• Name

  2-((4-Chlorophenyl)acetyl)benzoic acid

• EINECS 258-444-8
• CAS No. 53242-76-5
• Article Data3
• CAS DataBase
• Density 1.332 g/cm³
• Solubility
• Melting Point
• Formula C₁₅H₁₁ClO₃
• Boiling Point 456.8 °C at 760 mmHg
• Molecular Weight 274.704
• Flash Point 230.1 °C
• Transport Information
• Appearance off-white crystalline powder
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Benzoicacid, 2-[(4-chlorophenyl)acetyl]- (9CI);
• PSA 54.37000
• LogP 3.46360

Synthetic route

1878-66-6

4-chlorophenylacetic Acid

85-44-9

phthalic anhydride

53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

Conditions

Conditions	Yield
Stage #1: 4-chlorophenylacetic Acid; phthalic anhydride With sodium acetate at 240 - 250℃; for 3h; Stage #2: With water; sodium hydroxide In water for 4h; Time; Reflux;	80%

105279-16-1

(Z)-3-(4-chlorophenyl)methylidenephthalide

53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

Conditions

Conditions	Yield
With sodium hydroxide for 2h; Heating; Yield given;

1878-66-6

4-chlorophenylacetic Acid

53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: CH3COONa / 3 h / 245 - 250 °C 2: aq. NaOH / 2 h / Heating View Scheme

85-44-9

phthalic anhydride

3-<2-carboxy-phenyl>-pyridine-carboxylic acid-(2)

3-<2-carboxy-phenyl>-pyridine-carboxylic acid-(2)

53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: CH3COONa / 3 h / 245 - 250 °C 2: aq. NaOH / 2 h / Heating View Scheme

20526-97-0

3-(4-chlorobenzylidene)-2-benzofuran-1(3H)-one

53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

Conditions

Conditions	Yield
With potassium hydroxide In ethanol; water

53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

105279-16-1

(Z)-3-(4-chlorophenyl)methylidenephthalide

Conditions

Conditions	Yield
With O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12h; Inert atmosphere;	91%

53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

53242-88-9

4-[(4-chlorophenyl)methyl]-1(2H)-phthalazinone

Conditions

Conditions	Yield
With sodium hydroxide; hydrazinium sulfate for 2h; Heating;	90%

186581-53-3, 908094-01-9

diazomethane

53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

61653-04-1

methyl 2-(4-chlorophenylacetyl)benzoate

Conditions

Conditions	Yield
In diethyl ether

53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

2-Benzoyl-1-(hexahydro-1-methyl-1H-azepin-4-yl)hydrazin-hydrochlorid

58581-89-8

azelastine

Conditions

Conditions	Yield
With hydrogenchloride; potassium hydroxide 1.) reflux, 3 h, 2.) methanol, reflux, 2 h; Yield given. Multistep reaction;

53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

4-(p-Chlorbenzyl)-2-<2-(N-methylpyrrolidin-2-yl)-ethyl>-1(2H)-phthalazinon

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / hydrazine sulfate, aq. NaOH / 2 h / Heating 2: aq. NaOH / 1 h / 70 °C View Scheme

53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

58581-89-8

azelastine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 90 percent / hydrazine sulfate, aq. NaOH / 2 h / Heating 2: aq. NaOH / 1 h / 70 °C View Scheme

1H-azepine, 4-hydrazinohexahydro-1-methyl, dihydrochloride

53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

58581-89-8

azelastine

Conditions

Conditions	Yield
Stage #1: 1H-azepine, 4-hydrazinohexahydro-1-methyl, dihydrochloride; 2‐(4-chlorophenylacetyl)benzoic acid With sodium hydroxide In methanol; water for 4h; Heating / reflux; Stage #2: With hydrogenchloride In methanol; 2,8-dimethylnonan-5-one; water

75-03-6

ethyl iodide

53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

1107016-94-3

ethyl 2-(2-(4-chlorophenyl)acetyl)benzoate

Conditions

Conditions	Yield
With potassium fluoride In N,N-dimethyl-formamide

C14H23N3O(2+)*C4H2O4(2-)

53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

58581-89-8

azelastine

Conditions

Conditions	Yield
Stage #1: C14H23N3O(2+)*C4H2O4(2-) With hydrogenchloride at 20℃; for 2h; Reflux; Stage #2: 2‐(4-chlorophenylacetyl)benzoic acid for 2h; Reflux;	8.1 g

C14H23N3O(2+)*C4H2O4(2-)

53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

58581-89-8

azelastine

Conditions

Conditions	Yield
Stage #1: C14H23N3O(2+)*C4H2O4(2-) With hydrogenchloride at 20℃; for 2h; Reflux; Stage #2: 2‐(4-chlorophenylacetyl)benzoic acid for 2h; Reflux;	7.5 g

C14H23N3O(2+)*C4H4O4(2-)

53242-76-5

2‐(4-chlorophenylacetyl)benzoic acid

58581-89-8

azelastine

Conditions

Conditions	Yield
Stage #1: C14H23N3O(2+)*C4H4O4(2-) With hydrogenchloride at 20℃; for 2h; Reflux; Stage #2: 2‐(4-chlorophenylacetyl)benzoic acid for 2h; Reflux;	8 g

2-((4-Chlorophenyl)acetyl)benzoic acid Chemical Properties

2-((4-Chlorophenyl)acetyl)benzoic acid Specification