2-(3-Aminophenyl)ethanol supplier

Name
2-(3-Aminophenyl)ethanol
EINECS 803-888-5
CAS No. 52273-77-5
Article Data26
CAS DataBase
Density 1.124 g/cm³
Solubility
Melting Point 51-53 °C
Formula C₈H₁₁NO
Boiling Point 292.719 °C at 760 mmHg
Molecular Weight 137.181
Flash Point 130.832 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Phenethylalcohol, m-amino- (6CI);2-(3-Aminophenyl)ethanol;2-(m-Aminophenyl)ethanol;3-(2-Hydroxyethyl)aniline;3-Aminophenethyl alcohol;
PSA 46.25000
LogP 1.38480

Synthetic route

: 52022-77-2
2-(3-nitrophenyl)ethanol

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

Conditions

Conditions	Yield
With palladium on carbon (10%) In tetrahydrofuran Cooling with ice; Inert atmosphere;	100%
With hydrogen; palladium 10% on activated carbon In methanol under 2327.23 Torr;	99%
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; for 1.5h;	98%

: 125620-28-2
Pd-C

: 52022-77-2
2-(3-nitrophenyl)ethanol

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

Conditions

Conditions	Yield
In ethanol; water	100%

: 52273-79-7
(3-amino-phenyl)-acetic acid ethyl ester

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In 1,4-dioxane Ambient temperature;	40%

: 14338-36-4
3-amino phenylacetic acid

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride

: 15896-61-4
2-(4-amino-3-nitrophenyl)ethanol

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaNO2; aqueous HCl / anschliessendes Behandeln mit H3PO2 2: SnCl2; aqueous HCl View Scheme

: 92959-73-4
4-acetamido-3-nitrophenethyl acetate

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aqueous HCl 2: NaNO2; aqueous HCl / anschliessendes Behandeln mit H3PO2 3: SnCl2; aqueous HCl View Scheme

: 52022-77-2
2-(3-nitrophenyl)ethanol

: 7440-44-0
pyrographite

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

Conditions

Conditions	Yield
In ethanol

: 621-50-1
(3-nitrophenyl)acetonitrile

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: acetic acid; sulfuric acid / water / 110 °C 2: dimethylsulfide borane complex / tetrahydrofuran / Reflux 3: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C View Scheme
Multi-step reaction with 3 steps 1: sulfuric acid; acetic acid / water / 110 °C 2: dimethylsulfide borane complex / tetrahydrofuran / Reflux 3: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C View Scheme

: 1877-73-2
3-nitro-benzeneacetic acid

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dimethylsulfide borane complex / tetrahydrofuran / Reflux 2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C View Scheme
Multi-step reaction with 2 steps 1: dimethylsulfide borane complex / tetrahydrofuran / Reflux 2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C View Scheme

: 50893-53-3
carbonochloridic acid 1-chloro-ethyl ester

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: chloroethyl carbamate

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane; water	100%

: 10517-21-2
5-chloro-1H-Indole-2-carboxylic acid

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 1036750-34-1
C17H15ClN2O2

Conditions

Conditions	Yield
With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 14h;	97%

: 1236130-76-9
2,5-dichloro-N-[2-(3-methoxyphenyl)ethyl]pyrimidin-4-amine

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 1236130-79-2
2-{3-[(5-chloro-4-{[2-(3-methoxyphenyl)ethyl]amino}pyrimidin-2-yl)amino]phenyl}ethanol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In 1,4-dioxane at 100℃; for 16h;	96%

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 183322-18-1
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline

: 2-(3-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)phenyl)ethan-1-ol

Conditions

Conditions	Yield
With pyridine In isopropyl alcohol for 4h; Reflux; Inert atmosphere;	96%

: 1236130-81-6
2,5-dichloro-N-[3-(3-methoxyphenyl)propyl]pyrimidin-4-amine

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 1236130-89-4
2-{3-[(5-chloro-4-{[3-(3-methoxyphenyl)propyl]amino}pyrimidin-2-yl)amino]phenyl}ethanol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In 1,4-dioxane at 100℃; for 16h;	92%

: 24424-99-5
di-tert-butyl dicarbonate

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 180002-10-2
tert-butyl N-[3-(2-hydroxyethyl)phenyl]carbamate

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane; water at 20℃;	79%
With sodium hydroxide In 1,4-dioxane; water at 20℃;	79%

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 1005-56-7
phenylcarbonochloridothioate

: 366492-72-0
2-(3-((phenoxythioxomethyl)amino)phenyl)ethan-1-ol

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 0.5h;	77%

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 1493-27-2
ortho-nitrofluorobenzene

: 1429642-71-6
2-(3-((2-nitrophenyl)amino)phenyl)ethanol

Conditions

Conditions	Yield
With triethylamine at 110℃; for 15h; Sealed tube;	77%

: 1236130-57-6
2,5-dichloro-N-(3-methoxybenzyl)pyrimidin-4-amine

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 1236130-60-1
2-[3-({5-Chloro-4-[(3-methoxybenzyl)amino]pyrimidin-2-yl}amino)phenyl]ethanol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In 1,4-dioxane at 105℃; for 3h;	74%

: 53137-27-2
2,4-dimethyl-thiazole-5-carboxylic acid

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 844904-20-7
N-[3-(2-hydroxyethyl)phenyl]-2,4-dimethyl-1,3-thiazole-5-carboxamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In DMF (N,N-dimethyl-formamide) for 14h;	73%

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 127201-31-4
2-(3-iodophenyl)ethan-1-ol

Conditions

Conditions	Yield
Stage #1: 2-(3-aminophenyl)ethan-1-ol With sulfuric acid; sodium nitrite In water at 0℃; for 0.5h; Stage #2: With potassium iodide In water at 0 - 60℃; for 2.5h;	67%

: 16492-14-1
9-chloro-3-methoxyacridine

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 135785-71-6
9-[3'-(β-hydroxyethyl)anilino]-3-methoxyacridine

Conditions

Conditions	Yield
With methanesulfonic acid In methanol	65%

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 914605-41-7
BrH*C8H10BrN

Conditions

Conditions	Yield
With hydrogen bromide In water at 90℃; for 18h;	61%

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 292638-85-8
acrylic acid methyl ester

: 817642-95-8
methyl 2-chloro-3-[3-(2-hydroxyethyl)phenyl]propanoate

Conditions

Conditions	Yield
Stage #1: 2-(3-aminophenyl)ethan-1-ol With hydrogenchloride; sodium nitrite In water; acetone at 0℃; for 1h; Stage #2: acrylic acid methyl ester; copper(l) iodide In water; acetone at 20℃;	55%

: 946825-98-5
2-chloro-9-cyclopentyl-5-methyl-5,7,8,9-tetrahydro-6H-pyrimido[4,5-b][1,4]diazepin-6-one

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 6-cyclopentyl-9-[[3-(2-hydroxyethyl)phenyl]amino]-2-methyl-2,6,8,10-tetrazabicyclo[5.4.0]undeca-7,9,11-trien-3-one

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In Methyl isobutyl carbinol at 140℃; for 2h;	50%

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 74-11-3
para-chlorobenzoic acid

: C15H14ClNO2

Conditions

Conditions	Yield
Stage #1: para-chlorobenzoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In dichloromethane for 0.25h; Stage #2: 2-(3-aminophenyl)ethan-1-ol In dichloromethane at 25℃; for 12h;	49.6%

: 24424-99-5
di-tert-butyl dicarbonate

: 17176-77-1
Dibenzyl phosphite

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: dibenzyl (3-(N-Boc-amino)phenethyl)phosphonate

Conditions

Conditions	Yield
Stage #1: di-tert-butyl dicarbonate; 2-(3-aminophenyl)ethan-1-ol In 1,4-dioxane at 20℃; Stage #2: With triethylamine In dichloromethane for 0.166667h; Cooling with ice; Stage #3: Dibenzyl phosphite Further stages;	43%

...Expand

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 108-24-7
acetic anhydride

: 1′-(3-acetamidophenyl)ethan-2′-ol

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 24h; Inert atmosphere;	42%

: 1943-83-5
2-chloroethyl isothiocyanate

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 1-(2-chloro-ethyl)-3-[3-(2-hydroxy-ethyl)-phenyl]-urea

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 20h;	41%

: 117-80-6
2,3-Dichloro-1,4-naphthoquinone

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 2-chloro-3-((3-(2-hydroxyethyl)phenyl)amino)naphthalene-1,4-dione

Conditions

Conditions	Yield
In ethanol at 20℃;	31%

: 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: methyl trans-4-{[3-(2-hydroxyethyl)phenyl]amino}cyclohexanecarboxylate

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; acetic acid In tetrahydrofuran at 20℃; for 4h;	19%

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: N'-[3-(2-Hydroxy-ethyl)-phenyl]-N,N-dimethyl-formamidine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 20h; Ambient temperature;

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: (E)-3-(3,4-Dihydroxy-phenyl)-acrylic acid 2-(3-isothiocyanato-phenyl)-ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: 77 percent / tetrahydrofuran / 0.5 h / 20 °C 2.1: pyridine / toluene / 20 °C 2.2: 40 percent / Et3N; HSiCl3 / benzene / 1 h / 20 °C 3.1: 93 percent / HF*pyridine / tetrahydrofuran / 4 h / 20 °C View Scheme

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 2-(3-isothiocyanatophenyl)ethyl O,O-(3,4-bis(1,1,2,2-tetramethyl-1-silapropyl))caffeic acid ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 77 percent / tetrahydrofuran / 0.5 h / 20 °C 2.1: pyridine / toluene / 20 °C 2.2: 40 percent / Et3N; HSiCl3 / benzene / 1 h / 20 °C View Scheme

: 52273-77-5
2-(3-aminophenyl)ethan-1-ol

: 1026069-85-1
[3-(2-Bromo-ethyl)-phenyl]-carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 2: CBr4, PPh3 View Scheme

2-(3-Aminophenyl)ethanol Specification

The CAS register number of 2-(3-Aminophenyl)ethanol is 52273-77-5. It also can be called as Benzeneethanol,3-amino- and the systematic name about this chemical is 2-(3-aminophenyl)ethanol.

Physical properties about 2-(3-Aminophenyl)ethanol are: (1)ACD/LogP: 0.34; (2)ACD/BCF (pH 5.5): 1; (3)ACD/BCF (pH 7.4): 1; (4)ACD/KOC (pH 5.5): 24; (5)ACD/KOC (pH 7.4): 26; (6)#H bond acceptors: 2; (7)#H bond donors: 3; (8)#Freely Rotating Bonds: 4; (9)Polar Surface Area: 46.25Å²; (10)Index of Refraction: 1.597; (11)Molar Refractivity: 41.573 cm³; (12)Molar Volume: 122.037 cm³; (13)Polarizability: 16.481x10^-24cm³; (14)Surface Tension: 51.194 dyne/cm; (15)Enthalpy of Vaporization: 56.209 kJ/mol; (16)Boiling Point: 292.719 °C at 760 mmHg; (17)Vapour Pressure: 0.001 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: Nc1cc(CCO)ccc1
(2)InChI: InChI=1/C8H11NO/c9-8-3-1-2-7(6-8)4-5-10/h1-3,6,10H,4-5,9H2
(3)InChIKey: FNUKLSVGSFFSLI-UHFFFAOYAO
(4)Std. InChI: InChI=1S/C8H11NO/c9-8-3-1-2-7(6-8)4-5-10/h1-3,6,10H,4-5,9H2
(5)Std. InChIKey: FNUKLSVGSFFSLI-UHFFFAOYSA-N

Product Name

2-(3-Aminophenyl)ethanol

Synthetic route

2-(3-Aminophenyl)ethanol Specification

Related Products

Hot Products