1H-Pyrazole-1-carboxamidine hydrochloride supplier

Name
1H-Pyrazole-1-carboxamidine hydrochloride
EINECS 429-520-1
CAS No. 4023-02-3
Article Data10
CAS DataBase
Density 2.2 g/cm3
Solubility Soluble in water
Melting Point 167-170 °C(lit.)
Formula C₄H₆N₄^.HCl
Boiling Point 891.5oC at 760 mmHg。产品描述安全性：
Molecular Weight 146.579
Flash Point 493oC
Transport Information
Appearance white to light yellow crystals or crystalline
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 1H-Pyrazole-1-carboximidamide,monohydrochloride (9CI);Pyrazole-1-carboxamidine, hydrochloride (7CI,8CI);1H-Pyrazole-1-carboxamidine hydrochloride;Pyrazole-1-carboximidamidehydrochloride;
PSA 67.69000
LogP 1.22670

Synthetic route

: 152120-61-1
tert-butyl (1H-pyrazol-1-ylcarbonoimidoyl)carbamate

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

Conditions

Conditions	Yield
With sulfuric acid; sodium chloride In neat (no solvent) at 20℃; for 3h; Sealed tube;	99%

: 420-04-2
CYANAMID

: 35877-22-6
1H-pyrazole hydrochloride

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

Conditions

Conditions	Yield
at 80℃; for 0.1h;	98%

: 288-13-1
NH-pyrazole

: 420-04-2
CYANAMID

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane for 2h; Heating;	95%
With hydrogenchloride In 1,4-dioxane for 2h; Heating;	90%
With hydrogenchloride In 1,4-dioxane for 1h; Reflux;	43%
With hydrogenchloride In 1,4-dioxane
With hydrogenchloride In 1,4-dioxane

: 102-52-3
malonaldehydebis(dimethylacetal)

: 2582-30-1
aminoguanidine bicarbonate

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water at 20 - 45℃;	70.3%

: 102-52-3
malonaldehydebis(dimethylacetal)

: 1937-19-5
1-aminoguanidine hydrochloride

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

Conditions

Conditions	Yield
In water at 45℃; for 1h;

: 24424-99-5
di-tert-butyl dicarbonate

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 152120-61-1
tert-butyl (1H-pyrazol-1-ylcarbonoimidoyl)carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 2h;	100%
With triethylamine In dichloromethane; N,N-dimethyl-formamide at 4 - 20℃; for 8h; Inert atmosphere;	91%
With potassium carbonate In water; acetone at 20℃;	88%

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: (1S,3R)-3-amino-cyclopentanecarboxylic acid methyl ester hydrochloride

: 959680-24-1
methyl (1S,3R)-3-carbamimidamidocyclopentane-1-carboxylate

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 70℃; for 4h;	100%

: 298681-03-5
1-[4-[[(2-pyridinylmethyl)amino]methyl]phenyl]methylamine

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: C15H19N5

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 2h;	100%

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 103-67-3
benzyl-methyl-amine

: 330-69-8
N-benzyl-N-methylguanidine hydrochloride

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	100%
With N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethyl-formamide) at 20℃;	100%

: 893433-60-8
1-(2-aminoethyl)-5,5-dimethyl-imidazolidine-2,4-dione

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 893433-72-2
N-[2-(5,5-dimethyl-2,4-dioxo-imidazolidin-1-yl)-ethyl]-guanidine hydrochloride

Conditions

Conditions	Yield
In acetonitrile for 16h; Heating / reflux;	100%

: 57260-73-8
N-BOC-1,2-diaminoethane

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: guanidine N-[2-(amidinoamino)ethyl](tert-butoxy)carboxamide, hydrochloride

Conditions

Conditions	Yield
In acetonitrile	100%

: 1204587-47-2
N1,N1'-(1,10-phenanthroline-4,7-diyl)dibutane-1,4-diamine

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 1204587-52-9
1,1'-(4,4'-(1,10-phenanthroline-4,7-diyl)bis(azanediyl)bis(butane-4,1-diyl))diguanidine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 60℃;	100%

: 1204587-46-1
N1,N1'-(1,10-phenanthroline-4,7-diyl)diethane-1,2-diamine

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 1204587-50-7
1,1'-(2,2'-(1,10-phenanthroline-4,7-diyl)bis(azanediyl)bis(ethane-2,1-diyl))diguanidine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 60℃;	100%

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 156492-35-2
N1,N1'-(1,10-phenanthroline-4,7-diyl)dipropane-1,3-diamine

: 1204587-51-8
1,1'-(3,3'-(1,10-phenanthroline-4,7-diyl)bis(azanediyl)bis(propane-3,1-diyl))diguanidine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 60℃;	100%

: 51644-96-3
5-tert-butoxycarbonylamino-1-aminopentane

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 76-05-1
trifluoroacetic acid

: tert-butyl N-(5-guanidinopentyl)carbamate trifluoroacetate

Conditions

Conditions	Yield
Stage #1: 5-tert-butoxycarbonylamino-1-aminopentane; 1H-pyrazole-1-carboximidamide hydrochloride With triethylamine In dichloromethane at 20℃; Inert atmosphere; Stage #2: trifluoroacetic acid	100%

...Expand

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 152943-97-0
4-(2-methoxy-phenyl)-[1,4]diazepane-1-carboxylic acid tret-butyl ester

: C13H20N4O

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃;	100%

: 4-(3-aminopropoxy)-N-(2-phenoxyphenyl)benzamide

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 76-05-1
trifluoroacetic acid

: N-(2-phenoxyphenyl)-4-(3-guanidinopropoxy)benzamide trifluoroacetate

Conditions

Conditions	Yield
Stage #1: 4-(3-aminopropoxy)-N-(2-phenoxyphenyl)benzamide; 1H-pyrazole-1-carboximidamide hydrochloride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 44h; Inert atmosphere; Stage #2: trifluoroacetic acid In water; acetonitrile	100%

...Expand

: (10H-phenoxazin-10-yl)(4-(3-aminopropoxy))phenylmethanone

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 76-05-1
trifluoroacetic acid

: (10H-phenoxazin-10-yl)(4-(3-guanidinopropoxy))phenylmethanone trifluoroacetate

Conditions

Conditions	Yield
Stage #1: (10H-phenoxazin-10-yl)(4-(3-aminopropoxy))phenylmethanone; 1H-pyrazole-1-carboximidamide hydrochloride With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 44h; Inert atmosphere; Stage #2: trifluoroacetic acid In water; acetonitrile	100%

...Expand

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 246266-26-2
(6S,11Z,13S)-6-amino-8-(1',3'-dioxan-2'-yl)-2-methyl-13-triisopropylsiloxypentadeca-2,11-diene

: N-{(S)-5-Methyl-1-[2-((Z)-(S)-5-triisopropylsilanyloxy-hept-3-enyl)-[1,3]dioxan-2-ylmethyl]-hex-4-enyl}-guanidine; hydrochloride

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide	99%

4-aminophenyl-cellulose: 4-aminophenyl-cellulose

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

4-[1-(1H-pyrazol-1-yl-iminomethyl)triazen-3-yl]phenyl-cellulose: 4-[1-(1H-pyrazol-1-yl-iminomethyl)triazen-3-yl]phenyl-cellulose

Conditions

Conditions	Yield
Stage #1: 4-aminophenyl-cellulose With hydrogenchloride; sodium nitrite In water at 0℃; for 3h; Stage #2: 1H-pyrazole-1-carboximidamide hydrochloride With sodium hydrogencarbonate In water at 0 - 20℃; for 15h;	99%

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 2937-50-0
Allyl chloroformate

: 277334-62-0
1H-pyrazole-N-allyloxycarbonyl-1-carboxamidine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 4h;	99%

: 38212-33-8
4-(4-chlorophenyl) piperazine

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 17238-60-7
4-(4-chloro-phenyl)-piperazine-1-carboximidic acid amide

Conditions

Conditions	Yield
Stage #1: 4-(4-chlorophenyl) piperazine; 1H-pyrazole-1-carboximidamide hydrochloride With N-ethyl-N,N-diisopropylamine In ethanol for 7h; Heating / reflux; Stage #2: With water In ethanol	99%

: 111-86-4
n-Octylamine

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: octylguanidinium chloride

Conditions

Conditions	Yield
In neat (no solvent) at 25℃; for 0.17h; Sonication;	99%
In acetonitrile for 3h; Reflux;	59%
In ethanol at 35℃; for 48h;

4-methoxy-N-methylbenzylamine: 4-methoxy-N-methylbenzylamine

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 1344719-01-2
N-[(4-methoxyphenyl)methyl]-N-methylguanidine hydrochloride

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;	98%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;	45%

: 4-azatetracyclo[5.4.2.02,6.08.11]tridecane hydrochloride

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 4-amidino-4-azatetracyclo[5.4.2.02,6.08.11]tridecane hydrochloride

Conditions

Conditions	Yield
With triethylamine In acetonitrile for 6h; Reflux;	98%

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 1011-15-0
1-(o-fluorophenyl)piperazine

: 77723-19-4
4-(4-fluorophenyl)piperazine-1-carboximidamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃;	97%

: 1397-89-3
AmBisome

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 1033521-39-9
guanidine-AmB

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;	97%

: 18342-66-0
2,5-dioxopyrrolidin-1-yl methylcarbamate

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: N'-(N-methylcarbamoyl)-1H-pyrazole-1-carboxamidine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 9h; Inert atmosphere;	97%

: C106H140N10S

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: C114H156N26S

Conditions

Conditions	Yield
Stage #1: C106H140N10S With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; methanol at 20℃; for 1h; Stage #2: 1H-pyrazole-1-carboximidamide hydrochloride In tetrahydrofuran; methanol at 20℃; for 24h;	97%

: 208642-83-5
3-[3-(5-chloro-2-methoxyphenylsulfonyloxy)-5-methylphenoxy]propoxyamine

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 3-[3-(5-chloro-2-methoxyphenylsulfonyloxy)-5-methylphenoxy]propoxyguanidine hydrochloride

Conditions

Conditions	Yield
In N,N-dimethyl-formamide; acetonitrile	96%

: 1192471-20-7
5-(4-aminobutoxy)-2-(6-aminohexanamido)-N-(4-phenoxyphenyl)benzamide

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 5-(4-guanidinobutoxy)-2-(6-guanidinohexanamido)-N-(4-phenoxyphenyl)benzamide dihydrochloride

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide Inert atmosphere;	96%

: 3-azatetracyclo[5.2.1.15,8.01,5]undecane hydrochloride

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 3-amidino-3-azatetracyclo[5.2.1.15,8.01,5]undecane hydrochloride

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 70℃; for 6h;	96%

: 121194-34-1
1-(4-methylphenyl)-3,3,3-trifluoropropan-1-one

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 4-fluoro-2-(1H-pyrazol-1-yl)-6-(p-tolyl)pyrimidine

Conditions

Conditions	Yield
With potassium hydrogencarbonate In 1,4-dioxane at 60℃;	96%

1H-Pyrazole-1-carboxamidine hydrochloride Specification

The 1H-Pyrazole-1-carboxamidine hydrochloride with cas registry number of 4023-02-3, belongs to the following product categories: (1)Pyrazoles & Triazoles; (2)Miscellaneous Reagents; (3)Pyrazoles & Triazoles. It has the systematic name of pyrazole-1-carboxamidine hydrochloride.

Preparation: this chemical can be prepared by 1H-pyrazole and cyanamide. This reaction will need reagent 4N HCl and solvent dioxane.

Uses of 1H-Pyrazole-1-carboxamidine hydrochloride: it can be used to produce piperidine-1-carboxamidine; hydrochloride. This reaction will need reagent DIEA and solvent dimethylformamide. The reaction time is 4 hour(s). The yield is about 71%.

When you are using this chemical, please be cautious about it as the following:
The 1H-Pyrazole-1-carboxamidine hydrochloride irritates to eyes, respiratory system and skin. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice.In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) Besides this, it may cause burns.

You can still convert the following datas into molecular structure:
(1)SMILES: c1cnn(c1)C(=N)N.Cl;
(2)InChI: InChI=1/C4H6N4.ClH/c5-4(6)8-3-1-2-7-8;/h1-3H,(H3,5,6);1H;
(3)InChIKey: RBZRMBCLZMEYEH-UHFFFAOYAF;
(4)Std. InChI: InChI=1S/C4H6N4.ClH/c5-4(6)8-3-1-2-7-8;/h1-3H,(H3,5,6);1H;
(5)Std. InChIKey: RBZRMBCLZMEYEH-UHFFFAOYSA-N

Product Name

1H-Pyrazole-1-carboxamidine hydrochloride

Synthetic route

1H-Pyrazole-1-carboxamidine hydrochloride Specification

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