Product Name

  • Name

    2'-Hydroxy-3-phenylpropiophenone

  • EINECS 222-521-4
  • CAS No. 3516-95-8
  • Article Data56
  • CAS DataBase
  • Density 1.15 g/cm3
  • Solubility
  • Melting Point 36-37 °C(lit.)
  • Formula C15H14O2
  • Boiling Point 381.1 °C at 760 mmHg
  • Molecular Weight 226.275
  • Flash Point 162.7 °C
  • Transport Information
  • Appearance Slightly yellow crystals
  • Safety 26-37/39
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 3516-95-8 (2'-Hydroxy-3-phenylpropiophenone)
  • Hazard Symbols IrritantXi
  • Synonyms Propiophenone,2'-hydroxy-3-phenyl- (6CI,7CI,8CI);1-(2-Hydroxyphenyl)-3-phenylpropan-1-one;1-(o-Hydroxyphenyl)-3-phenylpropanone-1;2-Hydroxy-b-phenylpropiophenone;2'-Hydroxy-3-phenylpropiophenone;2'-Hydroxydihydrochalcone;b-Phenyl-2-hydroxypropiophenone;
  • PSA 37.30000
  • LogP 3.20770

Synthetic route

(E)-2'-hydroxy-chalcone
888-12-0

(E)-2'-hydroxy-chalcone

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
With ammonium formate; palladium on activated charcoal In tetrahydrofuran; methanol at 20℃; for 0.55h;99%
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; silica gel In benzene at 70℃; for 4h;95%
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate In benzene at 70℃; Rate constant; Product distribution; further reaction conditions; deuterium isotopic effect;
With hydrogen; palladium on activated charcoal In tetrahydrofuran Ambient temperature;
With hydrogen; palladium on activated charcoal In ethyl acetate for 1h;
1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one
1214-47-7

1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In dichloromethane at 20℃; under 760.051 Torr; for 6h; Catalytic behavior; Time;98%
With 10% Pd/C; diphenyl sulfide; hydrogen In methanol at 20℃; for 24h; chemoselective reaction;97%
With palladium 10% on activated carbon; hydrogen In ethanol under 1875.19 Torr; for 0.5h;95%
phenethylmagnesium chloride
90878-19-6

phenethylmagnesium chloride

salicylic acid
69-72-7

salicylic acid

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
Stage #1: salicylic acid With tert-butylmagnesium chloride In tetrahydrofuran; toluene at 0℃; for 0.25h; Inert atmosphere;
Stage #2: phenethylmagnesium chloride With diisopropylaminomagnesium chloride lithium chloride In tetrahydrofuran; toluene at 0 - 20℃; for 14.25h; Inert atmosphere; Sonication;
98%
2-{1-[(E)-Isopropylimino]-3-phenyl-propyl}-phenol

2-{1-[(E)-Isopropylimino]-3-phenyl-propyl}-phenol

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
With acetic acid In tetrahydrofuran; water at 40℃; for 4h;89%
1-(2'-hydroxyphenyl)prop-2-en-1-ol
38865-40-6

1-(2'-hydroxyphenyl)prop-2-en-1-ol

phenylboronic acid
98-80-6

phenylboronic acid

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
With 2.9-dimethyl-1,10-phenanthroline; palladium diacetate; copper(l) chloride In dimethyl sulfoxide at 50℃; under 760.051 Torr; for 12h;89%
With 2.9-dimethyl-1,10-phenanthroline; palladium diacetate; silver carbonate In acetonitrile at 60℃; for 24h; regioselective reaction;85%
styrene
100-42-5

styrene

salicylaldehyde
90-02-8

salicylaldehyde

A

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

B

1-(2-Hydroxyphenyl)-2-phenylpropan-1-one
42772-82-7

1-(2-Hydroxyphenyl)-2-phenylpropan-1-one

Conditions
ConditionsYield
With potassium phosphate; chloro(1,5-cyclooctadiene)rhodium(I) dimer; (11aR)-(+)-10,11,12,13-tetrahydrodiindeno[7,1-de:1', 7'-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine In 1,2-dichloro-ethane at 70℃; for 36h; Inert atmosphere; Overall yield = 98 %;A 87%
B n/a
phenyl 3-phenylpropanoate
726-26-1

phenyl 3-phenylpropanoate

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
With aluminium trichloride for 1h;84%
With aluminum (III) chloride at 100℃; for 1h; Fries Phenol Ester Rearrangement;
o-hydroxyacetophenone
118-93-4

o-hydroxyacetophenone

benzyl alcohol
100-51-6

benzyl alcohol

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
With lithium tert-butoxide In toluene at 110℃; for 12h; Inert atmosphere;84%
With C61H47N3OP2Ru; potassium hydroxide In toluene at 110℃; for 12h;80%
With C51H39As2N3O2RuS; sodium hydroxide In toluene at 105℃; for 8h;79%
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; potassium hydroxide In tert-Amyl alcohol at 110℃; for 24h; Sealed tube;50%
phenyl 3-phenylpropanoate
726-26-1

phenyl 3-phenylpropanoate

A

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

B

1-(4-hydroxyphenyl)-3-phenylpropan-1-one
36941-00-1

1-(4-hydroxyphenyl)-3-phenylpropan-1-one

Conditions
ConditionsYield
With methanesulfonic acid; Methanesulfonic anhydride at 65℃; Fries rearrangement; Inert atmosphere; regioselective reaction;A n/a
B 82%
phenyl Salicylate
118-55-8

phenyl Salicylate

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
With 1,10-Phenanthroline; nickel(II) bromide diethylene glycol dimethyl ether; zinc In N,N-dimethyl-formamide at 60℃; for 10h; Inert atmosphere; Sealed tube;71%
o-hydroxyacetophenone
118-93-4

o-hydroxyacetophenone

benzaldehyde
100-52-7

benzaldehyde

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
Stage #1: o-hydroxyacetophenone; benzaldehyde With sodium hydride In N,N-dimethyl-formamide at 20℃;
Stage #2: With palladium 10% on activated carbon; hydrogen In tetrahydrofuran at 20℃;
68%
With potassium hydroxide; tris(triphenylphosphine)ruthenium(II) chloride In 1,4-dioxane at 80℃; for 40h;49%
With sodium hydroxide; hydrogen; palladium on activated charcoal 1.) methanol, r.t., 60 h, 2.) methanol, normal pressure; Yield given. Multistep reaction;
Multistep reaction;
2-((Z)-3-hydroxy-3-phenylacryloyl)phenyl methylphenylcarbamate

2-((Z)-3-hydroxy-3-phenylacryloyl)phenyl methylphenylcarbamate

A

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

B

N-methyl-N-phenyl-3-phenylpropanamide
18859-20-6

N-methyl-N-phenyl-3-phenylpropanamide

C

salicylic acid
69-72-7

salicylic acid

Conditions
ConditionsYield
With water; sodium hydride In tetrahydrofuran for 24h; Reflux;A n/a
B 42%
C 42%
2-(5-phenyl-4,5-dihydroisoxazol-3-yl)phenol
18732-46-2

2-(5-phenyl-4,5-dihydroisoxazol-3-yl)phenol

A

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

B

3-hydroxy-1-(2-hydroxyphenyl)-3-phenylpropan-1-one
119841-71-3

3-hydroxy-1-(2-hydroxyphenyl)-3-phenylpropan-1-one

Conditions
ConditionsYield
With hydrogen; boric acid; nickel In methanol; waterA 14%
B 38%
(Z)-1-acetoxy-1-(2-acetoxyphenyl)-3-phenylpropene
129218-89-9

(Z)-1-acetoxy-1-(2-acetoxyphenyl)-3-phenylpropene

A

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

B

2-methyl-3-(phenylmethyl)chromone
113344-30-2

2-methyl-3-(phenylmethyl)chromone

C

1-(2-acetoxyphenyl)-3-phenyl-1-propane
113344-28-8

1-(2-acetoxyphenyl)-3-phenyl-1-propane

D

1-(2-acetoxyphenyl)-3-phenyl-1,4-pentanedione
113344-29-9

1-(2-acetoxyphenyl)-3-phenyl-1,4-pentanedione

Conditions
ConditionsYield
In hexane for 6h; Irradiation;A 6%
B 24%
C 32%
D 16%
In hexane for 6h; Mechanism; Irradiation;A 6%
B 24%
C 32%
D 16%
In hexane for 2h; Ambient temperature; Irradiation;A 30%
B 24%
C 6%
D 16%
Flavanone
487-26-3

Flavanone

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
With Penicillium raistrickii CBMAI 931 In aq. phosphate buffer at 32℃; for 168h; pH=7;30%
With sodium hydroxide; palladium on activated charcoal Hydrogenation;
With hydrogen; palladium
Flavanone
487-26-3

Flavanone

A

(E)-2'-hydroxy-chalcone
888-12-0

(E)-2'-hydroxy-chalcone

B

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
With Rhodococcus sp. DSM 364 In acetone at 28℃; for 168h; Microbiological reaction;A 30%
B 13%
Flavanone
487-26-3

Flavanone

A

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

B

1-(2'-hydroxyphenyl)-3-(4-hydroxyphenyl)propan-1-one
24271-94-1

1-(2'-hydroxyphenyl)-3-(4-hydroxyphenyl)propan-1-one

Conditions
ConditionsYield
With Fusarium sp. CBMAI 1830 at 32℃; for 168h;A 6%
B 30%
2'-bromoacetoxy-3-phenylpropiophenone

2'-bromoacetoxy-3-phenylpropiophenone

phosphorous acid trimethyl ester
121-45-9

phosphorous acid trimethyl ester

A

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

B

(2-oxo-4-phenethyl-2H-chromen-3-yl)-phosphonic acid dimethyl ester

(2-oxo-4-phenethyl-2H-chromen-3-yl)-phosphonic acid dimethyl ester

Conditions
ConditionsYield
at 110℃; for 0.5h; Condensation;A n/a
B 29%
1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one
1214-47-7

1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one

A

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

B

1-(2'-hydroxyphenyl)-3-(4-hydroxyphenyl)propan-1-one
24271-94-1

1-(2'-hydroxyphenyl)-3-(4-hydroxyphenyl)propan-1-one

Conditions
ConditionsYield
With Aspergillus sydowii CBMAI 935 In aq. phosphate buffer; dimethyl sulfoxide at 32℃; for 168h; pH=7; Microbiological reaction; chemoselective reaction;A n/a
B 26%
Multi-step reaction with 2 steps
1: potassium hydroxide; L-proline / water / 20 °C
2: Fusarium sp. CBMAI 1830 / 168 h / 32 °C
View Scheme
2-hydroxychalcone
644-78-0

2-hydroxychalcone

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
With sodium hydroxide; palladium on activated charcoal Hydrogenation;
1-(2-methoxyphenyl)-3-phenylpropan-1-one
22618-13-9

1-(2-methoxyphenyl)-3-phenylpropan-1-one

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
With boron trichloride In chloroform
o-hydroxyacetophenone
118-93-4

o-hydroxyacetophenone

benzyl chloride
100-44-7

benzyl chloride

A

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

B

2-benzyl-1-(2-hydroxyphenyl)-3-phenylpropan-1-one
102599-30-4

2-benzyl-1-(2-hydroxyphenyl)-3-phenylpropan-1-one

Conditions
ConditionsYield
With lithium diisopropyl amide 1.) THF, 0 deg C to 25 deg C, 1 h, 2.) THF, -50 deg C to 25 deg C; Yield given. Multistep reaction. Yields of byproduct given;
2'-oxy-chalcone

2'-oxy-chalcone

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
With acetic acid; platinum Hydrogenation;
2-(1-isopropyliminoethyl) phenol
74378-55-5

2-(1-isopropyliminoethyl) phenol

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) LDA / 1.) THF, 0 deg C to 25 deg C, 1 h, 2.) THF, -50 deg C to 25 deg C
2: 89 percent / AcOH / tetrahydrofuran; H2O / 4 h / 40 °C
View Scheme
benzyl chloride
100-44-7

benzyl chloride

sodium-compound of 1-cyclopentyl-ethanone

sodium-compound of 1-cyclopentyl-ethanone

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) LDA / 1.) THF, 0 deg C to 25 deg C, 1 h, 2.) THF, -50 deg C to 25 deg C
2: 89 percent / AcOH / tetrahydrofuran; H2O / 4 h / 40 °C
View Scheme
styrene
100-42-5

styrene

silicon dioxide zirconium dioxide aluminium oxide contacts

silicon dioxide zirconium dioxide aluminium oxide contacts

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 54 percent / N-chlorosuccinimide, pyridine / CHCl3 / 2 h / Heating
2: 14 percent / H2, boric acid / Raney-Ni / methanol; H2O
View Scheme
salicylaldehyde-oxime
94-67-7

salicylaldehyde-oxime

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 54 percent / N-chlorosuccinimide, pyridine / CHCl3 / 2 h / Heating
2: 14 percent / H2, boric acid / Raney-Ni / methanol; H2O
View Scheme
o-hydroxyacetophenone
118-93-4

o-hydroxyacetophenone

p-oxy-acetophenone

p-oxy-acetophenone

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 57 percent / KOH / ethanol; H2O / 10 h / Ambient temperature
2: 801 mg / H2 / Adams catalyst / ethyl acetate / 0.17 h / 2068.6 Torr / Ambient temperature
View Scheme
benzaldehyde
100-52-7

benzaldehyde

aminoguanidine salt

aminoguanidine salt

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 57 percent / KOH / ethanol; H2O / 10 h / Ambient temperature
2: 801 mg / H2 / Adams catalyst / ethyl acetate / 0.17 h / 2068.6 Torr / Ambient temperature
View Scheme
2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

1-(2-hydroxyphenyl)-3-phenyl-1-propanol
20760-12-7

1-(2-hydroxyphenyl)-3-phenyl-1-propanol

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol99%
With lithium aluminium tetrahydride In diethyl ether for 17h; Heating;94%
With sodium tetrahydroborate In methanol Reduction;89%
2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

epichlorohydrin
106-89-8

epichlorohydrin

1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one
22525-95-7

1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one

Conditions
ConditionsYield
With sodium hydroxide for 18h; Reflux;99%
With sodium hydroxide for 12h; Heating;90.6%
for 4h; Reflux;82%
2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

ethylene glycol
107-21-1

ethylene glycol

2-(2-phenethyl-1,3-dioxolan-2-yl)phenol
189766-45-8

2-(2-phenethyl-1,3-dioxolan-2-yl)phenol

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; trimethyl orthoformate In hexane at 40℃; for 72h;99%
With toluene-4-sulfonic acid In benzene for 86h; Heating;62.8%
2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

N-phenyl-N-methylcarbamoyl chloride
4285-42-1

N-phenyl-N-methylcarbamoyl chloride

2-((Z)-3-hydroxy-3-phenylacryloyl)phenyl methylphenylcarbamate

2-((Z)-3-hydroxy-3-phenylacryloyl)phenyl methylphenylcarbamate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 16h;99%
2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

2-(2-(3-phenylpropionyl)-phenoxy)-essigsaeureethylester
157493-96-4

2-(2-(3-phenylpropionyl)-phenoxy)-essigsaeureethylester

Conditions
ConditionsYield
With potassium carbonate In acetone for 24h; Heating;96%
With potassium carbonate In acetone for 24h; Heating;72%
2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

benzyl bromide
100-39-0

benzyl bromide

1-(2-(benzyloxy)phenyl)-3-phenylpropan-1-one

1-(2-(benzyloxy)phenyl)-3-phenylpropan-1-one

Conditions
ConditionsYield
With potassium phosphate; tetrabutylammomium bromide In water at 20℃; for 2h;95%
With potassium carbonate; potassium iodide In acetone at 50℃; for 11h;80%
2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

3-benzyl-4H-1-benzopyran-4-one
30779-85-2

3-benzyl-4H-1-benzopyran-4-one

Conditions
ConditionsYield
In toluene for 5h; Heating;94%
2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

2-(3-phenylpropyl)phenol
1481-90-9

2-(3-phenylpropyl)phenol

Conditions
ConditionsYield
With [(C6H6)(PCy3)(CO)RuH]+*BF4−; hydrogen; phenol In 1,4-dioxane; isopropyl alcohol at 130℃; under 1520.1 Torr; for 8h; Inert atmosphere; Glovebox; Schlenk technique; chemoselective reaction;92%
3-fluorobromobenzene
1073-06-9

3-fluorobromobenzene

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

1-(3'-fluoro-biphenyl-2-yl)-3-phenyl-propan-1-one

1-(3'-fluoro-biphenyl-2-yl)-3-phenyl-propan-1-one

Conditions
ConditionsYield
With bismuth(III) chloride; silver(I) bromide; magnesium; copper(ll) bromide In tetrahydrofuran; toluene at 96℃; for 12h; chemoselective reaction;92%
2-bromophenylacetic acid
4870-65-9

2-bromophenylacetic acid

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

phenylacetic acid
108920-05-4

phenylacetic acid

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran Heating;91%
3-methoxyphenyl bromide
2398-37-0

3-methoxyphenyl bromide

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

1-(3'-methoxy-biphenyl-2-yl)-3-phenyl-propan-1-one

1-(3'-methoxy-biphenyl-2-yl)-3-phenyl-propan-1-one

Conditions
ConditionsYield
With bismuth(III) chloride; silver(I) bromide; magnesium; copper(ll) bromide In tetrahydrofuran; toluene at 96℃; for 12h; chemoselective reaction;91%
2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

(E)-2'-hydroxy-chalcone
888-12-0

(E)-2'-hydroxy-chalcone

Conditions
ConditionsYield
With oxygen; palladium diacetate; trifluoroacetic acid In dimethyl sulfoxide at 80℃; for 9h; Sealed tube;91%
2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

cyanomethyl bromide
590-17-0

cyanomethyl bromide

2-(2-(3-Phenylpropionyl)-phenoxy)-acetonitril

2-(2-(3-Phenylpropionyl)-phenoxy)-acetonitril

Conditions
ConditionsYield
With potassium carbonate In acetone at 50℃; for 96h;88%
1-bromomethyl-1,2-dicarba-closo-dodecaborane(12)
19496-84-5

1-bromomethyl-1,2-dicarba-closo-dodecaborane(12)

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

C18H26B10O2

C18H26B10O2

Conditions
ConditionsYield
With 3-dodecyl-1,2-dimethyl-1H-imidazol-3-ium tetrafluoroborate; triethylamine at 60 - 70℃; for 6h; Reagent/catalyst; Temperature;84%
2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

FLAVONE
525-82-6

FLAVONE

Conditions
ConditionsYield
With palladium(II) trifluoroacetate; 5-Nitro-1,10-phenanthroline; oxygen In dimethyl sulfoxide at 100℃; for 48h; Catalytic behavior; Reagent/catalyst;81%
bromobenzene
108-86-1

bromobenzene

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

1-biphenyl-2-yl-3-phenyl-propan-1-one

1-biphenyl-2-yl-3-phenyl-propan-1-one

Conditions
ConditionsYield
With bismuth(III) chloride; silver(I) bromide; magnesium; copper(ll) bromide In tetrahydrofuran; toluene at 96℃; for 12h; chemoselective reaction;80%
With silver(I) bromide; bismuth(III) chloride; magnesium; copper(ll) bromide In tetrahydrofuran; toluene at 96℃; for 12h;
bromochlorobenzene
106-39-8

bromochlorobenzene

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

1-(4'-chlorobiphenyl-2-yl)-3-phenylpropan-1-one

1-(4'-chlorobiphenyl-2-yl)-3-phenylpropan-1-one

Conditions
ConditionsYield
With bismuth(III) chloride; silver(I) bromide; magnesium; copper(ll) bromide In tetrahydrofuran; toluene at 96℃; for 12h; chemoselective reaction;80%
2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

ethylene dibromide
106-93-4

ethylene dibromide

1-(2-(2-bromoethoxy)phenyl)-3-phenylpropan-1-one

1-(2-(2-bromoethoxy)phenyl)-3-phenylpropan-1-one

Conditions
ConditionsYield
With tetrabutylammomium bromide; potassium carbonate In water; toluene for 144h; Reflux;79%
2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

A

FLAVONE
525-82-6

FLAVONE

B

Flavanone
487-26-3

Flavanone

C

1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one
1214-47-7

1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one

Conditions
ConditionsYield
Stage #1: 2'-hydroxy-3-phenylpropiophenone With palladium(II) trifluoroacetate; copper diacetate In dimethyl sulfoxide at 100℃; for 15h; Inert atmosphere;
Stage #2: With hydrogenchloride In water; dimethyl sulfoxide; ethyl acetate at 100℃; for 24h; Reagent/catalyst; Inert atmosphere;
A 10%
B 79%
C 8%
para-bromotoluene
106-38-7

para-bromotoluene

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

1-(4'-methyl-biphenyl-2-yl)-3-phenyl-propan-1-one

1-(4'-methyl-biphenyl-2-yl)-3-phenyl-propan-1-one

Conditions
ConditionsYield
With bismuth(III) chloride; silver(I) bromide; magnesium; copper(ll) bromide In tetrahydrofuran; toluene at 96℃; for 12h; chemoselective reaction;78%
chloroacetaldehyde dimethyl acetal
97-97-2

chloroacetaldehyde dimethyl acetal

2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

1-(2-(2,2-Dimethoxyethoxy)phenyl)-3-phenyl-1-propanon
161458-29-3

1-(2-(2,2-Dimethoxyethoxy)phenyl)-3-phenyl-1-propanon

Conditions
ConditionsYield
With sodium hydroxide; potassium iodide for 24h; Heating;77%

2'-Hydroxy-3-phenylpropiophenone Chemical Properties

IUPAC Name: 1-(2-Hydroxyphenyl)-3-phenylpropan-1-one
Systematic of 1-Propanone,1-(2-hydroxyphenyl)-3-phenyl- (CAS NO.3516-95-8): EINECS 222-521-4 ; 1-(2-Hydroxyphenyl)-3-phenylpropan-1-one
CAS NO: 3516-95-8
Molecular Formula of 1-Propanone,1-(2-hydroxyphenyl)-3-phenyl- (CAS NO.3516-95-8): C15H14O2
Molecular Weight: 226.2705
Molecular Structure:

Melting Point: 36-37 °C 
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 5
Polar Surface Area: 26.3 Å2
Index of Refraction: 1.6
Molar Refractivity: 67.28 cm3
Molar Volume: 196.6 cm3
Surface Tension: 48.7 dyne/cm
Density of 1-Propanone,1-(2-hydroxyphenyl)-3-phenyl- (CAS NO.3516-95-8): 1.15 g/cm3
Flash Point: 162.7 °C
Enthalpy of Vaporization: 65.39 kJ/mol
Boiling Point: 381.1 °C at 760 mmHg
Vapour Pressure: 2.38E-06 mmHg at 25°C

2'-Hydroxy-3-phenylpropiophenone Uses

  1-Propanone,1-(2-hydroxyphenyl)-3-phenyl- (CAS NO.3516-95-8) is used as oyster preservatives.

2'-Hydroxy-3-phenylpropiophenone Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S37/39: Wear suitable gloves and eye/face protection.
WGK Germany: 3

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