

N’-[5-bromo-2-methyl-6-[1-methyl-2-propoxy-ethoxy]-3-pyridyl]-N-ethyl-N-methyl-formamidine

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20 - 40℃; for 1.66667h; Inert atmosphere;95%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 1.5h; Inert atmosphere;95%
methanol
67-56-1

methanol

1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

1-propoxy-2-propanyl formate

1-propoxy-2-propanyl formate

Conditions
ConditionsYield
With [bis({2‐[bis(propan‐2‐yl)phosphanyl]ethyl})amine](borohydride)(carbonyl)(hydride)iron(II); methacrylic acid methyl ester In toluene at 140℃; under 13689.1 Torr; for 4h; Autoclave; Inert atmosphere;71%
3-bromo-6-methyl-5-nitro-pyridin-2-ol
874493-25-1

3-bromo-6-methyl-5-nitro-pyridin-2-ol

1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-nitro-pyridine

5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-nitro-pyridine

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 40 - 65℃; for 12h; Inert atmosphere;60%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 65℃; for 12h; Inert atmosphere;60%
1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

N’-(5-chloro-6-hydroxy-2-methyl-3-pyridyl)-N-ethyl-N-methyl-formamidine

N’-(5-chloro-6-hydroxy-2-methyl-3-pyridyl)-N-ethyl-N-methyl-formamidine

N’-[5-chloro-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine

N’-[5-chloro-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 40 - 60℃; for 25h; Inert atmosphere;53%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 60℃; for 25h; Inert atmosphere;53%
1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

1-propoxy-propan-2-one
68058-77-5

1-propoxy-propan-2-one

Conditions
ConditionsYield
With sodium dichromate; sulfuric acid at 4 - 5℃;
1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

water
7732-18-5

water

Na2Cr2O7

Na2Cr2O7

1-propoxy-propan-2-one
68058-77-5

1-propoxy-propan-2-one

Conditions
ConditionsYield
at 4 - 5℃;
...Expand
1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

propoxy-acetone-phenylhydrazone

propoxy-acetone-phenylhydrazone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Na2Cr2O7; diluted H2SO4 / 4 - 5 °C
View Scheme
1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

carbonic acid dimethyl ester
616-38-6

carbonic acid dimethyl ester

A

propylpropylene glycol(2) methyl ether
4188-67-4

propylpropylene glycol(2) methyl ether

B

C8H16O4
1220964-45-3

C8H16O4

Conditions
ConditionsYield
With sodium methylate at 90℃; under 750.075 Torr; for 20h; Inert atmosphere;A 9 %Chromat.
B 91 %Chromat.
...Expand
1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)pyridin-3-amine

5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)pyridin-3-amine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 40 - 65 °C / Inert atmosphere
2: ammonium chloride; iron / ethanol; water / 14 h / 85 °C
View Scheme
Multi-step reaction with 2 steps
1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 12 h / 65 °C / Inert atmosphere
2: ammonium chloride; iron / ethanol; water / 14 h / 85 °C
View Scheme
1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

N’-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-formamidine

N’-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-formamidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 40 - 65 °C / Inert atmosphere
2.1: ammonium chloride; iron / ethanol; water / 14 h / 85 °C
3.1: trichlorophosphate / dichloromethane / 1 h / 20 °C
3.2: 2 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 12 h / 65 °C / Inert atmosphere
2.1: ammonium chloride; iron / ethanol; water / 14 h / 85 °C
3.1: trichlorophosphate / dichloromethane / 1 h / 20 °C
3.2: 2 h / 20 °C
View Scheme
1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

N’-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-isopropyl-N-methylformamidine

N’-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-isopropyl-N-methylformamidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 40 - 65 °C / Inert atmosphere
2.1: ammonium chloride; iron / ethanol; water / 14 h / 85 °C
3.1: trichlorophosphate / dichloromethane / 1 h / 20 °C
3.2: 2 h / 20 °C
View Scheme
1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

N’-(5-bromo-6-hydroxy-2-methyl-3-pyridyl)-N-ethyl-N-methyl-formamidine
1056233-21-6

N’-(5-bromo-6-hydroxy-2-methyl-3-pyridyl)-N-ethyl-N-methyl-formamidine

N’-[5-cyano-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine

N’-[5-cyano-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 1.67 h / 20 - 40 °C / Inert atmosphere
2: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 18 h / 120 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere
2: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 18 h / 120 °C / Inert atmosphere
View Scheme
formic acid
64-18-6

formic acid

1-(1-propyloxy)propan-2-ol
1569-01-3

1-(1-propyloxy)propan-2-ol

1-propoxy-2-propanyl formate

1-propoxy-2-propanyl formate

Conditions
ConditionsYield
at 80℃; for 24h; Equilibrium constant; Sealed tube;

1-PROPOXY-2-PROPANOL Chemical Properties

Synonyms: PNP;2-Propanol, 1-propoxy-;PROPYLENE GLYCOL PROPYL ETHER;PROPYLENE GLYCOL MONOPROPYL ETHER;PROPYLENE GLYCOL NORMAL PROPYL ETHER;ethermonopropyliquenormaldupropyleneglycol ;1-propoxy-2-propano;1-propoxy-propan-2-ol;
The Molecular formula of 1-PROPOXY-2-PROPANOL(1569-01-3): C6H14O2
The Molecular Weight of 1-PROPOXY-2-PROPANOL(1569-01-3): 118.17
Molecular Structure : 
EINECS: 216-372-4
Boiling point: 140-160 °C(lit.)
Flash point: 119 °F
density: 0.885 g/mL at 25 °C(lit.)
refractive index: n20/D 1.411(lit.)

1-PROPOXY-2-PROPANOL Toxicity Data With Reference

1.   

skn-rbt 500 mg

   VHTODE    Veterinary and Human Toxicology. 30 (1988),126.
2.   

eye-rbt 100 mg MOD

   VHTODE    Veterinary and Human Toxicology. 30 (1988),126.
3.   

orl-rat LD50:2504 mg/kg

   VHTODE    Veterinary and Human Toxicology. 30 (1988),126.
4.   

skn-rbt LD50:3550 mg/kg

   38MKAJ    Pattys Industrial Hygiene and Toxicology. 2C (1982),3983.

1-PROPOXY-2-PROPANOL Consensus Reports

Reported in EPA TSCA Inventory.

1-PROPOXY-2-PROPANOL Safety Profile

Moderately toxic by ingestion and skin contact. A skin and eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
The Hazard Codes of 1-PROPOXY-2-PROPANOL(1569-01-3):   Xi
The Risk Statements information of 1-PROPOXY-2-PROPANOL(1569-01-3):
10:  Flammable 
36/37/38:  Irritating to eyes, respiratory system and skin 
The Safety Statements information of 1-PROPOXY-2-PROPANOL(1569-01-3):
16:  Keep away from sources of ignition - No smoking 
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice  
36:  Wear suitable protective clothing 
RIDADR: UN 3271 3/PG 3

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