Amphotericin B supplier | CasNO.1397-89-3

Name
Amphotericin B
EINECS 215-742-2
CAS No. 1397-89-3
Article Data9
CAS DataBase
Density 1.34 g/cm³
Solubility <0.1 g/100 mL at 21 °C in water
Melting Point >170 °C
Formula C₄₇H₇₃NO₁₇
Boiling Point 1140.4 °C at 760 mmHg
Molecular Weight 924.093
Flash Point 643.5 °C
Transport Information UN 1759 8
Appearance crystalline yellow solid
Safety 26-36/37/39-45-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms Fungizone;Amphozone;component of Mysteclin-F;Mysteclin-F;33-((3-amino-3,6-dideoxyhexopyranosyl)oxy)-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid;Amphocin;IAB;Amphotericin B (JP14/USP);Amphotericin B (U.S. FDA Approved);AmphotericcinB;
PSA 319.61000
LogP 1.41200

Synthetic route

: 36148-89-7
amphotericin B methyl ester

: 1397-89-3
AmBisome

Conditions

Conditions	Yield
With lithium hydroxide In tetrahydrofuran; water at 25℃; for 1h;	80%

4-formylphenylcarbonyl-terminated poly(ethylene glycol)-poly[Nε-(4-formylphenyl-carbonyl)-L-lysine] amphotericin B Schiff's base, block copolymer, Mw = 26700, Mw/Mn = 1.11: 4-formylphenylcarbonyl-terminated poly(ethylene glycol)-poly[Nε-(4-formylphenyl-carbonyl)-L-lysine] amphotericin B Schiff's base, block copolymer, Mw = 26700, Mw/Mn = 1.11

: 1397-89-3
AmBisome

Conditions

Conditions	Yield
With water In phosphate buffer at 37℃; pH=5.5; Kinetics;

: N-(4-carboxybenzylidene)amphotericin B

: 1397-89-3
AmBisome

Conditions

Conditions	Yield
With phosphate buffer In methanol at 37℃; pH=5.5; Kinetics; Acid hydrolysis;

poly(ethylene glycol), Mw 10000 (of polyethylene glycol chain), conjugated with amphotericin B through O,O'-bis(1,4-C(O)C6H4-C=)-linker, in molar ratio 1:2: poly(ethylene glycol), Mw 10000 (of polyethylene glycol chain), conjugated with amphotericin B through O,O'-bis(1,4-C(O)C6H4-C=)-linker, in molar ratio 1:2

: 1397-89-3
AmBisome

Conditions

Conditions	Yield
With phosphate buffer In methanol at 37℃; pH=5.5; Kinetics; Acid hydrolysis;

poly(ethylene glycol), Mw 20000 (of polyethylene glycol chain), conjugated with amphotericin B through O,O'-bis-(1,4-C(O)C6H4-C=)-linker, in molar ratio 1:2: poly(ethylene glycol), Mw 20000 (of polyethylene glycol chain), conjugated with amphotericin B through O,O'-bis-(1,4-C(O)C6H4-C=)-linker, in molar ratio 1:2

: 1397-89-3
AmBisome

Conditions

Conditions	Yield
With phosphate buffer In methanol at 37℃; pH=5.5; Kinetics; Acid hydrolysis;

O-methylpoly(ethylene glycol), Mw 5000 (of polyethylene glycol chain), conjugated with amphotericin B through O'-(1,4-C6H4-CH=)-linker: O-methylpoly(ethylene glycol), Mw 5000 (of polyethylene glycol chain), conjugated with amphotericin B through O'-(1,4-C6H4-CH=)-linker

: 1397-89-3
AmBisome

Conditions

Conditions	Yield
With phosphate buffer In methanol at 37℃; pH=5.5; Kinetics; Acid hydrolysis;

O-methylpoly(ethylene glycol), Mw 5000 (of polyethylene glycol chain), conjugated with amphotericin B through O'-(1,4-CH2CH2NHCOC6H4C=)-linker: O-methylpoly(ethylene glycol), Mw 5000 (of polyethylene glycol chain), conjugated with amphotericin B through O'-(1,4-CH2CH2NHCOC6H4C=)-linker

: 1397-89-3
AmBisome

Conditions

Conditions	Yield
With phosphate buffer In methanol at 37℃; pH=5.5; Kinetics; Acid hydrolysis;

O-methylpoly(ethylene glycol), Mw 5000 (of polyethylene glycol chain), conjugated with amphotericin B through O'-(1,4-C(O)C6H4-C=)-linker: O-methylpoly(ethylene glycol), Mw 5000 (of polyethylene glycol chain), conjugated with amphotericin B through O'-(1,4-C(O)C6H4-C=)-linker

: 1397-89-3
AmBisome

Conditions

Conditions	Yield
With phosphate buffer In methanol at 37℃; pH=5.5; Kinetics; Acid hydrolysis;

: C55H85NO17

: 1397-89-3
AmBisome

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) CSA; 2.) H2O / 1.) MeOH, 25 deg C, 2 h; 2.) MeOH, 25 deg C, 4 h 2: 80 percent / LiOH / tetrahydrofuran; H2O / 1 h / 25 °C View Scheme

: C55H83N3O17

: 1397-89-3
AmBisome

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 90 percent / HS(CH2)3SH, Et3N / methanol / 24 h / 25 °C 2: 1.) CSA; 2.) H2O / 1.) MeOH, 25 deg C, 2 h; 2.) MeOH, 25 deg C, 4 h 3: 80 percent / LiOH / tetrahydrofuran; H2O / 1 h / 25 °C View Scheme

: 1112349-87-7
amphotericin B methyl pivalate

: 1397-89-3
AmBisome

Conditions

Conditions	Yield
With water In dimethyl sulfoxide at 37℃; pH=7; Phosphate buffer; Enzymatic reaction;

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 1397-89-3
AmBisome

: 127970-81-4
3′-N-Fmoc-AmB

Conditions

Conditions	Yield
With pyridine In N,N-dimethyl-formamide at 20℃; for 18h;	100%
With pyridine In methanol; N,N-dimethyl-formamide at 23℃; for 4h;	99%
With pyridine In methanol; N,N-dimethyl-formamide at 20℃; for 12h;	95%

: 135544-68-2
N-(allyloxycarbonyloxy)succinimide

: 1397-89-3
AmBisome

: C51H77NO19

Conditions

Conditions	Yield
With pyridine In methanol; N,N-dimethyl-formamide at 23℃; for 16h; Inert atmosphere;	100%
In methanol; N,N-dimethyl-formamide at 23℃; for 16h;	100%
With pyridine In methanol; N,N-dimethyl-formamide at 23℃; Inert atmosphere;	99%

: 135544-68-2
N-(allyloxycarbonyloxy)succinimide

: 1397-89-3
AmBisome

: C50H75NO19

Conditions

Conditions	Yield
With pyridine In methanol; N,N-dimethyl-formamide	99%

: 1397-89-3
AmBisome

: 4023-02-3
1H-pyrazole-1-carboximidamide hydrochloride

: 1033521-39-9
guanidine-AmB

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;	97%

: 1397-89-3
AmBisome

: 1499-46-3, 10331-70-1, 17720-12-6, 62013-45-0
L-histidine methyl ester

: amphotericin B

Conditions

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine In dimethyl sulfoxide at 23 - 25℃; for 24h; Reagent/catalyst; Solvent; Inert atmosphere; Darkness;	97%

: 1397-89-3
AmBisome

: 100-46-9
benzylamine

: amphotericin B N-benzylamide

Conditions

Conditions	Yield
With diphenyl phosphoryl azide; triethylamine In N,N-dimethyl acetamide at 20℃;	95.5%
With triethylamine In N,N-dimethyl acetamide at 20℃; Inert atmosphere;

: 3731-52-0
3-Aminomethylpyridine

: 1397-89-3
AmBisome

: amphotericin B 3-pyridylamide

Conditions

Conditions	Yield
With diphenyl phosphoryl azide; triethylamine In N,N-dimethyl acetamide at 20℃; Darkness; Inert atmosphere;	95.09%

: 1631-25-0
N-cyclohexylmaleimide

: 1397-89-3
AmBisome

: N-(N-cyclohexylsuccinimidyl)-amphotericin B

Conditions

Conditions	Yield
Michael Addition;	94.6%

: 14907-27-8, 5619-09-0, 7524-52-9, 26988-71-6, 41222-70-2, 67557-19-1, 109492-62-8
(R)-(+)-tryptophan methyl ester hydrochloride

: 1397-89-3
AmBisome

: amphotericin B N-(D)-methoxytryptophanamide

Conditions

Conditions	Yield
With diphenyl phosphoryl azide; triethylamine In N,N-dimethyl acetamide at 20℃;	93.85%

: 18783-53-4
O-tert-Butyl-D-serine

: 1397-89-3
AmBisome

: N-(O-tert-butyl-D-seryl)amphotericin B

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide	93.3%

: 1206-49-1
N-(2,6-dimethylphenyl)maleimide

: 1397-89-3
AmBisome

: N-(N-2,6-dimethylphenylsuccinimidyl)-amphotericin B

Conditions

Conditions	Yield
Michael Addition;	92.2%

O,O'-bis(4-formylphenylcarbonyl)poly(ethylene)glycol, Mw 20000 (of polyethylene glycol chain): O,O'-bis(4-formylphenylcarbonyl)poly(ethylene)glycol, Mw 20000 (of polyethylene glycol chain)

: 1397-89-3
AmBisome

poly(ethylene glycol), Mw 20000 (of polyethylene glycol chain), conjugated with amphotericin B through O,O'-bis-(1,4-C(O)C6H4-C=)-linker, in molar ratio 1:2: poly(ethylene glycol), Mw 20000 (of polyethylene glycol chain), conjugated with amphotericin B through O,O'-bis-(1,4-C(O)C6H4-C=)-linker, in molar ratio 1:2

Conditions

Conditions	Yield
With 4 A molecular sieve; trimethyl orthoformate In N,N-dimethyl-formamide at 20℃;	92%

: 51-45-6
histamine

: 1397-89-3
AmBisome

: amphotericin B N-histaminamide

Conditions

Conditions	Yield
With diphenyl phosphoryl azide; triethylamine In N,N-dimethyl acetamide at 20℃; for 12h; Inert atmosphere; Darkness;	92%

: 1397-89-3
AmBisome

: 156775-78-9
1-(2-tert-butylphenyl)-1H-pyrrole-2,5-dione

: 1513872-40-6
N-(N-2-tert-butylphenylsuccinimidyl)-amphotericin B

Conditions

Conditions	Yield
Michael Addition;	91.9%

: 2566-34-9
2-(methylamino)isobutyric acid

: 1397-89-3
AmBisome

: N-(N-methyl-α-methylalanyl)amphotericin B

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide	91.1%

: 55862-98-1
1-(2,4,6-trimethylphenyl)pyrrole-2,5-dione

: 1397-89-3
AmBisome

: 1513872-37-1
N-(N-2,4,6-trimethylphenylsuccinimidyl)-amphotericin B

Conditions

Conditions	Yield
Michael Addition;	89.9%
Stage #1: AmBisome With triethylamine In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 1-(2,4,6-trimethylphenyl)pyrrole-2,5-dione In N,N-dimethyl-formamide at 20℃;	30 mg

: Fmoc-Glu(OtBu)-OH

: 1397-89-3
AmBisome

: 1513872-70-2
N-(N-methyl-Oγ-tert-butyl-L-glutamyl)amphotericin B

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide	89.9%

: 1397-89-3
AmBisome

: 46277-44-5
1-[(pyridin-4-yl)methyl]pyrrole-2,5-dione

: N-{N-[(2-pyridin-4-yl)-methyl]succinimidyl}-amphotericin B

Conditions

Conditions	Yield
Michael Addition;	89.7%

: 1397-89-3
AmBisome

: 64960-75-4
(2R)-2-amino-4-tert-butoxy-4-oxobutanoic acid

: 1513872-71-3
N-(Oβ-tert-butyl-D-aspartyl)amphotericin B

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide	88.4%

: 1631-26-1
1-benzyl-1H-pyrrole-2,5-dione

: 1397-89-3
AmBisome

: 1513872-38-2
N-(N-benzylsuccinimidyl)-amphotericin B

Conditions

Conditions	Yield
Michael Addition;	88%

: 26371-07-3
1-piperidinepropionic acid

: 1397-89-3
AmBisome

: N-[(3-piperidin-1-yl)propionyl]amphotericin B

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide	87.9%

: 97731-02-7
(R)-2'-fluorophenylalanine

: 1397-89-3
AmBisome

: N-(2-fluoro-D-phenylalanyl)amphotericin B

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide	87.6%

: 875-74-1
(R)-phenylglycine

: 1397-89-3
AmBisome

: N-D-phenylglycyl-amphotericin B

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide	87%

4-formylphenylcarbonyl-terminated poly(ethylene glycol)-poly[Nε-(4-formylphenyl-carbonyl)-L-lysine], block copolymer, Mw = 15500, Mw/Mn = 1.18: 4-formylphenylcarbonyl-terminated poly(ethylene glycol)-poly[Nε-(4-formylphenyl-carbonyl)-L-lysine], block copolymer, Mw = 15500, Mw/Mn = 1.18

: 1397-89-3
AmBisome

4-formylphenylcarbonyl-terminated poly(ethylene glycol)-poly[Nε-(4-formylphenyl-carbonyl)-L-lysine] amphotericin B Schiff's base, block copolymer, Mw = 26700, Mw/Mn = 1.11: 4-formylphenylcarbonyl-terminated poly(ethylene glycol)-poly[Nε-(4-formylphenyl-carbonyl)-L-lysine] amphotericin B Schiff's base, block copolymer, Mw = 26700, Mw/Mn = 1.11

Conditions

Conditions	Yield
With 4 A molecular sieve; trimethyl orthoformate	86%

O-methyl-O'-(4-formylphenylcarbonyl)poly(ethylene)glycol, Mw 5000 (of polyethylene glycol chain): O-methyl-O'-(4-formylphenylcarbonyl)poly(ethylene)glycol, Mw 5000 (of polyethylene glycol chain)

: 1397-89-3
AmBisome

O-methylpoly(ethylene glycol), Mw 5000 (of polyethylene glycol chain), conjugated with amphotericin B through O'-(1,4-C(O)C6H4-C=)-linker: O-methylpoly(ethylene glycol), Mw 5000 (of polyethylene glycol chain), conjugated with amphotericin B through O'-(1,4-C(O)C6H4-C=)-linker

Conditions

Conditions	Yield
With 4 A molecular sieve; trimethyl orthoformate In N,N-dimethyl-formamide at 20℃;	86%

: 1021027-70-2
1-[3-(N,N-dimethylamino)-2,2-dimethylpropyl]-pyrrole-2,5-dione

: 1397-89-3
AmBisome

: 1513872-43-9
N-{N-[3-(N,N-dimethylamino)-2,2-dimethylpropyl]-succinimidyl}-amphotericin B

Conditions

Conditions	Yield
Michael Addition;	85.5%

: 2-methyl-3-(pyridin-3-yl)propanoic acid

: 1397-89-3
AmBisome

: 1513872-72-4
N-[β-(pyridine-1-yl)-D-alanyl]amphotericin B

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide	85.3%

: 1397-89-3
AmBisome

: 125697-63-4
6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid 2,5-dioxopyrrolidin-1-yl ester

: 942412-22-8
N-(Fmoc-6-aminohexanoyl)-amphotericin B

Conditions

Conditions	Yield
With pyridine In N,N-dimethyl-formamide for 20h;	85%

: 1397-89-3
AmBisome

: 619-66-9
4-Carboxybenzaldehyde

: N-(4-carboxybenzylidene)amphotericin B

Conditions

Conditions	Yield
With 4 A molecular sieve; trimethyl orthoformate In dimethyl sulfoxide at 25℃; for 48h;	84%

O,O'-bis(4-formylphenylcarbonyl)poly(ethylene)glycol, Mw 10000 (of polyethylene glycol chain): O,O'-bis(4-formylphenylcarbonyl)poly(ethylene)glycol, Mw 10000 (of polyethylene glycol chain)

: 1397-89-3
AmBisome

poly(ethylene glycol), Mw 10000 (of polyethylene glycol chain), conjugated with amphotericin B through O,O'-bis(1,4-C(O)C6H4-C=)-linker, in molar ratio 1:2: poly(ethylene glycol), Mw 10000 (of polyethylene glycol chain), conjugated with amphotericin B through O,O'-bis(1,4-C(O)C6H4-C=)-linker, in molar ratio 1:2

Conditions

Conditions	Yield
With 4 A molecular sieve; trimethyl orthoformate In N,N-dimethyl-formamide at 20℃;	83%

Amphotericin B Specification

The Amphotericin B, with the CAS registry number 1397-89-3,is also known as 33-[(3-Amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-Dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid; Fungizone. It belongs to the product categories of Antifungal;Carbohydrates & Derivatives;Chiral Reagents. This chemical's molecular formula is C₄₇H₇₃NO₁₇ and molecular weight is 924.08.Its EINECS number is 215-742-2. What's more,Its systematic name is Amphotericin B.It is a Crystalline Yellow Solid which is stable,incompatible with strong oxidizing agents,but may be light sensitive. It is a kind of polyene antifungal drugs,Isolated from Streptomyces culture.

Physical properties about Amphotericin B are:
(1)ACD/LogP: 1.164; (2)# of Rule of 5 Violations: 3; (3)ACD/LogD (pH 5.5): -1.34; (4)ACD/LogD (pH 7.4): -1.41; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 18; (10)#H bond donors: 13; (11)#Freely Rotating Bonds: 14; (12)Index of Refraction: 1.614; (13)Molar Refractivity: 240.249 cm³; (14)Molar Volume: 689.435 cm³; (15)Surface Tension: 71.6880035400391 dyne/cm; (16)Density: 1.34 g/cm³; (17)Flash Point: 643.47 °C; (18)Enthalpy of Vaporization: 189.982 kJ/mol; (19)Boiling Point: 1140.365 °C at 760 mmHg; (20)Vapour Pressure: 0 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:C[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O;
(2)Std. InChI:InChI=1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1;
(3)Std. InChIKey:APKFDSVGJQXUKY-INPOYWNPSA-N.

Safety Information of Amphotericin B:
The Amphotericin B is irritating to eyes, respiratory system and skin and harmful if swallowed.But there is limited evidence of a carcinogenic effect.It is toxic by inhalation, in contact with skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. When you use it ,wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) .

The toxicity data of Amphotericin B as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	6mg/kg (6mg/kg)	KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Biokhimiya Vol. 43, Pg. 2043, 1978.
infant	TDLo	intravenous	15mg/kg/4D-I (15mg/kg)		Journal of Toxicology, Clinical Toxicology. Vol. 28, Pg. 371, 1990.
infant	TDLo	intravenous	15mg/kg/4D-I (15mg/kg)		Journal of Toxicology, Clinical Toxicology. Vol. 28, Pg. 371, 1990.
man	LDLo	intravenous	164ug/kg/5H-I (0.164mg/kg)	CARDIAC: OTHER CHANGES	Drug Intelligence and Clinical Pharmacy. Vol. 17, Pg. 547, 1983.
mouse	LD	unreported	> 50mg/kg (50mg/kg)		Journal of Antibiotics. Vol. 24, Pg. 561, 1971.
mouse	LD12	oral	280mg/kg (280mg/kg)		British UK Patent Application. Vol. #2067993,
mouse	LD50	intramuscular	> 5gm/kg (5000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 108, 1976.
mouse	LD50	intraperitoneal	27740ug/kg (27.74mg/kg)		National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986,
mouse	LD50	intravenous	1200ug/kg (1.2mg/kg)		Pharmacy International. Vol. 6, Pg. 164, 1985.
rabbit	LDLo	intravenous	5mg/kg (5mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Antibiotics Annual. Vol. 5, Pg. 53, 1957/1958.
rat	LD50	intramuscular	> 5gm/kg (5000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 108, 1976.
rat	LD50	intraperitoneal	> 5gm/kg (5000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 108, 1976.
rat	LD50	intravenous	1600ug/kg (1.6mg/kg)		Journal of Antimicrobial Chemotherapy. Vol. 28(Suppl,
rat	LD50	oral	> 5gm/kg (5000mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 7, Pg. 108, 1976.
women	LDLo	intravenous	22mg/kg/4D-I (22mg/kg)	BLOOD: LEUKOPENIA	Southern Medical Journal. Vol. 76, Pg. 409, 1983.
women	TDLo	intravenous	20ug/kg (0.02mg/kg)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	New England Journal of Medicine. Vol. 315, Pg. 836, 1986.
women	TDLo	intravenous	1mg/kg/1H-C (1mg/kg)	CARDIAC: PULSE RATE	Lancet. Vol. 341, Pg. 372, 1993.

Product Name

Amphotericin B

Synthetic route

Amphotericin B Specification

Related Products

Hot Products