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LIDE PHARMACEUTICALS LIMITED

Lide pharmaceuticals limited is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of pharmaceutica

Amphotericin B

Cas:1397-89-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Josun International Limited

Dear Friend, welcome you choose us ! And thank you very much for trust us! We are one professional APIs and Chemicals supplier, we can provide you with good price and good service, ======================================================

API Amphotericin B oral or injection grade

Cas:1397-89-3

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Sinoway Industrial Co., Ltd.

Good production capacity, high qulaity with competitive price. Export in large qty to USA and european markets. Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier .

Best price for amphotericin B

Cas:1397-89-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 100.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Amphotericin B

Cas:1397-89-3

Min.Order:1

Negotiable

Type:Other

inquiry

Kono Chem Co.,Ltd

Superiority kono chem is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best

Glucose pentaacetate CAS.1397-89-3

Cas:1397-89-3

Min.Order:5000 Kilogram

FOB Price: $25.0 / 50.0

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Amphotericin B 1397-89-3 ISO Producer

Cas:1397-89-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Amphotericin B

Cas:1397-89-3

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c

Amphotericin B 1397-89-3 /manufacturer/low price/high quality/in stock

Cas:1397-89-3

Min.Order:1 Kilogram

FOB Price: $15.0 / 16.0

Type:Lab/Research institutions

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Amphotericin B 1397-89-3 supplier

Cas:1397-89-3

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

inquiry

Chemwill Asia Co., Ltd.

Amphotericin B -- CHemwill

Cas:1397-89-3

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Amphotericin B CAS NO:1397-89-3 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability

Amphotericin B CAS:1397-89-3 Chinese manufacturers high-quality

Cas:1397-89-3

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: Amphotericin B Synonyms: ABELCET;AMBISOME;AMPHOTERCIN B;AMPHOTERICIN B;AMPHOTERICIN B SOLUBILIZED;AMPHOTERICIN B, SOLUBLE;AMPHOTERICIN B, STREPTOMYCES NODOSUS;AMPHOTERICIN B, STREPTOMYCES SPECIES CAS: 1397-89-3

1397-89-3 Amphotericin B

Cas:1397-89-3

Min.Order:1 Gram

FOB Price: $8900.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Amphotericin B CAS 1397-89-3

Cas:1397-89-3

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 1397-89-3 with competitive price

Cas:1397-89-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Amphotericin B CAS1397-89-3

Cas:1397-89-3

Min.Order:1 Kilogram

FOB Price: $280.0 / 499.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

CAS1397-89-3 Amphotericin B

Cas:1397-89-3

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:Yellow to orange powder Storage:R.T Package:25kg/drum Application:Antifungal Transportation:Express/Sea/Air Port:Any port in China

API Amphotericin B cas 1397-89-3

Cas:1397-89-3

Min.Order:1 Kilogram

FOB Price: $950.0 / 1400.0

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white powder Storage:Store in sealed containers at cool & d

USP standard CAS 1397-89-3 Amphotericin B

Cas:1397-89-3

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Amphotericin B 1397-89-3

Cas:1397-89-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

Pharmaceutical Raw Material Amphotericin B

Cas:1397-89-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:yellow powder / Refer to COA Storage: 2-8°C Pa

Antibiotics Amphotericin B 1397-89-3 cas FUNGIZONE

Cas:1397-89-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

China Factory Manufacturer Supply Amphotericin B CAS 1397-89-3

Cas:1397-89-3

Min.Order:1 Gram

FOB Price: $1.0 / 5.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Amphotericin B Polyene drugs

Cas:1397-89-3

Min.Order:10 Gram

FOB Price: $6.0 / 8.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Amphotericin B CAS:1397-89-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

Amphotericin B CAS:1397-89-3

Cas:1397-89-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Amphotericin B

Cas:1397-89-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Amphotericin B

Cas:1397-89-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanxi Ankesi Biotechnology Co., Ltd

Our Advantage 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good qual

Best price Amphotericin B CAS 1397-89-3 AKS

Cas:1397-89-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:white or yellowish white flaky crystal Storage:Keep the sun from direct sunlight ;prevention against high temperature Package:As customer request Application:Used for research and industrial manufacture. Transportatio

Amphotericin BCAS: 1397-89-3

Cas:1397-89-3

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Amphotericin B

Cas:1397-89-3

Min.Order:1 Gram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

inquiry

Synthetic route

amphotericin B methyl ester
36148-89-7

amphotericin B methyl ester

AmBisome
1397-89-3

AmBisome

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran; water at 25℃; for 1h;80%
4-formylphenylcarbonyl-terminated poly(ethylene glycol)-poly[Nε-(4-formylphenyl-carbonyl)-L-lysine] amphotericin B Schiff's base, block copolymer, Mw = 26700, Mw/Mn = 1.11

4-formylphenylcarbonyl-terminated poly(ethylene glycol)-poly[Nε-(4-formylphenyl-carbonyl)-L-lysine] amphotericin B Schiff's base, block copolymer, Mw = 26700, Mw/Mn = 1.11

AmBisome
1397-89-3

AmBisome

Conditions
ConditionsYield
With water In phosphate buffer at 37℃; pH=5.5; Kinetics;
N-(4-carboxybenzylidene)amphotericin B

N-(4-carboxybenzylidene)amphotericin B

AmBisome
1397-89-3

AmBisome

Conditions
ConditionsYield
With phosphate buffer In methanol at 37℃; pH=5.5; Kinetics; Acid hydrolysis;
poly(ethylene glycol), Mw 10000 (of polyethylene glycol chain), conjugated with amphotericin B through O,O'-bis(1,4-C(O)C6H4-C=)-linker, in molar ratio 1:2

poly(ethylene glycol), Mw 10000 (of polyethylene glycol chain), conjugated with amphotericin B through O,O'-bis(1,4-C(O)C6H4-C=)-linker, in molar ratio 1:2

AmBisome
1397-89-3

AmBisome

Conditions
ConditionsYield
With phosphate buffer In methanol at 37℃; pH=5.5; Kinetics; Acid hydrolysis;
poly(ethylene glycol), Mw 20000 (of polyethylene glycol chain), conjugated with amphotericin B through O,O'-bis-(1,4-C(O)C6H4-C=)-linker, in molar ratio 1:2

poly(ethylene glycol), Mw 20000 (of polyethylene glycol chain), conjugated with amphotericin B through O,O'-bis-(1,4-C(O)C6H4-C=)-linker, in molar ratio 1:2

AmBisome
1397-89-3

AmBisome

Conditions
ConditionsYield
With phosphate buffer In methanol at 37℃; pH=5.5; Kinetics; Acid hydrolysis;
O-methylpoly(ethylene glycol), Mw 5000 (of polyethylene glycol chain), conjugated with amphotericin B through O'-(1,4-C6H4-CH=)-linker

O-methylpoly(ethylene glycol), Mw 5000 (of polyethylene glycol chain), conjugated with amphotericin B through O'-(1,4-C6H4-CH=)-linker

AmBisome
1397-89-3

AmBisome

Conditions
ConditionsYield
With phosphate buffer In methanol at 37℃; pH=5.5; Kinetics; Acid hydrolysis;
O-methylpoly(ethylene glycol), Mw 5000 (of polyethylene glycol chain), conjugated with amphotericin B through O'-(1,4-CH2CH2NHCOC6H4C=)-linker

O-methylpoly(ethylene glycol), Mw 5000 (of polyethylene glycol chain), conjugated with amphotericin B through O'-(1,4-CH2CH2NHCOC6H4C=)-linker

AmBisome
1397-89-3

AmBisome

Conditions
ConditionsYield
With phosphate buffer In methanol at 37℃; pH=5.5; Kinetics; Acid hydrolysis;
O-methylpoly(ethylene glycol), Mw 5000 (of polyethylene glycol chain), conjugated with amphotericin B through O'-(1,4-C(O)C6H4-C=)-linker

O-methylpoly(ethylene glycol), Mw 5000 (of polyethylene glycol chain), conjugated with amphotericin B through O'-(1,4-C(O)C6H4-C=)-linker

AmBisome
1397-89-3

AmBisome

Conditions
ConditionsYield
With phosphate buffer In methanol at 37℃; pH=5.5; Kinetics; Acid hydrolysis;
C55H85NO17

C55H85NO17

AmBisome
1397-89-3

AmBisome

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) CSA; 2.) H2O / 1.) MeOH, 25 deg C, 2 h; 2.) MeOH, 25 deg C, 4 h
2: 80 percent / LiOH / tetrahydrofuran; H2O / 1 h / 25 °C
View Scheme
C55H83N3O17

C55H83N3O17

AmBisome
1397-89-3

AmBisome

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90 percent / HS(CH2)3SH, Et3N / methanol / 24 h / 25 °C
2: 1.) CSA; 2.) H2O / 1.) MeOH, 25 deg C, 2 h; 2.) MeOH, 25 deg C, 4 h
3: 80 percent / LiOH / tetrahydrofuran; H2O / 1 h / 25 °C
View Scheme
amphotericin B methyl pivalate
1112349-87-7

amphotericin B methyl pivalate

AmBisome
1397-89-3

AmBisome

Conditions
ConditionsYield
With water In dimethyl sulfoxide at 37℃; pH=7; Phosphate buffer; Enzymatic reaction;
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

AmBisome
1397-89-3

AmBisome

3′-N-Fmoc-AmB
127970-81-4

3′-N-Fmoc-AmB

Conditions
ConditionsYield
With pyridine In N,N-dimethyl-formamide at 20℃; for 18h;100%
With pyridine In methanol; N,N-dimethyl-formamide at 23℃; for 4h;99%
With pyridine In methanol; N,N-dimethyl-formamide at 20℃; for 12h;95%
N-(allyloxycarbonyloxy)succinimide
135544-68-2

N-(allyloxycarbonyloxy)succinimide

AmBisome
1397-89-3

AmBisome

C51H77NO19

C51H77NO19

Conditions
ConditionsYield
With pyridine In methanol; N,N-dimethyl-formamide at 23℃; for 16h; Inert atmosphere;100%
In methanol; N,N-dimethyl-formamide at 23℃; for 16h;100%
With pyridine In methanol; N,N-dimethyl-formamide at 23℃; Inert atmosphere;99%
N-(allyloxycarbonyloxy)succinimide
135544-68-2

N-(allyloxycarbonyloxy)succinimide

AmBisome
1397-89-3

AmBisome

C50H75NO19

C50H75NO19

Conditions
ConditionsYield
With pyridine In methanol; N,N-dimethyl-formamide99%
AmBisome
1397-89-3

AmBisome

1H-pyrazole-1-carboximidamide hydrochloride
4023-02-3

1H-pyrazole-1-carboximidamide hydrochloride

guanidine-AmB
1033521-39-9

guanidine-AmB

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;97%
AmBisome
1397-89-3

AmBisome

amphotericin B

amphotericin B

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine In dimethyl sulfoxide at 23 - 25℃; for 24h; Reagent/catalyst; Solvent; Inert atmosphere; Darkness;97%
AmBisome
1397-89-3

AmBisome

benzylamine
100-46-9

benzylamine

amphotericin B N-benzylamide

amphotericin B N-benzylamide

Conditions
ConditionsYield
With diphenyl phosphoryl azide; triethylamine In N,N-dimethyl acetamide at 20℃;95.5%
With triethylamine In N,N-dimethyl acetamide at 20℃; Inert atmosphere;
3-Aminomethylpyridine
3731-52-0

3-Aminomethylpyridine

AmBisome
1397-89-3

AmBisome

amphotericin B 3-pyridylamide

amphotericin B 3-pyridylamide

Conditions
ConditionsYield
With diphenyl phosphoryl azide; triethylamine In N,N-dimethyl acetamide at 20℃; Darkness; Inert atmosphere;95.09%
N-cyclohexylmaleimide
1631-25-0

N-cyclohexylmaleimide

AmBisome
1397-89-3

AmBisome

N-(N-cyclohexylsuccinimidyl)-amphotericin B

N-(N-cyclohexylsuccinimidyl)-amphotericin B

Conditions
ConditionsYield
Michael Addition;94.6%
AmBisome
1397-89-3

AmBisome

amphotericin B N-(D)-methoxytryptophanamide

amphotericin B N-(D)-methoxytryptophanamide

Conditions
ConditionsYield
With diphenyl phosphoryl azide; triethylamine In N,N-dimethyl acetamide at 20℃;93.85%
O-tert-Butyl-D-serine
18783-53-4

O-tert-Butyl-D-serine

AmBisome
1397-89-3

AmBisome

N-(O-tert-butyl-D-seryl)amphotericin B

N-(O-tert-butyl-D-seryl)amphotericin B

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide93.3%
N-(2,6-dimethylphenyl)maleimide
1206-49-1

N-(2,6-dimethylphenyl)maleimide

AmBisome
1397-89-3

AmBisome

N-(N-2,6-dimethylphenylsuccinimidyl)-amphotericin B

N-(N-2,6-dimethylphenylsuccinimidyl)-amphotericin B

Conditions
ConditionsYield
Michael Addition;92.2%
O,O'-bis(4-formylphenylcarbonyl)poly(ethylene)glycol, Mw 20000 (of polyethylene glycol chain)

O,O'-bis(4-formylphenylcarbonyl)poly(ethylene)glycol, Mw 20000 (of polyethylene glycol chain)

AmBisome
1397-89-3

AmBisome

poly(ethylene glycol), Mw 20000 (of polyethylene glycol chain), conjugated with amphotericin B through O,O'-bis-(1,4-C(O)C6H4-C=)-linker, in molar ratio 1:2

poly(ethylene glycol), Mw 20000 (of polyethylene glycol chain), conjugated with amphotericin B through O,O'-bis-(1,4-C(O)C6H4-C=)-linker, in molar ratio 1:2

Conditions
ConditionsYield
With 4 A molecular sieve; trimethyl orthoformate In N,N-dimethyl-formamide at 20℃;92%
histamine
51-45-6

histamine

AmBisome
1397-89-3

AmBisome

amphotericin B N-histaminamide

amphotericin B N-histaminamide

Conditions
ConditionsYield
With diphenyl phosphoryl azide; triethylamine In N,N-dimethyl acetamide at 20℃; for 12h; Inert atmosphere; Darkness;92%
AmBisome
1397-89-3

AmBisome

1-(2-tert-butylphenyl)-1H-pyrrole-2,5-dione
156775-78-9

1-(2-tert-butylphenyl)-1H-pyrrole-2,5-dione

N-(N-2-tert-butylphenylsuccinimidyl)-amphotericin B
1513872-40-6

N-(N-2-tert-butylphenylsuccinimidyl)-amphotericin B

Conditions
ConditionsYield
Michael Addition;91.9%
2-(methylamino)isobutyric acid
2566-34-9

2-(methylamino)isobutyric acid

AmBisome
1397-89-3

AmBisome

N-(N-methyl-α-methylalanyl)amphotericin B

N-(N-methyl-α-methylalanyl)amphotericin B

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide91.1%
1-(2,4,6-trimethylphenyl)pyrrole-2,5-dione
55862-98-1

1-(2,4,6-trimethylphenyl)pyrrole-2,5-dione

AmBisome
1397-89-3

AmBisome

N-(N-2,4,6-trimethylphenylsuccinimidyl)-amphotericin B
1513872-37-1

N-(N-2,4,6-trimethylphenylsuccinimidyl)-amphotericin B

Conditions
ConditionsYield
Michael Addition;89.9%
Stage #1: AmBisome With triethylamine In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: 1-(2,4,6-trimethylphenyl)pyrrole-2,5-dione In N,N-dimethyl-formamide at 20℃;
30 mg
Fmoc-Glu(OtBu)-OH

Fmoc-Glu(OtBu)-OH

AmBisome
1397-89-3

AmBisome

N-(N-methyl-Oγ-tert-butyl-L-glutamyl)amphotericin B
1513872-70-2

N-(N-methyl-Oγ-tert-butyl-L-glutamyl)amphotericin B

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide89.9%
AmBisome
1397-89-3

AmBisome

1-[(pyridin-4-yl)methyl]pyrrole-2,5-dione
46277-44-5

1-[(pyridin-4-yl)methyl]pyrrole-2,5-dione

N-{N-[(2-pyridin-4-yl)-methyl]succinimidyl}-amphotericin B

N-{N-[(2-pyridin-4-yl)-methyl]succinimidyl}-amphotericin B

Conditions
ConditionsYield
Michael Addition;89.7%
AmBisome
1397-89-3

AmBisome

(2R)-2-amino-4-tert-butoxy-4-oxobutanoic acid
64960-75-4

(2R)-2-amino-4-tert-butoxy-4-oxobutanoic acid

N-(Oβ-tert-butyl-D-aspartyl)amphotericin B
1513872-71-3

N-(Oβ-tert-butyl-D-aspartyl)amphotericin B

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide88.4%
1-benzyl-1H-pyrrole-2,5-dione
1631-26-1

1-benzyl-1H-pyrrole-2,5-dione

AmBisome
1397-89-3

AmBisome

N-(N-benzylsuccinimidyl)-amphotericin B
1513872-38-2

N-(N-benzylsuccinimidyl)-amphotericin B

Conditions
ConditionsYield
Michael Addition;88%
1-piperidinepropionic acid
26371-07-3

1-piperidinepropionic acid

AmBisome
1397-89-3

AmBisome

N-[(3-piperidin-1-yl)propionyl]amphotericin B

N-[(3-piperidin-1-yl)propionyl]amphotericin B

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide87.9%
(R)-2'-fluorophenylalanine
97731-02-7

(R)-2'-fluorophenylalanine

AmBisome
1397-89-3

AmBisome

N-(2-fluoro-D-phenylalanyl)amphotericin B

N-(2-fluoro-D-phenylalanyl)amphotericin B

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide87.6%
(R)-phenylglycine
875-74-1

(R)-phenylglycine

AmBisome
1397-89-3

AmBisome

N-D-phenylglycyl-amphotericin B

N-D-phenylglycyl-amphotericin B

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide87%
4-formylphenylcarbonyl-terminated poly(ethylene glycol)-poly[Nε-(4-formylphenyl-carbonyl)-L-lysine], block copolymer, Mw = 15500, Mw/Mn = 1.18

4-formylphenylcarbonyl-terminated poly(ethylene glycol)-poly[Nε-(4-formylphenyl-carbonyl)-L-lysine], block copolymer, Mw = 15500, Mw/Mn = 1.18

AmBisome
1397-89-3

AmBisome

4-formylphenylcarbonyl-terminated poly(ethylene glycol)-poly[Nε-(4-formylphenyl-carbonyl)-L-lysine] amphotericin B Schiff's base, block copolymer, Mw = 26700, Mw/Mn = 1.11

4-formylphenylcarbonyl-terminated poly(ethylene glycol)-poly[Nε-(4-formylphenyl-carbonyl)-L-lysine] amphotericin B Schiff's base, block copolymer, Mw = 26700, Mw/Mn = 1.11

Conditions
ConditionsYield
With 4 A molecular sieve; trimethyl orthoformate86%
O-methyl-O'-(4-formylphenylcarbonyl)poly(ethylene)glycol, Mw 5000 (of polyethylene glycol chain)

O-methyl-O'-(4-formylphenylcarbonyl)poly(ethylene)glycol, Mw 5000 (of polyethylene glycol chain)

AmBisome
1397-89-3

AmBisome

O-methylpoly(ethylene glycol), Mw 5000 (of polyethylene glycol chain), conjugated with amphotericin B through O'-(1,4-C(O)C6H4-C=)-linker

O-methylpoly(ethylene glycol), Mw 5000 (of polyethylene glycol chain), conjugated with amphotericin B through O'-(1,4-C(O)C6H4-C=)-linker

Conditions
ConditionsYield
With 4 A molecular sieve; trimethyl orthoformate In N,N-dimethyl-formamide at 20℃;86%
1-[3-(N,N-dimethylamino)-2,2-dimethylpropyl]-pyrrole-2,5-dione
1021027-70-2

1-[3-(N,N-dimethylamino)-2,2-dimethylpropyl]-pyrrole-2,5-dione

AmBisome
1397-89-3

AmBisome

N-{N-[3-(N,N-dimethylamino)-2,2-dimethylpropyl]-succinimidyl}-amphotericin B
1513872-43-9

N-{N-[3-(N,N-dimethylamino)-2,2-dimethylpropyl]-succinimidyl}-amphotericin B

Conditions
ConditionsYield
Michael Addition;85.5%
2-methyl-3-(pyridin-3-yl)propanoic acid

2-methyl-3-(pyridin-3-yl)propanoic acid

AmBisome
1397-89-3

AmBisome

N-[β-(pyridine-1-yl)-D-alanyl]amphotericin B
1513872-72-4

N-[β-(pyridine-1-yl)-D-alanyl]amphotericin B

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide85.3%
AmBisome
1397-89-3

AmBisome

6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid 2,5-dioxopyrrolidin-1-yl ester
125697-63-4

6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid 2,5-dioxopyrrolidin-1-yl ester

N-(Fmoc-6-aminohexanoyl)-amphotericin B
942412-22-8

N-(Fmoc-6-aminohexanoyl)-amphotericin B

Conditions
ConditionsYield
With pyridine In N,N-dimethyl-formamide for 20h;85%
AmBisome
1397-89-3

AmBisome

4-Carboxybenzaldehyde
619-66-9

4-Carboxybenzaldehyde

N-(4-carboxybenzylidene)amphotericin B

N-(4-carboxybenzylidene)amphotericin B

Conditions
ConditionsYield
With 4 A molecular sieve; trimethyl orthoformate In dimethyl sulfoxide at 25℃; for 48h;84%
O,O'-bis(4-formylphenylcarbonyl)poly(ethylene)glycol, Mw 10000 (of polyethylene glycol chain)

O,O'-bis(4-formylphenylcarbonyl)poly(ethylene)glycol, Mw 10000 (of polyethylene glycol chain)

AmBisome
1397-89-3

AmBisome

poly(ethylene glycol), Mw 10000 (of polyethylene glycol chain), conjugated with amphotericin B through O,O'-bis(1,4-C(O)C6H4-C=)-linker, in molar ratio 1:2

poly(ethylene glycol), Mw 10000 (of polyethylene glycol chain), conjugated with amphotericin B through O,O'-bis(1,4-C(O)C6H4-C=)-linker, in molar ratio 1:2

Conditions
ConditionsYield
With 4 A molecular sieve; trimethyl orthoformate In N,N-dimethyl-formamide at 20℃;83%

Raw Materials

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